Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouse (original) (raw)

References

  1. Neil, J. C. & Cameron, E. R. Retroviral insertion sites and cancer: fountain of all knowledge? Cancer Cell 2, 253–255 (2002)
    Article CAS Google Scholar
  2. Jonkers, J. & Berns, A. Retroviral insertional mutagenesis as a strategy to identify cancer genes. Biochim. Biophys. Acta 1287, 29–57 (1996)
    PubMed Google Scholar
  3. Ivics, Z., Hackett, P. B., Plasterk, R. H. & Izsvak, Z. Molecular reconstruction of Sleeping Beauty, a Tc1-like transposon from fish, and its transposition in human cells. Cell 91, 501–510 (1997)
    Article CAS Google Scholar
  4. Dupuy, A. J., Fritz, S. & Largaespada, D. A. Transposition and gene disruption in the male germline of the mouse. Genesis 30, 82–88 (2001)
    Article CAS Google Scholar
  5. Horie, K. et al. Efficient chromosomal transposition of a Tc1/_mariner_-like transposon Sleeping Beauty in mice. Proc. Natl Acad. Sci. USA 98, 9191–9196 (2001)
    Article ADS CAS Google Scholar
  6. Fischer, S. E., Wienholds, E. & Plasterk, R. H. Regulated transposition of a fish transposon in the mouse germ line. Proc. Natl Acad. Sci. USA 98, 6759–6764 (2001)
    Article ADS CAS Google Scholar
  7. Yant, S. R. et al. Somatic integration and long-term transgene expression in normal and haemophilic mice using a DNA transposon system. Nature Genet. 25, 35–41 (2000)
    Article CAS Google Scholar
  8. Montini, E. et al. In vivo correction of murine tyrosinemia type I by DNA-mediated transposition. Mol. Ther. 6, 759–769 (2002)
    Article CAS Google Scholar
  9. Abdallah, B. et al. A powerful nonviral vector for in vivo gene transfer into the adult mammalian brain: polyethylenimine. Hum. Gene Ther. 7, 1947–1954 (1996)
    Article CAS Google Scholar
  10. Hawley, R. G., Lieu, F. H., Fong, A. Z. & Hawley, T. S. Versatile retroviral vectors for potential use in gene therapy. Gene Ther. 1, 136–138 (1994)
    CAS PubMed Google Scholar
  11. Cherry, S. R., Biniszkiewicz, D., van Parijs, L., Baltimore, D. & Jaenisch, R. Retroviral expression in embryonic stem cells and hematopoietic stem cells. Mol. Cell. Biol. 20, 7419–7426 (2000)
    Article CAS Google Scholar
  12. Okabe, M., Ikawa, M., Kominami, K., Nakanishi, T. & Nishimune, Y. ‘Green mice’ as a source of ubiquitous green cells. FEBS Lett. 407, 313–319 (1997)
    Article CAS Google Scholar
  13. Kamijo, T. et al. Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF. Cell 91, 649–659 (1997)
    Article CAS Google Scholar
  14. Kamijo, T., Bodner, S., van de Kamp, E., Randle, D. H. & Sherr, C. J. Tumor spectrum in _ARF_-deficient mice. Cancer Res. 59, 2217–2222 (1999)
    CAS PubMed Google Scholar
  15. Wu, X., Li, Y., Crise, B. & Burgess, S. M. Transcription start regions in the human genome are favored targets for MLV integration. Science 300, 1749–1751 (2003)
    Article ADS CAS Google Scholar
  16. Vigdal, T. J., Kaufman, C. D., Izsvak, Z., Voytas, D. F. & Ivics, Z. Common physical properties of DNA affecting target site selection of sleeping beauty and other Tc1/mariner transposable elements. J. Mol. Biol. 323, 441–452 (2002)
    Article CAS Google Scholar
  17. Carlson, C. M. et al. Transposon mutagenesis of the mouse germline. Genetics 165, 243–256 (2003)
    CAS PubMed PubMed Central Google Scholar
  18. Horie, K. et al. Characterization of Sleeping Beauty transposition and its application to genetic screening in mice. Mol. Cell. Biol. 23, 9189–9207 (2003)
    Article CAS Google Scholar
  19. Mikkers, H. et al. High-throughput retroviral tagging to identify components of specific signalling pathways in cancer. Nature Genet. 32, 153–159 (2002)
    Article CAS Google Scholar
  20. Johansson, F. K. et al. Identification of candidate cancer-causing genes in mouse brain tumors by retroviral tagging. Proc. Natl Acad. Sci. USA 101, 11334–11337 (2004)
    Article ADS CAS Google Scholar
  21. Dupuy, A. J., Akagi, K., Largaespada, D. A., Copeland, N. G. & Jenkins, N. A. Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system. Nature doi:10.1038/nature03691 (this issue)
  22. Akagi, K., Suzuki, T., Stephens, R. M., Jenkins, N. A. & Copeland, N. G. RTCGD: retroviral tagged cancer gene database. Nucleic Acids Res. 32, D523–D527 (2004)
    Article CAS Google Scholar
  23. Lund, A. H. et al. Genome-wide retroviral insertional tagging of genes involved in cancer in _Cdkn2a_-deficient mice. Nature Genet. 32, 160–165 (2002)
    Article CAS Google Scholar
  24. Davies, H. et al. Mutations of the BRAF gene in human cancer. Nature 417, 949–954 (2002)
    Article ADS CAS Google Scholar
  25. Seidel, C. et al. Alterations of cancer-related genes in soft tissue sarcomas: hypermethylation of RASSF1A is frequently detected in leiomyosarcoma and associated with poor prognosis in sarcoma. Int. J. Cancer 114, 442–447 (2005)
    Article CAS Google Scholar
  26. Heidecker, G. et al. Mutational activation of _c_-_raf_-1 and definition of the minimal transforming sequence. Mol. Cell. Biol. 10, 2503–2512 (1990)
    Article CAS Google Scholar
  27. Geurts, A. M. et al. Gene transfer into genomes of human cells by the Sleeping Beauty transposon system. Mol. Ther. 8, 108–117 (2003)
    Article CAS Google Scholar

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