Design, synthesis and selection of DNA-encoded small-molecule libraries (original) (raw)

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• 17 September 2009

In the version of this article initially published, the IC50 values in the table in Figure 3c were listed as nM instead of μM. The error has been corrected in the HTML and PDF versions of the article.

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1. Matthew A Clark, Raksha A Acharya, Christopher C Arico-Muendel, Svetlana L Belyanskaya, Dennis R Benjamin, Neil R Carlson, Paolo A Centrella, Cynthia H Chiu, Steffen P Creaser, John W Cuozzo, Christopher P Davie, Yun Ding, G Joseph Franklin, Kurt D Franzen, Malcolm L Gefter, Steven P Hale, Nils J V Hansen, David I Israel, Jinwei Jiang, Malcolm J Kavarana, Michael S Kelley, Christopher S Kollmann, Fan Li, Kenneth Lind, Sibongile Mataruse, Patricia F Medeiros, Jeffrey A Messer, Paul Myers, Heather O'Keefe, Matthew C Oliff, Cecil E Rise, Alexander L Satz, Steven R Skinner, Jennifer L Svendsen, Lujia Tang, Kurt van Vloten, Richard W Wagner, Gang Yao & Barry A Morgan
   Present address: Present addresses: GlaxoSmithKline, Molecular Discovery Research Boston, Waltham, Massachusetts, USA (M.A.C., C.C.A.-M., S.L.B., N.R.C., P.A.C., C.H.C., J.W.C., C.P.D., Y.D., G.J.F., D.I.I., M.S.K., C.S.K., K.L., P.F.M., J.A.M., H.O., C.E.R., A.L.S., S.R.S., G.Y. and B.A.M.); Bedford, Massachusetts, USA (R.A.A.); Seattle Genetics, Inc., Bothell, Washington, USA (D.R.B.); Satori Pharmaceuticals, Cambridge, Massachusetts, USA (S.P.C.); ParagonDx, LLC, Morrisville, North Carolina, USA (K.D.F.); Lincoln, Massachusetts, USA (M.L.G.); Ensemble Discovery Corporation, Cambridge, Massachusetts, USA (S.P.H.); Vipergen, Copenhagen, Denmark (N.J.V.H.); AVEO Pharmaceuticals, Inc., Cambridge, Massachusetts, USA (J.J.); Foley & Lardner LLP, Washington, DC, USA (M.J.K.); Medway, Massachusetts, USA (F.L.); Massachusetts College of Pharmacy and Health Sciences, Worcester, Massachusetts, USA (S.M. and J.L.S.); Monsanto, Cambridge, Massachusetts, USA (P.M.); Columbia University, College of Physicians and Surgeons, New York, New York, USA (M.C.O.); Novartis Pharmaceuticals, Cambridge, Massachusetts, USA (L.T.); Biogen IDEC, Cambridge, Massachusetts, USA (K.v.V.); SRU Biosystems, Woburn, Massachusetts, USA (R.W.W.).,

Authors and Affiliations

1. The former Praecis Pharmaceuticals, Waltham, Massachusetts, USA, presently GlaxoSmithKline, Molecular Discovery Research Boston, Waltham, Massachusetts, USA
   Matthew A Clark, Raksha A Acharya, Christopher C Arico-Muendel, Svetlana L Belyanskaya, Dennis R Benjamin, Neil R Carlson, Paolo A Centrella, Cynthia H Chiu, Steffen P Creaser, John W Cuozzo, Christopher P Davie, Yun Ding, G Joseph Franklin, Kurt D Franzen, Malcolm L Gefter, Steven P Hale, Nils J V Hansen, David I Israel, Jinwei Jiang, Malcolm J Kavarana, Michael S Kelley, Christopher S Kollmann, Fan Li, Kenneth Lind, Sibongile Mataruse, Patricia F Medeiros, Jeffrey A Messer, Paul Myers, Heather O'Keefe, Matthew C Oliff, Cecil E Rise, Alexander L Satz, Steven R Skinner, Jennifer L Svendsen, Lujia Tang, Kurt van Vloten, Richard W Wagner, Gang Yao & Barry A Morgan
2. GlaxoSmithKline, Computational and Structural Chemistry, King of Prussia, Pennsylvania, USA
   Baoguang Zhao

Authors

1. Matthew A Clark
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2. Raksha A Acharya
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3. Christopher C Arico-Muendel
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4. Svetlana L Belyanskaya
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5. Dennis R Benjamin
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6. Neil R Carlson
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7. Paolo A Centrella
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8. Cynthia H Chiu
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9. Steffen P Creaser
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10. John W Cuozzo
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11. Christopher P Davie
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12. Yun Ding
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13. G Joseph Franklin
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14. Kurt D Franzen
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15. Malcolm L Gefter
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16. Steven P Hale
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17. Nils J V Hansen
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18. David I Israel
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19. Jinwei Jiang
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20. Malcolm J Kavarana
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21. Michael S Kelley
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22. Christopher S Kollmann
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23. Fan Li
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24. Kenneth Lind
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25. Sibongile Mataruse
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26. Patricia F Medeiros
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27. Jeffrey A Messer
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28. Paul Myers
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29. Heather O'Keefe
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30. Matthew C Oliff
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31. Cecil E Rise
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32. Alexander L Satz
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33. Steven R Skinner
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34. Jennifer L Svendsen
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35. Lujia Tang
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36. Kurt van Vloten
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37. Richard W Wagner
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38. Gang Yao
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39. Baoguang Zhao
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40. Barry A Morgan
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Corresponding author

Correspondence toBarry A Morgan.

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Clark, M., Acharya, R., Arico-Muendel, C. et al. Design, synthesis and selection of DNA-encoded small-molecule libraries.Nat Chem Biol 5, 647–654 (2009). https://doi.org/10.1038/nchembio.211

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• Received: 20 November 2008
• Accepted: 18 June 2009
• Published: 02 August 2009
• Issue Date: September 2009
• DOI: https://doi.org/10.1038/nchembio.211