LNA-mediated microRNA silencing in non-human primates (original) (raw)

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ArrayExpress

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The microarray data have been submitted to the ArrayExpress database under accession number E-MEXP-1406.

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Acknowledgements

All primate studies were performed at the St Kitts Biomedical Research Foundation, St Kitts, West Indies. We thank A. Konge, A. Koustrup, B. Nordbo, H. W. Høvring, J. J. Jørgensen, K. R. Nielsen, L. Bang, H. Brostrøm, O. Olsen, R. Sølberg, U. Steinmeier, J. Staruk, C. Kent, E. Nisbett, M. Struharik and R. Valles for technical assistance. This study was supported by grants from the Danish National Advanced Technology Foundation, the Danish Medical Research Council and the Lundbeck Foundation (to S.K.) and by grants from the National Institutes of Health (to P.S.). The Wilhelm Johannsen Centre for Functional Genome Research was established by the Danish National Research Foundation.

Author Contributions J.E. and M. Lindow contributed equally to this study. J.E., M. Lindow, M. Lawrence, U.B., S.O., M.H., A.P., S.S. and E.M.S. performed experiments and contributed data. H.F.H. performed the synthesis of all oligonucleotides. J.E., M. Lindow, M. Lawrence, M. Lindholm, H.F.H., P.K., S.G., P.S., E.M.S. and S.K. designed experiments and discussed the data. S.K. supervised the study and wrote the paper together with J.E. and M. Lindow.

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Author notes

  1. Joacim Elmén and Morten Lindow: These authors contributed equally to this work.

Authors and Affiliations

  1. Santaris Pharma, Bøge Allé 3, DK-2970 Hørsholm, Denmark,
    Joacim Elmén, Morten Lindow, Andreas Petri, Susanna Obad, Marie Lindholm, Maj Hedtjärn, Henrik Frydenlund Hansen, Phil Kearney, Ellen Marie Straarup & Sakari Kauppinen
  2. Department of Microbiology and Immunology, 299 Campus Drive, Stanford University School of Medicine, Stanford, California 94305, USA,
    Sylvia Schütz & Peter Sarnow
  3. RxGen Inc, 100 Deepwood Drive, Hamden, Connecticut 06517, USA,
    Matthew Lawrence & Steven Gullans
  4. UB-in situ, PO Box 463, Natick, Massachusetts 01760, USA,
    Urs Berger
  5. Department of Cellular and Molecular Medicine, Wilhelm Johannsen Centre for Functional Genome Research, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark,
    Sakari Kauppinen

Authors

  1. Joacim Elmén
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  2. Morten Lindow
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  3. Sylvia Schütz
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  4. Matthew Lawrence
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  5. Andreas Petri
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  6. Susanna Obad
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  7. Marie Lindholm
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  8. Maj Hedtjärn
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  9. Henrik Frydenlund Hansen
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  10. Urs Berger
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  11. Steven Gullans
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  12. Phil Kearney
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  13. Peter Sarnow
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  14. Ellen Marie Straarup
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  15. Sakari Kauppinen
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Corresponding author

Correspondence toSakari Kauppinen.

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Competing interests

J.E., M. Lindow, A.P., S.O., M. Lindholm, M.H., H.F.H., P.K., E.M.S. and S.K. are employees of Santaris Pharma, a clinical stage biopharmaceutical company that develops RNA-based therapeutics.

Supplementary information

Supplementary Information 1

The file contains extensive Supplementary Information detailing the primate study and the data collected. (PDF 2781 kb)

Supplementary Information 2

The file contains Supplementary Figures 1-4 with Legends and Supplementary Methods. (PDF 5183 kb)

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Elmén, J., Lindow, M., Schütz, S. et al. LNA-mediated microRNA silencing in non-human primates.Nature 452, 896–899 (2008). https://doi.org/10.1038/nature06783

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