The GDI-like solubilizing factor PDEδ sustains the spatial organization and signalling of Ras family proteins (original) (raw)

• Colicelli, J. Human RAS superfamily proteins and related GTPases. Sci. STKE 2004, RE13 (2004).
  PubMed PubMed Central Google Scholar
• Goodwin, J. S. et al. Depalmitoylated Ras traffics to and from the Golgi complex via a nonvesicular pathway. J. Cell Biol. 170, 261–272 (2005).
  Article CAS Google Scholar
• Rocks, O. et al. The palmitoylation machinery is a spatially organizing system for peripheral membrane proteins. Cell 141, 458–471 (2010).
  Article CAS Google Scholar
• Rocks, O. et al. An acylation cycle regulates localization and activity of palmitoylated Ras isoforms. Science 307, 1746–1752 (2005).
  Article CAS Google Scholar
• Dekker, F. J. et al. Small-molecule inhibition of APT1 affects Ras localization and signaling. Nat. Chem. Biol. 6, 449–456 (2010).
  Article CAS Google Scholar
• Camp, L. A. & Hofmann, S. L. Purification and properties of a palmitoyl-protein thioesterase that cleaves palmitate from H-Ras. J. Biol. Chem. 268, 22566–22574 (1993).
  CAS PubMed Google Scholar
• Sang, S. L. & Silvius, J. R. Novel thioester reagents afford efficient and specific S-acylation of unprotected peptides under mild conditions in aqueous solution. J. Pept. Res. 66, 169–180 (2005).
  Article Google Scholar
• Peyker, A., Rocks, O. & Bastiaens, P. I. Imaging activation of two Ras isoforms simultaneously in a single cell. ChemBioChem 6, 78–85 (2005).
  Article CAS Google Scholar
• Hanzal-Bayer, M., Renault, L., Roversi, P., Wittinghofer, A. & Hillig, R. C. The complex of Arl2-GTP and PDE δ: from structure to function. EMBO J. 21, 2095–2106 (2002).
  Article CAS Google Scholar
• Nancy, V., Callebaut, I., El Marjou, A. & de Gunzburg, J. The δ subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases. J. Biol. Chem. 277, 15076–15084 (2002).
  Article CAS Google Scholar
• Paz, A., Haklai, R., Elad-Sfadia, G., Ballan, E. & Kloog, Y. Galectin-1 binds oncogenic H-Ras to mediate Ras membrane anchorage and cell transformation. Oncogene 20, 7486–7493 (2001).
  Article CAS Google Scholar
• Elad-Sfadia, G., Haklai, R., Balan, E. & Kloog, Y. Galectin-3 augments K-Ras activation and triggers a Ras signal that attenuates ERK but not phosphoinositide 3-kinase activity. J. Biol. Chem. 279, 34922–34930 (2004).
  Article CAS Google Scholar
• Florio, S. K., Prusti, R. K. & Beavo, J. A. Solubilization of membrane-bound rod phosphodiesterase by the rod phosphodiesterase recombinant δ subunit. J. Biol. Chem. 271, 24036–24047 (1996).
  Article CAS Google Scholar
• Marzesco, A. M., Galli, T., Louvard, D. & Zahraoui, A. The rod cGMP phosphodiesterase δ subunit dissociates the small GTPase Rab13 from membranes. J. Biol. Chem. 273, 22340–22345 (1998).
  Article CAS Google Scholar
• Zhang, H. et al. Deletion of PrBP/δ impedes transport of GRK1 and PDE6 catalytic subunits to photoreceptor outer segments. Proc. Natl Acad. Sci. USA 104, 8857–8862 (2007).
  Article CAS Google Scholar
• Wilson, S. J. & Smyth, E. M. Internalization and recycling of the human prostacyclin receptor is modulated through its isoprenylation-dependent interaction with the δ subunit of cGMP phosphodiesterase 6. J. Biol. Chem. 281, 11780–11786 (2006).
  Article CAS Google Scholar
• Bhagatji, P., Leventis, R., Rich, R., Lin, C. J. & Silvius, J. R. Multiple cellular proteins modulate the dynamics of K-ras association with the plasma membrane. Biophys. J. 99, 3327–3335 (2010).
  Article CAS Google Scholar
• Chen, Y. X. et al. Synthesis of the Rheb and K-Ras4B GTPases. Angew Chem. Int. Ed. 49, 6090–6095 (2010).
  Article CAS Google Scholar
• Griesbeck, O., Baird, G. S., Campbell, R. E., Zacharias, D. A. & Tsien, R. Y. Reducing the environmental sensitivity of yellow fluorescent protein. Mechanism and applications. J. Biol. Chem. 276, 29188–29194 (2001).
  Article CAS Google Scholar
• Shaner, N. C. et al. Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein. Nat. Biotechnol. 22, 1567–1572 (2004).
  Article CAS Google Scholar
• Apolloni, A., Prior, I. A., Lindsay, M., Parton, R. G. & Hancock, J. F. H-ras but not K-ras traffics to the plasma membrane through the exocytic pathway. Mol. Cell Biol. 20, 2475–2487 (2000).
  Article CAS Google Scholar
• Choy, E. et al. Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi. Cell 98, 69–80 (1999).
  Article CAS Google Scholar
• Drisdel, R. C. & Green, W. N. Labeling and quantifying sites of protein palmitoylation. Biotechniques 36, 276–285 (2004).
  Article CAS Google Scholar
• Farrell, F. X., Yamamoto, K. & Lapetina, E. G. Prenyl group identification of rap2 proteins: a ras superfamily member other than ras that is farnesylated. Biochem. J. 289 (Pt 2), 349–355 (1993).
  Article Google Scholar
• Winegar, D. A., Molina y Vedia, L. & Lapetina, E. G. Isoprenylation of rap2 proteins in platelets and human erythroleukemia cells. J. Biol. Chem. 266, 4381–4386 (1991).
  CAS PubMed Google Scholar
• Gosser, Y. Q. et al. C-terminal binding domain of Rho GDP-dissociation inhibitor directs N-terminal inhibitory peptide to GTPases. Nature 387, 814–819 (1997).
  Article CAS Google Scholar
• Longenecker, K. et al. How RhoGDI binds Rho. Acta Crystallogr. D Biol. Crystallogr. 55, 1503–1515 (1999).
  Article CAS Google Scholar
• Wouters, F. S., Verveer, P. J. & Bastiaens, P. I. Imaging biochemistry inside cells. Trends Cell Biol. 11, 203–211 (2001).
  Article CAS Google Scholar
• Zhang, H. et al. Photoreceptor cGMP phosphodiesterase δ subunit (PDEδ) functions as a prenyl-binding protein. J. Biol. Chem. 279, 407–413 (2004).
  Article CAS Google Scholar
• Webb, Y., Hermida-Matsumoto, L. & Resh, M. D. Inhibition of protein palmitoylation, raft localization, and T cell signaling by 2-bromopalmitate and polyunsaturated fatty acids. J. Biol. Chem. 275, 261–270 (2000).
  Article CAS Google Scholar
• Patterson, G. H. & Lippincott-Schwartz, J. A photoactivatable GFP for selective photolabeling of proteins and cells. Science 297, 1873–1877 (2002).
  Article CAS Google Scholar
• Heo, W. D. et al. PI(3,4,5)P3 and PI(4,5)P2 lipids target proteins with polybasic clusters to the plasma membrane. Science 314, 1458–1461 (2006).
  Article CAS Google Scholar
• Yeung, T. et al. Membrane phosphatidylserine regulates surface charge and protein localization. Science 319, 210–213 (2008).
  Article CAS Google Scholar
• Yeung, T. et al. Contribution of phosphatidylserine to membrane surface charge and protein targeting during phagosome maturation. J. Cell Biol. 185, 917–928 (2009).
  Article CAS Google Scholar
• Yeung, T. et al. Receptor activation alters inner surface potential during phagocytosis. Science 313, 347–351 (2006).
  Article CAS Google Scholar
• Kim, J., Shishido, T., Jiang, X., Aderem, A. & McLaughlin, S. Phosphorylation, high ionic strength, and calmodulin reverse the binding of MARCKS to phospholipid vesicles. J. Biol. Chem. 269, 28214–28219 (1994).
  CAS PubMed Google Scholar
• Bivona, T. G. et al. PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis. Mol. Cell 21, 481–493 (2006).
  Article CAS Google Scholar
• Lorentzen, A., Kinkhabwala, A., Rocks, O., Vartak, N. & Bastiaens, P. I. Regulation of Ras localization by acylation enables a mode of intracellular signal propagation. Sci. Signal 3, ra68 (2010).
  Article Google Scholar
• Richards, C. A., Short, S. A., Thorgeirsson, S. S. & Huber, B. E. Characterization of a transforming N-ras gene in the human hepatoma cell line Hep G2: additional evidence for the importance of c-myc and ras cooperation in hepatocarcinogenesis. Cancer Res. 50, 1521–1527 (1990).
  CAS PubMed Google Scholar
• Tuveson, D. A. et al. Endogenous oncogenic K-ras(G12D) stimulates proliferationand widespread neoplastic and developmental defects. Cancer Cell 5, 375–387 (2004).
  Article CAS Google Scholar
• Sarkisian, C. J. et al. Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis. Nat. Cell Biol. 9, 493–505 (2007).
  Article CAS Google Scholar
• Hingorani, S. R. et al. Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell 4, 437–450 (2003).
  Article CAS Google Scholar
• Hingorani, S. R. et al. Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell 7, 469–483 (2005).
  Article CAS Google Scholar
• Skoulidis, F. et al. Germline Brca2 heterozygosity promotes Kras(G12D)-driven carcinogenesis in a murine model of familial pancreatic cancer. Cancer Cell 18, 499–509 (2010).
  Article CAS Google Scholar
• Gidekel Friedlander, S. Y. et al. Context-dependent transformation of adult pancreatic cells by oncogenic K-Ras. Cancer Cell 16, 379–389 (2009).
  Article Google Scholar
• Singh, A. et al. A gene expression signature associated with ‘K-Ras addiction’ reveals regulators of EMT and tumor cell survival. Cancer Cell 15, 489–500 (2009).
  Article CAS Google Scholar
• Alexander, M. et al. Mapping the isoprenoid binding pocket of PDEδ by a semisynthetic, photoactivatable N-Ras lipoprotein. ChemBioChem 10, 98–108 (2009).
  Article CAS Google Scholar
• van Meer, G., Voelker, D. R. & Feigenson, G. W. Membrane lipids: where they are and how they behave. Nat. Rev. Mol. Cell Biol. 9, 112–124 (2008).
  Article CAS Google Scholar
• Daleke, D. L. Regulation of transbilayer plasma membrane phospholipid asymmetry. J. Lipid Res. 44, 233–242 (2003).
  Article CAS Google Scholar
• Williamson, P. & Schlegel, R. A. Back and forth: the regulation and function of transbilayer phospholipid movement in eukaryotic cells. Mol Membr. Biol. 11, 199–216 (1994).
  Article CAS Google Scholar
• Lorenz, B. et al. Cloning and gene structure of the rod cGMPphosphodiesterase δ subunit gene (PDED) in man and mouse. Eur. J. Hum. Genet. 6, 283–290 (1998).
  Article CAS Google Scholar
• Ismail, S. A. et al. Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo. Nat Chem. Biol. 7, 942–949 (2011).
  Article CAS Google Scholar
• Schreiber, F. S. et al. Successful growth and characterization of mouse pancreatic ductal cells: functional properties of the Ki-RAS(G12V) oncogene. Gastroenterology 127, 250–260 (2004).
  Article CAS Google Scholar
• Varga, M. et al. Pancreatic resection for metastatic renal cell carcinoma. Klin. Onkol. 22, 288–290 (2009).
  CAS PubMed Google Scholar
• Pfaffl, M. W. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 29, e45 (2001).
  Article CAS Google Scholar
• Livak, K. J. & Schmittgen, T. D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25, 402–408 (2001).
  Article CAS Google Scholar
• Politis, E. G., Roth, A. F. & Davis, N. G. Transmembrane topology of the protein palmitoyl transferase Akr1. J. Biol. Chem. 280, 10156–10163 (2005).
  Article CAS Google Scholar
• Lopez, A., Dupou, L., Altibelli, A., Trotard, J. & Tocanne, J. F. Fluorescence recovery after photobleaching (FRAP) experiments under conditions of uniform disk illumination. Critical comparison of analytical solutions, and a new mathematical method for calculation of diffusion coefficient D. Biophys. J. 53, 963–970 (1988).
  Article CAS Google Scholar
• Axelrod, D., Koppel, D. E., Schlessinger, J., Elson, E. & Webb, W. W. Mobility measurement by analysis of fluorescence photobleaching recovery kinetics. Biophys. J. 16, 1055–1069 (1976).
  Article CAS Google Scholar
• Elson, E. L. & Magde, D. Fluorescence correlation spectroscopy. I. Conceptual basis and theory. Biopolymers 13, 1–27 (1974).
  Article CAS Google Scholar
• Grecco, H. E., Roda-Navarro, P. & Verveer, P. J. Global analysis of time correlated single photon counting FRET-FLIM data. Opt. Express 17, 6493–6508 (2009).
  Article CAS Google Scholar