Nitric oxide induces coupling of mitochondrial signalling with the endoplasmic reticulum stress response (original) (raw)

References

1. Moncada, S. & Erusalimsky, J. D. Does nitric oxide modulate mitochondrial energy generation and apoptosis? Nature Rev. Mol. Biol. 3, 214–220 (2002).
   Article CAS Google Scholar
2. Brown, G. C. Regulation of mitochondrial respiration by nitric oxide inhibition of cytochrome c oxidase. Biochim. Biophys. Acta 1504, 46–57 (2001).
   Article CAS PubMed Google Scholar
3. Cooper, C. E. Nitric oxide and cytochrome oxidase: substrate, inhibitor or effector? Trends Biochem. Sci. 27, 33–39 (2002).
   Article CAS PubMed Google Scholar
4. Ye, J. et al. ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. Mol. Cell 6, 1355–1364 (2000).
   Article CAS PubMed Google Scholar
5. Brown, M. S., Ye, J., Rawson, R. B, & Goldstein, J. L. Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans. Cell 100, 391–398 (2000).
   Article CAS PubMed Google Scholar
6. Reddy, R. K. et al. Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: role of ATP binding site in suppression of caspase-7 activation. J. Biol. Chem. 278, 20915–20924 (2003).
   Article CAS PubMed Google Scholar
7. Thastrup, O., Cullen, P. J., Drobak, B. K., Hanley, M. R. & Dawson, A. P. Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2+-ATPase. Proc. Natl Acad. Sci. USA 87, 2466–2470 (1990).
   Article CAS PubMed PubMed Central Google Scholar
8. Crompton, M. The mitochondrial permeability transition pore and its role in cell death. Biochem. J. 341, 233–249 (1999).
   Article CAS PubMed PubMed Central Google Scholar
9. Chen, L. Y., Chiang, A. S., Hung, J. J., Hung, H.l., & Lai, Y. K. Thapsigargin-induced grp78 expression is mediated by the increase of cytosolic free calcium in 9L rat brain tumor cells. J. Cell Biochem. 78, 404–416 (2000).
   Article CAS PubMed Google Scholar
10. King, M. P. & Attardi, G. Isolation of human cell lines lacking mitochondrial DNA. Methods Enzymol. 264, 304–313 (1996).
    Article CAS PubMed Google Scholar
11. Xu, W., Liu, L., Smith, G. C. & Charles, I. G. Nitric oxide upregulates expression of DNA-PKcs to protect cells from DNA-damaging antitumour agents. Nature Cell Biol. 2, 339–345 (2000).
    Article CAS PubMed Google Scholar
12. Xu, W., Liu, L. & Charles, I. G. Microencapsulated iNOS-expressing cells cause tumor suppression in mice. FASEB J. 16, 213–215 (2002).
    Article CAS PubMed Google Scholar
13. Packer, M. A. & Murphy, M. P. Peroxynitrite causes calcium efflux from mitochondria which is prevented by cyclosporin A. FEBS Lett. 346, 237–240 (1994).
    Article Google Scholar
14. Horn, T. F. et al. Nitric oxide promotes intracellular calcium release from mitochondria in striatal neurons. FASEB J. 16, 1611–1622 (2002).
    Article CAS PubMed Google Scholar
15. Schweizer, M. & Richter C. Peroxynitrite stimulates the pyridine nucleotide-linked Ca2+ release from intact rat liver mitochondria. Biochemistry 35, 4524–4528 (1996).
    Article CAS PubMed Google Scholar
16. Yoshida, H. et al. Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6α and 6b that activates the mammalian unfolded protein response. Mol. Cell. Biol. 21, 1239–1248 (2001).
    Article CAS PubMed PubMed Central Google Scholar
17. Gotoh, T., Oyadomari, S., Mori, K. & Mori, M. Nitric oxide induced apoptosis in RAW 264.7 macrophages is mediated by endoplasmic reticulum stress pathway involving ATF6 and CHOP. J. Biol. Chem. 277, 12343–12350 (2002).
    Article CAS PubMed Google Scholar
18. Toure, B. B. et al. Biosynthesis and enzymatic characterization of human SKI-1/S1P and the processing of its inhibitory prosegment. J. Biol. Chem. 275, 2349–2358 (2000).
    Article CAS PubMed Google Scholar
19. Seidah, N. G. et al. Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization. Proc. Natl Acad. Sci. USA 96, 1321–1326 (1999).
    Article CAS PubMed PubMed Central Google Scholar
20. Lenz, O., ter Meulen, J., Klenk, H. D., Seidah, N. G. & Garten, W. The Lassa virus glycoprotein precursor GP-C is proteolytically processed by subtilase SKI-1/S1P. Proc. Natl Acad. Sci. USA 98, 12701–12705 (2001).
    Article CAS PubMed PubMed Central Google Scholar
21. Mateo, J., Garcia-Lecea, M., Cadenas, S., Hernandez, C., & Moncada, S. Regulation of hypoxia-inducible factor-1α by nitric oxide through mitochondria-dependent and -independent pathways. Biochem. J. 376, 537–544 (2003).
    Article CAS PubMed PubMed Central Google Scholar
22. Chen, X., Shen, J. & Prywes, R. The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the Golgi. J. Biol. Chem. 277, 13045–13052 (2002).
    Article CAS PubMed Google Scholar
23. Elbashir, S. M. et al. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411, 494–498 (2001).
    Article CAS PubMed Google Scholar
24. Rizzuto, R. et al. Close contacts with the endoplasmic reticulum as determinants of mitochondrial Ca2+ responses. Science 280, 1763–1766 (1998).
    Article CAS PubMed Google Scholar
25. Montero, M. et al. Chromaffin-cell stimulation triggers fast millimolar mitochondrial Ca2+ transients that modulate secretion. Nature Cell Biol. 2, 57–61 (2000).
    Article CAS PubMed Google Scholar
26. Nowicky, A. V. & Duchen, M. R. Changes in [Ca2+]i and membrane currents during impaired mitochondrial metabolism in dissociated rat hippocampal neurons. J. Physiol. 507, 131–145 (1998).
    Article CAS PubMed PubMed Central Google Scholar
27. Shen, J., Chen, X., Hendershot, L. & Prywes R. ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals. Dev. Cell 3, 99–111 (2002).
    Article CAS PubMed Google Scholar
28. Lee, K. et al. IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response. Genes Dev. 16, 452–466 (2002).
    Article CAS PubMed PubMed Central Google Scholar
29. Drummond, I. A., Lee, A. S., Resendez, E. & Steinhardt, R. A. Depletion of intracellular calcium stores by calcium ionophore A23187 induces the genes for glucose-regulated proteins in hamster fibroblasts. J. Biol. Chem. 262, 12801–12805 (1987).
    CAS PubMed Google Scholar
30. Beltrán, B., Quintero, M., García-Zaragozá, E., O'Connor, E., Esplugues, J. V. & Moncada, S. Inhibition of mitochondrial respiration by endogenous nitric oxide: a critical step in Fas signaling. Proc. Natl Acad. Sci. USA 99, 8892–8897 (2002).
    Article PubMed PubMed Central Google Scholar

Download references