Branched tricarboxylic acid metabolism in Plasmodium falciparum (original) (raw)

• Krebs, H. A. & Johnson, W. A. The role of citric acid in intermediate metabolism in animal tissues. Enzymologia 4, 148–156 (1937)
  CAS Google Scholar
• van Dooren, G. G., Stimmler, L. M. & McFadden, G. I. Metabolic maps and functions of the Plasmodium mitochondrion. FEMS Microbiol. Rev. 30, 596–630 (2006)
  Article CAS PubMed Google Scholar
• Sherman, I. W. in Malaria, Parasite Biology, Pathogenesis and Protection (ed. Sherman, I. W.) 135–143 (ASM, 1998)
  Google Scholar
• Gardner, M. J. et al. Genome sequence of the human malaria parasite Plasmodium falciparum . Nature 419, 498–511 (2002)
  Article ADS CAS PubMed Google Scholar
• Munger, J. et al. Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy. Nature Biotechnol. 26, 1179–1186 (2008)
  Article CAS Google Scholar
• Vaidya, A. B. & Mather, M. W. Mitochondrial evolution and functions in malaria parasites. Annu. Rev. Microbiol. 63, 249–267 (2009)
  Article CAS PubMed Google Scholar
• Painter, H. J., Morrisey, J. M., Mather, M. W. & Vaidya, A. B. Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum . Nature 446, 88–91 (2007)
  Article ADS CAS PubMed Google Scholar
• Bozdech, Z. et al. The transcriptome of the intraerythrocytic developmental cycle of Plasmodium falciparum . PLoS Biol. 1, e5 (2003)
  Article PubMed PubMed Central Google Scholar
• Tonkin, C. J. et al. Localization of organellar proteins in Plasmodium falciparum using a novel set of transfection vectors and a new immunofluorescence fixation method. Mol. Biochem. Parasitol. 137, 13–21 (2004)
  Article CAS PubMed Google Scholar
• Hodges, M. et al. An iron regulatory-like protein expressed in Plasmodium falciparum displays aconitase activity. Mol. Biochem. Parasitol. 143, 29–38 (2005)
  Article CAS PubMed Google Scholar
• Wrenger, C. & Muller, S. Isocitrate dehydrogenase of Plasmodium falciparum . Eur. J. Biochem. 270, 1775–1783 (2003)
  Article CAS PubMed Google Scholar
• Suraveratum, N. et al. Purification and characterization of Plasmodium falciparum succinate dehydrogenase. Mol. Biochem. Parasitol. 105, 215–222 (2000)
  Article CAS PubMed Google Scholar
• Olszewski, K. L. et al. Host-parasite interactions revealed by Plasmodium falciparum metabolomics. Cell Host Microbe 5, 191–199 (2009)
  Article CAS PubMed PubMed Central Google Scholar
• Foth, B. J. et al. The malaria parasite Plasmodium falciparum has only one pyruvate dehydrogenase complex, which is located in the apicoplast. Mol. Microbiol. 55, 39–53 (2005)
  Article CAS PubMed Google Scholar
• Blum, J. J. & Ginsburg, H. Absence of α-ketoglutarate dehydrogenase activity and presence of CO2-fixing activity in Plasmodium falciparum grown in vitro in human erythrocytes. J. Protozool. 31, 167–169 (1984)
  Article CAS PubMed Google Scholar
• Elford, B. C., Haynes, J. D., Chulay, J. D. & Wilson, R. J. Selective stage-specific changes in the permeability to small hydrophilic solutes of human erythrocytes infected with Plasmodium falciparum . Mol. Biochem. Parasitol. 16, 43–60 (1985)
  Article CAS PubMed Google Scholar
• Liu, J. et al. Plasmodium falciparum ensures its amino acid supply with multiple acquisition pathways and redundant proteolytic enzyme systems. Proc. Natl Acad. Sci. USA 103, 8840–8845 (2006)
  Article ADS CAS PubMed PubMed Central Google Scholar
• Yoo, H., Antoniewicz, M. R., Stephanopoulos, G. & Kelleher, J. K. Quantifying reductive carboxylation flux of glutamine to lipid in a brown adipocyte cell line. J. Biol. Chem. 283, 20621–20627 (2008)
  Article CAS PubMed PubMed Central Google Scholar
• Vaughan, A. M. et al. Type II fatty acid synthesis is essential only for malaria parasite late liver stage development. Cell. Microbiol. 11, 506–520 (2009)
  Article CAS PubMed Google Scholar
• Yu, M. et al. The fatty acid biosynthesis enzyme FabI plays a key role in the development of liver-stage malarial parasites. Cell Host Microbe 4, 567–578 (2008)
  Article PubMed PubMed Central Google Scholar
• Gowda, D. C. & Davidson, E. A. Protein glycosylation in the malaria parasite. Parasitol. Today 15, 147–152 (1999)
  Article CAS PubMed Google Scholar
• Downie, M. J., Kirk, K. & Mamoun, C. B. Purine salvage pathways in the intraerythrocytic malaria parasite Plasmodium falciparum . Eukaryot. Cell 7, 1231–1237 (2008)
  Article CAS PubMed PubMed Central Google Scholar
• Fry, M. & Beesley, J. E. Mitochondria of mammalian Plasmodium spp . Parasitology 102, 17–26 (1991)
  Article PubMed Google Scholar
• Wellen, K. E. et al. ATP-citrate lyase links cellular metabolism to histone acetylation. Science 324, 1076–1080 (2009)
  Article ADS CAS PubMed PubMed Central Google Scholar
• Wang, Q. et al. Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux. Science 327, 1004–1007 (2010)
  Article ADS CAS PubMed PubMed Central Google Scholar
• Zhao, S. et al. Regulation of cellular metabolism by protein lysine acetylation. Science 327, 1000–1004 (2010)
  Article ADS CAS PubMed PubMed Central Google Scholar
• Daily, J. P. et al. Distinct physiological states of Plasmodium falciparum in malaria-infected patients. Nature 450, 1091–1095 (2007)
  Article ADS CAS PubMed Google Scholar
• Lasonder, E. et al. Proteomic profiling of Plasmodium sporozoite maturation identifies new proteins essential for parasite development and infectivity. PLoS Pathog. 4, e1000195 (2008)
  Article PubMed PubMed Central Google Scholar
• Mather, M. W., Henry, K. W. & Vaidya, A. B. Mitochondrial drug targets in apicomplexan parasites. Curr. Drug Targets 8, 49–60 (2007)
  Article CAS PubMed Google Scholar
• Andrews, K. T., Tran, T. N., Wheatley, N. C. & Fairlie, D. P. Targeting histone deacetylase inhibitors for anti-malarial therapy. Curr. Top. Med. Chem. 9, 292–308 (2009)
  Article CAS PubMed Google Scholar
• Trager, W. & Jensen, J. B. Human malaria parasites in continuous culture. Science 193, 673–675 (1976)
  Article ADS CAS PubMed Google Scholar
• Lambros, C. & Vanderberg, J. P. Synchronization of Plasmodium falciparum erythrocytic stages in culture. J. Parasitol. 65, 418–420 (1979)
  Article CAS PubMed Google Scholar
• Moore, G. E., Gerner, R. E. & Franklin, H. A. Culture of normal human leukocytes. J. Am. Med. Assoc. 199, 519–524 (1967)
  Article CAS Google Scholar
• Lu, W., Bennett, B. D. & Rabinowitz, J. D. Analytical strategies for LC–MS-based targeted metabolomics. J. Chromatogr. B 871, 236–242 (2008)
  Article CAS Google Scholar
• Keller, A. et al. A uniform proteomics MS/MS analysis platform utilizing open XML file formats. Mol. Syst. Biol. 1, 2005.0017 (2005)
  Article PubMed PubMed Central Google Scholar
• Breiman, L. Random forests. Mach. Learn. 45, 5–32 (2001)
  Article MATH Google Scholar
• Mi-Ichi, F., Kita, K. & Mitamura, T. Intraerythrocytic Plasmodium falciparum utilize a broad range of serum-derived fatty acids with limited modification for their growth. Parasitology 133, 399–410 (2006)
  Article CAS PubMed Google Scholar
• Miao, J., Fan, Q., Cui, L. & Li, J. The malaria parasite Plasmodium falciparum histones: organization, expression, and acetylation. Gene 369, 53–65 (2006)
  Article CAS PubMed Google Scholar
• Shechter, D., Dormann, H. L., Allis, C. D. & Hake, S. B. Extraction, purification and analysis of histones. Nature Protocols 2, 1445–1457 (2007)
  Article CAS PubMed Google Scholar
• Garcia, B. A. et al. Chemical derivatization of histones for facilitated analysis by mass spectrometry. Nature Protocols 2, 933–938 (2007)
  Article CAS PubMed PubMed Central Google Scholar
• Takashima, E. et al. Isolation of mitochondria from Plasmodium falciparum showing dihydroorotate dependent respiration. Parasitol. Int. 50, 273–278 (2001)
  Article CAS PubMed Google Scholar
• Kornberg, A. & Pricer, W. E., Jr Di- and triphosphopyridine nucleotide isocitric dehydrogenases in yeast. J. Biol. Chem. 189, 123–136 (1951)
  CAS PubMed Google Scholar
• Ma, Z., Chu, C. H. & Cheng, D. A novel direct homogeneous assay for ATP citrate lyase. J. Lipid Res. 50, 2131–2135 (2009)
  Article CAS PubMed PubMed Central Google Scholar
• Bergmeyer, H. U., Gawehn, K. & Grassl, M. in Methods of Enzymatic Analysis Vol. 1 (ed. Bergmeyer, H. U.) 442–443 (Academic, 1974)
  Google Scholar
• Kadekoppala, M., Kline, K., Akompong, T. & Haldar, K. Stable expression of a new chimeric fluorescent reporter in the human malaria parasite Plasmodium falciparum . Infect. Immun. 68, 2328–2332 (2000)
  Article CAS PubMed PubMed Central Google Scholar
• O'Donnell, R. A. et al. A genetic screen for improved plasmid segregation reveals a role for Rep20 in the interaction of Plasmodium falciparum chromosomes. EMBO J. 21, 1231–1239 (2002)
  Article CAS PubMed PubMed Central Google Scholar
• Fidock, D. A. & Wellems, T. E. Transformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but does not affect the intrinsic activity of proguanil. Proc. Natl Acad. Sci. USA 94, 10931–10936 (1997)
  Article ADS CAS PubMed PubMed Central Google Scholar
• Forer, A. & Pickett-Heaps, J. D. Cytochalasin D and latrunculin affect chromosome behaviour during meiosis in crane-fly spermatocytes. Chromosome Res. 6, 533–549 (1998)
  Article CAS PubMed Google Scholar