Signal sequences directing cotranslational translocation expand the range of proteins amenable to phage display (original) (raw)

References

1. Smith, G.P. & Petrenko, V.A. Phage Display. Chem. Rev. 97, 391–410 (1997).
   Article CAS PubMed Google Scholar
2. Russel, M., Lowman, H.B. & Clackson, T. Introduction to phage biology and phage display. in Phage Display: A Practical Approach (eds. Lowman, H.B. & Clackson, T.) 1–26, (Oxford University Press, New York, USA, 2004).
   Google Scholar
3. Sidhu, S.S., Lowman, H.B., Cunningham, B.C. & Wells, J.A. Phage display for selection of novel binding peptides. Methods Enzymol. 328, 333–363 (2000).
   Article CAS PubMed Google Scholar
4. Bradbury, A.R. & Marks, J.D. Antibodies from phage antibody libraries. J. Immunol. Methods 290, 29–49 (2004).
   Article CAS PubMed Google Scholar
5. Rakonjac, J., Feng, J. & Model, P. Filamentous phage are released from the bacterial membrane by a two-step mechanism involving a short C-terminal fragment of pIII. J. Mol. Biol. 289, 1253–1265 (1999).
   Article CAS PubMed Google Scholar
6. Wilson, D.R. & Finlay, B.B. Phage display: applications, innovations, and issues in phage and host biology. Can. J. Microbiol. 44, 313–329 (1998).
   Article CAS PubMed Google Scholar
7. Deng, S.J. et al. Selection of antibody single-chain variable fragments with improved carbohydrate binding by phage display. J. Biol. Chem. 269, 9533–9538 (1994).
   CAS PubMed Google Scholar
8. Jung, S. & Plückthun, A. Improving in vivo folding and stability of a single-chain Fv antibody fragment by loop grafting. Protein Eng. 10, 959–966 (1997).
   Article CAS PubMed Google Scholar
9. Krebber, A., Burmester, J. & Plückthun, A. Inclusion of an upstream transcriptional terminator in phage display vectors abolishes background expression of toxic fusions with coat protein g3p. Gene 178, 71–74 (1996).
   Article CAS PubMed Google Scholar
10. Brinkmann, U., Chowdhury, P.S., Roscoe, D.M. & Pastan, I. Phage display of disulfide-stabilized Fv fragments. J. Immunol. Methods 182, 41–50 (1995).
    Article CAS PubMed Google Scholar
11. Rodi, D.J., Soares, A.S. & Makowski, L. Quantitative assessment of peptide sequence diversity in M13 combinatorial peptide phage display libraries. J. Mol. Biol. 322, 1039–1052 (2002).
    Article CAS PubMed Google Scholar
12. Krebber, A. et al. Reliable cloning of functional antibody variable domains from hybridomas and spleen cell repertoires employing a reengineered phage display system. J. Immunol. Methods 201, 35–55 (1997).
    Article CAS PubMed Google Scholar
13. Bothmann, H. & Plückthun, A. Selection for a periplasmic factor improving phage display and functional periplasmic expression. Nat. Biotechnol. 16, 376–380 (1998).
    Article CAS PubMed Google Scholar
14. Bothmann, H. & Plückthun, A. The periplasmic Escherichia coli peptidylprolyl cis,trans-isomerase FkpA. I. Increased functional expression of antibody fragments with and without cis-prolines. J. Biol. Chem. 275, 17100–17105 (2000).
    Article CAS PubMed Google Scholar
15. Kramer, R.A. et al. A novel helper phage that improves phage display selection efficiency by preventing the amplification of phages without recombinant protein. Nucleic Acids Res. 31, e59 (2003).
    Article PubMed PubMed Central Google Scholar
16. Baek, H., Suk, K.H., Kim, Y.H. & Cha, S. An improved helper phage system for efficient isolation of specific antibody molecules in phage display. Nucleic Acids Res. 30, e18 (2002).
    Article PubMed PubMed Central Google Scholar
17. Rondot, S., Koch, J., Breitling, F. & Dübel, S. A helper phage to improve single-chain antibody presentation in phage display. Nat. Biotechnol. 19, 75–78 (2001).
    Article CAS PubMed Google Scholar
18. Jestin, J.L., Volioti, G. & Winter, G. Improving the display of proteins on filamentous phage. Res. Microbiol. 152, 187–191 (2001).
    Article CAS PubMed Google Scholar
19. Forrer, P., Stumpp, M.T., Binz, H.K. & Plückthun, A. A novel strategy to design binding molecules harnessing the modular nature of repeat proteins. FEBS Lett. 539, 2–6 (2003).
    Article CAS PubMed Google Scholar
20. Binz, H.K., Stumpp, M.T., Forrer, P., Amstutz, P. & Plückthun, A. Designing repeat proteins: well-expressed, soluble and stable proteins from combinatorial libraries of consensus ankyrin repeat proteins. J. Mol. Biol. 332, 489–503 (2003).
    Article CAS PubMed Google Scholar
21. Binz, H.K. et al. High-affinity binders selected from designed ankyrin repeat protein libraries. Nat. Biotechnol. 22, 575–582 (2004).
    Article CAS PubMed Google Scholar
22. Amstutz, P. et al. Intracellular kinase inhibitors selected from combinatorial libraries of designed ankyrin repeat proteins. J. Biol. Chem. 280, 24715–24722 (2005).
    Article CAS PubMed Google Scholar
23. Fekkes, P. & Driessen, A.J. Protein targeting to the bacterial cytoplasmic membrane. Microbiol. Mol. Biol. Rev. 63, 161–173 (1999).
    CAS PubMed PubMed Central Google Scholar
24. Koch, H.G., Moser, M. & Müller, M. Signal recognition particle-dependent protein targeting, universal to all kingdoms of life. Rev. Physiol. Biochem. Pharmacol. 146, 55–94 (2003).
    Article CAS PubMed Google Scholar
25. Valent, Q.A. Signal recognition particle mediated protein targeting in Escherichia coli . Antonie Van Leeuwenhoek 79, 17–31 (2001).
    Article CAS PubMed Google Scholar
26. Luirink, J. & Sinning, I. SRP-mediated protein targeting: structure and function revisited. Biochim. Biophys. Acta 1694, 17–35 (2004).
    CAS PubMed Google Scholar
27. Fisher, A.C. & DeLisa, M.P. A little help from my friends: quality control of presecretory proteins in bacteria. J. Bacteriol. 186, 7467–7473 (2004).
    Article CAS PubMed PubMed Central Google Scholar
28. Robinson, C. & Bolhuis, A. Tat-dependent protein targeting in prokaryotes and chloroplasts. Biochim. Biophys. Acta 1694, 135–147 (2004).
    Article CAS PubMed Google Scholar
29. Rapoza, M.P. & Webster, R.E. The filamentous bacteriophage assembly proteins require the bacterial SecA protein for correct localization to the membrane. J. Bacteriol. 175, 1856–1859 (1993).
    Article CAS PubMed PubMed Central Google Scholar
30. Plückthun, A. et al. in Antibody Engineering, edn. 1 (eds. McCafferty, J., Hoogenboom, H.R. & Chiswell, D.J.) 203–252, (IRL Press, Oxford, 1996).
    Google Scholar
31. Debarbieux, L. & Beckwith, J. The reductive enzyme thioredoxin 1 acts as an oxidant when it is exported to the Escherichia coli periplasm. Proc. Natl. Acad. Sci. USA 95, 10751–10756 (1998).
    Article CAS PubMed PubMed Central Google Scholar
32. Jonda, S., Huber-Wunderlich, M., Glockshuber, R. & Mössner, E. Complementation of DsbA deficiency with secreted thioredoxin variants reveals the crucial role of an efficient dithiol oxidant for catalyzed protein folding in the bacterial periplasm. EMBO J. 18, 3271–3281 (1999).
    Article CAS PubMed PubMed Central Google Scholar
33. Schierle, C.F. et al. The DsbA signal sequence directs efficient, cotranslational export of passenger proteins to the Escherichia coli periplasm via the signal recognition particle pathway. J. Bacteriol. 185, 5706–5713 (2003).
    Article CAS PubMed PubMed Central Google Scholar
34. Yang, F. et al. Novel fold and capsid-binding properties of the lambda-phage display platform protein gpD. Nat. Struct. Biol. 7, 230–237 (2000).
    Article CAS PubMed Google Scholar
35. Huber, D. et al. Use of thioredoxin as a reporter to identify a subset of Escherichia coli signal sequences that promote signal recognition particle-dependent translocation. J. Bacteriol. 187, 2983–2991 (2005).
    Article CAS PubMed PubMed Central Google Scholar
36. Slootstra, J.W., Kuperus, D., Plückthun, A. & Meloen, R.H. Identification of new tag sequences with differential and selective recognition properties for the anti-FLAG monoclonal antibodies M1, M2 and M5. Mol. Divers. 2, 156–164 (1997).
    Article CAS PubMed Google Scholar
37. Georgescu, R.E., Li, J.H., Goldberg, M.E., Tasayco, M.L. & Chaffotte, A.F. Proline isomerization-independent accumulation of an early intermediate and heterogeneity of the folding pathways of a mixed alpha/beta protein, Escherichia coli thioredoxin. Biochemistry 37, 10286–10297 (1998).
    Article CAS PubMed Google Scholar
38. Huber, D. et al. A selection for mutants that interfere with folding of Escherichia coli thioredoxin-1 in vivo. Proc. Natl. Acad. Sci. USA 102, 18872–18877 (2005).
    Article CAS PubMed PubMed Central Google Scholar
39. Forrer, P., Chang, C., Ott, D., Wlodawer, A. & Plückthun, A. Kinetic stability and crystal structure of the viral capsid protein SHP. J. Mol. Biol. 344, 179–193 (2004).
    Article CAS PubMed Google Scholar
40. Ewert, S., Huber, T., Honegger, A. & Plückthun, A. Biophysical properties of human antibody variable domains. J. Mol. Biol. 325, 531–553 (2003).
    Article CAS PubMed Google Scholar
41. Jäger, M., Gehrig, P. & Plückthun, A. The scFv fragment of the antibody hu4D5–8: evidence for early premature domain interaction in refolding. J. Mol. Biol. 305, 1111–1129 (2001).
    Article PubMed Google Scholar
42. Paschke, M. & Höhne, W. A twin-arginine translocation (Tat)-mediated phage display system. Gene 350, 79–88 (2005).
    Article CAS PubMed Google Scholar
43. DeLisa, M.P., Tullman, D. & Georgiou, G. Folding quality control in the export of proteins by the bacterial twin-arginine translocation pathway. Proc. Natl. Acad. Sci. USA 100, 6115–6120 (2003).
    Article CAS PubMed PubMed Central Google Scholar
44. Crameri, R., Hemmann, S. & Blaser, K. PJuFo: a phagemid for display of cDNA libraries on phage surface suitable for selective isolation of clones expressing allergens. Adv. Exp. Med. Biol. 409, 103–110 (1996).
    Article CAS PubMed Google Scholar
45. Löhning, C., Urban, M. & Knappik, A. Novel methods for displaying (poly) peptides/proteins on bacteriophage particles via disulfide bonds Patent WO0105950 (2001).
46. Sambrook, J. & Russell David, W. (eds.). Molecular Cloning: A Laboratory Manual, edn. 3. (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 2001).
    Google Scholar
47. Clackson, T. & Lowman, H.B. . Phage Display: A Practical Approach (Oxford University Press, New York, 2004).
    Google Scholar
48. Barbas, C.F., III, Burton, D.R., Scott, J.K. & Silvermann, G.J. . Phage Display: A Laboratory Manual. (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY 2001).
    Google Scholar
49. Nielsen, H., Engelbrecht, J., Brunak, S. & von Heijne, G. Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites. Protein Eng. 10, 1–6 (1997).
    Article CAS PubMed Google Scholar
50. Gailus, V. & Rasched, I. The adsorption protein of bacteriophage fd and its neighbour minor coat protein build a structural entity. Eur. J. Biochem. 222, 927–931 (1994).
    Article CAS PubMed Google Scholar

Download references