A CREB3–ARF4 signalling pathway mediates the response to Golgi stress and susceptibility to pathogens (original) (raw)

• Chiu, V. K. et al. Ras signalling on the endoplasmic reticulum and the Golgi. Nat. Cell Biol. 4, 343–350 (2002).
  Article CAS PubMed Google Scholar
• Altan-Bonnet, N., Phair, R. D., Polishchuk, R. S., Weigert, R. & Lippincott-Schwartz, J. A role for Arf1 in mitotic Golgi disassembly, chromosome segregation, and cytokinesis. Proc. Natl Acad. Sci. USA 100, 13314–13319 (2003).
  Article CAS PubMed Google Scholar
• Sutterlin, C., Hsu, P., Mallabiabarrena, A. & Malhotra, V. Fragmentation and dispersal of the pericentriolar Golgi complex is required for entry into mitosis in mammalian cells. Cell 109, 359–369 (2002).
  Article CAS PubMed Google Scholar
• Yadav, S., Puri, S. & Linstedt, A. D. A primary role for Golgi positioning in directed secretion, cell polarity, and wound healing. Mol. Biol. Cell 20, 1728–1736 (2009).
  Article CAS PubMed PubMed Central Google Scholar
• Kupfer, A., Louvard, D. & Singer, S. J. Polarization of the Golgi apparatus and the microtubule-organizing center in cultured fibroblasts at the edge of an experimental wound. Proc. Natl Acad. Sci. USA 79, 2603–2607 (1982).
  Article CAS PubMed Google Scholar
• Singleton, V. L., Bohonos, N. & Ullstrup, A. J. Decumbin, a new compound from a species of Penicillium. Nature 181, 1072–1073 (1958).
  Article CAS PubMed Google Scholar
• Shao, R. G., Shimizu, T. & Pommier, Y. Brefeldin A is a potent inducer of apoptosis in human cancer cells independently of p53. Exp. Cell Res. 227, 190–196 (1996).
  Article CAS PubMed Google Scholar
• Nojiri, H., Manya, H., Isono, H., Yamana, H. & Nojima, S. Induction of terminal differentiation and apoptosis in human colonic carcinoma cells by brefeldin A, a drug affecting ganglioside biosynthesis. FEBS Lett. 453, 140–144 (1999).
  Article CAS PubMed Google Scholar
• Sausville, E. A. et al. Antiproliferative effect in vitro and antitumor activity in vivo of brefeldin A. The Cancer J. Sci. Am. 2, 52–58 (1996).
  CAS PubMed Google Scholar
• Anadu, N. O., Davisson, V. J. & Cushman, M. Synthesis and anticancer activity of brefeldin A ester derivatives. J. Med. Chem. 49, 3897–3905 (2006).
  Article CAS PubMed Google Scholar
• Donaldson, J. G. & Jackson, C. L. ARF family G proteins and their regulators: roles in membrane transport, development and disease. Nat. Rev. Mol. Cell Biol. 12, 362–375 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• D’Souza-Schorey, C. & Chavrier, P. ARF proteins: roles in membrane traffic and beyond. Nat. Rev. Mol. Cell Biol. 7, 347–358 (2006).
  Article PubMed Google Scholar
• Peyroche, A. et al. Brefeldin A acts to stabilize an abortive ARF-GDP-Sec7 domain protein complex: involvement of specific residues of the Sec7 domain. Mol. Cell 3, 275–285 (1999).
  Article CAS PubMed Google Scholar
• D’Souza-Schorey, C., Li, G., Colombo, M. I. & Stahl, P. D. A regulatory role for ARF6 in receptor-mediated endocytosis. Science 267, 1175–1178 (1995).
  Article PubMed Google Scholar
• Peters, P. J. et al. Overexpression of wild-type and mutant ARF1 and ARF6: distinct perturbations of nonoverlapping membrane compartments. J. Cell Biol. 128, 1003–1017 (1995).
  Article CAS PubMed Google Scholar
• Cavenagh, M. M. et al. Intracellular distribution of Arf proteins in mammalian cells. Arf6 is uniquely localized to the plasma membrane. J. Biol. Chem. 271, 21767–21774 (1996).
  Article CAS PubMed Google Scholar
• Reiling, J. H. et al. A haploid genetic screen identifies the major facilitator domain containing 2A (MFSD2A) transporter as a key mediator in the response to tunicamycin. Proc. Natl Acad. Sci. USA 108, 11756–11765 (2011).
  Article CAS PubMed Google Scholar
• Carette, J. E. et al. Haploid genetic screens in human cells identify host factors used by pathogens. Science 326, 1231–1235 (2009).
  Article CAS PubMed Google Scholar
• Carette, J. E. et al. Global gene disruption in human cells to assign genes to phenotypes by deep sequencing. Nature Biotechnol. 29, 542–546 (2011).
  Article CAS Google Scholar
• Volpicelli-Daley, L. A., Li, Y., Zhang, C. J. & Kahn, R. A. Isoform-selective effects of the depletion of ADP-ribosylation factors 1-5 on membrane traffic. Mol. Biol. Cell 16, 4495–4508 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Nakai, W. et al. ARF1 and ARF4 regulate recycling endosomal morphology and retrograde transport from endosomes to the Golgi apparatus. Mol. Biol. Cell 24, 2570–2581 (2013).
  Article CAS PubMed PubMed Central Google Scholar
• Kondo, Y. et al. ARF1 and ARF3 are required for the integrity of recycling endosomes and the recycling pathway. Cell Struct. Funct. 37, 141–154 (2012).
  Article CAS PubMed Google Scholar
• Claude, A. et al. GBF1: a novel Golgi-associated BFA-resistant guanine nucleotide exchange factor that displays specificity for ADP-ribosylation factor 5. J. Cell Biol. 146, 71–84 (1999).
  CAS PubMed PubMed Central Google Scholar
• Ooi, C. E., Dell’Angelica, E. C. & Bonifacino, J. S. ADP-Ribosylation factor 1 (ARF1) regulates recruitment of the AP-3 adaptor complex to membranes. J. Cell Biol. 142, 391–402 (1998).
  Article CAS PubMed PubMed Central Google Scholar
• Shinotsuka, C., Yoshida, Y., Kawamoto, K., Takatsu, H. & Nakayama, K. Overexpression of an ADP-ribosylation factor-guanine nucleotide exchange factor, BIG2, uncouples brefeldin A-induced adaptor protein-1 coat dissociation and membrane tubulation. J. Biol. Chem. 277, 9468–9473 (2002).
  Article CAS PubMed Google Scholar
• Alvarez, C., Garcia-Mata, R., Brandon, E. & Sztul, E. COPI recruitment ismodulated by a Rab1b-dependent mechanism. Mol. Biol. Cell 14, 2116–2127 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Teal, S. B., Hsu, V. W., Peters, P. J., Klausner, R. D. & Donaldson, J. G. An activating mutation in ARF1 stabilizes coatomer binding to Golgi membranes. J. Biol. Chem. 269, 3135–3138 (1994).
  CAS PubMed Google Scholar
• Santy, L. C. & Casanova, J. E. Activation of ARF6 by ARNO stimulates epithelial cell migration through downstream activation of both Rac1 and phospholipase D. J. Cell Biol. 154, 599–610 (2001).
  Article CAS PubMed PubMed Central Google Scholar
• Manolea, F. et al. Arf3 is activated uniquely at the trans-Golgi network by brefeldin A-inhibited guanine nucleotide exchange factors. Mol. Biol. Cell 21, 1836–1849 (2010).
  Article CAS PubMed PubMed Central Google Scholar
• Bui, Q. T., Golinelli-Cohen, M. P. & Jackson, C. L. Large Arf1 guanine nucleotide exchange factors: evolution, domain structure, and roles in membrane trafficking and human disease. Mol. Genet. Genom. 282, 329–350 (2009).
  Article CAS Google Scholar
• Nakagomi, S. et al. A Golgi fragmentation pathway in neurodegeneration. Neurobiol. Dis. 29, 221–231 (2008).
  Article CAS PubMed Google Scholar
• Lee, T. H. & Linstedt, A. D. Potential role for protein kinases in regulation of bidirectional endoplasmic reticulum-to-Golgi transport revealed by protein kinase inhibitor H89. Mol. Biol. Cell 11, 2577–2590 (2000).
  Article CAS PubMed PubMed Central Google Scholar
• Nickel, W., Helms, J. B., Kneusel, R. E. & Wieland, F. T. Forskolin stimulates detoxification of brefeldin A. J. Biol. Chem. 271, 15870–15873 (1996).
  Article CAS PubMed Google Scholar
• Jang, S. Y., Jang, S. W. & Ko, J. Regulation of ADP-ribosylation factor 4 expression by small leucine zipper protein and involvement in breast cancer cell migration. Cancer Lett. 314, 185–197 (2012).
  Article CAS PubMed Google Scholar
• Asada, R., Kanemoto, S., Kondo, S., Saito, A. & Imaizumi, K. The signalling from endoplasmic reticulum-resident bZIP transcription factors involved in diverse cellular physiology. J. Biochem. 149, 507–518 (2011).
  Article CAS PubMed Google Scholar
• Kondo, S. et al. Activation of OASIS family, ER stress transducers, is dependent on its stabilization. Cell Death Differ. 19, 1939–1949 (2012).
  Article CAS PubMed PubMed Central Google Scholar
• Denboer, L. M. et al. JAB1/CSN5 inhibits the activity of Luman/CREB3 by promoting its degradation. Biochim. Biophys. Acta 1829, 921–929 (2013).
  Article CAS PubMed PubMed Central Google Scholar
• Heuer, D. et al. Chlamydia causes fragmentation of the Golgi compartment to ensure reproduction. Nature 457, 731–735 (2009).
  Article CAS PubMed Google Scholar
• Burnaevskiy, N. et al. Proteolytic elimination of N-myristoyl modifications by the Shigella virulence factor IpaJ. Nature 496, 106–109 (2013).
  Article CAS PubMed PubMed Central Google Scholar
• Hackstadt, T., Scidmore, M. A. & Rockey, D. D. Lipid metabolism in _Chlamydia trachomatis_-infected cells: directed trafficking of Golgi-derived sphingolipids to the chlamydial inclusion. Proc. Natl Acad. Sci. USA 92, 4877–4881 (1995).
  Article CAS PubMed Google Scholar
• Elwell, C. A. et al. Chlamydia trachomatis co-opts GBF1 and CERT to acquire host sphingomyelin for distinct roles during intracellular development. PLoS Pathog. 7, e1002198 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• Gurumurthy, R. K. et al. A loss-of-function screen reveals Ras- and Raf-independent MEK-ERK signaling during Chlamydia trachomatis infection. Sci. Signal. 3, ra21 (2010).
  Article PubMed Google Scholar
• Dong, N. et al. Structurally distinct bacterial TBC-like GAPs link Arf GTPase to Rab1 inactivation to counteract host defenses. Cell 150, 1029–1041 (2012).
  Article CAS PubMed Google Scholar
• Brunham, R. C. & Rey-Ladino, J. Immunology of Chlamydia infection:implications for a Chlamydia trachomatis vaccine. Nat. Rev. Immunol. 5, 149–161 (2005).
  Article CAS PubMed Google Scholar
• Kotloff, K. L. et al. Global burden of Shigella infections: implications for vaccine development and implementation of control strategies. Bull. World Health Organ. 77, 651–666 (1999).
  CAS PubMed PubMed Central Google Scholar
• Raggo, C. et al. Luman, the cellular counterpart of herpes simplex virus VP16, is processed by regulated intramembrane proteolysis. Mol. Cell Biol. 22, 5639–5649 (2002).
  Article CAS PubMed PubMed Central Google Scholar
• DenBoer, L. M. et al. Luman is capable of binding and activating transcription from the unfolded protein response element. Biochem. Biophys. Res. Commun. 331, 113–119 (2005).
  Article CAS PubMed Google Scholar
• Liang, G. et al. Luman/CREB3 induces transcription of the endoplasmic reticulum (ER) stress response protein Herp through an ER stress response element. Mol. Cell Biol. 26, 7999–8010 (2006).
  Article CAS PubMed PubMed Central Google Scholar
• Chen, X., Shen, J. & Prywes, R. The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the Golgi. J. Biol. Chem. 277, 13045–13052 (2002).
  Article CAS PubMed Google Scholar
• Nadanaka, S., Okada, T., Yoshida, H. & Mori, K. Role of disulfide bridges formed in the luminal domain of ATF6 in sensing endoplasmic reticulum stress. Mol. Cell Biol. 27, 1027–1043 (2007).
  Article CAS PubMed Google Scholar
• Zhang, K. et al. Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response. Cell 124, 587–599 (2006).
  Article CAS PubMed Google Scholar
• Citterio, C. et al. Unfolded protein response and cell death after depletion of brefeldin A-inhibited guanine nucleotide-exchange protein GBF1. Proc. Natl Acad. Sci. USA 105, 2877–2882 (2008).
  Article CAS PubMed Google Scholar
• Saenz, J. B. et al. Golgicide A reveals essential roles for GBF1 in Golgi assembly and function. Nat. Chem. Biol. 5, 157–165 (2009).
  Article CAS PubMed PubMed Central Google Scholar
• Chun, J., Shapovalova, Z., Dejgaard, S. Y., Presley, J. F. & Melancon, P. Characterization of class I and II ADP-ribosylation factors (Arfs) in live cells: GDP-bound class II Arfs associate with the ER–Golgi intermediate compartment independently of GBF1. Mol. Biol. Cell 19, 3488–3500 (2008).
  Article CAS PubMed PubMed Central Google Scholar
• Feng, Y. et al. Exo1: a new chemical inhibitor of the exocytic pathway. Proc. Natl Acad. Sci. USA 100, 6469–6474 (2003).
  Article CAS PubMed Google Scholar
• Barzilay, E., Ben-Califa, N., Hirschberg, K. & Neumann, D. Uncoupling of brefeldin a-mediated coatomer protein complex-I dissociation from Golgi redistribution. Traffic 6, 794–802 (2005).
  Article CAS PubMed Google Scholar
• Dinter, A. & Berger, E. G. Golgi-disturbing agents. Histochem. Cell Biol. 109, 571–590 (1998).
  Article CAS PubMed Google Scholar
• Zhang, G. F., Driouich, A. & Staehelin, L. A. Effect of monensin on plant Golgi: re-examination of the monensin-induced changes in cisternal architecture and functional activities of the Golgi apparatus of sycamore suspension-cultured cells. J. Cell Sci. 104, 819–831 (1993).
  CAS PubMed Google Scholar
• Hicks, S. W. & Machamer, C. E. Golgi structure in stress sensing and apoptosis. Biochim. Biophys. Acta 1744, 406–414 (2005).
  Article CAS PubMed Google Scholar
• Oku, M. et al. Novel cis-acting element GASE regulates transcriptional induction by the Golgi stress response. Cell Struct. Funct. 36, 1–12 (2011).
  Article CAS PubMed Google Scholar
• Huynh, D. P., Yang, H.T., Vakharia, H., Nguyen, D. & Pulst, S.M. Expansion of the polyQ repeat in ataxin-2 alters its Golgi localization, disrupts the Golgi complex and causes cell death. Human Mol. Genet. 12, 1485–1496 (2003).
  Article CAS Google Scholar
• Winslow, A.R. et al. α-Synuclein impairs macroautophagy: implications for Parkinson’s disease. J. Cell Biol. 190, 1023–1037 (2010).
  Article CAS PubMed PubMed Central Google Scholar
• Cooper, A. A. et al. α-synuclein blocks ER–Golgi traffic and Rab1 rescues neuron loss in Parkinson’s models. Science 313, 324–328 (2006).
  Article CAS PubMed PubMed Central Google Scholar
• Walkley, S.U. & Suzuki, K. Consequences of NPC1 and NPC2 loss of function in mammalian neurons. Biochim. Biophys. Acta 1685, 48–62 (2004).
  Article CAS PubMed Google Scholar
• Gonatas, N. K., Stieber, A. & Gonatas, J. O. Fragmentation of the Golgiapparatus in neurodegenerative diseases and cell death. J. Neurol. Sci. 246, 21–30 (2006).
  Article CAS PubMed Google Scholar
• Jehl, S. P., Nogueira, C. V., Zhang, X. & Starnbach, M. N. IFNgamma inhibits the cytosolic replication of Shigella flexneri via the cytoplasmic RNA sensor RIG-I. PLoS Pathog. 8, e1002809 (2012).
  Article CAS PubMed PubMed Central Google Scholar
• Gondek, D. C., Olive, A. J., Stary, G. & Starnbach, M. N. CD4+ T cells are necessary and sufficient to confer protection against Chlamydia trachomatis infection in the murine upper genital tract. J. Immunol. 189, 2441–2449 (2012).
  Article CAS PubMed PubMed Central Google Scholar
• van der Velden, A. W., Dougherty, J. T. & Starnbach, M. N. Down-modulation of TCR expression by Salmonella enterica serovar Typhimurium. J. Immunol. 180, 5569–5574 (2008).
  Article CAS PubMed Google Scholar
• Coers, J. et al. Compensatory T cell responses in IRG-deficient mice prevent sustained Chlamydia trachomatis infections. PLoS Pathog. 7, e1001346 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• Cohen, L. A. & Donaldson, J. G. Curr. Protoc. Cell Biol. 48, 11–17 (2010).
  Article Google Scholar