PTOP interacts with POT1 and regulates its localization to telomeres (original) (raw)

References

  1. Blackburn, E.H. Switching and signaling at the telomere. Cell 106, 661–673 (2001).
    Article CAS PubMed Google Scholar
  2. Wright, W.E. & Shay, J.W. Cellular senescence as a tumor-protection mechanism: the essential role of counting. Curr. Opin. Genet. Dev. 11, 98–103 (2001).
    Article CAS PubMed Google Scholar
  3. de Lange, T. Protection of mammalian telomeres. Oncogene 21, 532–540 (2002).
    Article CAS PubMed Google Scholar
  4. Kim Sh, S.H., Kaminker, P. & Campisi, J. Telomeres, aging and cancer: in search of a happy ending. Oncogene 21, 503–511 (2002).
    Article PubMed Google Scholar
  5. Maser, R.S. & DePinho, R.A. Connecting chromosomes, crisis, and cancer. Science 297, 565–569 (2002).
    Article CAS PubMed Google Scholar
  6. van Steensel, B. & de Lange, T. Control of telomere length by the human telomeric protein TRF1. Nature 385, 740–743 (1997).
    Article CAS PubMed Google Scholar
  7. van Steensel, B., Smogorzewska, A. & de Lange, T. TRF2 protects human telomeres from end-to-end fusions. Cell 92, 401–413 (1998).
    Article CAS PubMed Google Scholar
  8. Smith, S., Giriat, I., Schmitt, A. & de Lange, T. Tankyrase, a poly(ADP-ribose) polymerase at human telomeres. Science 282, 1484–1487 (1998).
    Article CAS PubMed Google Scholar
  9. Kim, S.H., Kaminker, P. & Campisi, J. TIN2, a new regulator of telomere length in human cells. Nature Genet. 23, 405–412 (1999).
    Article CAS PubMed Google Scholar
  10. Baumann, P. & Cech, T.R. Pot1, the putative telomere end-binding protein in fission yeast and humans. Science 292, 1171–1175 (2001).
    Article CAS PubMed Google Scholar
  11. Cong, Y.S., Wright, W.E. & Shay, J.W. Human telomerase and its regulation. Microbiol. Mol. Biol. Rev. 66, 407–425 (2002).
    Article CAS PubMed PubMed Central Google Scholar
  12. Loayza, D. & De Lange, T. POT1 as a terminal transducer of TRF1 telomere length control. Nature 424, 1013–1018 (2003).
    Article Google Scholar
  13. Gottschling, D.E. & Zakian, V.A. Telomere proteins: specific recognition and protection of the natural termini of Oxytricha macronuclear DNA. Cell 47, 195–205 (1986).
    Article CAS PubMed Google Scholar
  14. Gray, J.T., Celander, D.W., Price, C.M. & Cech, T.R. Cloning and expression of genes for the Oxytricha telomere-binding protein: specific subunit interactions in the telomeric complex. Cell 67, 807–814 (1991).
    Article CAS PubMed Google Scholar
  15. Lin, J.J. & Zakian, V.A. The Saccharomyces CDC13 protein is a single-strand TG1-3 telomeric DNA-binding protein in vitro that affects telomere behavior in vivo. Proc. Natl Acad. Sc.i USA 93, 13760–13765 (1996).
    Article CAS Google Scholar
  16. Nugent, C.I., Hughes, T.R., Lue, N.F. & Lundblad, V. Cdc13p: a single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance. Science 274, 249–252 (1996).
    Article CAS PubMed Google Scholar
  17. Horvath, M.P., Schweiker, V.L., Bevilacqua, J.M., Ruggles, J.A. & Schultz, S.C. Crystal structure of the Oxytricha nova telomere end binding protein complexed with single strand DNA. Cell 95, 963–974 (1998).
    Article CAS PubMed Google Scholar
  18. Mitton-Fry, R.M., Anderson, E.M., Hughes, T.R., Lundblad, V. & Wuttke, D.S. Conserved structure for single-stranded telomeric DNA recognition. Science 296, 145–147 (2002).
    Article CAS PubMed Google Scholar
  19. Lei, M., Podell, E.R., Baumann, P. & Cech, T.R. DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA. Nature 426, 198–203 (2003).
    Article CAS PubMed Google Scholar
  20. Zhou, X.Z. & Lu, K.P. The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor. Cell 107, 347–359 (2001).
    Article CAS PubMed Google Scholar
  21. Smith, S. & de Lange, T. Tankyrase promotes telomere elongation in human cells. Curr. Biol. 10, 1299–1302 (2000).
    Article CAS PubMed Google Scholar
  22. Smogorzewska, A. et al. Control of human telomere length by TRF1 and TRF2. Mol. Cell. Biol. 20, 1659–1668 (2000).
    Article CAS PubMed PubMed Central Google Scholar
  23. Loayza, D., Parsons, H., Donigian, J., Hoke, K. & De Lange, T. DNA binding features of human POT1: A nonamer 5′-TAGGGTTAG-3′ minimal binding site, sequence specificity, and internal binding to multimeric sites. J. Biol. Chem. 7, (2004).
  24. Evans, S.K. & Lundblad, V. Est1 and Cdc13 as comediators of telomerase access. Science 286, 117–120 (1999).
    Article CAS PubMed Google Scholar
  25. Pennock, E., Buckley, K. & Lundblad, V. Cdc13 delivers separate complexes to the telomere for end protection and replication. Cell 104, 387–396 (2001).
    Article CAS PubMed Google Scholar
  26. Li, B., Oestreich, S. & de Lange, T. Identification of human Rap1: implications for telomere evolution. Cell 101, 471–483 (2000).
    Article CAS PubMed Google Scholar
  27. Rodriguez, M., Li, S.S., Harper, J.W. & Songyang, Z. An oriented peptide array library (OPAL) strategy to study protein-protein interactions. J. Biol. Chem. 279, 8802–8807 (2004).
    Article CAS PubMed Google Scholar
  28. Colgin, L.M., Baran, K., Baumann, P., Cech, T.R. & Reddel, R.R. Human POT1 facilitates telomere elongation by telomerase. Curr. Biol. 13, 942–946 (2003).
    Article CAS PubMed Google Scholar
  29. Walhout, A.J. & Vidal, M. High-throughput yeast two-hybrid assays for large-scale protein interaction mapping. Methods 24, 297–306 (2001).
    Article CAS PubMed Google Scholar
  30. Ouellette, M.M. et al. Subsenescent telomere lengths in fibroblasts immortalized by limiting amounts of telomerase. J. Biol. Chem. 275, 10072–10076 (2000).
    Article CAS PubMed Google Scholar

Download references