Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension (original) (raw)

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Acknowledgements

Full acknowledgments appear in the Supplementary Note.

Author information

Author notes

1. Anton J M de Craen and John Danesh: Deceased
2. Praveen Surendran, Fotios Drenos, Robin Young, Helen Warren, James P Cook, Alisa K Manning, Niels Grarup, Xueling Sim, Folkert W Asselbergs, Cecilia M Lindgren, John Danesh, Louise V Wain, Adam S Butterworth, Joanna M M Howson and Patricia B Munroe: These authors contributed equally to this work
3. Danish Saleheen, Joanna M M Howson and Patricia B Munroe: These authors jointly directed this work.
4. These authors contributed equally to this work
5. These authors jointly supervised directed this work.

Authors and Affiliations

1. Department of Public Health and Primary Care, MRC/BHF Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge, UK
   Praveen Surendran, Robin Young, Daniel R Barnes, James R Staley, Daniel F Freitag, Stephen Burgess, Emanuele Di Angelantonio, Rajiv Chowdhury, Danish Saleheen, John Danesh, Adam S Butterworth & Joanna M M Howson
2. Medical Research Council Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, UK
   Fotios Drenos
3. Centre for Cardiovascular Genetics, Institute of Cardiovascular Science, University College London, London, UK
   Fotios Drenos
4. Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, UK
   Helen Warren, Kate Witkowska, Susan Shaw-Hawkins, Morris J Brown, Mark J Caulfield & Patricia B Munroe
5. National Institute for Health Research Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, UK
   Helen Warren, Kate Witkowska, Andrew Tinker, Mark J Caulfield & Patricia B Munroe
6. Department of Health Sciences, University of Leicester, Leicester, UK
   James P Cook, Martin D Tobin & Louise V Wain
7. Department of Biostatistics, University of Liverpool, Liverpool, UK
   James P Cook & Andrew P Morris
8. Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA
   Alisa K Manning, Taru Tukiainen & Tõnu Esko
9. Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA
   Alisa K Manning, Taru Tukiainen, Niek Verweij, Tõnu Esko, Aarno Palotie, Sekar Kathiresan, Christopher Newton-Cheh & Cecilia M Lindgren
10. Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Alisa K Manning
11. Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
    Niels Grarup, Jette Bork-Jensen, Anette P Gjesing, Torben Hansen & Oluf Pedersen
12. Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA
    Xueling Sim, Anne U Jackson, Jeroen R Huyghe, Michael Boehnke & Heather M Stringham
13. Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA
    Xueling Sim, Anne U Jackson, Jeroen R Huyghe, Michael Boehnke & Heather M Stringham
14. Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore
    Xueling Sim
15. Department of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands
    Vinicius Tragante, Magdalena Harakalova & Folkert W Asselbergs
16. Department of Medicine, Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
    Taru Tukiainen & Aarno Palotie
17. Genetics of Complex Traits, Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK
    Hanieh Yaghootkar
18. Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    Nicholas Masca, Christopher P Nelson, Maciej Tomaszewski & Nilesh J Samani
19. National Institute for Health Research Leicester Biomedical Research Unit in Cardiovascular Disease, Leicester, UK
    Nicholas Masca, Christopher P Nelson, Maciej Tomaszewski & Nilesh J Samani
20. Nuffield Department of Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Teresa Ferreira, Lorraine Southam, N William Rayner, Neil R Robertson, Mark I McCarthy, Anubha Mahajan, Andrew P Morris & Cecilia M Lindgren
21. Heart Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    Olga Giannakopoulou, Andrew Tinker, Kathleen E Stirrups, Eirini Marouli & Panos Deloukas
22. Estonian Genome Center, University of Tartu, Tartu, Estonia
    Evelin Mihailov, Markus Perola, Tõnu Esko, Reedik Mägi & Andres Metspalu
23. National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, Massachusetts, USA
    Chunyu Liu, Jennifer E Huffman, Ramachandran S Vasan & Honghuang Lin
24. Division of Statistical Genomics, Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, USA
    Aldi T Kraja
25. Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA
    Aldi T Kraja
26. Department of Clinical Biochemistry Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark
    Sune Fallgaard Nielsen & Børge Grønne Nordestgaard
27. Centre for Non-Communicable Diseases, Karachi, Pakistan
    Asif Rasheed, Maria Samuel, Philippe Frossard & Danish Saleheen
28. Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Wei Zhao & Danish Saleheen
29. Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, US National Institutes of Health, Bethesda, Maryland, USA
    Lori L Bonnycastle, Narisu Narisu, Amy J Swift & Francis S Collins
30. Wellcome Trust Sanger Institute, Genome Campus, Hinxton, UK
    Lorraine Southam, Angela Matchan, N William Rayner, Samuli Ripatti & Eleftheria Zeggini
31. Medical Research Council Human Genetics Unit, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK
    Jonathan Marten, Jennifer E Huffman & Caroline Hayward
32. Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland
    Alena Stančáková, Johanna Kuusisto & Markku Laakso
33. Department of Clinical Sciences, University of Lund, Malmö, Sweden
    Cristiano Fava, Therese Ohlsson & Olle Melander
34. Department of Medicine, University of Verona, Verona, Italy
    Cristiano Fava
35. Department of Haematology, University of Cambridge, Cambridge, UK
    Kathleen E Stirrups & Nicole Soranzo
36. Department of Health, National Institute for Health and Welfare, Helsinki, Finland
    Jukka Kontto, Markus Perola, Aki S Havulinna, Eero Kajantie, Jaana Lindström, Pekka Jousilahti, Satu Männistö, Jaakko Tuomilehto, Veikko Salomaa, Kari Kuulasmaa & Jarmo Virtamo
37. Institute of Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland
    Markus Perola
38. Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA
    He Zhang & Cristen J Willer
39. Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
    Louise A Donnelly, John M Connell, Alex S F Doney & Colin N A Palmer
40. Radcliffe Department of Medicine, Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford, UK
    Christopher J Groves, N William Rayner, Matt J Neville, Neil R Robertson, Fredrik Karpe & Mark I McCarthy
41. National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospital Trusts, Oxford, UK
    Matt J Neville, Fredrik Karpe & Mark I McCarthy
42. Section of Investigative Medicine, Imperial College London, London, UK
    Andrianos M Yiorkas & Alexandra I F Blakemore
43. Department of Life Sciences, Brunel University London, London, UK
    Andrianos M Yiorkas & Alexandra I F Blakemore
44. Institute of Biomedicine, Biocenter Oulu, University of Oulu, Oulu, Finland
    Karl-Heinz Herzig
45. Department of Gastroenterology and Metabolism, Poznan University of Medical Sciences, Poznan, Poland
    Karl-Heinz Herzig
46. Hospital for Children and Adolescents, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
    Eero Kajantie
47. Department of Obstetrics and Gynaecology, Oulu University Hospital and University of Oulu, Oulu, Finland
    Eero Kajantie
48. Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK
    Weihua Zhang, Evangelos Evangelou, Alireza Moayyeri, Anne-Claire Vergnaud & John C Chambers
49. Department of Cardiology, Ealing Hospital, Middlesex, UK
    Weihua Zhang, John C Chambers & Jaspal S Kooner
50. Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK
    Sara M Willems, Jian’an Luan, Robert A Scott, Claudia Langenberg & Nick J Wareham
51. Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
    Lars Lannfelt
52. Department of Neurosciences, Section of Biology and Genetics, Biomedicine and Movement Sciences, University of Verona, Verona, Italy
    Giovanni Malerba & Elisabetta Trabetti
53. Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK
    Nicole Soranzo
54. NIHR Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK
    Nicole Soranzo, Emanuele Di Angelantonio, John Danesh & Adam S Butterworth
55. Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
    Niek Verweij, Rudolf A de Boer, Peter van der Meer & Pim van der Harst
56. Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA
    Niek Verweij, Sekar Kathiresan & Christopher Newton-Cheh
57. Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece
    Evangelos Evangelou
58. Farr Institute of Health Informatics Research, Institute of Health Informatics, University College London, London, UK
    Alireza Moayyeri
59. Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden
    Alaitz Poveda, Tibor V Varga, Frida Renström & Paul W Franks
60. Department of Genetics, Physical Anthropology and Animal Physiology, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), Bilbao, Spain
    Alaitz Poveda
61. Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK
    Muriel Caslake, Ian Ford & Chris J Packard
62. Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands
    Anton J M de Craen & Stella Trompet
63. Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands
    Stella Trompet & J Wouter Jukema
64. Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK
    Sarah E Harris, David C M Liewald, Riccardo Marioni, Ian J Deary & John M Starr
65. Centre for Genomic and Experimental Medicine, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK
    Sarah E Harris, Riccardo Marioni & David J Porteous
66. Department of Psychology, University of Edinburgh, Edinburgh, UK
    David C M Liewald & Ian J Deary
67. Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia
    Riccardo Marioni
68. Department of Twin Research and Genetic Epidemiology, King's College London, London, UK
    Cristina Menni & Timothy D Spector
69. Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece
    Aliki-Eleni Farmaki & George Dedoussis
70. Department of Biobank Research, Umeå University, Umeå, Sweden
    Göran Hallmans & Frida Renström
71. Kuopio Research Institute of Exercise Medicine, Kuopio, Finland
    Maija Hassinen, Pirjo Komulainen, Timo A Lakka & Rainer Rauramaa
72. Department of Medicine, Section of Cardiology, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, USA
    Ramachandran S Vasan
73. Department of Medicine, Sections of Preventive Medicine and Epidemiology, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, USA
    Ramachandran S Vasan
74. Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands
    Janine F Felix
75. Development Management and Planning, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, USA
    Maria Uria-Nickelsen
76. Pfizer Worldwide Research and Development, Stockholm, Sweden
    Anders Malarstig
77. Merck Research Laboratories, Genetics and Pharmacogenomics, Boston, Massachusetts, USA
    Dermot F Reilly
78. Merck Research Laboratories, Cardiometabolic Disease, Kenilworth, New Jersey, USA
    Maarten Hoek & Thomas F Vogt
79. CHDI Management/CHDI Foundation, Princeton, New Jersey, USA
    Thomas F Vogt
80. Department of Medicine, Section of Computational Biomedicine, Boston University School of Medicine, Boston, Massachusetts, USA
    Honghuang Lin
81. Institute of Epidemiology and Biobank Popgen, Kiel University, Kiel, Germany
    Wolfgang Lieb
82. Neurology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK
    Matthew Traylor & Hugh S Markus
83. Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Heather M Highland & Anne E Justice
84. Department of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
    Matti Uusitupa
85. Research Unit, Kuopio University Hospital, Kuopio, Finland
    Matti Uusitupa
86. Institute of Biomedicine/Physiology, University of Eastern Finland, Kuopio Campus, Kuopio, Finland
    Timo A Lakka
87. Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland
    Timo A Lakka & Rainer Rauramaa
88. Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK
    Ozren Polasek & Igor Rudan
89. Faculty of Medicine, University of Split, Split, Croatia
    Ozren Polasek
90. Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden
    Olov Rolandsson & Paul W Franks
91. Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Paul W Franks
92. Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK
    John M Starr
93. Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK
    Anna F Dominiczak, Naveed Sattar & Sandosh Padmanabhan
94. Interuniversity Cardiology Institute of the Netherlands, Utrecht, the Netherlands
    J Wouter Jukema
95. Division of Endocrinology, Boston Children's Hospital, Boston, Massachusetts, USA
    Tõnu Esko
96. Institute of Molecular and Cell Biology, Tartu, Estonia
    Andres Metspalu
97. Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
    Pim van der Harst
98. Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, the Netherlands
    Pim van der Harst & Folkert W Asselbergs
99. Division of Nephrology, Department of Internal Medicine and Medical Specialties, Columbus-Gemelli University Hospital, Catholic University, Rome, Italy
    Giovanni Gambaro
100. Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden
     Erik Ingelsson & Lars Lind
101. Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, USA
     Erik Ingelsson
102. Department of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands
     Paul I W de Bakker
103. Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands
     Paul I W de Bakker & Mattijs E Numans
104. Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands
     Mattijs E Numans
105. Department of Clinical Biochemistry, Lillebaelt Hospital, Vejle, Denmark
     Ivan Brandslund
106. Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark
     Ivan Brandslund
107. Medical Department, Lillebaelt Hospital, Vejle, Denmark
     Cramer Christensen
108. Department of Clinical Immunology and Biochemistry, Lillebaelt Hospital, Vejle, Denmark
     Eva R B Petersen
109. Department of Internal Medicine, South Ostrobothnia Central Hospital, Seinäjoki, Finland
     Eeva Korpi-Hyövälti
110. Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
     Heikki Oksa
111. Imperial College Healthcare NHS Trust, London, UK
     John C Chambers & Jaspal S Kooner
112. National Heart and Lung Institute, Imperial College London, London, UK
     Jaspal S Kooner & Peter Sever
113. Institute of Reproductive and Developmental Biology, Imperial College London, London, UK
     Steve Franks
114. Department of Epidemiology and Biostatistics, Medical Research Council Public Health England Centre for Environment and Health, School of Public Health, Faculty of Medicine, Imperial College London, St. Mary′s Campus, London, UK
     Marjo-Riitta Jarvelin & Paul Elliott
115. Centre for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland
     Marjo-Riitta Jarvelin
116. Biocenter Oulu, University of Oulu, Oulu, Finland
     Marjo-Riitta Jarvelin
117. Unit of Primary Care, Oulu University Hospital, Oulu, Finland
     Marjo-Riitta Jarvelin
118. Research Centre for Prevention and Health, Capital Region of Denmark, Copenhagen, Denmark
     Lise L Husemoen, Allan Linneberg, Tea Skaaby & Betina Thuesen
119. Department of Clinical Experimental Research, Glostrup University Hospital, Glostrup, Denmark
     Allan Linneberg
120. Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
     Allan Linneberg
121. Dasman Diabetes Institute, Dasman, Kuwait
     Jaakko Tuomilehto
122. Centre for Vascular Prevention, Danube University Krems, Krems, Austria
     Jaakko Tuomilehto
123. Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia
     Jaakko Tuomilehto
124. School of Molecular, Genetic and Population Health Sciences, University of Edinburgh, Medical School, Teviot Place, Edinburgh, UK
     Andrew D Morris
125. Department of Public Health and General Practice, HUNT Research Centre, Norwegian University of Science and Technology, Levanger, Norway
     Oddgeir Lingaas Holmen & Kristian Hveem
126. St. Olav Hospital, Trondheim University Hospital, Trondheim, Norway
     Oddgeir Lingaas Holmen
127. Department of Medicine, Levanger Hospital, Nord-Trøndelag Health Trust, Levanger, Norway
     Kristian Hveem
128. Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA
     Cristen J Willer
129. Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA
     Cristen J Willer
130. Folkhälsan Research Centre, Helsinki, Finland
     Tiinamaija Tuomi
131. Department of Endocrinology, Helsinki University Central Hospital, Helsinki, Finland
     Tiinamaija Tuomi
132. Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland
     Tiinamaija Tuomi, Leif Groop, Aarno Palotie & Samuli Ripatti
133. Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden
     Leif Groop
134. Department of Primary Health Care, Vaasa Central Hospital, Vaasa, Finland
     AnneMari Käräjämäki
135. Diabetes Center, Vaasa Health Care Center, Vaasa, Finland
     AnneMari Käräjämäki
136. Department of Psychiatry, Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
     Aarno Palotie
137. Department of Public Health, University of Helsinki, Helsinki, Finland
     Samuli Ripatti
138. ICDDR, B, Mohakhali, Dhaka, Bangladesh
     Dewan S Alam
139. National Institute of Cardiovascular Diseases, Sher-e-Bangla Nagar, Dhaka, Bangladesh
     Abdulla al Shafi Majumder
140. School of Public Health, Imperial College London, London, UK
     Neil Poulter
141. Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland
     Alice V Stanton
142. University of Lille, UMR 1167, Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France
     Philippe Amouyel
143. INSERM, Lille, France
     Philippe Amouyel
144. CHU Lille, Public Health, Lille, France
     Philippe Amouyel
145. Institut Pasteur de Lille, Lille, France
     Philippe Amouyel
146. Department of Epidemiology and Public Health, EA 3430, University of Strasbourg, Strasbourg, France
     Dominique Arveiler
147. Department of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany
     Stefan Blankenberg
148. University Medical Center Hamburg-Eppendorf, Hamburg, Germany
     Stefan Blankenberg
149. Department of Epidemiology, UMR 1027, INSERM, Toulouse University, CHU Toulouse, Toulouse, France
     Jean Ferrières
150. UKCRC Centre of Excellence for Public Health, Queens University, Belfast, UK
     Frank Kee
151. Institute of Genetic Epidemiology, Helmholtz Zentrum München -German Research Center for Environmental Health, Neuherberg, Germany
     Martina Müller-Nurasyid
152. Department of Medicine I, University Hospital Grosshadern, Ludwig Maximilians Universität, Munich, Germany
     Martina Müller-Nurasyid
153. DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany
     Martina Müller-Nurasyid
154. Department of Clinical and Experimental Medicine, Research Center in Epidemiology and Preventive Medicine, University of Insubria, Varese, Italy
     Giovanni Veronesi
155. Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia
     Panos Deloukas
156. Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA
     Sekar Kathiresan & Christopher Newton-Cheh
157. Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
     Sekar Kathiresan
158. A collaboration between the University Medical Schools and NHS, Aberdeen, Dundee, Edinburgh and Glasgow, UK
     Generation Scotland
159. Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
     Karen L Mohlke
160. Division of Cardiovascular Sciences, University of Manchester, Manchester, UK
     Maciej Tomaszewski
161. Faculty of Population Health Sciences, Institute of Cardiovascular Science, University College London, London, UK
     Folkert W Asselbergs
162. Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK
     Cecilia M Lindgren
163. Wellcome Trust Sanger Institute, Hinxton, UK
     John Danesh

Authors

1. Praveen Surendran
2. Fotios Drenos
3. Robin Young
4. Helen Warren
5. James P Cook
6. Alisa K Manning
7. Niels Grarup
8. Xueling Sim
9. Daniel R Barnes
10. Kate Witkowska
11. James R Staley
12. Vinicius Tragante
13. Taru Tukiainen
14. Hanieh Yaghootkar
15. Nicholas Masca
16. Daniel F Freitag
17. Teresa Ferreira
18. Olga Giannakopoulou
19. Andrew Tinker
20. Magdalena Harakalova
21. Evelin Mihailov
22. Chunyu Liu
23. Aldi T Kraja
24. Sune Fallgaard Nielsen
25. Asif Rasheed
26. Maria Samuel
27. Wei Zhao
28. Lori L Bonnycastle
29. Anne U Jackson
30. Narisu Narisu
31. Amy J Swift
32. Lorraine Southam
33. Jonathan Marten
34. Jeroen R Huyghe
35. Alena Stančáková
36. Cristiano Fava
37. Therese Ohlsson
38. Angela Matchan
39. Kathleen E Stirrups
40. Jette Bork-Jensen
41. Anette P Gjesing
42. Jukka Kontto
43. Markus Perola
44. Susan Shaw-Hawkins
45. Aki S Havulinna
46. He Zhang
47. Louise A Donnelly
48. Christopher J Groves
49. N William Rayner
50. Matt J Neville
51. Neil R Robertson
52. Andrianos M Yiorkas
53. Karl-Heinz Herzig
54. Eero Kajantie
55. Weihua Zhang
56. Sara M Willems
57. Lars Lannfelt
58. Giovanni Malerba
59. Nicole Soranzo
60. Elisabetta Trabetti
61. Niek Verweij
62. Evangelos Evangelou
63. Alireza Moayyeri
64. Anne-Claire Vergnaud
65. Christopher P Nelson
66. Alaitz Poveda
67. Tibor V Varga
68. Muriel Caslake
69. Anton J M de Craen
70. Stella Trompet
71. Jian’an Luan
72. Robert A Scott
73. Sarah E Harris
74. David C M Liewald
75. Riccardo Marioni
76. Cristina Menni
77. Aliki-Eleni Farmaki
78. Göran Hallmans
79. Frida Renström
80. Jennifer E Huffman
81. Maija Hassinen
82. Stephen Burgess
83. Ramachandran S Vasan
84. Janine F Felix
85. Maria Uria-Nickelsen
86. Anders Malarstig
87. Dermot F Reilly
88. Maarten Hoek
89. Thomas F Vogt
90. Honghuang Lin
91. Wolfgang Lieb
92. Matthew Traylor
93. Hugh S Markus
94. Heather M Highland
95. Anne E Justice
96. Eirini Marouli
97. Jaana Lindström
98. Matti Uusitupa
99. Pirjo Komulainen
100. Timo A Lakka
101. Rainer Rauramaa
102. Ozren Polasek
103. Igor Rudan
104. Olov Rolandsson
105. Paul W Franks
106. George Dedoussis
107. Timothy D Spector
108. Pekka Jousilahti
109. Satu Männistö
110. Ian J Deary
111. John M Starr
112. Claudia Langenberg
113. Nick J Wareham
114. Morris J Brown
115. Anna F Dominiczak
116. John M Connell
117. J Wouter Jukema
118. Naveed Sattar
119. Ian Ford
120. Chris J Packard
121. Tõnu Esko
122. Reedik Mägi
123. Andres Metspalu
124. Rudolf A de Boer
125. Peter van der Meer
126. Pim van der Harst
127. Giovanni Gambaro
128. Erik Ingelsson
129. Lars Lind
130. Paul I W de Bakker
131. Mattijs E Numans
132. Ivan Brandslund
133. Cramer Christensen
134. Eva R B Petersen
135. Eeva Korpi-Hyövälti
136. Heikki Oksa
137. John C Chambers
138. Jaspal S Kooner
139. Alexandra I F Blakemore
140. Steve Franks
141. Marjo-Riitta Jarvelin
142. Lise L Husemoen
143. Allan Linneberg
144. Tea Skaaby
145. Betina Thuesen
146. Fredrik Karpe
147. Jaakko Tuomilehto
148. Alex S F Doney
149. Andrew D Morris
150. Colin N A Palmer
151. Oddgeir Lingaas Holmen
152. Kristian Hveem
153. Cristen J Willer
154. Tiinamaija Tuomi
155. Leif Groop
156. AnneMari Käräjämäki
157. Aarno Palotie
158. Samuli Ripatti
159. Veikko Salomaa
160. Dewan S Alam
161. Abdulla al Shafi Majumder
162. Emanuele Di Angelantonio
163. Rajiv Chowdhury
164. Mark I McCarthy
165. Neil Poulter
166. Alice V Stanton
167. Peter Sever
168. Philippe Amouyel
169. Dominique Arveiler
170. Stefan Blankenberg
171. Jean Ferrières
172. Frank Kee
173. Kari Kuulasmaa
174. Martina Müller-Nurasyid
175. Giovanni Veronesi
176. Jarmo Virtamo
177. Panos Deloukas
178. Paul Elliott
179. Eleftheria Zeggini
180. Sekar Kathiresan
181. Olle Melander
182. Johanna Kuusisto
183. Markku Laakso
184. Sandosh Padmanabhan
185. David J Porteous
186. Caroline Hayward
187. Generation Scotland
188. Francis S Collins
189. Karen L Mohlke
190. Torben Hansen
191. Oluf Pedersen
192. Michael Boehnke
193. Heather M Stringham
194. Philippe Frossard
195. Christopher Newton-Cheh
196. Martin D Tobin
197. Børge Grønne Nordestgaard
198. Mark J Caulfield
199. Anubha Mahajan
200. Andrew P Morris
201. Maciej Tomaszewski
202. Nilesh J Samani
203. Danish Saleheen
204. Folkert W Asselbergs
205. Cecilia M Lindgren
206. John Danesh
207. Louise V Wain
208. Adam S Butterworth
209. Joanna M M Howson
210. Patricia B Munroe

Consortia

CHARGE-Heart Failure Consortium

EchoGen Consortium

METASTROKE Consortium

GIANT Consortium

EPIC-InterAct Consortium

Lifelines Cohort Study

Wellcome Trust Case Control Consortium

Understanding Society Scientific Group

EPIC-CVD Consortium

CHARGE+ Exome Chip Blood Pressure Consortium

T2D-GENES Consortium

GoT2DGenes Consortium

ExomeBP Consortium

CHD Exome+ Consortium

Contributions

Supervision and management of the project: J.M.H.H. and P.B.M. The following authors contributed to the drafting of the manuscript: J.M.M.H., P.B.M. P. Surendran, H.W., A.S.B., F.D., J.P.C., D.R.B., K.W., M. Tomaszewski, F.W.A., L.V.W., N.J.S., J.D., A.K.M., H.Y., C.M.L., N.G., X.S., T. Tukiainen, D.F.F., O.G., T.F. and V.T. All authors critically reviewed and approved the final version of the manuscript. Statistical analysis review: J.M.M.H., P. Surendran, F.D., H.W., J.P.C., R.Y., N.M., P.B.M., L.V.W., H.Y., T.F., E. Mihailov, A.D.M., A. Mahajan, A. Moayyeri, E.E., A.S.B., F.W.A., M.J.C., C.F., T.F., S.E.H., A.S.H., J.E.H., J.L., G.M., J.M., N.M., A.P.M., A. Poveda, N.J.S., R.A.S., L.S., K.E.S., M. Tomaszewski, V.T., T.V.V., N.V., K.W., A.M.Y., W. Zhang, N.G., C.M.L., A.K.M., X.S. and T. Tuomi. Central data quality control: J.M.M.H., A.S.B., P. Surendran, R.Y., F.D., H.W., J.P.C., T.F., L.V.W., P.B.M., E. Mihailov, N.M., C.M.L., N.G., X.S. and A.K.M. Central data analysis: J.M.M.H., P. Surendran, F.D., H.W., J.P.C., N.G., C.M.L., A.K.M. and X.S. Pathway analysis and literature review: J.M.M.H., D.R.B., P.B.M., M. Tomaszewski, K.W., V.T., O.G., A.T. and F.W.A. GWAS lookups, eQTL analysis, GRS analysis, variant annotation and enrichment analyses: J.M.M.H., A.S.B., D.R.B., J.R.S., D.F.F., F.D., M. Harakalova, P.B.M., F.W.A., T. Tuomi, C.M.L., A.K.M. and S. Burgess. Study investigators in alphabetical order by consortium (CHD Exome+, ExomeBP and GoT2D): D.S.A., P.A., E.D.A., D.A., A.S.B., R.C., J.D., J.F., I.F., P.F., J.W.J., F. Kee, A.S.M., S.F.N., B.G.N., D.S., N. Sattar, J.V., F.W.A., P.I.W.d.B., M.J.B., M.J.C., J.C.C., J.M.C., I.J.D., G.D., A.F.D., P.E., T.E., P.W.F., G.G., P.v.d.H., C.H., K.H., E.I., M.-R.J., F. Karpe, S.K., J.S.K., L. Lind, M.I.M., O.M., A. Metspalu, A.D.M., A.P.M., P.B.M., M.E.N., S.P., C.N.A.P., O. Polasek, D.J.P., S.R., O.R., I.R., V.S., N.J.S., P. Sever, T.D.S., J.M.S., N.J.W., C.J.W., E.Z., M.B., I.B., F.S.C., L.G., T.H., E.K.-H., P.J., J. Kuusisto, M.L., T.A.L., A.L., K.L.M., H.O., O. Pedersen, R.R., J.T., M.U. M.U.-N., A. Malarstig, D.F.R., M. Hoek, T.F.V. Study phenotyping in alphabetical order by consortium (CHD Exome+, ExomeBP and GoT2D): P.A., D.A., S. Blankenberg, M.C., J.F., J.W.J., F. Kee, K.K., S.F.N., B.G.N., C.J.P., A.R., M.S., N. Sattar, J.V., W. Zhao, R.A.d.B., M.J.B., M.J.C., J.C.C., J.M.C., A.F.D., A.S.F.D., L.A.D., T.E., A.-E.F., G.G., G.H., P.v.d.H., A.S.H., O.L.H., M. Hassinen, E.I., M.-R.J., F. Karpe, J.S.K., L. Lind, L. Lannfelt, G.M., A. Matchan, P.v.d.M., A. Metspalu, R. Mägi, M.J.N., M.E.N., O. Polasek, N.P., F.R., V.S., N.J.S., T.D.S., A.V.S., J.M.S., M. Tomaszewski, A.-C.V., N.V., N.J.W., T. Tuomi, C.C., L.L.H., A.T.K., P.K., J.L., S.M., E.R.B.P., A.S., T.S., H.M.S., B.T. Study data quality control and analysis in alphabetical order by consortium (CHD Exome+, ExomeBP and GoT2D): A.S.B., A.J.M.d.C., K.-H.H., J.M.M.H., A.K., J. Kontto, C. Langenberg, S.F.N., B.G.N., M.M.-N., S.P., M.P., P. Surendran, S.T., G.V., S.M.W., R.Y., F.W.A., J.P.C., F.D., A.-E.F., T.F., C.H., A. Matchan, A. Mahajan, A.P.M., P.B.M., C.N.A.P., N.W.R., F.R., N.J.S., M. Tomaszewski, V.T., H.W., H.Y., N.G., A.K.M., X.S. Exome chip data quality control in alphabetical order by consortium (CHD Exome+, ExomeBP and GoT2D): A.S.B., K.-H.H., J.M.M.H., A.K., C. Langenberg, S.F.N., B.G.N., P. Surendran, R.Y., F.W.A., P.I.W.d.B., A.I.F.B., J.C.C., J.P.C., P.D., L.A.D., F.D., E.E., C.F., T.F., S.E.H., P.v.d.H., S.S.-H., K.H., J.E.H., E.K., A. Mahajan, G.M., J.M., N.M., E. Mihailov, A. Moayyeri, A.P.M., P.B.M., C.P.N., M.J.N., C.N.A.P., A. Poveda, N.W.R., N.R.R., R.A.S., N. Soranzo, L.S., K.E.S., M.D.T., V.T., T.V.V., N.V., H.W., H.Y., A.M.Y., E.Z., W. Zhang, N.G., C.M.L., A.K.M., X.S. Exome chip data analysis in alphabetical order by consortium (CHD Exome+, ExomeBP and GoT2D): J.M.M.H., P. Surendran, R.Y., F.W.A., P.I.W.d.B., A.I.F.B., R.A.d.B., M.J.C., J.C.C., J.P.C., P.D., L.A.D., P.E., E.E., C.F., T.F., P.W.F., S.F., C.J.G., S.E.H., P.v.d.H., A.S.H., C.H., O.L.H., J.E.H., E.I., M.-R.J., F. Karpe, J.S.K., D.C.M.L., L. Lind, J.L., G.M., R. Marioni, J.M., N.M., M.I.M., P.v.d.M., O.M., C.M., E. Mihailov, A. Moayyeri, A.P.M., R. Mägi, P.B.M., C.P.N., M.J.N., T.O., A. Palotie, A. Poveda, N.W.R., N.R.R., N.J.S., R.A.S., N. Soranzo, L.S., T.D.S., K.E.S., M.D.T., E.T., V.T., T.V.V., N.V., L.V.W., N.J.W., H.W., H.Y., A.M.Y., E.Z., H.Z., W. Zhang, L.L.B., A.P.G., N.G., J.R.H., A.U.J., J.B.-J., C.M.L., A.K.M., N.N., X.S., A.S., A.J.S. GRS lookups: A.E.J., E. Marouli, H.S.M., H.L., H.M.H., J.F.F., M. Traylor, R.S.V., W.L. CHARGE EXOME-BP lookups: Study design. A.T.K., C. Liu, C.N.-C. Analysis. A.T.K., C. Liu.

Corresponding authors

Correspondence toJoanna M M Howson or Patricia B Munroe.

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Competing interests

N.P. has received financial support from several pharmaceutical companies that manufacture either blood pressure -lowering or lipid-lowering agents, or both, and consultancy fees. S.K. has received research grants from Merck, Bayer and Aegerion, is on the SAB of Catabasis, Regeneron Genetics Center, Merck and Celera, has equity in San Therapeutics and Catabasis, and performs consulting for Novartis, Aegerion, Bristol Myers Squibb, Sanofi, AstraZeneca and Alnylam. P. Sever has received research awards from Pfizer. A. Malarstig and M.U.-N. are full-time employees of Pfizer. D.F.R. and M. Hoek are full-time employees of Merck. M.J.C. is Chief Scientist for Genomics England, a UK government company. The authors declare no other competing financial interests.

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Surendran, P., Drenos, F., Young, R. et al. Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension.Nat Genet 48, 1151–1161 (2016). https://doi.org/10.1038/ng.3654

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• Received: 23 July 2015
• Accepted: 02 August 2016
• Published: 12 September 2016
• Issue date: October 2016
• DOI: https://doi.org/10.1038/ng.3654