Immunomodulation of enzyme function in plants by single-domain antibody fragments (original) (raw)

• De Jaeger, G., De Wilde, C., Eeckhout, D., Fiers, E. & Depicker, A. The plantibody approach: expression of antibody genes in plants to modulate plant metabolism or to obtain pathogen resistance. Plant Mol. Biol. 43, 419–428 (2000).
  Article CAS Google Scholar
• Conrad, U. & Manteuffel, R. Immunomodulation of phytohormones and functional proteins in plant cells. Trends Plant Sci. 6, 399–402 (2001).
  Article CAS Google Scholar
• Hiatt, A., Cafferkey, R. & Bowdish, K. Production of antibodies in transgenic plants. Nature 342, 76–78 (1989).
  Article CAS Google Scholar
• Hamers-Casterman, C. et al. Naturally occurring antibodies devoid of light chains. Nature 363, 446–448 (1993).
  Article CAS Google Scholar
• Muyldermans, S. Cambillau, C. & Wyns, L. Recognition of antigens by single-domain antibody fragments: the superfluous luxury of paired domains. Trends Biochem. Sci. 26, 230–235 (2001).
  Article CAS Google Scholar
• Frenken, L.G.J. et al. Isolation of antigen specific llama VHH antibody fragments and their high level secretion by Saccharomyces cerevisiae. J. Biotechnol. 78, 11–21 (2000).
  Article CAS Google Scholar
• Van der Linden, R.H.J. et al. Improved production and function of llama heavy chain antibody fragments by molecular evolution. J. Biotechnol. 80, 261–270 (2000).
  Article CAS Google Scholar
• Lauwereys, M. et al. Potent enzyme inhibitors derived from dromedary heavy-chain antibodies. EMBO J. 17, 3512–3120 (1998).
  Article CAS Google Scholar
• Jobling, S.A. et al. A minor form of starch branching enzyme in potato (Solanum tuberosum L.) tubers has a major effect on starch structure: cloning and characterisation of multiple forms of SBE A. Plant J. 18, 163–171 (1999).
  Article CAS Google Scholar
• Schwall, G.P. et al. Production of very-high amylose potato starch by inhibition of SBE A and B. Nat. Biotechnol. 18, 551–554 (2000).
  Article CAS Google Scholar
• Kortsee, A.J. et al. Expression of Escherichia coli branching enzyme in tubers of amylose-free potato leads to an increased branching degree of the amylopectin. Plant J. 10, 83–90 (1996).
  Article Google Scholar
• Safford, R. et al. Consequences of antisense RNA inhibition of starch branching enzyme activity on properties of potato starch. Carbohyd. Polym. 35, 155–168 (1998).
  Article CAS Google Scholar
• Hovenkamp-Hermelink, J.H.M. et al. Rapid estimation of the amylose/amylopectin ratio in small amounts of tuber and leaf tissue of the potato. Potato Res. 31, 241–246 (1988).
  Article CAS Google Scholar
• Morrison, W.R. and Laignelet, B. An improved colourimetric procedure for determining apparent total amylose in cereal and other starches. J. Cereal Sci. 1, 9–20 (1983).
  Article CAS Google Scholar
• Lecerf, J.-M. et al. Human single-chain Fv intrabodies counteract in situ huntingtin aggregation in cellular models of Huntington's disease. Proc. Natl. Acad. Sci. USA 98, 4764–4769 (2001).
  Article CAS Google Scholar
• Lasowski, R.A., Luscombe, N.M., Swindells, M.B. & Thornton, J.M. Protein clefts in molecular recognition and function. Protein Sci. 5, 2438–2452 (1996).
  Google Scholar
• Wörn, A et al. Correlation between in vitro stability and in vivo performance of anti-GCN4 intrabodies as cytoplasmic inhibitors. J. Biol. Chem. 275, 2795–2803 (2000).
  Article Google Scholar
• Auf der Maur, A. Escher, D. & Barberis, A. Antigen-independent selection of stable intracellular single-chain antibodies. FEBS Lett. 508, 407–412 (2001).
  Article CAS Google Scholar
• Visintin, M. et al. The intracellular antibody capture technology (IACT): towards a consensus sequence for intracellular antibodies J. Mol. Biol. 317, 73–83 (2002).
  Article CAS Google Scholar
• Harmsen, M.M et al. Llama heavy-chain V regions consist of at least four distinct subfamilies revealing novel sequence features. Mol. Immunol. 37, 579–590 (2000).
  Article CAS Google Scholar
• Harrison, J.L., Williams, S.C., Winter, G. & Nissim, A. Screening of phage antibody libraries. Meth. Enzymol. 267, 83–109 (1996).
  Article CAS Google Scholar
• Hull, R., Sadler, J. & Longstaff, M. The sequence of carnation etched ring virus-DNA—comparison with cauliflower mosaic-virus and retroviruses. EMBO J. 5, 3083–3090 (1986).
  Article CAS Google Scholar
• Becker, D., Kemper, E., Schell, J. & Masterson, R. New plant binary vectors with selectable markers located proximal to the left T-DNA border. Plant Mol. Biol. 20, 1195–1197 (1992).
  Article CAS Google Scholar