Behrens, J., Mareel, M. M., Van Roy, F. M. & Birchmeier, W. Dissecting tumour cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell–cell adhesion. J. Cell Biol.108, 2435–2447 (1989). ArticleCAS Google Scholar
Larue, L., Ohsugi, M., Hirchenhain, J. & Kemler, R. E-cadherin null mutant embryos fail to form a trophectoderm epithelium. Proc. Natl Acad. Sci. USA91, 8263–8267 (1994). ArticleCAS Google Scholar
Riethmacher, D., Brinkmann, V. & Birchmeier, C. A targeted mutation in the mouse E-cadherin gene results in defective preimplantation development. Proc. Natl Acad. Sci. USA92, 855–859 (1995). ArticleCAS Google Scholar
Perl, A. K., Wilgenbus, P., Dahl, U., Semb, H. & Christofori, G. A causal role for E-cadherin in the transition from adenoma to carcinoma. Nature392, 190–193 (1998). ArticleCAS Google Scholar
Weidner, K. M., Behrens, J., Vandekerckhove, J. & Birchmeier, W. Scatter factor: molecular characteristics and effect on the invasiveness of epithelial cells. J. Cell Biol.111, 2097–2108 (1990). ArticleCAS Google Scholar
Stoker, M. & Gherardi, E. Regulation of cell movement: the motogenic cytokines. Biochim. Biophys. Acta1072, 81–102 (1991). CASPubMed Google Scholar
Behrens, J. et al. Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/β-catenin complex in cells transformed with a temperature-sensitive v-SRC gene. J. Cell Biol.120, 757–766 (1993). ArticleCAS Google Scholar
Hamaguchi, M. et al. p60v-src causes tyrosine phosphorylation and inactivation of the N-cadherin-catenin cell adhesion system. EMBO J.12, 307–314 (1993). ArticleCAS Google Scholar
Bauer, A., Lickert, H., Kemler, R. & Stappert, J. Modification of the E-cadherin-catenin complex in mitotic Madin-Darby canine kidney epithelial cells. J. Biol. Chem.273, 28314–28321 (1998). ArticleCAS Google Scholar
Kamei, T. et al. Coendocytosis of cadherin and c-Met coupled to disruption of cell–cell adhesion in MDCK cells — regulation by Rho, Rac and Rab small G proteins. Oncogene18, 6776–6784 (1999). ArticleCAS Google Scholar
Le, T. L., Yap, A. S. & Stow, J. L. Recycling of E-cadherin: a potential mechanism for regulating cadherin dynamics. J. Cell Biol.146, 219–232 (1999). CASPubMedPubMed Central Google Scholar
Hershko, A. & Ciechanover, A. The ubiquitin system. Annu. Rev. Biochem.67, 425–479 (1998). ArticleCAS Google Scholar
Hicke, L. Gettin' down with ubiquitin: turning off cell-surface receptors, transporters and channels. Trends Cell Biol.9, 107–112 (1999). ArticleCAS Google Scholar
Strous, G. J. & Govers, R. The ubiquitin-proteasome system and endocytosis. J. Cell Sci.112, 1417–1423 (1999). CASPubMed Google Scholar
Hicke, L., Zanolari, B. & Riezman, H. Cytoplasmic tail phosphorylation of the α-factor receptor is required for its ubiquitination and internalization. J. Cell Biol.141, 349–358 (1998). ArticleCAS Google Scholar
Joazeiro, C. A. et al. The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase. Science286, 309–312 (1999). ArticleCAS Google Scholar
Levkowitz, G. et al. Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1. Mol. Cell4, 1029–1040 (1999). ArticleCAS Google Scholar
Deveraux, Q., Ustrell, V., Pickart, C. & Rechsteiner, M. A 26 S protease subunit that binds ubiquitin conjugates. J. Biol. Chem.269, 7059–7061 (1994). CASPubMed Google Scholar
Roth, A. F. & Davis, N. G. Ubiquitination of the yeast α-factor receptor. J. Cell Biol.134, 661–674 (1996). ArticleCAS Google Scholar
Terrell, J., Shih, S., Dunn, R. & Hicke, L. A function for monoubiquitination in the internalization of a G protein-coupled receptor. Mol. Cell1, 193–202 (1998). ArticleCAS Google Scholar
Chau, V. et al. A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein. Science243, 1576–1583 (1989). ArticleCAS Google Scholar
Galan, J. & Haguenauer, T. R. Ubiquitin lys63 is involved in ubiquitination of a yeast plasma membrane protein. EMBO J.16, 5847–5854 (1997). ArticleCAS Google Scholar
Horak, J. & Wolf, D. H. Catabolite inactivation of the galactose transporter in the yeast Saccharomyces cerevisiae: ubiquitination, endocytosis, and degradation in the vacuole. J. Bacteriol.179, 1541–1549 (1997). ArticleCAS Google Scholar
Schaeper, U. et al. Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses. J. Cell Biol.149, 1419–1432 (2000). ArticleCAS Google Scholar
Gumbiner, B. M. Regulation of cadherin adhesive activity. J. Cell Biol.148, 399–404 (2000). ArticleCAS Google Scholar
Xu, Y., Guo, D. F., Davidson, M., Inagami, T. & Carpenter, G. Interaction of the adaptor protein Shc and the adhesion molecule cadherin. J. Biol. Chem.272, 13463–13466 (1997). ArticleCAS Google Scholar
Kozak, M. An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNAs. Nucleic Acids Res.15, 8125–8148 (1987). ArticleCAS Google Scholar
Lorick, K. L. et al. RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination. Proc. Natl Acad. Sci. USA96, 11364–11369 (1999). ArticleCAS Google Scholar
Thoreson, M. A. et al. Selective uncoupling of p120(ctn) from E-cadherin disrupts strong adhesion. J. Cell Biol.148, 189–202 (2000). ArticleCAS Google Scholar
Wang, Y., Yeung, Y. G., Langdon, W. Y. & Stanley, E. R. c-Cbl Is Transiently Tyrosine-phosphorylated, Ubiquitinated, and Membrane-targeted following CSF-1 Stimulation of Macrophages. J. Biol. Chem.271, 17–20 (1996). ArticleCAS Google Scholar
Tagawa, M. et al. Expression of novel DNA-binding protein with zinc finger structure in various tumour cells. J. Biol. Chem.265, 20021–20026 (1990). CASPubMed Google Scholar
Weidner, K. M. et al. Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis. Nature384, 173–176 (1996). ArticleCAS Google Scholar
Nagafuchi, A., Ishihara, S. & Tsukita, S. The roles of catenins in the cadherin-mediated cell adhesion: functional analysis of E-cadherin-α-catenin fusion molecules. J. Cell Biol.127, 235–245 (1994). ArticleCAS Google Scholar
Meng, W., Sawasdikosol, S., Burakoff, S. J. & Eck, M. J. Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase. Nature398, 84–90 (1999). ArticleCAS Google Scholar
Takata, K. & Singer, S. J. Phosphotyrosine-modified proteins are concentrated at the membranes of epithelial and endothelial cells during tissue development in chick embryos. J. Cell Biol.106, 1757–1764 (1988). ArticleCAS Google Scholar
Maher, P. A. & Pasquale, E. B. Heat shock induces protein tyrosine phosphorylation in cultured cells. J. Cell Biol.108, 2029–2035 (1989). ArticleCAS Google Scholar
Tsukita, S. et al. Specific proto-oncogenic tyrosine kinases of src family are enriched in cell-to-cell adherens junctions where the level of tyrosine phosphorylation is elevated. J. Cell Biol.113, 867–879 (1991). ArticleCAS Google Scholar
Ukropec, J. A., Hollinger, M. K., Salva, S. M. & Woolkalis, M. J. SHP2 association with VE-cadherin complexes in human endothelial cells is regulated by thrombin. J. Biol. Chem.275, 5983–5986 (2000). ArticleCAS Google Scholar
Tsukamoto, T. & Nigam, S. K. Cell–cell dissociation upon epithelial cell scattering requires a step mediated by the proteasome. J. Biol. Chem.274, 24579–24584 (1999). ArticleCAS Google Scholar
Taya, S., Yamamoto, T., Kanai-Azuma, M., Wood, S. A. & Kaibuchi, K. The deubiquitinating enzyme Fam interacts with and stabilizes β-catenin. Genes Cells4, 757–767 (1999). ArticleCAS Google Scholar
Pece, S., Chiariello, M., Murga, C. & Gutkind, J. S. Activation of the protein kinase Akt/PKB by the formation of E-cadherin-mediated cell–cell junctions. Evidence for the association of phosphatidylinositol 3-kinase with the E-cadherin adhesion complex. J. Biol. Chem.274, 19347–19351 (1999). ArticleCAS Google Scholar
Birchmeier, W. & Behrens, J. Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness. Biochim. Biophys. Acta1198, 11–26 (1994). CASPubMed Google Scholar
Behrens, J. et al. Functional interaction of β-catenin with the transcription factor LEF-1. Nature382, 638–642 (1996). ArticleCAS Google Scholar
Nuber, U., Schwarz, S., Kaiser, P., Schneider, R. & Scheffner, M. Cloning of human ubiquitin-conjugating enzymes UbcH6 and UbcH7(E2-F1) and characterization of their interaction with E6-AP and RSP5. J. Biol. Chem.271, 2795–2800 (1996). ArticleCAS Google Scholar