Large recurrent microdeletions associated with schizophrenia (original) (raw)

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Acknowledgements

We want to thank the subjects and their relatives and staff at the recruitment centres. This work was sponsored by EU grant LSHM-CT-2006-037761 (Project SGENE), Simons Foundation and R01MH71425-01A1. Genotyping of the Dutch samples was sponsored by NIMH funding, R01 MH078075. This work was also supported by the Chinese National Natural Science Foundation and the National Genomic Network (NGFN-2) of the German Federal Ministry of Education and Research (BMBF). M.M.N. received support from the Alfried Krupp von Bohlen und Halbach-Stiftung. We are grateful to S. Schreiber and M. Krawczak for providing genotype data for PopGen controls, and to K.-H. Jöckel and R. Erbel for providing control individuals from the Heinz Nixdorf Recall Study. We thank L. Priebe and M. Alblas for technical assistance and analysis of CNV data from Bonn.

Author Contributions H.S., D.R., E.S., D.C., L.P., D.S.C. and K.S. wrote the first draft of the paper. M.H., B.B.M., K.D.J., P.M., I.G., H.-J.M., A.H., A.C.N., C.C., G.F., N.W., J.L., J.S., A.T., T.T., E.B., M.D.F., R.M., M.R, S.T., M.W., T.L., C.V., T.W.M., A.G.W., H.U., S.D., I.M., J.O., O.A.A., A.G., M.R., R.O., J.B., R.S.K., L.A.K. and B.F. recruited, diagnosed and gathered phenotypes. H.S., D.R., R.F., E.S., T.S., C.F., P.M., T.T, J.R.G., U.T., H.P., D.G., T.W., D.C., L.P., D.S.C. and K.S. planned, supervised and coordinated the work. H.S., S.C., A.I., S.S., A.G., T.E.T., O.P.H.P., B.V.H., D.G., K.V.S., M.M.N., T.H. and A.K. analysed the data. A.S., A.J., A.J., A.B., S.M. and T.B. performed genotyping and experimental work. All authors contributed to the current version of the paper.

Author information

Author notes

  1. Hreinn Stefansson, Dan Rujescu and Sven Cichon: These authors contributed equally to this work.

Authors and Affiliations

  1. CNS Division, deCODE genetics, Sturlugata 8, IS-101 Reykjavík, Iceland,
    Hreinn Stefansson, Andres Ingason, Stacy Steinberg, Ragnheidur Fossdal, Arnaldur Gylfason, Bjarni V. Halldorsson, Daniel Gudbjartsson, Thorgeir E. Thorgeirsson, Asgeir Sigurdsson, Adalbjorg Jonasdottir, Aslaug Jonasdottir, Asgeir Bjornsson, Sigurborg Mattiasdottir, Thorarinn Blondal, Jeffrey R. Gulcher, Unnur Thorsteinsdottir, Augustine Kong & Kari Stefansson
  2. Division of Molecular and Clinical Neurobiology, Department of Psychiatry, Genetics Research Centre, Ludwig-Maximilians-University, Nußbaumstrasse 7, 80336 Munich, Germany,
    Dan Rujescu, Ina Giegling, Hans-Jürgen Möller & Annette Hartmann
  3. Department of Genomics, Life & Brain Center, University of Bonn, Sigmund-Freud-Strasse 25, D-53127 Bonn, Germany,
    Sven Cichon, Catalina Vasilescu, Thomas W. Mühleisen & Markus M. Nöthen
  4. Institute of Human Genetics, University of Bonn, Wilhelmstrasse 31, D-53111 Bonn, Germany ,
    Sven Cichon & Markus M. Nöthen
  5. Department for Molecular Medicine, National Public Health Institute, Biomedicum, Haartmaninkatu 8, 00290 Helsinki, Finland,
    Olli P. H. Pietiläinen, Tiina Paunio & Leena Peltonen
  6. Department of Psychiatry, National University Hospital, Hringbraut, 101 Reykjavík, Iceland,
    Engilbert Sigurdsson, Thordur Sigmundsson, Magnus Haraldsson, Brynja B. Magnusdottir & Hannes Petursson
  7. The Netherlands Department of Medical Genetics and Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands,
    Jacobine E. Buizer-Voskamp & Roel A. Ophoff
  8. Research Institute of Biological Psychiatry, Mental Health Centre Sct. Hans Copenhagen University Hospital, DK-4000 Roskilde, Denmark
    Thomas Hansen, Klaus D. Jakobsen & Thomas Werge
  9. Centre for Pharmacogenomics, University of Copenhagen, DK-2200 Copenhagen N, Denmark
    Thomas Hansen & Klaus D. Jakobsen
  10. Medical Genetics, GlaxoSmithKline R&D, Via A. Fleming 4, 37135 Verona, Italy ,
    Pierandrea Muglia & Clyde Francks
  11. Clinical Imaging Centre, Clinical Pharmacology and Discovery Medicine, GlaxoSmithKline, Hammersmith Hospital, London W12 ONN, UK ,
    Paul M. Matthews
  12. Institute for Genome Sciences & Policy, Center for Population Genomics & Pharmacogenetics, 4011 GSRB II 103 Research Drive, Duke University, DUMC Box 3471, Durham, North Carolina 27708, USA ,
    Kevin V. Shianna, Dongliang Ge, Anna C. Need & David B. Goldstein
  13. Department of Mental Health, University of Aberdeen, Royal Cornhill Hospital, Aberdeen AB25 2ZD, UK
    Caroline Crombie, Gillian Fraser & David St Clair
  14. Ravenscraig hospital, Inverkip Road, Greenock PA16 9HA, UK ,
    Nicholas Walker
  15. Department of Mental Health and Addiction, National Public Health Institute, Mannerheimintie 166, FIN-00300 Helsinki, Finland,
    Jouko Lonnqvist, Jaana Suvisaari, Annamarie Tuulio-Henriksson & Tiina Paunio
  16. Division of Psychological Medicine and Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King’s College, London SE5 8AF, UK
    Timi Toulopoulou, Elvira Bramon, Marta Di Forti, Robin Murray, Evangelos Vassos, Muriel Walshe, Tao Li & David A. Collier
  17. Section of Psychiatry and Clinical Psychology, University of Verona, Verona, 37134 Verona, Italy ,
    Mirella Ruggeri & Sarah Tosato
  18. Department of Psychiatry, Psychiatric Laboratory, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China,
    Tao Li & David A. Collier
  19. Department of Clinical Immunology, Copenhagen University Hospital, DK-2200 Copenhagen N, Denmark
    August G. Wang
  20. Mental Health Centre Amager, Copenhagen University Hospital, DK-2300 Copenhagen S, Denmark
    Henrik Ullum
  21. Institute of Psychiatry, University of Oslo, PO Box 1130, Blindern, N-0318 Oslo, Norway ,
    Srdjan Djurovic & Ole A. Andreassen
  22. Departments of Medical Genetics and Psychiatry, Ulleval University Hospital, Kirkeveien 166, N-0407 Oslo, Norway,
    Srdjan Djurovic, Ingrid Melle & Ole A. Andreassen
  23. Department of Neurology, 57 Nordre Ringvej, Glostrup Hospital, Glostrup, DK-2600 Copenhagen, Denmark,
    Jes Olesen
  24. Department of Epidemiology & Biostatistics (133 EPIB)/Department of Urology (659 URO), Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands,
    Lambertus A. Kiemeney
  25. Department of Human Genetics, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands,
    Barbara Franke
  26. Departments of Human Genetics and Statistics, UCLA, 695 Charles Young Drive South, Los Angeles, California 90095, USA,
    Chiara Sabatti
  27. UCLA Center for Neurobehavioral Genetics, Charles E. Young Drive South, Los Angeles, California 90024, USA ,
    Nelson B. Freimer & Roel A. Ophoff
  28. Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, J5, D-68159 Mannheim, Germany,
    Alexander Georgi & Marcella Rietschel
  29. Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK ,
    Leena Peltonen
  30. The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA ,
    Leena Peltonen
  31. University of Iceland, School of Medicine, Sturlugata 8, 101 Reykjavik, Iceland ,
    Kari Stefansson
  32. Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.,
    René S. Kahn & Wiepke Cahn
  33. Department of Psychiatry, Academic Medical Centre University of Amsterdam, Amsterdam, The Netherlands.,
    Don H. Linszen & Lieuwe de Haan
  34. Maastricht University Medical Centre, South Limburg Mental Health Research and Teaching Network, Maastricht, The Netherlands.,
    Jim van Os, Lydia Krabbendam & Inez Myin-Germeys
  35. Department of Psychiatry, University Medical Centre Groningen, University of Groningen, The Netherlands.,
    Richard Bruggeman

Authors

  1. Hreinn Stefansson
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  2. Dan Rujescu
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  3. Sven Cichon
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  4. Olli P. H. Pietiläinen
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  5. Andres Ingason
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  6. Stacy Steinberg
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  7. Ragnheidur Fossdal
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  8. Engilbert Sigurdsson
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  9. Thordur Sigmundsson
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  10. Jacobine E. Buizer-Voskamp
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  11. Thomas Hansen
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  12. Klaus D. Jakobsen
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  13. Pierandrea Muglia
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  14. Clyde Francks
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  15. Paul M. Matthews
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  18. Asgeir Sigurdsson
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  20. Aslaug Jonasdottir
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  21. Asgeir Bjornsson
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  22. Sigurborg Mattiasdottir
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  23. Thorarinn Blondal
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  43. Mirella Ruggeri
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  48. Catalina Vasilescu
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  49. Thomas W. Mühleisen
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  50. August G. Wang
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  51. Henrik Ullum
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Correspondence toDavid St Clair or Kari Stefansson.

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K.S. and J.R.G. are CEO and CSO, respectively, of deCODE genetics and hold equity positions in the company.

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The authors declare competing financial interests: details accompany the full-text HTML version of the paper at www.nature.com/nature.

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Stefansson, H., Rujescu, D., Cichon, S. et al. Large recurrent microdeletions associated with schizophrenia.Nature 455, 232–236 (2008). https://doi.org/10.1038/nature07229

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