Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer (original) (raw)

• Ford, D. et al. Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. The Breast Cancer Linkage Consortium. Am. J. Hum. Genet. 62, 676–689 (1998).
  Article CAS Google Scholar
• Scully, R. & Livingston, D.M. In search of the tumour-suppressor functions of BRCA1 and BRCA2. Nature 408, 429–432 (2000).
  Article CAS Google Scholar
• Venkitaraman, A.R. The breast cancer susceptibility gene, BRCA2: at the crossroads between DNA replication and recombination? Phil. Trans. R. Soc. Lond. B Biol. Sci. 355, 191–198 (2000).
  Article CAS Google Scholar
• Yu, V.P. et al. Gross chromosomal rearrangements and genetic exchange between nonhomologous chromosomes following BRCA2 inactivation. Genes Dev. 14, 1400–1406 (2000).
  CAS PubMed PubMed Central Google Scholar
• Patel, K.J. et al. Involvement of Brca2 in DNA repair. Mol. Cell 1, 347–357 (1998).
  Article CAS Google Scholar
• Moynahan, M.E., Pierce, A.J. & Jasin, M. BRCA2 is required for homology-directed repair of chromosomal breaks. Mol. Cell 7, 263–272 (2001).
  Article CAS Google Scholar
• Chen, J. et al. Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells. Mol. Cell 2, 317–328 (1998).
  Article CAS Google Scholar
• Marmorstein, L.Y. et al. A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression. Cell 104, 247–257 (2001).
  Article CAS Google Scholar
• Chen, P.L. et al. The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment. Proc. Natl Acad. Sci. USA 95, 5287–5292 (1998).
  Article CAS Google Scholar
• Marmorstein, L.Y., Ouchi, T. & Aaronson, S.A. The BRCA2 gene product functionally interacts with p53 and RAD51. Proc. Natl Acad. Sci. USA 95, 13869–13874 (1998).
  Article CAS Google Scholar
• Wong, A.K., Pero, R., Ormonde, P.A., Tavtigian, S.V., & Bartel, P.L. RAD51 interacts with the evolutionarily conserved BRC motifs in the human breast cancer susceptibility gene Brca2. J. Biol. Chem. 272, 31941–31944 (1997).
  Article CAS Google Scholar
• Sharan, S.K. et al. Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2. Nature 386, 804–810 (1997).
  Article CAS Google Scholar
• Davies, A.A. et al. Role of BRCA2 in control of the RAD51 recombination and DNA repair protein. Mol. Cell 7, 273–282 (2001).
  Article CAS Google Scholar
• Ludwig, T., Chapman, D.L., Papaioannou, V.E. & Efstratiadis, A. Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos. Genes Dev. 11, 1226–1241 (1997).
  Article CAS Google Scholar
• Suzuki, A. et al. Brca2 is required for embryonic cellular proliferation in the mouse. Genes Dev. 11, 1242–1252 (1997).
  Article CAS Google Scholar
• Connor, F. et al. Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation. Nature Genet. 17, 423–430 (1997).
  Article CAS Google Scholar
• Friedman, L.S. et al. Thymic lymphomas in mice with a truncating mutation in Brca2. Cancer Res. 58, 1338–1343 (1998).
  CAS PubMed Google Scholar
• Crook, T. et al. p53 mutation with frequent novel codons but not a mutator phenotype in BRCA1- and BRCA2-associated breast tumours. Oncogene 17, 1681–1689 (1998).
  Article CAS Google Scholar
• Ramus, S.J. et al. Increased frequency of TP53 mutations in BRCA1 and BRCA2 ovarian tumours. Genes Chromosom. Cancer 25, 91–96 (1999).
  Article CAS Google Scholar
• Lee, H. et al. Mitotic checkpoint inactivation fosters transformation in cells lacking the breast cancer susceptibility gene, Brca2. Mol. Cell 4, 1–10 (1999).
  Article CAS Google Scholar
• Vasioukhin, V., Degenstein, L., Wise, B. & Fuchs, E. The magical touch: genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin. Proc. Natl Acad. Sci. USA 96, 8551–8556 (1999).
  Article CAS Google Scholar
• Vassar, R., Rosenberg, M., Ross, S., Tyner, A. & Fuchs, E. Tissue-specific and differentiation-specific expression of a human K14 keratin gene in transgenic mice. Proc. Natl Acad. Sci. USA 86, 1563–1567 (1989).
  Article CAS Google Scholar
• Sternberg, N. & Hamilton, D. Bacteriophage P1 site-specific recombination. I. Recombination between loxP sites. J. Mol. Biol. 150, 467–486 (1981).
  Article CAS Google Scholar
• Sauer, B. Inducible gene targeting in mice using the Cre/lox system. Methods 14, 381–392 (1998).
  Article CAS Google Scholar
• Rajewsky, K. et al. Conditional gene targeting. J. Clin. Invest 98, 600–603 (1996).
  Article CAS Google Scholar
• Schwenk, F., Baron, U. & Rajewsky, K. A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells. Nucleic Acids Res. 23, 5080–5081 (1995).
  Article CAS Google Scholar
• Brugarolas, J. & Jacks, T. Double indemnity: p53, BRCA and cancer. p53 mutation partially rescues developmental arrest in Brca1 and Brca2 null mice, suggesting a role for familial breast cancer genes in DNA damage repair. Nature Med. 3, 721–722 (1997).
  Article CAS Google Scholar
• Donehower, L.A. et al. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 356, 215–221 (1992).
  Article CAS Google Scholar
• Harvey, M. et al. Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice. Nature Genet. 5, 225–229 (1993).
  Article CAS Google Scholar
• Harvey, M., McArthur, M.J., Montgomery, C.A., Bradley, A. & Donehower, L.A. Genetic background alters the spectrum of tumors that develop in p53-deficient mice. FASEB J. 7, 938–943 (1993).
  Article CAS Google Scholar
• Jacks, T. et al. Tumor spectrum analysis in p53-mutant mice. Curr. Biol. 4, 1–7 (1994).
  Article CAS Google Scholar
• Purdie, C.A. et al. Tumour incidence, spectrum and ploidy in mice with a large deletion in the p53 gene. Oncogene 9, 603–609 (1994).
  CAS PubMed Google Scholar
• Wagner, K.U. et al. Cre-mediated gene deletion in the mammary gland. Nucleic Acids Res. 25, 4323–4330 (1997).
  Article CAS Google Scholar
• Soriano, P. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nature Genet. 21, 70–71 (1999).
  Article CAS Google Scholar
• Xu, X. et al. Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation. Nature Genet. 22, 37–43 (1999).
  Article CAS Google Scholar
• Kinzler, K.W. & Vogelstein, B. Cancer-susceptibility genes. Gatekeepers and caretakers. Nature 386, 761–763 (1997).
  Article CAS Google Scholar
• Perou, C.M. et al. Molecular portraits of human breast tumours. Nature 406, 747–752 (2000).
  Article CAS Google Scholar
• Cancer risks in BRCA2 mutation carriers. The Breast Cancer Linkage Consortium. J. Natl Cancer Inst. 91, 1310–1316 (1999).
• Berneburg, M. & Lehmann, A.R. Xeroderma pigmentosum and related disorders: defects in DNA repair and transcription. Adv. Genet. 43, 71–102 (2001).
  Article CAS Google Scholar
• Bogliolo, M., Taylor, R.M., Caldecott, K.W. & Frosina, G. Reduced ligation during DNA base excision repair supported by BRCA2 mutant cells. Oncogene 19, 5781–5787 (2000).
  Article CAS Google Scholar
• Cavalieri, E., Frenkel, K., Liehr, J.G., Rogan, E. & Roy, D. Estrogens as endogenous genotoxic agents—DNA adducts and mutations. J. Natl Cancer Inst. Monogr. 75–93 (2000).
• Liehr, J.G. Is estradiol a genotoxic mutagenic carcinogen? Endocr. Rev. 21, 40–54 (2000).
  CAS PubMed Google Scholar
• Robanus-Maandag, E. et al. p107 is a suppressor of retinoblastoma development in pRb-deficient mice. Genes Dev. 12, 1599–1609 (1998).
  Article CAS Google Scholar
• O'Gorman, S., Dagenais, N.A., Qian, M. & Marchuk, Y. Protamine–Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cells. Proc. Natl Acad. Sci. USA 94, 14602–14607 (1997).
  Article CAS Google Scholar
• Munz, B. et al. Overexpression of activin A in the skin of transgenic mice reveals new activities of activin in epidermal morphogenesis, dermal fibrosis and wound repair. EMBO J. 18, 5205–5215 (1999).
  Article CAS Google Scholar
• Hogan, B., Beddington, R., Costantini, F. & Lacy, E. Manipulating the Mouse Embryo: a Laboratory Manual (Cold Spring Harbor Laboratory Press, Plainview, 1994).
  Google Scholar
• van der Putten, H., Terwindt, E., Berns, A. & Jaenisch, R. The integration sites of endogenous and exogenous Moloney murine leukemia virus. Cell 18, 109–116 (1979).
  Article CAS Google Scholar
• Laird, P.W. et al. Simplified mammalian DNA isolation procedure. Nucleic Acids Res. 19, 4293 (1991).
  Article CAS Google Scholar
• Sambrook, J., Fritsch, E.F., & Maniatis, T. Molecular Cloning: a Laboratory Manual (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, 1989).
  Google Scholar
• Rasmussen, S.B., Young, L.J. & Smith, G.H. Preparing mammary gland whole mounts from mice. in Methods in Mammary Gland Biology and Cancer Research (eds. Ip, M.M. & Asch, B.B.) 75–85 (Kluwer Academic/Plenum, New York, 2000).
  Chapter Google Scholar