Targeted integration in rat and mouse embryos with zinc-finger nucleases (original) (raw)

• Capecchi, M.R. Gene targeting in mice: functional analysis of the mammalian genome for the twenty-first century. Nat. Rev. Genet. 6, 507–512 (2005).
  Article CAS Google Scholar
• Geurts, A.M. et al. Knockout rats via embryo microinjection of zinc-finger nucleases. Science 325, 433 (2009).
  Article CAS Google Scholar
• Mashimo, T. et al. Generation of knockout rats with X-linked severe combined immunodeficiency (X-SCID) using zinc-finger nucleases. PLoS ONE 5, e8870 (2010).
  Article Google Scholar
• Carbery, I.D. et al. Targeted genome modification in mice using zinc finger nucleases. Genetics 186, 451–459 (2010).
  Article CAS Google Scholar
• Ledermann, B. Embryonic stem cells and gene targeting. Exp. Physiol. 85, 603–613 (2000).
  Article CAS Google Scholar
• Aitman, T.J. et al. Progress and prospects in rat genetics: a community view. Nat. Genet. 40, 516–522 (2008).
  Article CAS Google Scholar
• Tong, C., Li, P., Wu, N.L., Yan, Y. & Ying, Q.L. Production of p53 gene knockout rats by homologous recombination in embryonic stem cells. Nature 467, 211–213 (2010).
  Article CAS Google Scholar
• Kawamata, M. & Ochiya, T. Generation of genetically modified rats from embryonic stem cells. Proc. Natl. Acad. Sci. USA 107, 14223–14228 (2010).
  Article CAS Google Scholar
• Kim, Y.-G., Cha, J. & Chandrasegaran, S. Hybrid restriction enzymes: zinc finger fusions to Fok I cleavage domain. Proc. Natl. Acad. Sci. USA 93, 1156–1160 (1996).
  Article CAS Google Scholar
• Mani, M., Smith, J., Kandavelou, K., Berg, J.M. & Chandrasegaran, S. Binding of two zinc finger nuclease monomers to two specific sites is required for effective double-strand DNA cleavage. Biochem. Biophys. Res. Commun. 334, 1191–1197 (2005).
  Article CAS Google Scholar
• Doyon, Y. et al. Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases. Nat. Biotechnol. 26, 702–708 (2008).
  Article CAS Google Scholar
• Meng, X., Noyes, M.B., Zhu, L.J., Lawson, N.D. & Wolfe, S.A. Targeted gene inactivation in zebrafish using engineered zinc-finger nucleases. Nat. Biotechnol. 26, 695–701 (2008).
  Article CAS Google Scholar
• Foley, J.E. et al. Rapid mutation of endogenous zebrafish genes using zinc finger nucleases made by oligomerized pool engineering (OPEN). PLoS ONE 4, e4348 (2009).
  Article Google Scholar
• Lieber, M.R. The biochemistry and biological significance of nonhomologous DNA end joining: an essential repair process in multicellular eukaryotes. Genes Cells 4, 77–85 (1999).
  Article CAS Google Scholar
• Brinster, R.L. et al. Targeted correction of a major histocompatibility class II E alpha gene by DNA microinjected into mouse eggs. Proc. Natl. Acad. Sci. USA 86, 7087–7091 (1989).
  Article CAS Google Scholar
• Moehle, E.A. et al. Targeted gene addition into a specified location in the human genome using designed zinc finger nucleases. Proc. Natl. Acad. Sci. USA 104, 3055–3060 (2007).
  Article CAS Google Scholar
• Porteus, M.H. & Baltimore, D. Chimeric nucleases stimulate gene targeting in human cells. Science 300, 763 (2003).
  Article Google Scholar
• Urnov, F.D. et al. Highly efficient endogenous human gene correction using designed zinc-finger nucleases. Nature 435, 646–651 (2005).
  Article CAS Google Scholar
• Bozas, A., Beumer, K.J., Trautman, J.K. & Carroll, D. Genetic analysis of zinc-finger nuclease-induced gene targeting in Drosophila. Genetics 182, 641–651 (2009).
  Article CAS Google Scholar
• Filipiak, W.E. & Saunders, T.L. Advances in transgenic rat production. Transgenic Res. 15, 673–686 (2006).
  Article CAS Google Scholar
• Meyer, M., de Angelis, M.H., Wurst, W. & Kühn, R. Gene targeting by homologous recombination in mouse zygotes mediated by zinc-finger nucleases. Proc. Natl. Acad. Sci. USA 107, 15022–15026 (2010).
  Article CAS Google Scholar
• DeKelver, R.C. et al. Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome. Genome Res. 20, 1133–1142 (2010).
  Article CAS Google Scholar
• Hockemeyer, D. et al. Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases. Nat. Biotechnol. 27, 851–857 (2009).
  Article CAS Google Scholar
• Perez, E.E. et al. Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases. Nat. Biotechnol. 26, 808–816 (2008).
  Article CAS Google Scholar
• Miller, J.C. et al. An improved zinc-finger nuclease architecture for highly specific genome editing. Nat. Biotechnol. 25, 778–785 (2007).
  Article CAS Google Scholar
• Szczepek, M. et al. Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases. Nat. Biotechnol. 25, 786–793 (2007).
  Article CAS Google Scholar