Senescence is an endogenous trigger for microRNA-directed transcriptional gene silencing in human cells (original) (raw)

• Collado, M. & Serrano, M. Senescence in tumours: evidence from mice and humans. Nat. Rev. Cancer 10, 51–57 (2010).
  Article CAS Google Scholar
• Narita, M. et al. Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell 113, 703–716 (2003).
  Article CAS Google Scholar
• Adams, P. D. Remodeling chromatin for senescence. Aging Cell 6, 425–427 (2007).
  Article CAS Google Scholar
• Moazed, D. Small RNAs in transcriptional gene silencing and genome defence. Nature 457, 413–420 (2009).
  Article CAS Google Scholar
• Morris, K. V. RNA-mediated transcriptional gene silencing in human cells. Curr. Top. Microbiol. Immunol. 320, 211–224 (2008).
  CAS PubMed Google Scholar
• Janowski, B. A. et al. Involvement of AGO1 and AGO2 in mammalian transcriptional silencing. Nat. Struct. Mol. Biol. 13, 787–792 (2006).
  Article CAS Google Scholar
• Kim, D. H., Saetrom, P., Snove, O. Jr. & Rossi, J. J. MicroRNA-directed transcriptional gene silencing in mammalian cells. Proc. Natl Acad. Sci. USA 105, 16230–16235 (2008).
  Article CAS Google Scholar
• Rabinovich, A., Jin, V. X., Rabinovich, R., Xu, X. & Farnham, P. J. E2F in vivo binding specificity: comparison of consensus versus nonconsensus binding sites. Genome Res. 18, 1763–1777 (2008).
  Article CAS Google Scholar
• Xu, X. et al. A comprehensive ChIP–chip analysis of E2F1, E2F4, and E2F6 in normal and tumor cells reveals interchangeable roles of E2F family members. Genome Res. 17, 1550–1561 (2007).
  Article CAS Google Scholar
• Ross, J. F., Naar, A., Cam, H., Gregory, R. & Dynlacht, B. D. Active repression and E2F inhibition by pRB are biochemically distinguishable. Genes Dev. 15, 392–397 (2001).
  Article CAS Google Scholar
• Bieda, M., Xu, X., Singer, M. A., Green, R. & Farnham, P. J. Unbiased location analysis of E2F1-binding sites suggests a widespread role for E2F1 in the human genome. Genome Res. 16, 595–605 (2006).
  Article CAS Google Scholar
• Rudel, S., Flatley, A., Weinmann, L., Kremmer, E. & Meister, G. A multifunctional human Argonaute2-specific monoclonal antibody. RNA 14, 1244–1253 (2008).
  Article Google Scholar
• Zhou, Y. et al. High-risk myeloma is associated with global elevation of miRNAs and overexpression of EIF2C2/AGO2. Proc. Natl Acad. Sci. USA 107, 7904–7909 (2010).
  Article CAS Google Scholar
• Kim, M. S. et al. Somatic mutations and losses of expression of microRNA regulation-related genes AGO2 and TNRC6A in gastric and colorectal cancers. J. Pathol. 221, 139–146 (2010).
  Article CAS Google Scholar
• Li, L., Yu, C., Gao, H. & Li, Y. Argonaute proteins: potential biomarkers for human colon cancer. BMC Cancer 10, 38 (2010).
  Article Google Scholar
• Michaloglou, C. et al. BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature 436, 720–724 (2005).
  Article CAS Google Scholar
• Dhomen, N. et al. Oncogenic Braf induces melanocyte senescence and melanoma in mice. Cancer Cell 15, 294–303 (2009).
  Article CAS Google Scholar
• Gray-Schopfer, V. C. et al. Cellular senescence in naevi and immortalisation in melanoma: a role for p16? Br. J. Cancer 95, 496–505 (2006).
  Article CAS Google Scholar
• Sporn, J. C. et al. Histone macroH2A isoforms predict the risk of lung cancer recurrence. Oncogene 28, 3423–3428 (2009).
  Article CAS Google Scholar
• Zhang, R. et al. Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA. Dev. Cell 8, 19–30 (2005).
  Article CAS Google Scholar
• Ricke, R. M. & Bielinsky, A. K. Easy detection of chromatin binding proteins by the Histone Association Assay. Biol. Proced Online 7, 60–69 (2005).
  Article CAS Google Scholar
• Nielsen, S. J. et al. Rb targets histone H3 methylation and HP1 to promoters. Nature 412, 561–565 (2001).
  Article CAS Google Scholar
• Luo, R. X., Postigo, A. A. & Dean, D. C. Rb interacts with histone deacetylase to repress transcription. Cell 92, 463–473 (1998).
  Article CAS Google Scholar
• Brehm, A. et al. Retinoblastoma protein recruits histone deacetylase to repress transcription. Nature 391, 597–601 (1998).
  Article CAS Google Scholar
• Magnaghi-Jaulin, L. et al. Retinoblastoma protein represses transcription by recruiting a histone deacetylase. Nature 391, 601–605 (1998).
  Article CAS Google Scholar
• Ohtani, K., DeGregori, J. & Nevins, J. R. Regulation of the cyclin E gene by transcription factor E2F1. Proc. Natl Acad. Sci. USA 92, 12146–12150 (1995).
  Article CAS Google Scholar
• Ro, S. et al. Cloning and expression profiling of testis-expressed piRNA-like RNAs. RNA 13, 1693–1702 (2007).
  Article CAS Google Scholar
• Krueger, J. & Rehmsmeier, M. RNAhybrid: microRNA target prediction easy, fast and flexible. Nucleic Acid Res. 34, W451–W454 (2006).
  Article CAS Google Scholar
• Dalton, S. Cell cycle regulation of the human cdc2 gene. EMBO J. 11, 1797–1804 (1992).
  Article CAS Google Scholar
• Han, J., Kim, D. & Morris, K. V. Promoter-associated RNA is required for RNA-directed transcriptional gene silencing in human cells. Proc. Natl Acad. Sci. USA 104, 12422–12427 (2007).
  Article CAS Google Scholar
• Bischof, O. et al. The E3 SUMO ligase PIASy is a regulator of cellular senescence and apoptosis. Mol. Cell 22, 783–794 (2006).
  Article CAS Google Scholar
• Ji, P. et al. An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant. Mol. Cell 16, 47–58 (2004).
  Article CAS Google Scholar
• Chang, B. D. et al. A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents. Cancer Res. 59, 3761–3767 (1999).
  CAS PubMed Google Scholar
• Bischof, O, Nacerddine, K. & Dejean, A. Human papillomavirus oncoprotein E7 targets the promyelocytic leukemia protein and circumvents cellular senescence via the Rb and p53 tumor suppressor pathways. Mol. Cell Biol. 25, 1013–1024 (2005).
  Article CAS Google Scholar
• Kumar, P. P. et al. Functional interaction between PML and SATB1 regulates chromatin-loop architecture and transcription of the MHC class I locus. Nat. Cell Biol. 9, 45–56 (2007).
  Article Google Scholar
• Frank, S. R., Schroeder, M., Fernandez, P., Taubert, S. & Amati, B. Binding of c-Myc to chromatin mediates mitogen-induced acetylation of histone H4 and gene activation. Genes Dev. 15, 2069–2082 (2001).
  Article CAS Google Scholar
• Meng, L., Bregitzer, P., Zhang, S. & Lemaux, P. G. Methylation of the exon/intron region in the Ubi1 promoter complex correlates with transgene silencing in barley. Plant Mol. Biol. 53, 327–340 (2003).
  Article CAS Google Scholar
• Huang, D. W., Sherman, B. T. & Lempicki, R. A. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat. Protocols 4, 44–57 (2008).
  Article Google Scholar
• Liu, C. G., Spizzo, R., Calin, G. A. & Croce, C. M. Expression profiling of microRNA using oligo DNA arrays. Methods 44, 22–30 (2008).
  Article Google Scholar