Bernstein, E., Caudy, A.A., Hammond, S.M. & Hannon, G.J. Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature409, 363–366 (2001). ArticleCAS Google Scholar
Hammond, S.M., Bernstein, E., Beach, D. & Hannon, G.J. An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells. Nature404, 293–296 (2000). ArticleCAS Google Scholar
Elbashir, S.M. et al. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature411, 494–498 (2001). ArticleCAS Google Scholar
Tuschl, T. Expanding small RNA interference. Nat. Biotechnol.20, 446–448 (2002). ArticleCAS Google Scholar
Novina, C.D. et al. siRNA-directed inhibition of HIV-1 infection. Nat. Med.8, 681–686 (2002). ArticleCAS Google Scholar
Lee, N.S. et al. Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells. Nat. Biotechnol.20, 500–505 (2002). ArticleCAS Google Scholar
Jacque, J.M., Triques, K. & Stevenson, M. Modulation of HIV-1 replication by RNA interference. Nature418, 435–438 (2002). ArticleCAS Google Scholar
Hu, W., Myers, C., Kilzer, J., Pfaff, S. & Bushman, F. Inhibition of retroviral pathogenesis by RNA interference. Curr. Biol.12, 1301 (2002). ArticleCAS Google Scholar
Coburn, G.A. & Cullen, B.R. Potent and specific inhibition of human immunodeficiency virus type 1 replication by RNA interference. J. Virol.76, 9225–9231 (2002). ArticleCAS Google Scholar
Gitlin, L., Karelsky, S. & Andino, R. Short interfering RNA confers intracellular antiviral immunity in human cells. Nature418, 430–434 (2002). ArticleCAS Google Scholar
Jiang, M. & Milner, J. Selective silencing of viral gene expression in HPV-positive human cervical carcinoma cells treated with siRNA, a primer of RNA interference. Oncogene21, 6041–6048 (2002). ArticleCAS Google Scholar
Shlomai, A. & Shaul, Y. Inhibition of hepatitis B virus expression and replication by RNA interference. Hepatology37, 764–770 (2003). ArticleCAS Google Scholar
McCaffrey, A.P. et al. RNA interference in adult mice. Nature418, 38–39 (2002). ArticleCAS Google Scholar
Yang, P.L., Althage, A., Chung, J. & Chisari, F.V. Hydrodynamic injection of viral DNA: a mouse model of acute hepatitis B virus infection. Proc. Natl. Acad. Sci. USA99, 13825–13830 (2002). ArticleCAS Google Scholar
McLachlan, A. Molecular Biology of the Hepatitis B Virus (CRC Press, Boca Raton, Florida, 1991). Google Scholar
Marion, P.L. et al. in Frontiers in Viral Hepatitis (eds. Schinazi, R.F. and Sommadossi, J.P.) 197–209 (Elsevier Science, Amsterdam, 2003). Book Google Scholar
Yant, S.R. et al. Somatic integration and long-term transgene expression in normal and haemophilic mice using a DNA transposon system. Nat. Genet.25, 35–41 (2000). ArticleCAS Google Scholar
Kay, M.A., Graham, F., Leland, F. & Woo, S.L. Therapeutic serum concentrations of human α1-antitrypsin after adenoviral-mediated gene transfer into mouse hepatocytes. Hepatology21, 815–819 (1995). CAS Google Scholar
Zhang, G., Budker, V. & Wolff, J.A. High levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA. Hum. Gene Ther.10, 1735–1737 (1999). ArticleCAS Google Scholar
Liu, F., Song, Y. & Liu, D. Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA. Gene Ther.6, 1258–1266 (1999). ArticleCAS Google Scholar
Song, E. et al. RNA interference targeting Fas protects mice from fulminant hepatitis. Nat. Med.9, 347–351 (2003). ArticleCAS Google Scholar
Paddison, P.J., Caudy, A.A., Bernstein, E., Hannon, G.J. & Conklin, D.S. Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells. Genes Dev.16, 948–958 (2002). ArticleCAS Google Scholar
Sells, M.A., Chen, M.L. & Acs, G. Production of hepatitis B virus particles in Hep G2 cells transfected with cloned hepatitis B virus DNA. Proc. Natl. Acad. Sci. USA84, 1005–1009 (1987). ArticleCAS Google Scholar