Microarray-based method for monitoring yeast overexpression strains reveals small-molecule targets in TOR pathway (original) (raw)
References
Harding, M.W., Galat, A., Uehling, D.E. & Schreiber, S.L. A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase. Nature341, 758–760 (1989). ArticleCAS Google Scholar
Sigal, N.H., Dumont, F.J. Cyclosporin A FK-506, and rapamycin: pharmacologic probes of lymphocyte signal transduction. Annu. Rev. Immunol.10, 519–560 (1992). ArticleCAS Google Scholar
Heitman, J., Movva, N.R. & Hall, M.N. Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science253, 905–909 (1991). ArticleCAS Google Scholar
Brown, E.J. et al. A mammalian protein targeted by G1-arresting rapamycin-receptor complex. Nature369, 756–758 (1994). ArticleCAS Google Scholar
Chiu, M.I., Katz, H. & Berlin, V. RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex. Proc. Natl. Acad. Sci. USA91, 12574–12578 (1994). ArticleCAS Google Scholar
Sabatini, D.M., Erdjument-Bromage, H., Lui, M., Tempst, P. & Snyder, S.H. RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs. Cell78, 35–43 (1994). ArticleCAS Google Scholar
Jacinto, E. & Hall, M.N. Tor signalling in bugs, brain and brawn. Nat. Rev. Mol. Cell Biol.4, 117–126 (2003). ArticleCAS Google Scholar
Crespo, J.L. & Hall, M.N. Elucidating TOR signaling and rapamycin action: lessons from Saccharomyces cerevisiae. Microbiol. Mol. Biol. Rev.66, 579–591 (2002). ArticleCAS Google Scholar
Shamji, A.F., Nghiem, P. & Schreiber, S.L. Integration of growth factor and nutrient signaling: implications for cancer biology. Mol. Cell12, 271–280 (2003). ArticleCAS Google Scholar
Inoki, K., Corradetti, M.N. & Guan, K.L. Dysregulation of the TSC-mTOR pathway in human disease. Nat. Genet.37, 19–24 (2005). ArticleCAS Google Scholar
Huang, J. et al. Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips. Proc. Natl. Acad. Sci. USA101, 16594–16599 (2004). ArticleCAS Google Scholar
Giaever, G. et al. Functional profiling of the Saccharomyces cerevisiae genome. Nature418, 387–391 (2002). ArticleCAS Google Scholar
Winzeler, E.A. et al. Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. Science285, 901–906 (1999). ArticleCAS Google Scholar
Giaever, G. et al. Genomic profiling of drug sensitivities via induced haploinsufficiency. Nat. Genet.21, 278–283 (1999). ArticleCAS Google Scholar
Lum, P.Y. et al. Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes. Cell116, 121–137 (2004). ArticleCAS Google Scholar
Giaever, G. et al. Chemogenomic profiling: identifying the functional interactions of small molecules in yeast. Proc. Natl. Acad. Sci. USA101, 793–798 (2004). ArticleCAS Google Scholar
Rine, J., Hansen, W., Hardeman, E. & Davis, R.W. Targeted selection of recombinant clones through gene dosage effects. Proc. Natl. Acad. Sci. USA80, 6750–6754 (1983). ArticleCAS Google Scholar
Chan, T.F., Carvalho, J., Riles, L. & Zheng, X.F. A chemical genomics approach toward understanding the global functions of the target of rapamycin protein (TOR). Proc. Natl. Acad. Sci. USA97, 13227–13232 (2000). ArticleCAS Google Scholar
Xie, M.W. et al. Insights into TOR function and rapamycin response: chemical genomic profiling by using a high-density cell array method. Proc. Natl. Acad. Sci. USA102, 7215–7220 (2005). ArticleCAS Google Scholar
Parsons, A.B. et al. Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways. Nat. Biotechnol.22, 62–69 (2004). ArticleCAS Google Scholar
Mulsch, A., Busse, R., Liebau, S. & Forstermann, U. LY 83583 interferes with the release of endothelium-derived relaxing factor and inhibits soluble guanylate cyclase. J. Pharmacol. Exp. Ther.247, 283–288 (1988). CASPubMed Google Scholar
Mulsch, A., Luckhoff, A., Pohl, U., Busse, R. & Bassenge, E. LY 83583 (6-anilino-5,8-quinolinedione) blocks nitrovasodilator-induced cyclic GMP increases and inhibition of platelet activation. Naunyn Schmiedebergs Arch. Pharmacol.340, 119–125 (1989). CASPubMed Google Scholar
Kiser, G.L. & Weinert, T.A. GUF1, a gene encoding a novel evolutionarily conserved GTPase in budding yeast. Yeast11, 1311–1316 (1995). ArticleCAS Google Scholar
Hughes, T.R. et al. Functional discovery via a compendium of expression profiles. Cell102, 109–126 (2000). ArticleCAS Google Scholar
Leinders-Zufall, T. & Zufall, F. Block of cyclic nucleotide-gated channels in salamander olfactory receptor neurons by the guanylyl cyclase inhibitor LY83583. J. Neurophysiol.74, 2759–2762 (1995). ArticleCAS Google Scholar
Prasad, R.K., Behrooz, A. & Ismail-Beigi, F. LY-83583 stimulates glucose transporter-1-mediated glucose transport independent of changes in cGMP levels. Eur. J. Pharmacol.366, 101–109 (1999). ArticleCAS Google Scholar
Marchler-Bauer, A. et al. CDD: a Conserved Domain Database for protein classification. Nucleic Acids Res.33, D192–D196 (2005). ArticleCAS Google Scholar
Hardwick, J.S., Kuruvilla, F.G., Tong, J.K., Shamji, A.F. & Schreiber, S.L. Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins. Proc. Natl. Acad. Sci. USA96, 14866–14870 (1999). ArticleCAS Google Scholar
Liu, C.L., Schreiber, S.L. & Bernstein, B.E. Development and validation of a T7 based linear amplification for genomic DNA. BMC Genomics4, 19 (2003). ArticleCAS Google Scholar
Gollub, J. et al. The Stanford Microarray Database: data access and quality assessment tools. Nucleic Acids Res.31, 94–96 (2003). ArticleCAS Google Scholar