Stem cell quiescence acts as a tumour suppressor in squamous tumours (original) (raw)

• Lowry, W. E. & Richter, L. Signaling in adult stem cells. Front. Biosci. 12, 3911–3927 (2007).
  Article CAS Google Scholar
• Fuchs, E. The tortoise and the hair: slow-cycling cells in the stem cell race. Cell 137, 811–819 (2009).
  Article CAS Google Scholar
• Lapouge, G. et al. Identifying the cellular origin of squamous skin tumors. Proc. Natl Acad. Sci. USA 108, 7431–7436 (2011).
  Article CAS Google Scholar
• White, A. C. et al. Defining the origins of Ras/p53-mediated squamous cell carcinoma. Proc. Natl Acad. Sci. USA 108, 7425–7430 (2011).
  Article CAS Google Scholar
• Barker, N. et al. Crypt stem cells as the cells-of-origin of intestinal cancer. Nature 457, 608–611 (2009).
  Article CAS Google Scholar
• Visvader, J. E. Cells of origin in cancer. Nature 469, 314–322 (2011).
  Article CAS Google Scholar
• Paus, R., Muller-Rover, S. & Botchkarev, V. A. Chronobiology of the hair follicle: hunting the ‘hair cycle clock’. J. Invest. Dermatol. Symp. Proc. 4, 338–345 (1999).
  Article CAS Google Scholar
• Greco, V. et al. A two-step mechanism for stem cell activation during hair regeneration. Cell Stem Cell 4, 155–169 (2009).
  Article CAS Google Scholar
• Trempus, C. S. et al. CD34 expression by hair follicle stem cells is required for skin tumor development in mice. Cancer Res. 67, 4173–4181 (2007).
  Article CAS Google Scholar
• Finch, J. S., Albino, H. E. & Bowden, G. T. Quantitation of early clonal expansion of two mutant 61st codon c-Ha-ras alleles in DMBA/TPA treated mouse skin by nested PCR/RFLP. Carcinogenesis 17, 2551–2557 (1996).
  Article CAS Google Scholar
• Andreasen, E. & Borum, K. The influence of the mouse hair cycle on 9, 10-dimethyl-1, 2-benzanthracene-induced skin tumors. Acta Pathol. Microbiol. Scand. Suppl. 39, 76–77 (1956).
  Article CAS Google Scholar
• Klinken-Rasmussen, L. Effect of croton oil applied to mouse skin originally painted with suboptimal doses of carcinogen during the growth and resting phases of the hair follicles. Acta Pathol. Microbiol. Scand. Suppl. 39, 78–79 (1956).
  Article CAS Google Scholar
• Miller, S. J. et al. Mouse skin is particularly susceptible to tumor initiation during early anagen of the hair cycle: possible involvement of hair follicle stem cells. J. Invest. Dermatol. 101, 591–594 (1993).
  Article CAS Google Scholar
• Lavker, R. M. et al. Hair follicle stem cells: their location, role in hair cycle, and involvement in skin tumor formation. J. Invest. Dermatol. 101, 16S–26S (1993).
  Article CAS Google Scholar
• Grachtchouk, M. et al. Basal cell carcinomas in mice arise from hair follicle stem cells and multiple epithelial progenitor populations. J. Clin. Invest. 121, 1768–1781 (2011).
  Article CAS Google Scholar
• Mancuso, M. et al. Hair cycle-dependent basal cell carcinoma tumorigenesis in Ptc1neo67/ + mice exposed to radiation. Cancer Res. 66, 6606–6614 (2006).
  Article CAS Google Scholar
• Li, S. et al. A keratin 15 containing stem cell population from the hair follicle contributes to squamous papilloma development in the mouse. Mol. Carcinog. 52, 751–759 (2012).
  PubMed PubMed Central Google Scholar
• Groszer, M. et al. Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo. Science 294, 2186–2189 (2001).
  Article CAS Google Scholar
• Jaks, V. et al. Lgr5 marks cycling, yet long-lived, hair follicle stem cells. Nature Genet. 40, 1291–1299 (2008).
  Article CAS Google Scholar
• Snippert, H. J. et al. Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin. Science 327, 1385–1389 (2010).
  Article CAS Google Scholar
• Zhang, J. et al. BMP signaling inhibits hair follicle anagen induction by restricting epithelial stem/progenitor cell activation and expansion. Stem Cells 24, 2826–2839 (2006).
  Article CAS Google Scholar
• Gu, T. et al. CREB is a novel nuclear target of PTEN phosphatase. Cancer Res. 71, 2821–2825 (2011).
  Article CAS Google Scholar
• Vivanco, I. et al. Identification of the JNK signaling pathway as a functional target of the tumor suppressor PTEN. Cancer Cell 11, 555–569 (2007).
  Article CAS Google Scholar
• Tran, L. M. et al. Determining PTEN functional status by network component deduced transcription factor activities. PLoS ONE 7, e31053 (2012).
  Article CAS Google Scholar
• Rozenberg, J. et al. Inhibition of CREB function in mouse epidermis reduces papilloma formation. Mol. Cancer Res. 7, 654–664 (2009).
  Article CAS Google Scholar
• Ji, J. et al. Elevated coding mutation rate during the reprogramming of human somatic cells into induced pluripotent stem cells. Stem Cells 30, 435–440 (2012).
  Article CAS Google Scholar
• Plikus, M. V. New activators and inhibitors in the hair cycle clock: targeting stem cells’ state of competence. J. Invest. Dermatol. 132, 1321–1324 (2012).
  Article CAS Google Scholar
• Ahmed, M. I., Mardaryev, A. N., Lewis, C. J., Sharov, A. A. & Botchkareva, N. V. MicroRNA-21 is an important downstream component of BMP signalling in epidermal keratinocytes. J. Cell Sci. 124, 3399–3404 (2011).
  Article CAS Google Scholar
• Wang, T. et al. TGF-beta-induced miR-21 negatively regulates the antiproliferative activity but has no effect on EMT of TGF-beta in HaCaT cells. Int. J. Biochem. Cell Biol. 44, 366–376 (2012).
  Article Google Scholar
• Zhong, X., Chung, A. C., Chen, H. Y., Meng, X. M. & Lan, H. Y. Smad3-mediated upregulation of miR-21 promotes renal fibrosis. J. Am. Soc. Nephrol. 22, 1668–1681 (2011).
  Article CAS Google Scholar
• Yao, Q. et al. Micro-RNA-21 regulates TGF-beta-induced myofibroblast differentiation by targeting PDCD4 in tumor-stroma interaction. Int. J. Cancer 128, 1783–1792 (2011).
  Article CAS Google Scholar
• Kim, Y. J., Hwang, S. J., Bae, Y. C. & Jung, J. S. MiR-21 regulates adipogenic differentiation through the modulation of TGF-beta signaling in mesenchymal stem cells derived from human adipose tissue. Stem Cells 27, 3093–3102 (2009).
  CAS PubMed Google Scholar
• Ma, X. et al. Loss of the miR-21 allele elevates the expression of its target genes and reduces tumorigenesis. Proc. Natl Acad. Sci. USA 108, 10144–10149 (2011).
  Article CAS Google Scholar
• Zhu, H. et al. MicroRNA expression abnormalities in limited cutaneous scleroderma and diffuse cutaneous scleroderma. J. Clin. Immunol. 32, 514–522 (2012).
  Article CAS Google Scholar
• Darido, C. et al. Targeting of the tumor suppressor GRHL3 by a miR-21-dependent proto-oncogenic network results in PTEN loss and tumorigenesis. Cancer Cell 20, 635–648 (2011).
  Article CAS Google Scholar
• Narducci, M. G. et al. MicroRNA profiling reveals that miR-21, miR486 and miR-214 are upregulated and involved in cell survival in Sezary syndrome. Cell Death Dis. 2, e151 (2011).
  Article CAS Google Scholar
• Oshimori, N. & Fuchs, E. Paracrine TGF-beta signaling counterbalances BMP-mediated repression in hair follicle stem cell activation. Cell Stem Cell 10, 63–75 (2012).
  Article CAS Google Scholar
• Sugawara, K., Schneider, M. R., Dahlhoff, M., Kloepper, J. E. & Paus, R. Cutaneous consequences of inhibiting EGF receptor signaling in vivo: normal hair follicle development, but retarded hair cycle induction and inhibition of adipocyte growth in Egfr(Wa5) mice. J. Dermatol. Sci. 57, 155–161 (2010).
  Article CAS Google Scholar
• Lowry, W. E. et al. Defining the impact of beta-catenin/Tcf transactivation on epithelial stem cells. Genes Dev. 19, 1596–1611 (2005).
  Article CAS Google Scholar
• Kimura-Ueki, M. et al. Hair cycle resting phase is regulated by cyclic epithelial FGF18 signaling. J. Invest. Dermatol. 132, 1338–1345 (2012).
  Article CAS Google Scholar
• Kobielak, K., Stokes, N., de la Cruz, J., Polak, L. & Fuchs, E. Loss of a quiescent niche but not follicle stem cells in the absence of bone morphogenetic protein signaling. Proc. Natl Acad. Sci. USA 104, 10063–10068 (2007).
  Article CAS Google Scholar
• Brownstein, M. H., Mehregan, A. H. & Bilowski, J. B. Trichilemmomas in Cowden’s disease. Jama 238, 26 (1977).
  Article CAS Google Scholar
• Lazarov, M. et al. CDK4 coexpression with Ras generates malignant human epidermal tumorigenesis. Nat. Med. 8, 1105–1114 (2002).
  Article CAS Google Scholar
• Agrawal, N. et al. Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science 333, 1154–1157 (2011).
  Article CAS Google Scholar
• Stransky, N. et al. The mutational landscape of head and neck squamous cell carcinoma. Science 333, 1157–1160 (2011).
  Article CAS Google Scholar
• Kubo, Y., Urano, Y., Hida, Y. & Arase, S. Lack of somatic mutation in the PTENgene in squamous cell carcinomas of human skin. J. Dermatol. Sci. 19, 199–201 (1999).
  Article CAS Google Scholar
• Al-Zaid, T. et al. Trichilemmomas show loss of PTEN in Cowden syndrome but only rarely in sporadic tumors. J. Cutan. Pathol. 39, 493–499 (2012).
  Article Google Scholar
• Kurose, K., Zhou, X. P., Araki, T. & Eng, C. Biallelic inactivating mutations and an occult germline mutation of PTEN in primary cervical carcinomas. Genes Chromosom. Cancer 29, 166–172 (2000).
  Article CAS Google Scholar
• Tuveson, D. A. et al. Endogenous oncogenic K-ras(G12D) stimulates proliferationand widespread neoplastic and developmental defects. Cancer Cell 5, 375–387 (2004).
  Article CAS Google Scholar
• Jonkers, J. et al. Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer. Nature Gen. 29, 418–425 (2001).
  Article CAS Google Scholar
• Jackson, E. L. et al. Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. Genes Dev. 15, 3243–3248 (2001).
  Article CAS Google Scholar
• Horenstein, M. G. & Bacheler, C. J. Follicular density and ratios in scarring and nonscarring alopecia. Am. J. Dermatopathol. 35, 818–826 (2013).
  Article Google Scholar
• Chin, M. H., Pellegrini, M., Plath, K. & Lowry, W. E. Molecular analyses of human induced pluripotent stem cells and embryonic stem cells. Cell Stem Cell 7, 263–269 (2010).
  Article CAS Google Scholar
• Wang, D. et al. Quantitative functions of Argonaute proteins in mammalian development. Genes Dev. 26, 693–704 (2012).
  Article Google Scholar