Cdk5 is essential for synaptic vesicle endocytosis - Nature Cell Biology (original) (raw)

• Liu, J.P., Sim, A.T.R. & Robinson, P.J. Calcineurin inhibition of dynamin I GTPase activity coupled to nerve terminal depolarization. Science 265, 970–973 (1994).
  Article CAS Google Scholar
• Marks, B. & McMahon, H.T. Calcium triggers calcineurin-dependent synaptic vesicle recycling in mammalian nerve terminals. Curr.Biol. 8, 740–749 (1998).
  Article CAS Google Scholar
• Cousin, M.A., Tan, T.C. & Robinson, P.J. Protein phosphorylation is required for endocytosis in nerve terminals. Potential role for the dephosphins dynamin I and synaptojanin, but not AP180 or amphiphysin. J. Neurochem. 76, 105–116 (2001).
  Article CAS Google Scholar
• Cousin, M.A. Synaptic vesicle endocytosis: calcium works overtime in the nerve terminal. Mol. Neurobiol. 22, 115–128 (2000).
  Article CAS Google Scholar
• Cousin, M.A. & Robinson, P.J. The dephosphins: Dephosphorylation by calcineurin triggers synaptic vesicle endocytosis. Trends Neurosci. 24, 659–665 (2001).
  Article CAS Google Scholar
• Wenk, M.R. et al. PIP Kinase Iγ is the major PI(4,5)P2 synthesizing enzyme at the synapse. Neuron 32, 79–88 (2001).
  Article CAS Google Scholar
• Powell, K.A. et al. Phosphorylation of dynamin I on Ser-795 by protein kinase C blocks its association with phospholipids. J. Biol. Chem. 275, 11610–11617 (2000).
  Article CAS Google Scholar
• Marks, B. et al. GTPase activity of dynamin and resulting conformation change are essential for endocytosis. Nature 410, 231–235 (2001).
  Article CAS Google Scholar
• Shupliakov, O. et al. Synaptic vesicle endocytosis impaired by disruption of dynamin-SH3 domain interactions. Science 276, 259–263 (1997).
  Article CAS Google Scholar
• Gad, H. et al. Fission and uncoating of synaptic clathrin-coated vesicles are perturbed by disruption of interactions with the SH3 domain of endophilin. Neuron 27, 301–312 (2000).
  Article CAS Google Scholar
• Robinson, P.J. Dephosphin, a 96,000 dalton substrate of protein kinase C in synaptosomal cytosol is phosphorylated in intact synaptosomes. FEBS Lett. 282, 388–392 (1991).
  Article CAS Google Scholar
• Robinson, P.J. et al. Dynamin GTPase regulated by protein kinase C phosphorylation in nerve terminals. Nature 365, 163–166 (1993).
  Article CAS Google Scholar
• Hosoya, H. et al. Phosphorylation of dynamin by cdc2 kinase. Biochem. Biophys. Res. Commun. 202, 1127–1133 (1994).
  Article CAS Google Scholar
• Earnest, S., Khokhlatchev, A., Albanesi, J.P. & Barylko, B. Phosphorylation of dynamin by ERK2 inhibits the dynamin–microtubule interaction. FEBS Lett. 396, 62–66 (1996).
  Article CAS Google Scholar
• Chen-Hwang, M.-C., Chen, H.-R., Elzinga, M. & Hwang, Y.-W. Dynamin is a minibrain kinase/Dyrk1A substrate. J. Biol. Chem. 277, 17597–17604 (2002).
  Article CAS Google Scholar
• Songyang, Z. et al. A structural basis for substrate specificities of protein Ser/Thr kinases: primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5, and Erk1. Mol. Cell. Biol. 16, 6486–6493 (1996).
  Article CAS Google Scholar
• Tomizawa, K. et al. Cdk5/p35 regulates neurotransmitter release through phosphorylation and downregulation of P/Q-type voltage-dependent calcium channel activity. J. Neurosci. 22, 2590–2597 (2002).
  Article CAS Google Scholar
• Matsubara, M. et al. Site-specific phosphorylation of synapsin I by mitogen-activated protein kinase and Cdk5 and its effects on physiological functions. J. Biol. Chem. 271, 21108–21113 (1996).
  Article CAS Google Scholar
• Shuang, R.Q. et al. Regulation of Munc-18 syntaxin 1A interaction by cyclin-dependent kinase 5 in nerve endings. J. Biol. Chem. 273, 4957–4966 (1998).
  Article CAS Google Scholar
• Floyd, S.R. et al. Amphiphysin binds the cdk5 regulatory subunit p35 and is phosphorylated by cdk5 and cdc2. J. Biol. Chem. 276, 8104–8110 (2001).
  Article CAS Google Scholar
• Hill, E., van der, K.J., Downes, C.P. & Smythe, E. The role of dynamin and its binding partners in coated pit invagination and scission. J. Cell Biol. 152, 309–324 (2001).
  Article CAS Google Scholar
• Grabs, D. et al. The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding consensus sequence. J. Biol. Chem. 272, 13419–13425 (1997).
  Article CAS Google Scholar
• Meijer, L. et al. Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5. Eur. J. Biochem. 243, 527–536 (1997).
  Article CAS Google Scholar
• Davies, S.P., Reddy, H., Caivano, M. & Cohen, P. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem. J. 351, 95–105 (2000).
  Article CAS Google Scholar
• Cousin, M.A. et al. Synapsin I-associated phosphatidylinositol 3-kinase mediates synaptic vesicle delivery to the readily releasable pool. J. Biol. Chem. (cited 16 May 2003) DOI: 10.1074/jbc.M302386200 (2003).
• Rosales, J.L., Nodwell, M.J., Johnston, R.N. & Lee, K.Y. Cdk5/p25(nck5a) interaction with synaptic proteins in bovine brain. J. Cell. Biochem. 78, 151–159 (2000).
  Article CAS Google Scholar
• Cousin, M.A. & Robinson, P.J. Ca2+ inhibition of dynamin arrests synaptic vesicle recycling at the active zone. J. Neurosci. 20, 949–957 (2000).
  Article CAS Google Scholar
• Koenig, J.H. & Ikeda, K. Disappearance and reformation of synaptic vesicle membrane upon transmitter release observed under reversible blockage of membrane retrieval. J. Neurosci. 9, 3844–3860 (1989).
  Article CAS Google Scholar
• Liu, J.P., Powell, K.A., Südhof, T.C. & Robinson, P.J. Dynamin I is a Ca2+-sensitive phospholipid-binding protein with very high affinity for protein kinase C. J. Biol. Chem. 269, 21043–21050 (1994).
  CAS PubMed Google Scholar
• Robinson, P.J. Differential stimulation of protein kinase C activity by phorbol ester or calcium/phosphatidylserine in vitro and in intact synaptosomes. J. Biol. Chem. 267, 21637–21644 (1992).
  CAS PubMed Google Scholar
• Robinson, P.J., Liu, J.P., Powell, K.A., Fykse, E.M. & Südhof, T.C. Phosphorylation of dynamin I and synaptic vesicle recycling. Trends Neurosci. 17, 348–353 (1994).
  Article CAS Google Scholar
• Dhavan, R., Tsai, L.H. & Tsai, L.H. A decade of cdk5. Nature Rev. Mol. Cell Biol. 2, 749–759 (2001).
  Article CAS Google Scholar
• Ohshima, T. et al. Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death. Proc. Natl Acad. Sci. USA 93, 11173–11178 (1996).
  Article CAS Google Scholar
• Kwon, Y.T., Tsai, L.H. & Crandall, J.E. Callosal axon guidance defects in p35(−/−) mice. J. Comp. Neurol. 415, 218–229 (1999).
  Article CAS Google Scholar
• Tsai, L.H., Takahashi, T., Caviness, V.S.J. & Harlow, E. Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system. Development 119, 1029–1040 (1993).
  CAS PubMed Google Scholar
• Bibb, J.A. et al. Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5. Nature 410, 376–380 (2001).
  Article CAS Google Scholar
• Fletcher, A.I. et al. Regulation of exocytosis by cyclin-dependent kinase 5 via phosphorylation of munc18. J. Biol. Chem. 274, 4027–4035 (1999).
  Article CAS Google Scholar
• Li, B.S. et al. Regulation of NMDA receptors by cyclin-dependent kinase-5. Proc. Natl Acad. Sci. USA 98, 12742–12747 (2001).
  Article CAS Google Scholar
• Yan, Z., Chi, P., Bibb, J.A., Ryan, T.A. & Greengard, P. Roscovitine: a novel regulator of P/Q-type calcium channels and transmitter release in central neurons. J. Physiol. 540, 761–770 (2002).
  Article CAS Google Scholar
• Nicholls, D.G. The glutamatergic nerve terminal. Eur. J. Biochem. 212, 613–631 (1993).
  Article CAS Google Scholar
• Wilde, A. & Brodsky, F.M. In vivo phosphorylation of adaptors regulates their interaction with clathrin. J. Cell Biol. 135, 635–645 (1996).
  Article CAS Google Scholar
• Kariya, K. et al. Regulation of complex formation of POB1/epsin/adaptor protein complex 2 by mitotic phosphorylation. J. Biol. Chem. 275, 18399–18406 (2000).
  Article CAS Google Scholar
• Slepnev, V.I., Ochoa, G.C., Butler, M.H., Grabs, D. & DeCamilli, P. Role of phosphorylation in regulation of the assembly of endocytic coat complexes. Science 281, 821–824 (1998).
  Article CAS Google Scholar
• Rasmussen, R.K., Rusak, J., Price, G., Robinson, P.J. & Dorow, D.S. Mixed lineage kinase 2–SH3 domain binds dynamin and greatly enhances GTPase activation by phospholipid. Biochem. J. 335, 119–124 (1998).
  Article CAS Google Scholar
• Negash, S., Wang, H.S., Gao, C., Ledee, D. & Zelenka, P. Cdk5 regulates cell-matrix and cell-cell adhesion in lens epithelial cells. J. Cell Sci. 115, 2109–2117 (2002).
  CAS PubMed Google Scholar
• van den Heuvel, S. & Harlow, E. Distinct roles for cyclin-dependent kinases in cell cycle control. Science 262, 2050–2054 (1993).
  Article CAS Google Scholar
• Stowell, M.H., Marks, B., Wigge, P. & McMahon, H.T. Nucleotide-dependent conformational changes in dynamin: evidence for a mechanochemical molecular spring. Nature Cell Biol. 1, 27–32 (1999).
  Article CAS Google Scholar
• Wang, L.-H., Südhof, T.C. & Anderson, R.G. The appendage domain of α-adaptin is a high-affinity binding site for dynamin. J. Biol. Chem. 270, 10079–10083 (1995).
  Article CAS Google Scholar
• Micheva, K.D., Ramjaun, A.R., Kay, B.K. & McPherson, P.S. SH3 domain-dependent interactions of endophilin with amphiphysin. FEBS Lett. 414, 308–312 (1997).
  Article CAS Google Scholar
• Zhou, W., Merrick, B.A., Khaledi, M.G. & Tomer, K.B. Detection and sequencing of phosphopeptides affinity bound to immobilized metal ion beads by matrix-assisted laser desorption/ionization mass spectrometry. J. Am. Soc. Mass Spectrom. 11, 273–282 (2000).
  Article CAS Google Scholar