Adaptation to culture of human embryonic stem cells and oncogenesis in vivo (original) (raw)

• O'Neill, L.P., Vermilyea, M.D. & Turner, B.M. Epigenetic characterization of the early embryo with a chromatin immunoprecipitation protocol applicable to small cell populations. Nat. Genet. 38, 835–841 (2006).
  Article CAS Google Scholar
• Bradley, A., Evans, M., Kaufman, M.H. & Robertson, E. Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines. Nature 309, 255–256 (1984).
  Article CAS Google Scholar
• Hoffman, L.M. & Carpenter, M.K. Characterization and culture of human embryonic stem cells. Nat. Biotechnol. 23, 699–708 (2005).
  Article CAS Google Scholar
• Enver, T. et al. Cellular differentiation hierarchies in normal and culture-adapted human embryonic stem cells. Hum. Mol. Genet. 14, 3129–3140 (2005).
  Article CAS Google Scholar
• Herszfeld, D. et al. CD30 is a survival factor and a biomarker for transformed human pluripotent stem cells. Nat. Biotechnol. 24, 351–357 (2006).
  Article CAS Google Scholar
• Andrews, P.W. et al. Embryonic stem (ES) cells and embryonal carcinoma (EC) cells: opposite sides of the same coin. Biochem. Soc. Trans. 33, 1526–1530 (2005).
  Article CAS Google Scholar
• Liu, Y. et al. Genome wide profiling of human embryonic stem cells (hESCs), their derivatives and embryonal carcinoma cells to develop base profiles of U.S. Federal government approved hESC lines. BMC Dev. Biol. 6, 20 (2006).
  Article CAS Google Scholar
• Boveri, T. The origin of malignant tumours (Williams and Walkin, Baltimore, 1914).
  Google Scholar
• Oosterhuis, J.W. & Looijenga, L.H. Testicular germ-cell tumours in a broader perspective. Nat. Rev. Cancer 5, 210–222 (2005).
  Article CAS Google Scholar
• Damjanov, I. Teratocarcinoma stem cells. Cancer Surv. 9, 303–319 (1990).
  CAS PubMed Google Scholar
• Moller, H. Clues to the aetiology of testicular germ cell tumours from descriptive epidemiology. Eur. Urol. 23, 8–13; discussion 14–15 (1993).
  Article CAS Google Scholar
• Damjanov, I. Pathogenesis of testicular germ cell tumours. Eur. Urol. 23, 2–5; discussion 6–7 (1993).
  Article Google Scholar
• Andrews, P.W. From teratocarcinomas to embryonic stem cells. Phil. Trans. R. Soc. Lond. B 357, 405–417 (2002).
  Article Google Scholar
• Draper, J.S. et al. Recurrent gain of chromosomes 17q and 12 in cultured human embryonic stem cells. Nat. Biotechnol. 22, 53–54 (2004).
  Article CAS Google Scholar
• Mitalipova, M.M. et al. Preserving the genetic integrity of human embryonic stem cells. Nat. Biotechnol. 23, 19–20 (2005).
  Article CAS Google Scholar
• Brimble, S.N. et al. Karyotypic stability, genotyping, differentiation, feeder-free maintenance, and gene expression sampling in three human embryonic stem cell lines derived prior to August 9, 2001. Stem Cells Dev. 13, 585–597 (2004).
  Article CAS Google Scholar
• Buzzard, J.J., Gough, N.M., Crook, J.M. & Colman, A. Karyotype of human ES cells during extended culture. Nat Biotechnol. 22, 381–382; author reply 382 (2004).
  Article CAS Google Scholar
• Imreh, M.P. et al. In vitro culture conditions favoring selection of chromosomal abnormalities in human ES cells. J. Cell. Biochem. 99, 508–516 (2006).
  Article CAS Google Scholar
• Maitra, A. et al. Genomic alterations in cultured human embryonic stem cells. Nat. Genet. 37, 1099–1103 (2005).
  Article CAS Google Scholar
• Josephson, R. et al. A molecular scheme for improved characterization of human embryonic stem cell lines. BMC Biol. 4, 28 (2006).
  Article Google Scholar
• Reuter, V.E. Origins and molecular biology of testicular germ cell tumors. Mod. Pathol. 18 (suppl. 2), S51–S60 (2005).
  Article CAS Google Scholar
• Samaniego, F. et al. Cytogenetic and molecular analysis of human male germ cell tumors: chromosome 12 abnormalities and gene amplification. Genes Chromosom. Cancer 1, 289–300 (1990).
  Article CAS Google Scholar
• Kraggerud, S.M. et al. Genome profiles of familial/bilateral and sporadic testicular germ cell tumors. Genes Chromosom. Cancer 34, 168–174 (2002).
  Article CAS Google Scholar
• Summersgill, B.M. et al. Definition of chromosome aberrations in testicular germ cell tumor cell lines by 24-color karyotyping and complementary molecular cytogenetic analyses. Cancer Genet. Cytogenet. 128, 120–129 (2001).
  Article CAS Google Scholar
• von Eyben, F.E. Chromosomes, genes, and development of testicular germ cell tumors. Cancer Genet. Cytogenet. 151, 93–138 (2004).
  Article CAS Google Scholar
• Sugawara, A., Goto, K., Sotomaru, Y., Sofuni, T. & Ito, T. Current status of chromosomal abnormalities in mouse embryonic stem cell lines used in Japan. Comp. Med. 56, 31–34 (2006).
  CAS PubMed Google Scholar
• Lastowska, M. et al. Breakpoint position on 17q identifies the most aggressive neuroblastoma tumors. Genes Chromosom. Cancer 34, 428–436 (2002).
  Article CAS Google Scholar
• Tirkkonen, M. et al. Molecular cytogenetics of primary breast cancer by CGH. Genes Chromosom. Cancer 21, 177–184 (1998).
  Article CAS Google Scholar
• Azuhata, T. et al. The inhibitor of apoptosis protein survivin is associated with high-risk behavior of neuroblastoma. J. Pediatr. Surg. 36, 1785–1791 (2001).
  Article CAS Google Scholar
• Cowan, C.A. et al. Derivation of embryonic stem-cell lines from human blastocysts. N. Engl. J. Med. 350, 1353–1356 (2004).
  Article CAS Google Scholar
• Korkola, J.E. et al. Down-regulation of stem cell genes, including those in a 200-kb gene cluster at 12p13.31, is associated with in vivo differentiation of human male germ cell tumors. Cancer Res. 66, 820–827 (2006).
  Article CAS Google Scholar
• Skotheim, R.I. et al. Novel genomic aberrations in testicular germ cell tumors by array-CGH, and associated gene expression changes. Cell. Oncol. 28, 315–326 (2006).
  CAS PubMed PubMed Central Google Scholar
• Roelofs, H. et al. Restricted 12p amplification and RAS mutation in human germ cell tumors of the adult testis. Am. J. Pathol. 157, 1155–1166 (2000).
  Article CAS Google Scholar
• Zafarana, G. et al. 12p-amplicon structure analysis in testicular germ cell tumors of adolescents and adults by array CGH. Oncogene 22, 7695–7701 (2003).
  Article CAS Google Scholar
• Ludwig, T.E. et al. Derivation of human embryonic stem cells in defined conditions. Nat. Biotechnol. 24, 185–187 (2006).
  Article CAS Google Scholar
• Inzunza, J. et al. Comparative genomic hybridization and karyotyping of human embryonic stem cells reveals the occurrence of an isodicentric X chromosome after long-term cultivation. Mol. Hum. Reprod. 10, 461–466 (2004).
  Article CAS Google Scholar
• Sperger, J.M. et al. Gene expression patterns in human embryonic stem cells and human pluripotent germ cell tumors. Proc. Natl. Acad. Sci. USA 100, 13350–13355 (2003).
  Article CAS Google Scholar
• Dhara, S.K. & Benvenisty, N. Gene trap as a tool for genome annotation and analysis of X chromosome inactivation in human embryonic stem cells. Nucleic Acids Res. 32, 3995–4002 (2004).
  Article CAS Google Scholar
• Sandberg, A.A., Meloni, A.M. & Suijkerbuijk, R.F. Reviews of chromosome studies in urological tumors. III. Cytogenetics and genes in testicular tumors. J. Urol. 155, 1531–1556 (1996).
  Article CAS Google Scholar
• Kawakami, T. et al. The roles of supernumerical X chromosomes and XIST expression in testicular germ cell tumors. J. Urol. 169, 1546–1552 (2003).
  Article Google Scholar
• Yang, S.H., Jaffray, E., Hay, R.T. & Sharrocks, A.D. Dynamic interplay of the SUMO and ERK pathways in regulating Elk-1 transcriptional activity. Mol. Cell 12, 63–74 (2003).
  Article CAS Google Scholar
• Wu, X., Noh, S.J., Zhou, G., Dixon, J.E. & Guan, K.L. Selective activation of MEK1 but not MEK2 by A-Raf from epidermal growth factor-stimulated HeLa cells. J. Biol. Chem. 271, 3265–3271 (1996).
  Article CAS Google Scholar
• Ishitani, K. et al. p54nrb acts as a transcriptional coactivator for activation function 1 of the human androgen receptor. Biochem. Biophys. Res. Commun. 306, 660–665 (2003).
  Article CAS Google Scholar
• Bai, V.U., Cifuentes, E., Menon, M., Barrack, E.R. & Reddy, G.P. Androgen receptor regulates Cdc6 in synchronized LNCaP cells progressing from G1 to S phase. J. Cell. Physiol. 204, 381–387 (2005).
  Article CAS Google Scholar
• Rapley, E.A. et al. Localization to Xq27 of a susceptibility gene for testicular germ-cell tumours. Nat. Genet. 24, 197–200 (2000).
  Article CAS Google Scholar
• Daley, G.Q. & Baltimore, D. Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P210bcr/abl protein. Proc. Natl. Acad. Sci. USA 85, 9312–9316 (1988).
  Article CAS Google Scholar
• Wang, N., Trend, B., Bronson, D.L. & Fraley, E.E. Nonrandom abnormalities in chromosome 1 in human testicular cancers. Cancer Res. 40, 796–802 (1980).
  CAS PubMed Google Scholar
• Looijenga, L.H. et al. Comparative genomic hybridization of microdissected samples from different stages in the development of a seminoma and a non-seminoma. J. Pathol. 191, 187–192 (2000).
  Article CAS Google Scholar
• Biedler, J.L. & Spengler, B.A. A novel chromosome abnormality in human neuroblastoma and antifolate-resistant Chinese hamster cell lives in culture. J. Natl. Cancer Inst. 57, 683–695 (1976).
  Article CAS Google Scholar
• Benner, S.E., Wahl, G.M. & Von Hoff, D.D. Double minute chromosomes and homogeneously staining regions in tumors taken directly from patients versus in human tumor cell lines. Anticancer Drugs 2, 11–25 (1991).
  Article CAS Google Scholar
• Albrecht, S., Armstrong, D.L., Mahoney, D.H., Cheek, W.R. & Cooley, L.D. Cytogenetic demonstration of gene amplification in a primary intracranial germ cell tumor. Genes Chromosom. Cancer 6, 61–63 (1993).
  Article CAS Google Scholar
• van Dartel, M. & Hulsebos, T.J. Amplification and overexpression of genes in 17p11.2 ∼ p12 in osteosarcoma. Cancer Genet. Cytogenet. 153, 77–80 (2004).
  Article CAS Google Scholar
• Skotheim, R.I. et al. Novel genomic aberrations in testicular germ cell tumours by array-CGH, and associated gene expression changes. Cell. Oncol. 28, 315–326 (2006).
  CAS PubMed PubMed Central Google Scholar
• Feng, G.S. et al. Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway. J. Biol. Chem. 271, 12129–12132 (1996).
  Article CAS Google Scholar
• Burdon, T., Smith, A. & Savatier, P. Signalling, cell cycle and pluripotency in embryonic stem cells. Trends Cell Biol. 12, 432–438 (2002).
  Article CAS Google Scholar
• Kang, H.B. et al. Basic fibroblast growth factor activates ERK and induces c-fos in human embryonic stem cell line MizhES1. Stem Cells Dev. 14, 395–401 (2005).
  Article CAS Google Scholar
• Cervantes, R.B., Stringer, J.R., Shao, C., Tischfield, J.A. & Stambrook, P.J. Embryonic stem cells and somatic cells differ in mutation frequency and type. Proc. Natl. Acad. Sci. USA 99, 3586–3590 (2002).
  Article CAS Google Scholar
• Hong, Y. & Stambrook, P.J. Restoration of an absent G1 arrest and protection from apoptosis in embryonic stem cells after ionizing radiation. Proc. Natl. Acad. Sci. USA 101, 14443–14448 (2004).
  Article CAS Google Scholar
• Fluckiger, A.C. et al. Cell cycle features of primate embryonic stem cells. Stem Cells 24, 547–556 (2006).
  Article CAS Google Scholar
• Downes, C.S. et al. A topoisomerase II-dependent G2 cycle checkpoint in mammalian cells. Nature 372, 467–470 (1994).
  Article CAS Google Scholar
• Damelin, M., Sun, Y.E., Sodja, V.B. & Bestor, T.H. Decatenation checkpoint deficiency in stem and progenitor cells. Cancer Cell 8, 479–484 (2005).
  Article CAS Google Scholar
• Amon, A. The spindle checkpoint. Curr. Opin. Genet. Dev. 9, 69–75 (1999).
  Article CAS Google Scholar
• Wilton, L. Preimplantation genetic diagnosis for aneuploidy screening in early human embryos: a review. Prenat. Diagn. 22, 512–518 (2002).
  Article Google Scholar
• Hardy, K. Cell death in the mammalian blastocyst. Mol. Hum. Reprod. 3, 919–925 (1997).
  Article CAS Google Scholar
• von Zglinicki, T., Pilger, R. & Sitte, N. Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts. Free Radic. Biol. Med. 28, 64–74 (2000).
  Article CAS Google Scholar
• Andrews, P.W. et al. Pluripotent embryonal carcinoma clones derived from the human teratocarcinoma cell line Tera-2. Differentiation in vivo and in vitro. Lab. Invest. 50, 147–162 (1984).
  CAS PubMed Google Scholar
• Andrews, P.W., Goodfellow, P.N., Shevinsky, L.H., Bronson, D.L. & Knowles, B.B. Cell-surface antigens of a clonal human embryonal carcinoma cell line: morphological and antigenic differentiation in culture. Int. J. Cancer 29, 523–531 (1982).
  Article CAS Google Scholar
• Amit, M. et al. Clonally derived human embryonic stem cell lines maintain pluripotency and proliferative potential for prolonged periods of culture. Dev. Biol. 227, 271–278 (2000).
  Article CAS Google Scholar
• Pyle, A.D., Lock, L.F. & Donovan, P.J. Neurotrophins mediate human embryonic stem cell survival. Nat. Biotechnol. 24, 344–350 (2006).
  Article CAS Google Scholar
• Liu, X. et al. Trisomy eight in ES cells is a common potential problem in gene targeting and interferes with germ line transmission. Dev. Dyn. 209, 85–91 (1997).
  Article CAS Google Scholar
• Longo, L., Bygrave, A., Grosveld, F.G. & Pandolfi, P.P. The chromosome make-up of mouse embryonic stem cells is predictive of somatic and germ cell chimaerism. Transgenic Res. 6, 321–328 (1997).
  Article CAS Google Scholar
• Draper, J.S., Moore, H.D., Ruban, L.N., Gokhale, P.J. & Andrews, P.W. Culture and characterization of human embryonic stem cells. Stem Cells Dev. 13, 325–336 (2004).
  Article CAS Google Scholar
• Caisander, G. et al. Chromosomal integrity maintained in five human embryonic stem cell lines after prolonged in vitro culture. Chromosome Res. 14, 131–137 (2006).
  Article CAS Google Scholar
• Rosler, E.S. et al. Long-term culture of human embryonic stem cells in feeder-free conditions. Dev. Dyn. 229, 259–274 (2004).
  Article CAS Google Scholar
• Xiao, L., Yuan, X. & Sharkis, S.J. Activin A maintains self-renewal and regulates fibroblast growth factor, Wnt, and bone morphogenic protein pathways in human embryonic stem cells. Stem Cells 24, 1476–1486 (2006).
  Article CAS Google Scholar
• Kim, S.J. et al. Efficient derivation of new human embryonic stem cell lines. Mol. Cells 19, 46–53 (2005).
  CAS PubMed Google Scholar
• Thomson, J.A. et al. Embryonic stem cell lines derived from human blastocysts. Science 282, 1145–1147 (1998).
  Article CAS Google Scholar
• Smith, A.C. et al. Interstitial deletion of (17)(p11.2p11.2) in nine patients. Am. J. Med. Genet. 24, 393–414 (1986).
  Article CAS Google Scholar