Studnicka, F. K. in Lehrbuch der vergleichende mikroskopischen Anatomie der Wirbeltiere (ed. Oppel, A.) 1–256 (Fischer, Germany, 1905). Google Scholar
Levi-Montalcini, R. The nerve growth factor: its mode of action on sensory and sympathetic nerve cells. Harvey Lect.60, 217–259 (1966). CASPubMed Google Scholar
Lockshin, R. A. & Williams, C. M. Programmed cell death. II. Endocrine potentiation of the breakdown of the intersegmental muscles of silkmoths. J. Insect Physiol.10, 643–649 (1964). ArticleCAS Google Scholar
Kerr, J. F., Wyllie, A. H. & Currie, A. R. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer26, 239–257 (1972). ArticleCAS Google Scholar
Clarke, P. G. Developmental cell death: morphological diversity and multiple mechanisms. Anat. Embryol.181, 195–213 (1990). ArticleCAS Google Scholar
Cunningham, T. J. Naturally occurring neuron death and its regulation by developing neural pathways. Int. Rev. Cytol.74, 163–186 (1982). ArticleCAS Google Scholar
Dal Canto, M. C. & Gurney, M. E. Development of central nervous system pathology in a murine transgenic model of human amyotrophic lateral sclerosis. Am. J. Pathol.145, 1271–1279 (1994). CASPubMedPubMed Central Google Scholar
Schweichel, J. U. & Merker, H. J. The morphology of various types of cell death in prenatal tissues. Teratology7, 253–266 (1973). ArticleCAS Google Scholar
Sperandio, S., de Belle, I. & Bredesen, D. E. An alternative, non-apoptotic form of programmed cell death. Proc. Natl Acad. Sci. USA97, 14376–14381 (2000). ArticleADSCAS Google Scholar
Oppenheim, R. W. Naturally occurring cell death during neural development. Trends Neurosci.17, 487–493 (1985). Article Google Scholar
Fadok, V. A. et al. Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. J. Immunol.148, 2207–2216 (1992). CASPubMed Google Scholar
Thornberry, N. A. & Lazebnik, Y. Caspases: enemies within. Science281, 1312–1316 (1998). ArticleCAS Google Scholar
Yuan, J., Shaham, S., Ledoux, S., Ellis, H. M. & Horvitz, H. R. The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme. Cell75, 641–652 (1993). ArticleCAS Google Scholar
Salvesen, G. S. & Dixit, V. M. Caspases: intracellular signaling by proteolysis. Cell91, 443–446 (1997). ArticleCAS Google Scholar
Morishima, N., Nakanishi, K., Takenouchi, H., Shibata, T. & Yasuhiko, Y. An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12. J. Biol. Chem.277, 34287–34294 (2002). ArticleCAS Google Scholar
Rao, R. V. et al. Coupling endoplasmic reticulum stress to the cell death program. An Apaf-1-independent intrinsic pathway. J. Biol. Chem.277, 21836–21842 (2002). ArticleCAS Google Scholar
Yuan, J. & Yankner, B. A. Caspase activity sows the seeds of neuronal death. Nature Cell Biol.1, E44–E45 (1999). ArticleCAS Google Scholar
Green, D. R. & Kroemer, G. Pharmacological manipulation of cell death: clinical applications in sight? J. Clin. Invest.115, 2610–2617 (2005). ArticleCAS Google Scholar
Fuentes-Prior, P. & Salvesen, G. S. The protein structures that shape caspase activity, specificity, activation and inhibition. Biochem. J.384, 201–232 (2004). ArticleCAS Google Scholar
Kopito, R. R. & Ron, D. Conformational disease. Nature Cell Biol.2, E207–E209 (2000). ArticleCAS Google Scholar
Taylor, J. P., Hardy, J. & Fischbeck, K. H. Toxic proteins in neurodegenerative disease. Science296, 1991–1995 (2002). ArticleADSCAS Google Scholar
Sitia, R. & Braakman, I. Quality control in the endoplasmic reticulum protein factory. Nature426, 891–894 (2003). ArticleADSCAS Google Scholar
Sherman, M. Y. & Goldberg, A. L. Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases. Neuron29, 15–32 (2001). ArticleCAS Google Scholar
Rao, R. V. & Bredesen, D. E. Misfolded proteins, endoplasmic reticulum stress and neurodegeneration. Curr. Opin. Cell Biol.16, 653–662 (2004). ArticleCAS Google Scholar
Scorrano, L. et al. BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis. Science300, 135–139 (2003). ArticleADSCAS Google Scholar
Ruiz-Vela, A., Opferman, J. T., Cheng, E. H. & Korsmeyer, S. J. Proapoptotic BAX and BAK control multiple initiator caspases. EMBO Rep.6, 379–385 (2005). ArticleCAS Google Scholar
Chae, H. J. et al. BI-1 regulates an apoptosis pathway linked to endoplasmic reticulum stress. Mol. Cell15, 355–366 (2004). ArticleCAS Google Scholar
Li, J., Lee, B. & Lee, A. S. Endoplasmic reticulum stress-induced apoptosis: multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53. J. Biol. Chem.281, 7260–7270 (2006). ArticleCAS Google Scholar
Hegde, R. S. et al. A transmembrane form of the prion protein in neurodegenerative disease. Science279, 827–834 (1998). ArticleADSCAS Google Scholar
Levine, B. & Yuan, J. Autophagy in cell death: an innocent convict? J. Clin. Invest.115, 2679–2688 (2005). ArticleCAS Google Scholar
Komatsu, M. et al. Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J. Cell Biol.169, 425–434 (2005). ArticleCAS Google Scholar
Yue, Z., Jin, S., Yang, C., Levine, A. J. & Heintz, N. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc. Natl Acad. Sci. USA100, 15077–15082 (2003). ArticleADSCAS Google Scholar
Shimizu, S. et al. Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. Nature Cell Biol.6, 1221–1228 (2004). ArticleCAS Google Scholar
Yu, L. et al. Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8. Science304, 1500–1502 (2004). ArticleADSCAS Google Scholar
Yu, L. et al. Autophagic programmed cell death by selective catalase degradation. Proc. Natl Acad. Sci. USA103, 4952–4957 (2006). ArticleADSCAS Google Scholar
Gomez-Santos, C. et al. Dopamine induces autophagic cell death and α-synuclein increase in human neuroblastoma SH-SY5Y cells. J. Neurosci. Res.73, 341–350 (2003). ArticleCAS Google Scholar
Sperandio, S. et al. Paraptosis: mediation by MAP kinases and inhibition by AIP-1/Alix. Cell Death Differ.11, 1066–1075 (2004). ArticleCAS Google Scholar
Koh, J. Y., Gwag, B. J., Lobner, D. & Choi, D. W. Potentiated necrosis of cultured cortical neurons by neurotrophins. Science268, 573–575 (1995). ArticleADSCAS Google Scholar
Formigli, L. et al. Aponecrosis: morphological and biochemical exploration of a syncretic process of cell death sharing apoptosis and necrosis. J. Cell Physiol.182, 41–49 (2000). ArticleCAS Google Scholar
Ankarcrona, M. et al. Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron15, 961–973 (1995). ArticleCAS Google Scholar
Syntichaki, P., Xu, K., Driscoll, M. & Tavernarakis, N. Specific aspartyl and calpain proteases are required for neurodegeneration in C. elegans. Nature419, 939–944 (2002). ArticleADSCAS Google Scholar
Yu, S. W. et al. Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor. Science297, 259–263 (2002). ArticleADSCAS Google Scholar
Susin, S. A. et al. Molecular characterization of mitochondrial apoptosis-inducing factor. Nature397, 441–446 (1999). ArticleADSCAS Google Scholar
Liu, X., Van Vleet, T. & Schnellmann, R. G. The role of calpain in oncotic cell death. Annu. Rev. Pharmacol. Toxicol.44, 349–370 (2004). ArticleCAS Google Scholar
Galvan, V. et al. Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664. Proc. Natl Acad. Sci. USA103, 7130–7135 (2006). ArticleADSCAS Google Scholar
Graham, R. K. et al. Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin. Cell125, 1179–1191 (2006). ArticleCAS Google Scholar
Yang, F. et al. Antibody to caspase-cleaved actin detects apoptosis in differentiated neuroblastoma and plaque-associated neurons and microglia in Alzheimer's disease. Am. J. Pathol.152, 379–389 (1998). CASPubMedPubMed Central Google Scholar
Friedlander, R. M., Brown, R. H., Gagliardini, V., Wang, J. & Yuan, J. Inhibition of ICE slows ALS in mice. Nature388, 31 (1997). ArticleADSCAS Google Scholar
Ona, V. O. et al. Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease. Nature399, 263–267 (1999). ArticleADSCAS Google Scholar
Kostic, V., Jackson-Lewis, V., de Bilbao, F., Dubois-Dauphin, M. & Przedborski, S. Bcl-2: prolonging life in a transgenic mouse model of familial amyotrophic lateral sclerosis. Science277, 559–562 (1997). ArticleCAS Google Scholar
Friedlander, R. M. Apoptosis and caspases in neurodegenerative diseases. N. Engl. J. Med.348, 1365–1375 (2003). ArticleCAS Google Scholar
Jin, K. et al. FGF-2 promotes neurogenesis and neuroprotection and prolongs survival in a transgenic mouse model of Huntington's disease. Proc. Natl Acad. Sci. USA102, 18189–18194 (2005). ArticleADSCAS Google Scholar
Tuszynski, M. H. et al. A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease. Nature Med.11, 551–555 (2005). ArticleCAS Google Scholar
Lang, A. E. et al. Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease. Ann. Neurol.59, 459–466 (2006). ArticleCAS Google Scholar
Kordower, J. H., Isacson, O. & Emerich, D. F. Cellular delivery of trophic factors for the treatment of Huntington's disease: is neuroprotection possible? Exp. Neurol.159, 4–20 (1999). ArticleCAS Google Scholar
Borrell-Pages, M. et al. Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase. J. Clin. Invest.116, 1410–1424 (2006). ArticleCAS Google Scholar
Kerr, J. F. R. & Harmon, B. V. in Apoptosis: The Molecular Basis of Cell Death (eds Tomei, L. D. & Cope, F. O.) 321 (Cold Spring Harbor Laboratory Press, Plainview, New York, 1991). Google Scholar
Bursch, W. et al. Autophagic and apoptotic types of programmed cell death exhibit different fates of cytoskeletal filaments. J. Cell Sci.113, 1189–1198 (2000). CASPubMed Google Scholar
Hall, I. H., Elkins, A. L., Karthikeyan, S. & Spielvogel, B. F. The cytotoxicity of 1-(phenylmethyl)-4,7,10-tris-[(4'methylphenyl) sulfonyl]-1,4,7,10-tetraazacyclododecane in human Tmolt3 T leukemic cells. Anticancer Res.17, 1195–1198 (1997). CASPubMed Google Scholar
Susin, S. A. et al. Two distinct pathways leading to nuclear apoptosis. J. Exp. Med.192, 571–580 (2000). ArticleADSCAS Google Scholar
Ohno, M. et al. 'Apoptotic' myocytes in infarct area in rabbit hearts may be oncotic myocytes with DNA fragmentation: analysis by immunogold electron microscopy combined with in situ nick end-labeling. Circulation98, 1422–1430 (1998). ArticleCAS Google Scholar
Muzio, M. et al. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex. Cell85, 817–827 (1996). ArticleCAS Google Scholar
Kuwana, T. et al. Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane. Cell111, 331–342 (2002). ArticleCAS Google Scholar
Guo, B. et al. Humanin peptide suppresses apoptosis by interfering with Bax activation. Nature423, 456–461 (2003). ArticleADSCAS Google Scholar
Schuler, M., Bossy-Wetzel, E., Goldstein, J. C., Fitzgerald, P. & Green, D. R. p53 induces apoptosis by caspase activation through mitochondrial cytochrome c release. J. Biol. Chem.275, 7337–7342 (2000). ArticleCAS Google Scholar
Lin, B. et al. Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3. Cell116, 527–540 (2004). ArticleCAS Google Scholar
Deveraux, Q. L., Takahashi, R., Salvesen, G. S. & Reed, J. C. X-linked IAP is a direct inhibitor of cell-death proteases. Nature388, 300–304 (1997). ArticleADSCAS Google Scholar
Holley, C. L., Olson, M. R., Colon-Ramos, D. A. & Kornbluth, S. Reaper eliminates IAP proteins through stimulated IAP degradation and generalized translational inhibition. Nature Cell Biol.4, 439–444 (2002). ArticleCAS Google Scholar
Du, C., Fang, M., Li, Y., Li, L. & Wang, X. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell102, 33–42 (2000). ArticleCAS Google Scholar
Verhagen, A. M. et al. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. Cell102, 43–53 (2000). ArticleCAS Google Scholar
Martins, L. M. et al. The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif. J. Biol. Chem.277, 439–444 (2002). ArticleCAS Google Scholar
Bossy-Wetzel, E., Barsoum, M. J., Godzik, A., Schwarzenbacher, R. & Lipton, S. A. Mitochondrial fission in apoptosis, neurodegeneration and aging. Curr. Opin. Cell Biol.15, 706–716 (2003). ArticleCAS Google Scholar
Lee, Y. J., Jeong, S. Y., Karbowski, M., Smith, C. L. & Youle, R. J. Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis. Mol. Biol. Cell.15, 5001–5011 (2004). ArticleCAS Google Scholar
Frezza, C. et al. OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion. Cell126, 177–189 (2006). ArticleCAS Google Scholar
Cipolat, S. et al. Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling. Cell126, 163–175 (2006). ArticleCAS Google Scholar
Ng, F. W. et al. p28 Bap31, a Bcl-2/Bcl-XL- and procaspase-8-associated protein in the endoplasmic reticulum. J. Cell Biol.139, 327–338 (1997). ArticleCAS Google Scholar
Breckenridge, D. G., Stojanovic, M., Marcellus, R. C. & Shore, G. C. Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol. J. Cell Biol.160, 1115–1127 (2003). ArticleCAS Google Scholar
Roth, W. et al. Bifunctional apoptosis inhibitor (BAR) protects neurons from diverse cell death pathways. Cell Death Differ.10, 1178–1187 (2003). ArticleCAS Google Scholar
Mahul-Mellier, A. L., Hemming, F. J., Blot, B., Fraboulet, S. & Sadoul, R. Alix, making a link between apoptosis-linked gene-2, the endosomal sorting complexes required for transport, and neuronal death in vivo. J. Neurosci.26, 542–549 (2006). ArticleCAS Google Scholar