Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis (original) (raw)

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Acknowledgements

The full list of acknowledgments for each study is provided in the Supplementary Note.

Author information

Author notes

1. Lavinia Paternoster, Marie Standl and Marjo-Riitta Jarvelin: These authors contributed equally to this work.
2. Joachim Heinrich, David M Evans and Stephan Weidinger: These authors jointly directed this work.

Authors and Affiliations

1. Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology (CAiTE), School of Social & Community Medicine, University of Bristol, Bristol, UK
   Lavinia Paternoster, George Davey Smith, John P Kemp, Nicholas J Timpson & David M Evans
2. Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
   Marie Standl, H-Erich Wichmann, Carla M T Tiesler, Elisabeth Thiering & Joachim Heinrich
3. Department for Paediatric Pneumology, Allergy and Neonatology, Hannover Medical School, Hannover, Germany
   Chih-Mei Chen
4. Respiratory Epidemiology and Public Health, Imperial College London, London, UK
   Adaikalavan Ramasamy & Deborah L Jarvis
5. Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK
   Adaikalavan Ramasamy, Alexessander Couto Alves & Marjo-Riitta Jarvelin
6. Department of Medical and Molecular Genetics, King's College London, Guy's Hospital, London, UK
   Adaikalavan Ramasamy
7. Copenhagen Prospective Studies on Asthma in Childhood (COPSAC), Health Sciences, University of Copenhagen and Copenhagen University Hospital, Gentofte, Denmark
   Klaus Bønnelykke, Bo Chawes, Eskil Kreiner-Møller & Hans Bisgaard
8. The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
   Liesbeth Duijts, Albert Hofman, André G Uitterlinden, Fernando Rivadeneira, Ralf J P van der Valk & Vincent W V Jaddoe
9. Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
   Liesbeth Duijts, Albert Hofman, André G Uitterlinden, Cornélia M van Duijn, Fernando Rivadeneira, Ralf J P van der Valk & Vincent W V Jaddoe
10. Department of Pediatrics, Division of Respiratory Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Liesbeth Duijts, Johan C de Jongste & Ralf J P van der Valk
11. Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Manuel A Ferreira, David L Duffy, Grant W Montgomery & Nicholas G Martin
12. Department of Dermato-Allergology, National Allergy Research Centre, Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark
    Jacob P Thyssen & Torkil Menné
13. Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
    Eva Albrecht, Martina Müller-Nurasyid & Christian Gieger
14. Department of Dermatology and Allergy, Technische Universität München, Munich, Germany
    Hansjörg Baurecht
15. Department of Dermatology, Allergology, and Venerology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany
    Hansjörg Baurecht, Regina Fölster-Holst, Elke Rodríguez & Stephan Weidinger
16. Graduate School of Information Science in Health, Technische Universität München, Munich, Germany
    Hansjörg Baurecht
17. Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
    Bjarke Feenstra, Frank Geller, Heather A Boyd & Mads Melbye
18. The Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Patrick M A Sleiman, Cecilia Kim, Frank Mentch, Michael March & Hakon Hakonarson
19. Department of Twin Research and Genetic Epidemiology, King's College London, London, UK
    Pirro Hysi, Massimo Mangino, Tim D Spector, Veronique Bataille & Daniel Glass
20. School of Women's and Infants' Health, The University of Western Australia, Perth, Western Australia, Australia
    Nicole M Warrington & Craig E Pennell
21. Swiss Tropical and Public Health Institute (Swiss TPH), Basel, Switzerland
    Ivan Curjuric, Medea Imboden & Nicole M Probst-Hensch
22. University of Basel, Basel, Switzerland
    Ivan Curjuric, Medea Imboden & Nicole M Probst-Hensch
23. Department of Genes and Environment, Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway
    Ronny Myhre & Bo Jacobsson
24. Manchester Academic Health Science Centre, National Institute for Health Research (NIHR) Translational Research Facility in Respiratory Medicine, The University of Manchester, University Hospital of South Manchester National Health Service Foundation Trust, Manchester, UK
    John A Curtin, Angela Simpson & Adnan Custovic
25. Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands
    Maria M Groen-Blokhuis, Jouke-Jan Hottenga & Dorret I Boomsma
26. Department of Epidemiology, Groningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Marjan Kerkhof
27. Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Annika Sääf & Erik Melén
28. Institute of Clinical Molecular Biology, Christian-Albrechts-Universität zu Kiel, Kiel, Germany
    Andre Franke & David Ellinghaus
29. Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland
    Emmanouil Dermitzakis & Stephen B Montgomery
30. Wellcome Trust Sanger Institute, Cambridge, UK
    Emmanouil Dermitzakis, Stephen B Montgomery & Panos Deloukas
31. Institute of Human Genetics, Technische Universität München, Munich, Germany
    Holger Prokisch
32. Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
    Holger Prokisch & Katharina Heim
33. Department of Obstetrics and Gynaecology, University of Oulu, Oulu, Finland
    Anna-Liisa Hartikainen & Anneli Pouta
34. National Institute for Health and Welfare (THL), Kuopio & Oulu, Finland
    Anneli Pouta, Juha Pekkanen & Marjo-Riitta Jarvelin
35. Department of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
    Juha Pekkanen
36. Department of Genomics of Common Disease, Imperial College London, London, UK
    Alexandra I F Blakemore & Jessica L Buxton
37. Institute of Health Sciences, Biocenter Oulu, University of Oulu, Oulu, Finland
    Marika Kaakinen & Marjo-Riitta Jarvelin
38. Washington University School of Medicine, Saint Louis, Missouri, USA
    Pamela A Madden & Andrew C Heath
39. Lung Institute of Western Australia, Perth, Western Australia, Australia
    Philip J Thompson
40. Centre for Asthma, Allergy and Respiratory Research, University of Western Australia, Perth, Western Australia, Australia
    Philip J Thompson
41. Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, The University of Melbourne, Melbourne, Victoria, Australia
    Melanie C Matheson
42. School of Paediatrics and Child Health, Princess Margaret Hospital for Children, Perth, Western Australia, Australia
    Peter Le Souëf
43. The School of Social & Community Medicine, University of Bristol, Bristol, UK
    Beate St. Pourcain, John Henderson & Susan M Ring
44. Chair of Epidemiology, Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität München, Munich, Germany
    H-Erich Wichmann & Martina Müller-Nurasyid
45. Klinikum Grosshadern, Munich, Germany
    H-Erich Wichmann
46. Chair of Genetic Epidemiology, Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität München, Munich, Germany
    Martina Müller-Nurasyid
47. Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität München, Munich, Germany
    Martina Müller-Nurasyid
48. Department of Dermatology and Allergy, University of Bonn Medical Center, Bonn, Germany
    Natalija Novak
49. Unit for Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
    Norman Klopp & Thomas Illig
50. ZAUM–Center for Allergy and Environment, Helmholtz-Zentrum and Technische Universität, Munich, Germany
    Elke Rodríguez
51. Avon Longitudinal Study of Parents and Children (ALSPAC) Laboratory, School of Social & Community Medicine, University of Bristol, Bristol, UK
    Wendy McArdle
52. Research Center for Prevention and Health, Glostrup University Hospital, Copenhagen, Denmark
    Allan Linneberg
53. Institute of Public Health, Aarhus University, Aarhus, Denmark
    Ellen A Nohr
54. Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    André G Uitterlinden & Fernando Rivadeneira
55. Comprehensive Pneumology Center and Institute of Lung Biology and Disease, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
    Matthias Wjst
56. Lung Clinic, Tartu University Hospital, Tartu, Estonia
    Rain Jogi
57. Department of Pediatrics, University of Iowa, Iowa City, Iowa, USA
    Jeffrey C Murray
58. Telethon Institute for Child Health Research and Centre for Child Health Research, The University of Western Australia, Perth, Western Australia, Australia
    Patrick G Holt
59. Queensland Children's Medical Research Institute, University of Queensland, World Health Organization (WHO) Collaborating Centre for Research on Children's Environmental Health, Brisbane, Queensland, Australia
    Peter Sly
60. Division of Metabolic Diseases and Nutritional Medicine, Dr von Hauner Children's Hospital, Ludwig-Maximilians-Universität München, Munich, Germany
    Carla M T Tiesler
61. Hannover Unified Biobank, Hannover Medical School, Hannover, Germany
    Thomas Illig
62. Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway
    Wenche Nystad
63. Department of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Dirkje Postma
64. Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, GRIAC, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Gerard H Koppelman
65. Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Henriette A Smit
66. Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden
    Cilla Söderhäll
67. Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden
    Erik Melén
68. Department of Obstetrics and Gynecology, Sahlgrenska University Hospital, Sahlgrenska Academy, Göteborg University, Göteborg, Sweden
    Bo Jacobsson
69. Ontario Institute for Cancer Research, Toronto, University of Toronto, Toronto, Canada
    Lyle J Palmer
70. Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Hakon Hakonarson
71. Department of Pediatrics, Erasmus Medical Center, Rotterdam, The Netherlands
    Vincent W V Jaddoe
72. Division of Population Health Sciences and Education, St George's University of London, London, UK
    David P Strachan
73. MRC-HPA Centre for Environment and Health, Faculty of Medicine, Imperial College London, London, UK
    Marjo-Riitta Jarvelin

Authors

1. Lavinia Paternoster
2. Marie Standl
3. Chih-Mei Chen
4. Adaikalavan Ramasamy
5. Klaus Bønnelykke
6. Liesbeth Duijts
7. Manuel A Ferreira
8. Alexessander Couto Alves
9. Jacob P Thyssen
10. Eva Albrecht
11. Hansjörg Baurecht
12. Bjarke Feenstra
13. Patrick M A Sleiman
14. Pirro Hysi
15. Nicole M Warrington
16. Ivan Curjuric
17. Ronny Myhre
18. John A Curtin
19. Maria M Groen-Blokhuis
20. Marjan Kerkhof
21. Annika Sääf
22. Andre Franke
23. David Ellinghaus
24. Regina Fölster-Holst
25. Emmanouil Dermitzakis
26. Stephen B Montgomery
27. Holger Prokisch
28. Katharina Heim
29. Anna-Liisa Hartikainen
30. Anneli Pouta
31. Juha Pekkanen
32. Alexandra I F Blakemore
33. Jessica L Buxton
34. Marika Kaakinen
35. David L Duffy
36. Pamela A Madden
37. Andrew C Heath
38. Grant W Montgomery
39. Philip J Thompson
40. Melanie C Matheson
41. Peter Le Souëf
42. Beate St. Pourcain
43. George Davey Smith
44. John Henderson
45. John P Kemp
46. Nicholas J Timpson
47. Panos Deloukas
48. Susan M Ring
49. H-Erich Wichmann
50. Martina Müller-Nurasyid
51. Natalija Novak
52. Norman Klopp
53. Elke Rodríguez
54. Wendy McArdle
55. Allan Linneberg
56. Torkil Menné
57. Ellen A Nohr
58. Albert Hofman
59. André G Uitterlinden
60. Cornélia M van Duijn
61. Fernando Rivadeneira
62. Johan C de Jongste
63. Ralf J P van der Valk
64. Matthias Wjst
65. Rain Jogi
66. Frank Geller
67. Heather A Boyd
68. Jeffrey C Murray
69. Cecilia Kim
70. Frank Mentch
71. Michael March
72. Massimo Mangino
73. Tim D Spector
74. Veronique Bataille
75. Craig E Pennell
76. Patrick G Holt
77. Peter Sly
78. Carla M T Tiesler
79. Elisabeth Thiering
80. Thomas Illig
81. Medea Imboden
82. Wenche Nystad
83. Angela Simpson
84. Jouke-Jan Hottenga
85. Dirkje Postma
86. Gerard H Koppelman
87. Henriette A Smit
88. Cilla Söderhäll
89. Bo Chawes
90. Eskil Kreiner-Møller
91. Hans Bisgaard
92. Erik Melén
93. Dorret I Boomsma
94. Adnan Custovic
95. Bo Jacobsson
96. Nicole M Probst-Hensch
97. Lyle J Palmer
98. Daniel Glass
99. Hakon Hakonarson
100. Mads Melbye
101. Deborah L Jarvis
102. Vincent W V Jaddoe
103. Christian Gieger
104. David P Strachan
105. Nicholas G Martin
106. Marjo-Riitta Jarvelin
107. Joachim Heinrich
108. David M Evans

Consortia

Australian Asthma Genetics Consortium (AAGC)

The Genetics of Overweight Young Adults (GOYA) Consortium

the EArly Genetics & Lifecourse Epidemiology (EAGLE) Consortium

• Stephan Weidinger

Contributions

Study-level data analysis: L.P., M.S., A.R., K.B., L.D., M.A.F., A.C.A., J.P.T., E.A., H. Baurecht, B.F., P.H., N.M.W., I.C., R.M., J.A.C., M.M.G.-B., M. Kerkhof, A. Sääf, A.F., D.E., S.B.M., B.S.P., J.P.K., N.J.T., M.M.-N., F.G., M. March, M. Mangino, T.D.S., V.B., C.M.T.T., E.T., M.I., A. Simpson, J.-J.H., H.A.S., B.C., E.K.-M., E.M., A.C., B.J., N.M.P.-H., D.G., D.L.J., H.P., K.H. and D.P.S. Study design: L.P., M.S., C.-M.C., L.D., J.P.T., B.F., P.M.A.S., M. Kerkhof, E.D., A.-L.H., A.P., J.P., M. Kaakinen, G.D.S., J. Henderson, H.-E.W., N.N., A.L., T.M., E.A.N., A.H., A.G.U., C.M.v.D., F.R., J.C.d.J., R.J.P.v.d.V., H.A.B., J.C.M., T.D.S., P.S., W.N., A. Simpson, D.P., G.H.K., H.A.S., H. Bisgaard, D.I.B., A.C., N.M.P.-H., H.H., M. Melbye, D.L.J., V.W.V.J., C.G., M.-R.J., J. Heinrich, D.M.E. and S.W. Manuscript writing: L.P., M.S., A.R., K.B., J. Heinrich, D.M.E. and S.W. Data collection: K.B., L.D., J.P.T., B.F., R.M., M. Kerkhof, R.F.-H., E.D., S.B.M., A.-L.H., A.P., J.P., M. Kaakinen, D.L.D., P.A.M., A.C.H., G.W.M., P.J.T., M.C.M., P.L.S., J. Henderson, S.M.R., W.M., A.L., T.M., E.A.N., J.C.d.J., R.J.P.v.d.V., M.W., R.J., F.G., H.A.B., J.C.M., F.M., T.D.S., V.B., C.E.P., P.G.H., P.S., M.I., W.N., A. Simpson, D.P., G.H.K., H.A.S., B.C., E.K.-M., H. Bisgaard, E.M., D.I.B., A.C., B.J., N.M.P.-H., L.J.P., M. Melbye, D.L.J., V.W.V.J., N.G.M., M.-R.J., J. Heinrich and S.W. Genotyping: R.M., A.F., A.I.F.B., J.L.B., P.D., S.M.R., N.K., E.R., W.M., A.L., A.G.U., F.R., M.W., C.K., C.E.P., T.I., C.S., B.J., L.J.P. and M.-R.J. Revising and reviewing paper: L.P., M.S., C.-M.C., A.R., K.B., L.D., M.A.F., A.C.A., J.P.T., E.A., H. Baurecht, B.F., P.M.A.S., P.H., N.M.W., I.C., R.M., J.A.C., M.M.G.-B., M. Kerkhof, A. Sääf, A.F., D.E., R.F. -H., E.D., S.B.M., A.-L.H., A.P., J.P., A.I.F.B., J.L.B., M. Kaakinen, D.L.D., P.A.M., A.C.H., G.W.M., P.J.T., M.C.M., P.L.S., B.S.P., G.D.S., J. Henderson, J.P.K., N.J.T., P.D., S.M.R., H.-E.W., M.M.-N., N.N., N.K., E.R., W.M., A.L., T.M., E.A.N., A.H., A.G.U., C.M.v.D., F.R., J.C.d.J., R.J.P.v.d.V., M.W., R.J., F.G., H.A.B., J.C.M., C.K., F.M., M. March, M. Mangino, T.D.S., V.B., C.E.P., P.G.H., P.S., C.M.T.T., E.T., T.I., M.I., W.N., A. Simpson, J.-J.H., D.P., G.H.K., H.A.S., C.S., B.C., E.K.-M., H. Bisgaard, E.M., D.I.B., A.C., B.J., N.M.P.-H., L.J.P., D.G., H.H., M. Melbye, D.L.J., V.W.V.J., C.G., D.P.S., N.G.M., M.-R.J., J. Heinrich, D.M.E., H.P., K.H. and S.W.

AAGC provided results for the replication analysis, and GOYA provided results for the discovery analysis.

Corresponding author

Correspondence toLavinia Paternoster.

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Competing interests

D.P. received funding for research from AstraZeneca, GlaxoSmithKline (GSK) and Nycomed. Travel to the European Respiratory Society (ERS) or American Thoracic Society (ATS) conferences was partially funded by AstraZeneca, GSK, Chiesi and Nycomed. She has been a consultant for AstraZeneca, Boehringer Ingelheim, Chiesi, GSK, Nycomed and Teva Pharmaceutical Industries.

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Paternoster, L., Standl, M., Chen, CM. et al. Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis.Nat Genet 44, 187–192 (2012). https://doi.org/10.1038/ng.1017

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• Received: 08 July 2011
• Accepted: 01 November 2011
• Published: 25 December 2011
• Issue date: February 2012
• DOI: https://doi.org/10.1038/ng.1017