Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk (original) (raw)

References

1. Sun, T. et al. Nat. Genet. 39, 605–613 (2007).
   Article CAS Google Scholar
2. Amundadottir, L.T. et al. Nat. Genet. 38, 652–658 (2006).
   Article CAS Google Scholar
3. Gudmundsson, J. et al. Nat. Genet. 39, 631–637 (2007).
   Article CAS Google Scholar
4. Haiman, C.A. et al. Nat. Genet. 39, 638–644 (2007).
   Article CAS Google Scholar
5. Yeager, M. et al. Nat. Genet. 39, 645–649 (2007).
   Article CAS Google Scholar
6. Easton, D.F. et al. Nature 447, 1087–1093 (2007).
   Article CAS Google Scholar
7. Haiman, C.A. et al. Nat. Genet. 39, 954–956 (2007).
   Article CAS Google Scholar
8. Tomlinson, I. et al. Nat. Genet. 39, 984–988 (2007).
   Article CAS Google Scholar
9. Zanke, B.W. et al. Nat. Genet. 39, 989–994 (2007).
   Article CAS Google Scholar
10. Whitelaw, S.C. et al. Gastroenterology 112, 327–334 (1997).
    Article CAS Google Scholar
11. Jaeger, E.E. et al. Am. J. Hum. Genet. 72, 1261–1267 (2003).
    Article CAS Google Scholar
12. Tomlinson, I. et al. Gastroenterology 116, 789–795 (1999).
    Article CAS Google Scholar
13. Burnham, K.P. & Anderson, D.R. Model Selection and Multimodel Inference. A Practical Information Theoretic Approach (Springer, New York, 2002).
    Google Scholar
14. Sneddon, J.B. et al. Proc. Natl. Acad. Sci. USA 103, 14842–14847 (2006).
    Article CAS Google Scholar
15. Seidah, N.G. & Chretien, M. Brain Res. 848, 45–62 (1999).
    Article CAS Google Scholar

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Acknowledgements

We are very grateful to all individuals in the study; colleagues at Clinical Genetics Centres and the National Cancer Research Network, S. Whitelaw and staff colleagues at St. Mark's Hospital for work on HMPS, the Genome Centre at the Institute of Cancer, Bart's and the London Medical School, and the Equipment Park, London Research Institute, Cancer Research UK. Cancer Research UK provided principal funding for this study. Additional funding was provided by CORE, the European Union (CPRB LSHC-CT-2004-503465) and the Bobby Moore Fund.

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Author notes

1. Emma Jaeger, Emily Webb, Kimberley Howarth, Luis Carvajal-Carmona, Andrew Rowan, Peter Broderick, Axel Walther, Sarah Spain and Alan Pittman: These authors contributed equally to this work.

Authors and Affiliations

1. Molecular and Population Genetics Laboratory, Cancer Research UK, London, WC2A 3PX, UK
   Emma Jaeger, Kimberley Howarth, Luis Carvajal-Carmona, Andrew Rowan, Axel Walther, Sarah Spain, Zoe Kemp, Karl Heinimann, Enric Domingo, Ella Barclay, Lynn Martin, Maggie Gorman & Ian Tomlinson
2. Section of Cancer Genetics, Institute of Cancer Research, Sutton, SM2 5NG, UK
   Emily Webb, Peter Broderick, Alan Pittman, Kate Sullivan, Steven Lubbe, Ian Chandler, Jayaram Vijayakrishnan, Wendy Wood, Elli Papaemmanuil, Steven Penegar, Mobshra Qureshi & Richard Houlston
3. Institute of Cancer, Bart's and the London Medical School, Queen Mary College, University of London, EC1M 6BQ, London, UK
   Luis Carvajal-Carmona & Ian Tomlinson
4. Department of Clinical and Biological Sciences (KBW) Center for Biomedicine, Research Group Human Genetics, Mattenstrasse 28, Basel, 4058, Switzerland
   Karl Heinimann
5. Department of Medical Genetics, St. Mary's Hospital, Manchester, M13 0JH, UK
   Lynn Martin
6. Department of Medical Genetics, Birmingham Women's Hospital, Edgbaston, B15 2TG, Birmingham, UK
   Lynn Martin
7. Colon Cancer Genetics Group, University of Edinburgh Cancer Research Centre and UK Medical Research Council (MRC) Human Genetics Unit, Western General Hospital, Edinburgh, EH4 2XU, UK, UK
   Susan Farrington & Malcolm Dunlop
8. Public Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, UK
   Albert Tenesa & Harry Campbell
9. Bioinformatics and Biostatistics, Cancer Research UK, WC2A 3PX, London, UK
   Jean-Baptiste Cazier
10. Department of Clinical Pharmacology, Oxford University, Radcliffe Infirmary, Oxford, OX2 6HA, UK
    David Kerr
11. Birmingham Clinical Trials Unit, University of Birmingham, Birmingham, B15 2TT, UK
    Richard Gray
12. The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, SW3 6JB, UK
    Julian Peto
13. Non-Communicable Disease Epidemiology Unit, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK
    Julian Peto
14. Institute of Cancer Research, Sutton, SM2 5NG, Surrey, UK
    Julian Peto
15. Family Cancer Clinic and Imperial College, St Mark's Hospital, Harrow, HA1 3UJ, UK
    Huw Thomas

Authors

1. Emma Jaeger
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2. Emily Webb
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3. Kimberley Howarth
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4. Luis Carvajal-Carmona
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5. Andrew Rowan
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6. Peter Broderick
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7. Axel Walther
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8. Sarah Spain
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9. Alan Pittman
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10. Zoe Kemp
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11. Kate Sullivan
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12. Karl Heinimann
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13. Steven Lubbe
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14. Enric Domingo
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15. Ella Barclay
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16. Lynn Martin
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17. Maggie Gorman
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18. Ian Chandler
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19. Jayaram Vijayakrishnan
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20. Wendy Wood
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21. Elli Papaemmanuil
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22. Steven Penegar
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23. Mobshra Qureshi
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24. Susan Farrington
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25. Albert Tenesa
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26. Jean-Baptiste Cazier
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27. David Kerr
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28. Richard Gray
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29. Julian Peto
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30. Malcolm Dunlop
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31. Harry Campbell
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32. Huw Thomas
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33. Richard Houlston
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34. Ian Tomlinson
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Consortia

members of the CORGI Consortium

Contributions

E.J. undertook the bulk of the laboratory work on HMPS, with assistance from K.H. and A.R. Laboratory work on the common variants was undertaken by E.J., K.H., L.C.C., A.R., P.B., S.S., A.P., A.W., Z.K., K.S., S.L., E.D., I.C. and E.P. E.W., S.S. and J.B.C. undertook data analysis. E.B., L.M., M.G., J.V., W.W., S.P. and M.Q. recruited subjects. The CORGI Consortium, D.K., R.G. and J.P. planned and supervised recruitment of subjects. H.T. co-planned the work on HMPS and was part of the CORGI Consortium. S.F., A.T., M.D. and H.C. were involved in study planning. R.H. and I.T. planned and supervised the study, obtained grant funding and co-wrote the manuscript.

Corresponding authors

Correspondence toRichard Houlston or Ian Tomlinson.

Additional information

A full list of consortium members is provided in Supplementary Note.

Supplementary information

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Jaeger, E., Webb, E., Howarth, K. et al. Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk.Nat Genet 40, 26–28 (2008). https://doi.org/10.1038/ng.2007.41

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• Received: 03 August 2007
• Accepted: 11 October 2007
• Published: 16 December 2007
• Issue Date: January 2008
• DOI: https://doi.org/10.1038/ng.2007.41