Histone H4 lysine 16 acetylation regulates cellular lifespan (original) (raw)

• Collado, M., Blasco, M. A. & Serrano, M. Cellular senescence in cancer and aging. Cell 130, 223–233 (2007)
  Article CAS Google Scholar
• Herbig, U. et al. Cellular senescence in aging primates. Science 311, 1257 (2006)
  Article CAS Google Scholar
• Mair, W. & Dillin, A. Aging and survival: the genetics of life span extension by dietary restriction. Annu. Rev. Biochem. 77, 727–754 (2008)
  Article CAS Google Scholar
• Guarente, L. & Kenyon, C. Genetic pathways that regulate ageing in model organisms. Nature 408, 255–262 (2000)
  Article ADS CAS Google Scholar
• Fraga, M. F. & Esteller, M. Epigenetics and aging: the targets and the marks. Trends Genet. 23, 413–418 (2007)
  Article CAS Google Scholar
• Oberdoerffer, P. & Sinclair, D. A. The role of nuclear architecture in genomic instability and ageing. Nature Rev. Mol. Cell Biol. 8, 692–702 (2007)
  Article CAS Google Scholar
• Krishnamoorthy, T. et al. Phosphorylation of histone H4 Ser1 regulates sporulation in yeast and is conserved in fly and mouse spermatogenesis. Genes Dev. 20, 2580–2592 (2006)
  Article CAS Google Scholar
• Longo, V. D. & Kennedy, B. K. Sirtuins in aging and age-related disease. Cell 126, 257–268 (2006)
  Article CAS Google Scholar
• Moazed, D. Enzymatic activities of Sir2 and chromatin silencing. Curr. Opin. Cell Biol. 13, 232–238 (2001)
  Article CAS Google Scholar
• Kimura, A., Umehara, T. & Horikoshi, M. Chromosomal gradient of histone acetylation established by Sas2p and Sir2p functions as a shield against gene silencing. Nature Genet. 32, 370–377 (2002)
  Article Google Scholar
• Suka, N., Luo, K. & Grunstein, M. Sir2p and Sas2p opposingly regulate acetylation of yeast histone H4 lysine16 and spreading of heterochromatin. Nature Genet. 32, 378–383 (2002)
  Article CAS Google Scholar
• Sinclair, D. A. & Guarente, L. Extrachromosomal rDNA circles–a cause of aging in yeast. Cell 91, 1033–1042 (1997)
  Article CAS Google Scholar
• Kaeberlein, M., McVey, M. & Guarente, L. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev. 13, 2570–2580 (1999)
  Article CAS Google Scholar
• Johzuka, K. & Horiuchi, T. Replication fork block protein, Fob1, acts as an rDNA region specific recombinator in S. cerevisiae . Genes Cells 7, 99–113 (2002)
  Article CAS Google Scholar
• Defossez, P. A. et al. Elimination of replication block protein Fob1 extends the life span of yeast mother cells. Mol. Cell 3, 447–455 (1999)
  Article CAS Google Scholar
• Johnson, F. B., Sinclair, D. A. & Guarente, L. Molecular biology of aging. Cell 96, 291–302 (1999)
  Article CAS Google Scholar
• Laun, P. et al. Yeast mother cell-specific ageing, genetic (in)stability, and the somatic mutation theory of ageing. Nucleic Acids Res. 35, 7514–7526 (2007)
  Article CAS Google Scholar
• Lin, Y. Y. et al. Protein acetylation microarray reveals that NuA4 controls key metabolic target regulating gluconeogenesis. Cell 136, 1073–1084 (2009)
  Article CAS Google Scholar
• Kouzarides, T. Acetylation: a regulatory modification to rival phosphorylation? EMBO J. 19, 1176–1179 (2000)
  Article CAS Google Scholar
• Glozak, M. A. & Seto, E. Histone deacetylases and cancer. Oncogene 26, 5420–5432 (2007)
  Article CAS Google Scholar
• Haigis, M. C. & Guarente, L. P. Mammalian sirtuins–emerging roles in physiology, aging, and calorie restriction. Genes Dev. 20, 2913–2921 (2006)
  Article CAS Google Scholar
• Michishita, E. et al. SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature 452, 492–496 (2008)
  Article ADS CAS Google Scholar
• Saunders, L. R. & Verdin, E. Sirtuins: critical regulators at the crossroads between cancer and aging. Oncogene 26, 5489–5504 (2007)
  Article CAS Google Scholar
• Smeal, T. et al. Loss of transcriptional silencing causes sterility in old mother cells of S. cerevisiae . Cell 84, 633–642 (1996)
  Article CAS Google Scholar
• Xu, F. et al. Sir2 deacetylates histone H3 lysine 56 to regulate telomeric heterochromatin structure in yeast. Mol. Cell 27, 890–900 (2007)
  Article CAS Google Scholar
• Kaeberlein, M. & Powers, R. W. 3rd Sir2 and calorie restriction in yeast: a skeptical perspective. Ageing Res. Rev. 6, 128–140 (2007)
  Article CAS Google Scholar
• Lesur, I. & Campbell, J. L. The transcriptome of prematurely aging yeast cells is similar to that of telomerase-deficient cells. Mol. Biol. Cell 15, 1297–1312 (2004)
  Article CAS Google Scholar
• Rusche, L. N., Kirchmaier, A. L. & Rine, J. The establishment, inheritance, and function of silenced chromatin in Saccharomyces cerevisiae . Annu. Rev. Biochem. 72, 481–516 (2003)
  Article CAS Google Scholar
• Pryde, F. E. & Louis, E. J. Limitations of silencing at native yeast telomeres. EMBO J. 18, 2538–2550 (1999)
  Article CAS Google Scholar
• Robyr, D. et al. Microarray deacetylation maps determine genome-wide functions for yeast histone deacetylases. Cell 109, 437–446 (2002)
  Article CAS Google Scholar
• Grubisha, O., Smith, B. C. & Denu, J. M. Small molecule regulation of Sir2 protein deacetylases. FEBS J. 272, 4607–4616 (2005)
  Article CAS Google Scholar
• Shia, W. J., Li, B. & Workman, J. L. SAS-mediated acetylation of histone H4 Lys 16 is required for H2A.Z incorporation at subtelomeric regions in Saccharomyces cerevisiae . Genes Dev. 20, 2507–2512 (2006)
  Article CAS Google Scholar
• Dion, M. F., Altschuler, S. J., Wu, L. F. & Rando, O. J. Genomic characterization reveals a simple histone H4 acetylation code. Proc. Natl Acad. Sci. USA 102, 5501–5506 (2005)
  Article ADS CAS Google Scholar
• Celic, I. et al. The sirtuins hst3 and Hst4p preserve genome integrity by controlling histone h3 lysine 56 deacetylation. Curr. Biol. 16, 1280–1289 (2006)
  Article CAS Google Scholar
• Driscoll, R., Hudson, A. & Jackson, S. P. Yeast Rtt109 promotes genome stability by acetylating histone H3 on lysine 56. Science 315, 649–652 (2007)
  Article ADS CAS Google Scholar
• Han, J. et al. Rtt109 acetylates histone H3 lysine 56 and functions in DNA replication. Science 315, 653–655 (2007)
  Article ADS CAS Google Scholar
• Schneider, J. et al. Rtt109 is required for proper H3K56 acetylation: a chromatin mark associated with the elongating RNA polymerase II. J. Biol. Chem. 281, 37270–37274 (2006)
  Article CAS Google Scholar
• Tsuchiya, M. et al. Sirtuin-independent effects of nicotinamide on lifespan extension from calorie restriction in yeast. Aging Cell 5, 505–514 (2006)
  Article CAS Google Scholar
• Huang, J. & Moazed, D. Association of the RENT complex with nontranscribed and coding regions of rDNA and a regional requirement for the replication fork block protein Fob1 in rDNA silencing. Genes Dev. 17, 2162–2176 (2003)
  Article CAS Google Scholar
• Aguilaniu, H., Gustafsson, L., Rigoulet, M. & Nystrom, T. Asymmetric inheritance of oxidatively damaged proteins during cytokinesis. Science 299, 1751–1753 (2003)
  Article ADS CAS Google Scholar
• Blasco, M. A. The epigenetic regulation of mammalian telomeres. Nature Rev. Genet. 8, 299–309 (2007)
  Article CAS Google Scholar
• Kawahara, T. L. et al. SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span. Cell 136, 62–74 (2009)
  Article CAS Google Scholar
• Mostoslavsky, R. et al. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell 124, 315–329 (2006)
  Article CAS Google Scholar
• Park, P. U., McVey, M. & Guarente, L. Separation of mother and daughter cells. Methods Enzymol. 351, 468–477 (2002)
  Article Google Scholar
• Wyce, A. et al. H2B ubiquitylation acts as a barrier to Ctk1 nucleosomal recruitment prior to removal by Ubp8 within a SAGA-related complex. Mol. Cell 27, 275–288 (2007)
  Article CAS Google Scholar