Ingelfinger, D., Arndt-Jovin, D. J., Luhrmann, R. & Achsel, T. The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci. RNA8, 1489–1501 (2002). CASPubMedPubMed Central Google Scholar
van Dijk, E. et al. Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures. EMBO J.21, 6915–6924 (2002). ArticleCAS Google Scholar
Lykke-Andersen, J. Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay. Mol. Cell. Biol.22, 8114–8121 (2002). ArticleCAS Google Scholar
Sheth, U. & Parker, R. Decapping and decay of messenger RNA occur in cytoplasmic processing bodies. Science300, 805–808 (2003). ArticleCAS Google Scholar
Teixeira, D., Sheth, U., Valencia-Sanchez, M. A., Brengues, M. & Parker, R. Processing bodies require RNA for assembly and contain nontranslating mRNAs. RNA11, 371–382 (2005). ArticleCAS Google Scholar
Cougot, N., Babajko, S. & Seraphin, B. Cytoplasmic foci are sites of mRNA decay in human cells. J. Cell. Biol.165, 31–40 (2004). ArticleCAS Google Scholar
Meister, G. & Tuschl, T. Mechanisms of gene silencing by double-stranded RNA. Nature431, 343–349 (2004). ArticleCAS Google Scholar
Wightman, B., Ha, I. & Ruvkun, G. Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell75, 855–862 (1993). ArticleCAS Google Scholar
Lee, R. C., Feinbaum, R. L. & Ambros, V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell75, 843–854 (1993). ArticleCAS Google Scholar
Ketting, R. F. et al. Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans. Genes Dev.15, 2654–2659 (2001). ArticleCAS Google Scholar
Knight, S. W. & Bass, B. L. A role for the RNase III enzyme DCR-1 in RNA interference and germ line development in Caenorhabditis elegans. Science293, 2269–2271 (2001). ArticleCAS Google Scholar
Hutvagner, G. et al. A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA. Science293, 834–838 (2001). ArticleCAS Google Scholar
Bartel, D. P. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell116, 281–297 (2004). ArticleCAS Google Scholar
Liu, J. et al. Argonaute2 is the catalytic engine of mammalian RNAi. Science305, 1437–1441 (2004). ArticleCAS Google Scholar
Eystathioy, T. et al. The GW182 protein colocalizes with mRNA degradation associated proteins hDcp1 and hLSm4 in cytoplasmic GW bodies. RNA9, 1171–1173 (2003). ArticleCAS Google Scholar
Tharun, S. et al. Yeast Sm-like proteins function in mRNA decapping and decay. Nature404, 515–518 (2000). ArticleCAS Google Scholar
Ma, J. B., Ye, K. & Patel, D. J. Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain. Nature429, 318–322 (2004). ArticleCAS Google Scholar
Janicki, S. M. et al. From silencing to gene expression: real-time analysis in single cells. Cell116, 683–698 (2004). ArticleCAS Google Scholar
Lewis, B. P., Shih, I. H., Jones-Rhoades, M. W., Bartel, D. P. & Burge, C. B. Prediction of mammalian microRNA targets. Cell115, 787–798 (2003). ArticleCAS Google Scholar
Doench, J. G., Petersen, C. P. & Sharp, P. A. siRNAs can function as miRNAs. Genes Dev.17, 438–442 (2003). ArticleCAS Google Scholar
Souret, F. F., Kastenmayer, J. P. & Green, P. J. AtXRN4 degrades mRNA in Arabidopsis and its substrates include selected miRNA targets. Mol. Cell15, 173–183 (2004). ArticleCAS Google Scholar
Orban, T. I. & Izaurralde, E. Decay of mRNAs targeted by RISC requires XRN1, the Ski complex, and the exosome. RNA11, 459–469 (2005). ArticleCAS Google Scholar
Newbury, S. & Woollard, A. The 5′-3′ exoribonuclease xrn-1 is essential for ventral epithelial enclosure during C. elegans embryogenesis. RNA10, 59–65 (2004). ArticleCAS Google Scholar
Gazzani, S., Lawrenson, T., Woodward, C., Headon, D. & Sablowski, R. A link between mRNA turnover and RNA interference in Arabidopsis. Science306, 1046–1048 (2004). ArticleCAS Google Scholar
Lim, L. P. et al. Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature433, 769–773 (2005). ArticleCAS Google Scholar
Jing, Q. et al. Involvement of microRNA in AU-rich element-mediated mRNA instability. Cell120, 623–634 (2005). ArticleCAS Google Scholar
Andrei, M. A. et al. A role for eIF4E and eIF4E-transporter in targeting mRNPs to mammalian processing bodies. RNA11, 717–727 (2005). ArticleCAS Google Scholar
Sen, G. L. & Blau, H. M. Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies. Nature Cell Biol.7, 633–636 (2205). Article Google Scholar