Evidence for two independent prostate cancer risk–associated loci in the HNF1B gene at 17q12 (original) (raw)

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Acknowledgements

We thank all the study subjects who participated in this study. We also thank the Regional Cancer Registries and the CAPS-steering committee, including E. Varenhorst. We acknowledge the support of W.T. Gerrard, M. Duhon, Jennifer and John Chalsty and D. Koch. We also thank the National Cancer Institute Cancer Genetic Markers of Susceptibility Initiative (CGEMS) for making the data available publicly. We take full responsibility for the study design, data collection, analysis and interpretation of the data, the decision to submit the manuscript for publication, and the writing of the manuscript. The study is supported by National Cancer Institute (CA106523, CA106523 and CA95052 to J.X., CA112517, CA58236 to W.B.I., CA86323 to A.W.P., Department of Defense grant PC051264 to J.X.), as well as support from Swedish Cancer Society (Cancerfonden) and Swedish Research Council to H.G.

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Author notes

1. Jielin Sun and Siqun Lilly Zheng: These authors contributed equally to this work.

Authors and Affiliations

1. Center for Cancer Genomics, Wake Forest University School of Medicine, Winston-Salem, 27157, North Carolina, USA
   Jielin Sun, Siqun Lilly Zheng, Lina D Purcell, Zhengrong Gao, Fang-Chi Hsu, Seong-Tae Kim, Wennuan Liu, Yi Zhu, Latchezar Dimitrov, Jishan Sun, Tao Li, Aubrey R Turner, Tamara S Adams, Bao-Li Chang & Jianfeng Xu
2. Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, 27157, North Carolina, USA
   Jielin Sun, Siqun Lilly Zheng, Lina D Purcell, Zhengrong Gao, Seong-Tae Kim, Wennuan Liu, Yi Zhu, Latchezar Dimitrov, Jishan Sun, Tao Li, Aubrey R Turner, Tamara S Adams, Bao-Li Chang & Jianfeng Xu
3. Department of Medical Epidemiology and Biostatistics, CLINTEC, Karolinska Institute, Stockholm, SE-17177, Sweden
   Fredrik Wiklund, Hans-Olov Adami & Henrik Grönberg
4. Department of Urology, Johns Hopkins Medical Institutions, Baltimore, 21287, Maryland, USA
   Sarah D Isaacs, Kathleen E Wiley, Bruce J Trock, Alan W Partin, Patrick C Walsh & William B Isaacs
5. Department of Biostatistical Sciences, Wake Forest University School of Medicine, Winston-Salem, 27157, North Carolina, USA
   Fang-Chi Hsu
6. Department of Surgical and Perioperative sciences, Urology and Andrology, Umeå University Hospital, Umeå, SE-90787, Sweden
   Pär Stattin
7. Department of Epidemiology, Harvard School of Public Health, Boston, 02115, Massachusetts, USA
   Hans-Olov Adami
8. Oncological Center, CLINTEC, Karolinska Institutet, Stockholm, SE-17177, Sweden
   Jan Adolfsson
9. Department of Urology, Örebro University Hospital, Örebro, SE-70182, Sweden
   Jan-Erik Johansson
10. Translational Genomics Research Institute, Phoenix, 85004, Arizona, USA
    James Lowey, Jeffrey M Trent, David Duggan & John Carpten

Authors

1. Jielin Sun
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2. Siqun Lilly Zheng
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3. Fredrik Wiklund
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4. Sarah D Isaacs
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5. Lina D Purcell
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6. Zhengrong Gao
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7. Fang-Chi Hsu
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8. Seong-Tae Kim
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9. Wennuan Liu
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10. Yi Zhu
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11. Pär Stattin
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12. Hans-Olov Adami
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13. Kathleen E Wiley
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14. Latchezar Dimitrov
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15. Jishan Sun
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16. Tao Li
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17. Aubrey R Turner
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18. Tamara S Adams
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19. Jan Adolfsson
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20. Jan-Erik Johansson
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21. James Lowey
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22. Bruce J Trock
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23. Alan W Partin
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24. Patrick C Walsh
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25. Jeffrey M Trent
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26. David Duggan
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27. John Carpten
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28. Bao-Li Chang
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29. Henrik Grönberg
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30. William B Isaacs
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31. Jianfeng Xu
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Contributions

J.X., W.B.I., H.G., J.C., D.D. and J.M.T. designed and directed the study. S.L.Z. directed genotyping. Jielin Sun, F.W., F.-C.H., S.-T.K., Y.Z., L.D., Jishan Sun, J.L., B.-L.C. and J.X. conducted data analysis. S.D.I., K.E.W., B.J.T., A.W.P., P.C.W. and W.B.I. were involved in the sample collection at Johns Hopkins Hospital. P.S., H.-O.A., J.A., J.-E.J. and H.G. were involved in the sample collection in Sweden. L.D.P., Z.G., W.L. and T.L. performed laboratory analyses. A.R.T. and T.S.A. provided administrative and technical support for the study.

Corresponding authors

Correspondence toHenrik Grönberg or William B Isaacs.

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Sun, J., Zheng, S., Wiklund, F. et al. Evidence for two independent prostate cancer risk–associated loci in the HNF1B gene at 17q12.Nat Genet 40, 1153–1155 (2008). https://doi.org/10.1038/ng.214

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• Received: 21 March 2008
• Accepted: 01 July 2008
• Published: 31 August 2008
• Issue Date: October 2008
• DOI: https://doi.org/10.1038/ng.214