Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH (original) (raw)
Miller, R. A. Genes against aging. J. Gerontol. A Biol. Sci. Med. Sci.67A, 495–502 (2012) ArticleCAS Google Scholar
Mattson, M. P. Pathways towards and away from Alzheimer’s disease. Nature430, 631–639 (2004) ArticleADSCAS Google Scholar
Masoro, E. J. Overview of caloric restriction and ageing. Mech. Ageing Dev.126, 913–922 (2005) ArticleCAS Google Scholar
Finch, C. E. Neurons, glia, and plasticity in normal brain aging. Adv. Gerontol.10, 35–39 (2002) CASPubMed Google Scholar
Zitnik, G. & Martin, G. M. Age-related decline in neurogenesis: old cells or old environment? J. Neurosci. Res.70, 258–263 (2002) ArticleCAS Google Scholar
Martin, G. M. Epigenetic gambling and epigenetic drift as an antagonistic pleiotropic mechanism of aging. Aging Cell8, 761–764 (2009) ArticleCAS Google Scholar
Bishop, N. A. & Guarente, L. Two neurons mediate diet-restriction-induced longevity in C.elegans . Nature447, 545–549 (2007) ArticleADSCAS Google Scholar
Fridell, Y. W., Sanchez-Blanco, A., Silvia, B. A. & Helfand, S. L. Targeted expression of the human uncoupling protein 2 (hUCP2) to adult neurons extends life span in the fly. Cell Metab.1, 145–152 (2005) ArticleCAS Google Scholar
Alcedo, J. & Kenyon, C. Regulation of C.elegans longevity by specific gustatory and olfactory neurons. Neuron41, 45–55 (2004) ArticleCAS Google Scholar
Wolkow, C. A., Kimura, K. D., Lee, M. S. & Ruvkun, G. Regulation of C.elegans life-span by insulinlike signaling in the nervous system. Science290, 147–150 (2000) ArticleADSCAS Google Scholar
Taguchi, A., Wartschow, L. M. & White, M. F. Brain IRS2 signaling coordinates life span and nutrient homeostasis. Science317, 369–372 (2007) ArticleADSCAS Google Scholar
Li, J., Tang, Y. & Cai, D. IKKβ/NF-κB disrupts adult hypothalamic neural stem cells to mediate a neurodegenerative mechanism of dietary obesity and pre-diabetes. Nature Cell Biol.14, 999–1012 (2012) ArticleCAS Google Scholar
Zhang, X. et al. Hypothalamic IKKβ/NF-κB and ER stress link overnutrition to energy imbalance and obesity. Cell135, 61–73 (2008) ArticleCAS Google Scholar
Purkayastha, S. et al. Neural dysregulation of peripheral insulin action and blood pressure by brain endoplasmic reticulum stress. Proc. Natl Acad. Sci. USA108, 2939–2944 (2011) ArticleADSCAS Google Scholar
Purkayastha, S., Zhang, G. & Cai, D. Uncoupling the mechanisms of obesity and hypertension by targeting hypothalamic IKK-β and NF-κB. Nature Med.17, 883–887 (2011) ArticleCAS Google Scholar
Okun, E., Griffioen, K. J. & Mattson, M. P. Toll-like receptor signaling in neural plasticity and disease. Trends Neurosci.34, 269–281 (2011) ArticleCAS Google Scholar
Glass, C. K., Saijo, K., Winner, B., Marchetto, M. C. & Gage, F. H. Mechanisms underlying inflammation in neurodegeneration. Cell140, 918–934 (2010) ArticleCAS Google Scholar
Saijo, K. et al. A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death. Cell137, 47–59 (2009) ArticleCAS Google Scholar
Saijo, K., Collier, J. G., Li, A. C., Katzenellenbogen, J. A. & Glass, C. K. An ADIOL-ERβ-CtBP transrepression pathway negatively regulates microglia-mediated inflammation. Cell145, 584–595 (2011) ArticleCAS Google Scholar
Saijo, K. & Glass, C. K. Microglial cell origin and phenotypes in health and disease. Nature Rev. Immunol.11, 775–787 (2011) ArticleCAS Google Scholar
Lucin, K. M. & Wyss-Coray, T. Immune activation in brain aging and neurodegeneration: too much or too little? Neuron64, 110–122 (2009) ArticleCAS Google Scholar
Villeda, S. & Wyss-Coray, T. Microglia–a wrench in the running wheel? Neuron59, 527–529 (2008) ArticleCAS Google Scholar
Villeda, S. A. et al. The ageing systemic milieu negatively regulates neurogenesis and cognitive function. Nature477, 90–94 (2011) ArticleADSCAS Google Scholar
Yoshiyama, Y. et al. Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neuron53, 337–351 (2007) ArticleCAS Google Scholar
Adler, A. S. et al. Motif module map reveals enforcement of aging by continual NF-κB activity. Genes Dev.21, 3244–3257 (2007) ArticleCAS Google Scholar
Peng, B. et al. Defective feedback regulation of NF-κB underlies Sjogren’s syndrome in mice with mutated κB enhancers of the IκBα promoter. Proc. Natl Acad. Sci. USA107, 15193–15198 (2010) ArticleADSCAS Google Scholar
Harrison, D. E. et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature460, 392–395 (2009) ArticleADSCAS Google Scholar
Barger, S. W. et al. Tumor necrosis factors α and β protect neurons against amyloid β-peptide toxicity: evidence for involvement of a κ B-binding factor and attenuation of peroxide and Ca2+ accumulation. Proc. Natl Acad. Sci. USA92, 9328–9332 (1995) ArticleADSCAS Google Scholar
Bruce, A. J. et al. Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors. Nature Med.2, 788–794 (1996) ArticleADSCAS Google Scholar
Taoufik, E. et al. Transmembrane tumour necrosis factor is neuroprotective and regulates experimental autoimmune encephalomyelitis via neuronal nuclear factor-κB. Brain134, 2722–2735 (2011) Article Google Scholar
Kaltschmidt, B. et al. NF-κB regulates spatial memory formation and synaptic plasticity through protein kinase A/CREB signaling. Mol. Cell. Biol.26, 2936–2946 (2006) ArticleCAS Google Scholar
Meffert, M. K., Chang, J. M., Wiltgen, B. J., Fanselow, M. S. & Baltimore, D. NF-κB functions in synaptic signaling and behavior. Nature Neurosci.6, 1072–1078 (2003) ArticleCAS Google Scholar
O’Mahony, A. et al. NF-κB/Rel regulates inhibitory and excitatory neuronal function and synaptic plasticity. Mol. Cell. Biol.26, 7283–7298 (2006) Article Google Scholar
Huang, W., Ghisletti, S., Perissi, V., Rosenfeld, M. G. & Glass, C. K. Transcriptional integration of TLR2 and TLR4 signaling at the NCoR derepression checkpoint. Mol. Cell35, 48–57 (2009) Article Google Scholar
Kawahara, T. L. et al. SIRT6 links histone H3 lysine 9 deacetylation to NF-κB-dependent gene expression and organismal life span. Cell136, 62–74 (2009) ArticleCAS Google Scholar
Michishita, E. et al. SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature452, 492–496 (2008) ArticleADSCAS Google Scholar
Meng, Q. & Cai, D. Defective hypothalamic autophagy directs the central pathogenesis of obesity via the IκB kinase β (IKKβ)/NF-κB pathway. J. Biol. Chem.286, 32324–32332 (2011) ArticleCAS Google Scholar
Banks, W. A. et al. Effects of a growth hormone-releasing hormone antagonist on telomerase activity, oxidative stress, longevity, and aging in mice. Proc. Natl Acad. Sci. USA107, 22272–22277 (2010) ArticleADSCAS Google Scholar
Tillerson, J. L. & Miller, G. W. Grid performance test to measure behavioral impairment in the MPTP-treated-mouse model of parkinsonism. J. Neurosci. Methods123, 189–200 (2003) Article Google Scholar
Mueller, J. M. & Pahl, H. L. Assaying NF-κB and AP-1 DNA-binding and transcriptional activity. Methods Mol. Biol.99, 205–216 (2000) CASPubMed Google Scholar
Flurkey, K., Papaconstantinou, J., Miller, R. A. & Harrison, D. E. Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production. Proc. Natl Acad. Sci. USA98, 6736–6741 (2001) ArticleADSCAS Google Scholar
Ramanadham, S. et al. Age-related changes in bone morphology are accelerated in group VIA phospholipase A2 (iPLA2β)-null mice. Am. J. Pathol.172, 868–881 (2008) ArticleCAS Google Scholar
Meylan, E. et al. Requirement for NF-κB signalling in a mouse model of lung adenocarcinoma. Nature462, 104–107 (2009) ArticleADSCAS Google Scholar
Wang, C., Li, Q., Redden, D. T., Weindruch, R. & Allison, D. B. Statistical methods for testing effects on “maximum lifespan”. Mech. Ageing Dev.125, 629–632 (2004) Article Google Scholar