Hayes DF et al. (1996) Tumor marker utility grading system: a framework to evaluate clinical utility of tumor markers. J Natl Cancer Inst88: 1456–1466 ArticleCASPubMed Google Scholar
Jones HB (1848) On a new substance occuring in the urine with mollities ossium. Phil Trans R Soc Lond138: 55–62 Google Scholar
Abelev GI et al. (1963) Production of embryonal alpha-globulin by transplantable mouse hepatomas. Transplantation1: 174–180 ArticleCASPubMed Google Scholar
Papsidero LD et al. (1980) A prostate antigen in sera of prostatic cancer patients. Cancer Res40: 2428–2432 CASPubMed Google Scholar
Anderson NL and Anderson NG (2002) The human plasma proteome: history, character, and diagnostic prospects. Mol Cell Proteomics1: 845–867 ArticleCASPubMed Google Scholar
Tomlins SA et al. (2005) Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. Science310: 644–648 ArticleCASPubMed Google Scholar
Ono K et al. (2000) Identification by cDNA microarray of genes involved in ovarian carcinogenesis. Cancer Res60: 5007–5011 CASPubMed Google Scholar
Welsh JB et al. (2001) Analysis of gene expression profiles in normal and neoplastic ovarian tissue samples identifies candidate molecular markers of epithelial ovarian cancer. Proc Natl Acad Sci USA98: 1176–1181 ArticleCASPubMedPubMed Central Google Scholar
Hellstrom I et al. (2003) The HE4 (WFDC2) protein is a biomarker for ovarian carcinoma. Cancer Res63: 3695–3700 PubMed Google Scholar
Galgano MT et al. (2006) Comprehensive analysis of HE4 expression in normal and malignant human tissues. Mod Pathol19: 847–853 ArticleCASPubMed Google Scholar
Jarjanazi H et al. (2008) Biological implications of SNPs in signal peptide domains of human proteins. Proteins70: 394–403 ArticleCASPubMed Google Scholar
Abelev GI and Eraiser TL (1999) Cellular aspects of alpha-fetoprotein reexpression in tumors. Semin Cancer Biol9: 95–107 ArticleCASPubMed Google Scholar
Slamon DJ et al. (1987) Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science235: 177–182 ArticleCASPubMed Google Scholar
Shak S (1999) Overview of the trastuzumab (Herceptin) anti-HER2 monoclonal antibody clinical program in HER2-overexpressing metastatic breast cancer. Herceptin Multinational Investigator Study Group. Semin Oncol26: 71–77 CASPubMed Google Scholar
Molina R et al. (1996) C-erbB-2 oncoprotein in the sera and tissue of patients with breast cancer: utility in prognosis. Anticancer Res16: 2295–2300 CASPubMed Google Scholar
Golub TR et al. (1999) Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science286: 531–537 ArticleCASPubMed Google Scholar
Alizadeh AA et al. (2001) Towards a novel classification of human malignancies based on gene expression patterns. J Pathol195: 41–52 ArticleCASPubMed Google Scholar
Weigelt B et al. (2005) Molecular portraits and 70-gene prognosis signature are preserved throughout the metastatic process of breast cancer. Cancer Res65: 9155–9158 ArticleCASPubMed Google Scholar
Alizadeh AA et al. (2000) Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature403: 503–511 ArticleCASPubMed Google Scholar
Rosenwald A et al. (2002) The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma. N Engl J Med346: 1937–1947 ArticlePubMed Google Scholar
Pomeroy SL et al. (2002) Prediction of central nervous system embryonal tumour outcome based on gene expression. Nature415: 436–442 ArticleCASPubMed Google Scholar
Iizuka N et al. (2004) Predicting individual outcomes in hepatocellular carcinoma. Lancet364: 1837–1839 ArticlePubMed Google Scholar
Chen HY et al. (2007) A five-gene signature and clinical outcome in non-small-cell lung cancer. N Engl J Med356: 11–20 ArticleCASPubMed Google Scholar
van de Vijver MJ et al. (2002) A gene-expression signature as a predictor of survival in breast cancer. N Engl J Med347: 1999–2009 ArticleCASPubMed Google Scholar
Paik S et al. (2004) A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer. N Engl J Med351: 2817–2826 ArticleCASPubMed Google Scholar
Michiels S et al. (2005) Prediction of cancer outcome with microarrays: a multiple random validation strategy. Lancet365: 488–492 ArticleCASPubMed Google Scholar
Ioannidis JP (2005) Microarrays and molecular research: noise discovery. Lancet365: 454–455 ArticlePubMed Google Scholar
Wulfkuhle JD et al. (2003) Proteomic approaches to the diagnosis, treatment, and monitoring of cancer. Adv Exp Med Biol532: 59–68 ArticleCASPubMed Google Scholar
Petricoin EF et al. (2002) Use of proteomic patterns in serum to identify ovarian cancer. Lancet359: 572–577 ArticleCASPubMed Google Scholar
Li J et al. (2002) Proteomics and bioinformatics approaches for identification of serum biomarkers to detect breast cancer. Clin Chem48: 1296–1304 ArticleCASPubMed Google Scholar
Petricoin EF III et al. (2002) Serum proteomic patterns for detection of prostate cancer. J Natl Cancer Inst94: 1576–1578 ArticleCASPubMed Google Scholar
Chen YD et al. (2004) Artificial neural networks analysis of surface-enhanced laser desorption/ionization mass spectra of serum protein pattern distinguishes colorectal cancer from healthy population. Clin Cancer Res10: 8380–8385 ArticleCASPubMed Google Scholar
Paradis V et al. (2005) Identification of a new marker of hepatocellular carcinoma by serum protein profiling of patients with chronic liver diseases. Hepatology41: 40–47 ArticleCASPubMed Google Scholar
Tolson J et al. (2004) Serum protein profiling by SELDI mass spectrometry: detection of multiple variants of serum amyloid alpha in renal cancer patients. Lab Invest84: 845–856 ArticleCASPubMed Google Scholar
Rosty C et al. (2002) Identification of hepatocarcinoma-intestine-pancreas/pancreatitis-associated protein I as a biomarker for pancreatic ductal adenocarcinoma by protein biochip technology. Cancer Res62: 1868–1875 CASPubMed Google Scholar
Wadsworth JT et al. (2004) Identification of patients with head and neck cancer using serum protein profiles. Arch Otolaryngol Head Neck Surg130: 98–104 ArticlePubMed Google Scholar
Diamandis EP (2003) Point: proteomic patterns in biological fluids: do they represent the future of cancer diagnostics? Clin Chem49: 1272–1275 ArticleCASPubMed Google Scholar
Karsan A et al. (2005) Analytical and preanalytical biases in serum proteomic pattern analysis for breast cancer diagnosis. Clin Chem51: 1525–1528 ArticleCASPubMed Google Scholar
Banks RE et al. (2005) Influences of blood sample processing on low-molecular-weight proteome identified by surface-enhanced laser desorption/ionization mass spectrometry. Clin Chem51: 1637–1649 ArticleCASPubMed Google Scholar
Ransohoff DF (2005) Lessons from controversy: ovarian cancer screening and serum proteomics. J Natl Cancer Inst97: 315–319 ArticleCASPubMed Google Scholar
Baggerly KA et al. (2005) Signal in noise: evaluating reported reproducibility of serum proteomic tests for ovarian cancer. J Natl Cancer Inst97: 307–309 ArticleCASPubMed Google Scholar
Tirumalai RS et al. (2003) Characterization of the low molecular weight human serum proteome. Mol Cell Proteomics2: 1096–1103 ArticleCASPubMed Google Scholar
Harper RG et al. (2004) Low-molecular-weight human serum proteome using ultrafiltration, isoelectric focusing, and mass spectrometry. Electrophoresis25: 1299–1306 ArticleCASPubMed Google Scholar
Rai DK et al. (2004) Accurate mass measurement and tandem mass spectrometry of intact globin chains identify the low proportion variant hemoglobin Lepore-Boston-Washington from the blood of a heterozygote. J Mass Spectrom39: 289–294 ArticleCASPubMed Google Scholar
Villanueva J et al. (2006) Differential exoprotease activities confer tumor-specific serum peptidome patterns. J Clin Invest116: 271–284 ArticleCASPubMedPubMed Central Google Scholar
Lopez MF et al. (2007) A novel, high-throughput workflow for discovery and identification of serum carrier protein-bound peptide biomarker candidates in ovarian cancer samples. Clin Chem53: 1067–1074 ArticleCASPubMed Google Scholar
Koomen JM et al. (2005) Direct tandem mass spectrometry reveals limitations in protein profiling experiments for plasma biomarker discovery. J Proteome Res4: 972–981 ArticleCASPubMed Google Scholar
Diamandis EP (2006) Peptidomics for cancer diagnosis: present and future. J Proteome Res5: 2079–2082 ArticleCASPubMed Google Scholar
Borgono CA and Diamandis EP (2004) The emerging roles of human tissue kallikreins in cancer. Nat Rev Cancer4: 876–890 ArticleCASPubMed Google Scholar
Rittenhouse HG et al. (1998) Human Kallikrein 2 (hK2) and prostate-specific antigen (PSA): two closely related, but distinct, kallikreins in the prostate. Crit Rev Clin Lab Sci35: 275–368 ArticleCASPubMed Google Scholar
Diamandis EP et al. (2003) Human kallikrein 6 (hK6): a new potential serum biomarker for diagnosis and prognosis of ovarian carcinoma. J Clin Oncol21: 1035–1043 ArticleCASPubMed Google Scholar
Liotta LA and Kohn EC (2001) The microenvironment of the tumour-host interface. Nature411: 375–379 ArticleCASPubMed Google Scholar
Jung YD et al. (2002) The role of the microenvironment and intercellular cross-talk in tumor angiogenesis. Semin Cancer Biol12: 105–112 ArticleCASPubMed Google Scholar
Celis JE et al. (2004) Proteomic characterization of the interstitial fluid perfusing the breast tumor microenvironment: a novel resource for biomarker and therapeutic target discovery. Mol Cell Proteomics3: 327–344 ArticleCASPubMed Google Scholar
Nowell PC and Hungerford DA (1960) Chromosome studies on normal and leukemic human leukocytes. J Natl Cancer Inst25: 85–109 CASPubMed Google Scholar
Caprioli RM (2005) Deciphering protein molecular signatures in cancer tissues to aid in diagnosis, prognosis, and therapy. Cancer Res65: 10642–10645 ArticleCASPubMed Google Scholar
Yanagisawa K et al. (2003) Proteomic patterns of tumour subsets in non-small-cell lung cancer. Lancet362: 433–439 ArticleCASPubMed Google Scholar
Faca V et al. (2007) Contribution of protein fractionation to depth of analysis of the serum and plasma proteomes. J Proteome Res6: 3558–3565 ArticleCASPubMed Google Scholar
Kuick R et al. (2007) Discovery of cancer biomarkers through the use of mouse models. Cancer Lett249: 40–48 ArticleCASPubMed Google Scholar
Whiteaker JR et al. (2007) Integrated pipeline for mass spectrometry-based discovery and confirmation of biomarkers demonstrated in a mouse model of breast cancer. J Proteome Res6: 3962–3975 ArticleCASPubMed Google Scholar
Pepe MS et al. (2001) Phases of biomarker development for early detection of cancer. J Natl Cancer Inst93: 1054–1061 ArticleCASPubMed Google Scholar
Bast RC Jr et al. (2001) 2000 update of recommendations for the use of tumor markers in breast and colorectal cancer: clinical practice guidelines of the American Society of Clinical Oncology. J Clin Oncol19: 1865–1878 ArticlePubMed Google Scholar
Finne P et al. (2000) Predicting the outcome of prostate biopsy in screen-positive men by a multilayer perceptron network. Urology56: 418–422 ArticleCASPubMed Google Scholar
Stephan C et al. (2002) Multicenter evaluation of an artificial neural network to increase the prostate cancer detection rate and reduce unnecessary biopsies. Clin Chem48: 1279–1287 ArticleCASPubMed Google Scholar
Diamandis EP et al. (2002) Tumor Markers: Physiology, Pathobiology, Technology, and Clinical Applications. Washington, DC: AACC Press Google Scholar
Melvin KE et al. (1971) Early diagnosis of medullary carcinoma of the thyroid gland by means of calcitonin assay. N Engl J Med285: 1115–1120 ArticleCASPubMed Google Scholar
Sturgeon C (2002) Practice guidelines for tumor marker use in the clinic. Clin Chem48: 1151–1159 ArticleCASPubMed Google Scholar
Kufe D et al. (1984) Differential reactivity of a novel monoclonal antibody (DF3) with human malignant versus benign breast tumors. Hybridoma3: 223–232 ArticleCASPubMed Google Scholar
Hilkens J et al. (1984) Monoclonal antibodies against human milk-fat globule membranes detecting differentiation antigens of the mammary gland and its tumors. Int J Cancer34: 197–206 ArticleCASPubMed Google Scholar
Koprowski H et al. (1979) Colorectal carcinoma antigens detected by hybridoma antibodies. Somatic Cell Genet5: 957–971 ArticleCASPubMed Google Scholar
Ludwig JA and Weinstein JN (2005) Biomarkers in cancer staging, prognosis and treatment selection. Nat Rev Cancer5: 845–856 ArticleCASPubMed Google Scholar
McGuire WL et al. (1977) Current status of estrogen and progesterone receptors in breast cancer. Cancer39: 2934–2947 ArticleCASPubMed Google Scholar
Coussens L et al. (1985) Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene. Science230: 1132–1139 ArticleCASPubMed Google Scholar
Yamamoto T et al. (1986) Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor. Nature319: 230–234 ArticleCASPubMed Google Scholar
Hill BR and Levi C (1954) Elevation of a serum component in neoplastic disease. Cancer Res14: 513–515 CASPubMed Google Scholar
Wang MC et al. (1979) Purification of a human prostate specific antigen. Invest Urol17: 159–163 CASPubMed Google Scholar
Carayanniotis G and Rao VP (1977) Searching for pathogenic epitopes in thyroglobulin: parameters and caveats. Immunol Today18: 83–88 Article Google Scholar