Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis (original) (raw)
References
- Rowland, L.P. & Shneider, N.A. N. Engl. J. Med. 344, 1688–1700 (2001).
Article CAS Google Scholar - Pasinelli, P. & Brown, R.H. Nat. Rev. Neurosci. 7, 710–723 (2006).
Article CAS Google Scholar - Graham, A.J., Macdonald, A.M. & Hawkes, C.H. J. Neurol. Neurosurg. Psychiatry 62, 562–569 (1997).
Article CAS Google Scholar - Greenway, M.J. et al. Nat. Genet. 38, 411–413 (2006).
Article CAS Google Scholar - Lambrechts, D. et al. Nat. Genet. 34, 383–394 (2003).
Article CAS Google Scholar - Sutedja, N.A. et al. Arch. Neurol. 64, 63–67 (2007).
Article Google Scholar - Saeed, M. et al. Neurology 67, 771–776 (2006).
Article CAS Google Scholar - Veldink, J.H. et al. Neurology 65, 820–825 (2005).
Article CAS Google Scholar - Schymick, J.C. et al. Lancet Neurol. 6, 322–328 (2007).
Article CAS Google Scholar - Skol, A.D., Scott, L.J., Abecasis, G.R. & Boehnke, M. Nat. Genet. 38, 209–213 (2006).
Article CAS Google Scholar - Zaitlen, N., Kang, H.M., Eskin, E. & Halperin, E. Am. J. Hum. Genet. 80, 683–691 (2007).
Article CAS Google Scholar - Wada, K. et al. Mamm. Genome 4, 234–237 (1993).
Article CAS Google Scholar - Tachibana, T., Noguchi, K. & Ruda, M.A. Neurosci. Lett. 327, 133–137 (2002).
Article CAS Google Scholar - Dorus, S. et al. Cell 119, 1027–1040 (2004).
Article CAS Google Scholar
Acknowledgements
We are indebted to the individuals and their families who participated in this project. This project has been generously supported by The Netherlands Organisation for Scientific Research (NWO) and the “Prinses Beatrix Fonds” (L.H.vdB.). We would also like to thank H. Kersten and M. Kersten for their generous support (L.H.vdB.) as well as J.R. van Dijk and the Adessium foundation (L.H.vdB.), the US National Institutes of Health grants GM68875 and MH078075 (R.A.O.), the Kempe Foundation (P.M.A.), the Swedish Brain Research Foundation and Bertil Hållsten (P.M.A.), the Björklund Foundation for ALS Research (P.M.A.), the Interuniversity Attraction Pole Programme P6/43 (Belgian Science Policy Office) (W.R., L.V.D.B. and C.V.B.) and the E. von Behring Chair for Neuromuscular and Neurodegenerative Disorders (W.R.). C.V.B., W.R. and L.V.D.B. are supported by the Fund for Scientific Research Flanders (FWO-F), and K.S. holds a postdoctoral fellowship of the FWO-F. P.M.A. and A.B. are supported by the 'Swedish Brain Power Foundation'. This study used data from the SNP Database at the US National Institute of Neurological Disorders and Stroke Human Genetics Resource Center DNA and Cell Line Repository (http://ccr.coriell.org/ninds/). The authors thank E. Strengman, P. Sodaar, H. Veldman, H. Yigittop, W. Scheveneels, A. D'hondt, P. Tilkin and A. Nilsson for assistance with genotyping and DNA preparation. We also thank F.G. Jennekens and G. Hille Ris Lambers for helping with the DNA sample collection.
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Author notes
- Michael A van Es, Paul WJ van Vught, Hylke M Blauw and Lude Franke: These authors contributed equally to this work.
Authors and Affiliations
- Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands
Michael A van Es, Paul WJ van Vught, Hylke M Blauw, Christiaan GJ Saris, Sonja W de Jong, John HJ Wokke, Jan H Veldink & Leonard H van den Berg - Department of Biomedical Genetics, Complex Genetics Section, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands
Lude Franke, Ruben van't Slot & Cisca Wijmenga - Department of Neurology, University Hospital Gasthuisberg, Leuven, B-3000, Belgium
Ludo Van Den Bosch, Robin Lemmens & Wim Robberecht - Department of Neurology, Academic Medical Center, Amsterdam, 1105 AZ, The Netherlands
Vianney de Jong - Department of Neurogenetics, Academic Medical Center, Amsterdam, 1105 AZ, The Netherlands
Frank Baas - Department of Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, 6525 GA, The Netherlands
Helenius J Schelhaas - Institute of Clinical Neuroscience, Umeå University Hospital, Umeå, SE-901 85, Sweden
Anna Birve & Peter M Andersen - Department of Molecular Genetics, Neurodegenerative Brain Diseases Group, VIB, Antwerpen, B-2610, Belgium
Kristel Sleegers & Christine Van Broeckhoven - University of Antwerp, Antwerpen, B-2610, Belgium
Kristel Sleegers & Christine Van Broeckhoven - Laboratory of Neurogenetics, National Institute of Aging, National Institutes of Health, Bethesda, 20892, Maryland, USA
Jennifer C Schymick - Section on Developmental Genetic Epidemiology, National Institute of Mental Health, Bethesda, 20892, Maryland, USA
Bryan J Traynor - Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, 9700 RB, The Netherlands
Cisca Wijmenga - Department of Medical Genetics and Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands
Roel A Ophoff - Neuropsychiatric Institute, University of California, Los Angeles, 90095, California, USA
Roel A Ophoff
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- Michael A van Es
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Contributions
M.A.vE., P.W.J.vV., H.M.B. and L.F. contributed equally to this study. M.A.vE., P.W.J.vV., H.M.B. and R.vS. participated in the Illumina and TaqMan SNP genotyping and data analysis. M.A.vE., J.H.V. and L.F. were involved in the design of the study, handled genotype data and performed statistical analyses. M.A.vE., H.M.B., C.G.J.S., P.M.A., L.V.D.B., S.W.dJ., A.B., R.L., V.dJ., F.B., H.J.S., K.S., C.V.B., J.H.J.W., C.W. and W.R. were responsible for DNA collection and clinical characterization of affected individuals in the study. J.C.S. and B.J.T. obtained all DNA samples from the United States and performed genotyping experiments and analysis on these samples. M.A.vE. drafted the manuscript. R.A.O. and L.H.vdB. are lead investigators and contributed equally to this work. They designed and supervised the study and contributed in the writing of the manuscript. All authors participated in the critical revisions of the manuscript.
Corresponding authors
Correspondence toRoel A Ophoff or Leonard H van den Berg.
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van Es, M., van Vught, P., Blauw, H. et al. Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis.Nat Genet 40, 29–31 (2008). https://doi.org/10.1038/ng.2007.52
- Received: 26 June 2007
- Accepted: 16 October 2007
- Published: 16 December 2007
- Issue Date: January 2008
- DOI: https://doi.org/10.1038/ng.2007.52