Mechanisms of Disease: leukotrienes and lipoxins in scleroderma lung disease—insights and potential therapeutic implications (original) (raw)
White B (2003) Interstitial lung disease in scleroderma. Rheum Dis Clin North Am29: 371–390 Article Google Scholar
Thannickal VJ et al. (2004) Mechanisms of pulmonary fibrosis. Annu Rev Med55: 395–417 ArticleCAS Google Scholar
Samuelsson B et al. (1987) Leukotrienes and lipoxins: structures, biosynthesis, and biological effects. Science237: 1171–1176 ArticleCAS Google Scholar
Henderson WR (1994) The role of leukotrienes in inflammation. Ann Intern Med121: 684–697 ArticleCAS Google Scholar
Serhan CN (2005) Lipoxins and aspirin-triggered 15-epi-lipoxins are the first lipid mediators of endogenous anti-inflammation and resolution. Prostaglandins Leukot Essent Fatty Acids73: 141–162 ArticleCAS Google Scholar
Koyama S et al. (1998) Human lung fibroblasts release chemokinetic activity for monocytes constitutively. Am J Physiol275: L223–L230 CASPubMed Google Scholar
Palmantier R et al. (1991) Thrombin-activated platelets promote leukotriene B4 synthesis in polymorphonuclear leucocytes stimulated by physiological agonists. Br J Pharmacol103: 1909–1916 ArticleCAS Google Scholar
Fiore S et al. (1990) Formation of lipoxins and leukotrienes during receptor-mediated interactions of human platelets and recombinant human granulocyte/macrophage colony-stimulating factor-primed neutrophils. J Exp Med172: 1451–1457 ArticleCAS Google Scholar
Schonfeld W et al. (1988) Leukotriene generation and metabolism in isolated human lung macrophages. Immunology65: 529–536 CASPubMedPubMed Central Google Scholar
Levy BD et al. (1993) Human alveolar macrophages have 15-lipoxygenase and generate 15(S)-hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid and lipoxins. J Clin Invest92: 1572–1579 ArticleCAS Google Scholar
Nassar GM et al. (1994) Induction of 15-lipoxygenase by interleukin-13 in human blood monocytes. J Biol Chem269: 27631–27634 CASPubMed Google Scholar
Profita M et al. (2002) Leukotriene B4 production in human mononuclear phagocytes is modulated by interleukin-4-induced 15-lipoxygenase. J Pharmacol Exp Ther300: 868–875 ArticleCAS Google Scholar
Levy BD et al. (2001) Lipid mediator class switching during acute inflammation: signals in resolution. Nat Immunol2: 612–619 ArticleCAS Google Scholar
Peters-Golden M et al. (2005) Leukotrienes: underappreciated mediators of innate immune responses. J Immunol174: 589–594 ArticleCAS Google Scholar
Tager AM et al. (2003) Leukotriene B4 receptor BLT1 mediates early effector T cell recruitment. Nat Immunol4: 982–990 ArticleCAS Google Scholar
Prinz I et al. (2005) The type 1 cysteinyl leukotriene receptor triggers calcium influx and chemotaxis in mouse alpha beta- and gamma delta effector T cells. J Immunol175: 713–719 ArticleCAS Google Scholar
Brink C et al. (2003) International Union of Pharmacology XXXVII. Nomenclature for leukotriene and lipoxin receptors. Pharmacol Rev55: 195–227 ArticleCAS Google Scholar
Gronert K et al. (2001) Selectivity of recombinant human leukotriene D(4), leukotriene B(4), and lipoxin A(4) receptors with aspirin-triggered 15-epi-LXA(4) and regulation of vascular and inflammatory responses. Am J Pathol158: 3–9 ArticleCAS Google Scholar
Serhan CN et al. (2003) Reduced inflammation and tissue damage in transgenic rabbits overexpressing 15-lipoxygenase and endogenous anti-inflammatory lipid mediators. J Immunol171: 6856–6865 ArticleCAS Google Scholar
Mensing H et al. (1984) Leukotriene B4 induces in vitro fibroblast chemotaxis. J Invest Dermatol82: 9–12 ArticleCAS Google Scholar
Baud L et al. (1987) Modulation of fibroblast proliferation by sulfidopeptide leukotrienes: effect of indomethacin. J Immunol138: 1190–1195 CASPubMed Google Scholar
Phan SH et al. (1988) Binding of leukotriene C4 to rat lung fibroblasts and stimulation of collagen synthesis in vitro. Biochemistry27: 2846–2853 ArticleCAS Google Scholar
Perng DW et al. (2006) Leukotriene C4 induces TGF-beta1 production in airway epithelium via p38 kinase pathway. Am J Respir Cell Mol Biol34: 101–107 ArticleCAS Google Scholar
Peters-Golden M et al. (2002) Protection from pulmonary fibrosis in leukotriene-deficient mice. Am J Respir Crit Care Med165: 229–235 Article Google Scholar
Beller TC et al. (2004) Cysteinyl leukotriene 1 receptor controls the severity of chronic pulmonary inflammation and fibrosis. Proc Natl Acad Sci USA101: 3047–3052 ArticleCAS Google Scholar
Vargaftig BB et al. (2003) Leukotrienes mediate murine bronchopulmonary hyperreactivity, inflammation, and part of mucosal metaplasia and tissue injury induced by recombinant murine interleukin-13. Am J Respir Cell Mol Biol28: 410–419 ArticleCAS Google Scholar
Kolodsick JE et al. (2004) Protection from fluorescein isothiocyanate-induced fibrosis in IL-13-deficient, but not IL-4-deficient, mice results from impaired collagen synthesis by fibroblasts. J Immunol172: 4068–4076 ArticleCAS Google Scholar
Beller TC et al. (2004) Targeted gene disruption reveals the role of the cysteinyl leukotriene 2 receptor in increased vascular permeability and in bleomycin-induced pulmonary fibrosis in mice. J Biol Chem279: 46129–46134 ArticleCAS Google Scholar
McMahon B et al. (2002) Lipoxin, leukotriene, and PDGF receptors cross-talk to regulate mesangial cell proliferation. FASEB J16: 1817–1819 ArticleCAS Google Scholar
Sato Y et al. (2004) Down-regulation of lipoxin A4 receptor by thromboxane A2 signaling in RAW246.7 cells in vitro and bleomycin-induced lung fibrosis in vivo. Biomed Pharmacother58: 381–387 ArticleCAS Google Scholar
Wu SH et al. (2006) Lipoxin A4 inhibits proliferation of human lung fibroblasts induced by connective tissue growth factor. Am J Respir Cell Mol Biol34: 65–72 ArticleCAS Google Scholar
Mitchell D et al. (2004) Lipoxins inhibit Akt/PKB activation and cell cycle progression in human mesangial cells. Am J Pathol164: 937–946 ArticleCAS Google Scholar
McMahon B et al. (2000) Lipoxin A4 antagonizes the mitogenic effects of leukotriene D4 in human renal mesangial cells. Differential activation of MAP kinases through distinct receptors. J Biol Chem275: 27566–27575 CASPubMed Google Scholar
Wu SH et al. (2005) Lipoxin A4 inhibits TNF-alpha-induced production of interleukins and proliferation of rat mesangial cells. Kidney Int68: 35–46 ArticleCAS Google Scholar
Wu SH et al. (2005) High dose of lipoxin A4 induces apoptosis in rat renal interstitial fibroblasts. Prostaglandins Leukot Essent Fatty Acids73: 127–137 ArticleCAS Google Scholar
Rodgers K et al. (2005) Lipoxin A4 modifies platelet-derived growth factor-induced pro-fibrotic gene expression in human renal mesangial cells. Am J Pathol167: 683–694 ArticleCAS Google Scholar
Wu SH et al. (2006) Lipoxin A4 inhibits connective tissue growth factor-induced production of chemokines in rat mesangial cells. Kidney Int69: 248–256 ArticleCAS Google Scholar
Vachier I et al. (2005) Severe asthma is associated with a loss of LX4, an endogenous anti-inflammatory compound. J Allergy Clin Immunol115: 55–60 ArticleCAS Google Scholar
Kowal-Bielecka O et al. (2003) Elevated levels of leukotriene B4 and leukotriene E4 in bronchoalveolar lavage fluid from patients with scleroderma lung disease. Arthritis Rheum48: 1639–1646 ArticleCAS Google Scholar
Silver RM et al. (1990) Evaluation and management of scleroderma lung disease using bronchoalveolar lavage. Am J Med88: 470–476 ArticleCAS Google Scholar
Wilborn J et al. (1996) Constitutive activation of 5-lipoxygenase in the lungs of patients with idiopathic pulmonary fibrosis. J Clin Invest97: 1827–1836 ArticleCAS Google Scholar
Kowal-Bielecka O et al. (2005) Beta thromboglobulin and platelet factor 4 in bronchoalveolar lavage fluid of patients with systemic sclerosis. Ann Rheum Dis64: 484–486 ArticleCAS Google Scholar
Witt C et al. (1999) Pulmonary involvement in diffuse cutaneous systemic sclerosis: bronchoalveolar fluid granulocytosis predicts progression of fibrosing alveolitis. Ann Rheum Dis58: 635–640 ArticleCAS Google Scholar
White B et al. (2000) Cyclophosphamide is associated with pulmonary function and survival benefit in patients with scleroderma and alveolitis. Ann Intern Med132: 947–954 ArticleCAS Google Scholar
Kowal-Bielecka O et al. (2005) Cyclophosphamide reduces neutrophilic alveolitis in patients with scleroderma lung disease: a retrospective analysis of serial bronchoalveolar lavage investigations. Ann Rheum Dis64: 1343–1346 ArticleCAS Google Scholar
Goldstein RA et al. (1990) Clinical role of bronchoalveolar lavage in adults with pulmonary disease. Am Rev Respir Dis142: 481–486 ArticleCAS Google Scholar
Kowal-Bielecka O et al. (2001) Evidence of 5-lipoxygenase overexpression in the skin of patients with systemic sclerosis: a newly identified pathway to skin inflammation in systemic sclerosis. Arthritis Rheum44: 1865–1875 ArticleCAS Google Scholar
Huang L et al. (2004) Leukotriene B4 strongly increases monocyte chemoattractant protein-1 in human monocytes. Arterioscler Thromb Vasc Biol24: 1783–1788 ArticleCAS Google Scholar
Ichiyama T et al. (2005) Cysteinyl leukotrienes induce monocyte chemoattractant protein 1 in human monocytes/macrophages. Clin Exp Allergy35: 1214–1219 ArticleCAS Google Scholar
Meloni F et al. (2004) BAL cytokine profile in different interstitial lung diseases: a focus on systemic sclerosis. Sarcoidosis Vasc Diffuse Lung Dis21: 111–118 PubMed Google Scholar
Distler O et al. (2001) Overexpression of monocyte chemoattractant protein 1 in systemic sclerosis: role of platelet-derived growth factor and effects on monocyte chemotaxis and collagen synthesis. Arthritis Rheum44: 2665–2678 ArticleCAS Google Scholar
Distler JH et al. (2006) Monocyte chemoattractant protein 1 released from glycosaminoglycans mediates its profibrotic effects in systemic sclerosis via the release of interleukin-4 from T cells. Arthritis Rheum54: 214–225 ArticleCAS Google Scholar
Kowal-Bielecka O et al. (2005) Cyclooxygenase- and lipoxygenase-derived eicosanoids in bronchoalveolar lavage fluid from patients with scleroderma lung disease: an imbalance between proinflammatory and antiinflammatory lipid mediators. Arthritis Rheum52: 3783–3791 ArticleCAS Google Scholar
Flaherty KR et al. (2004) Zileuton versus azathioprine/prednisone in idiopathic pulmonary fibrosis. Europ Respir J24 (Suppl 48): S254 Google Scholar
Petasis NA et al. (2005) Design, synthesis and bioactions of novel stable mimetics of lipoxins and aspirin-triggered lipoxins. Prostaglandins Leukot Essent Fatty Acids73: 301–321 ArticleCAS Google Scholar
Tager AM et al. (2003) BLT1 and BLT2: the leukotriene B(4) receptors. Prostaglandins Leukot Essent Fatty Acids69: 123–134 ArticleCAS Google Scholar
Qiu H et al. (2006) Differential induction of BLT receptor expression on human endothelial cells by lipopolysaccharide, cytokines, and leukotriene B4. Proc Natl Acad Sci USA103: 6913–6918 ArticleCAS Google Scholar
Kanaoka Y et al. (2004) Cysteinyl leukotrienes and their receptors: cellular distribution and function in immune and inflammatory responses. J Immunol173: 1503–1510 ArticleCAS Google Scholar
Uzonyi B et al. (2006) Cysteinyl leukotriene 2 receptor and protease-activated receptor 1 activate strongly correlated early genes in human endothelial cells. Proc Natl Acad Sci USA103: 6326–6331 ArticleCAS Google Scholar