Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure (original) (raw)

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Acknowledgements

A number of the participating studies and authors are members of the CHARGE and Global BPgen consortia. Many funding mechanisms by the US National Institutes of Health and National Heart, Lung, and Blood Institute, European and private funding agencies contributed to this work, and a full list of acknowledgements is provided in the Supplementary Note.

Author information

Author notes

1. Louise V Wain, Germaine C Verwoert, Paul F O'Reilly, Gang Shi, Toby Johnson, Patricia B Munroe, Bruce M Psaty, Mark J Caulfield, Dabeeru C Rao, Martin D Tobin, Paul Elliott and Cornelia M van Duijn: These authors contributed equally to this work.

Authors and Affiliations

1. Department of Health Sciences, University of Leicester, Leicester, UK
   Louise V Wain & Martin D Tobin
2. Department of Genetics, University of Leicester, Leicester, UK
   Louise V Wain & Martin D Tobin
3. Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
   Germaine C Verwoert, Francesco U S Mattace-Raso, Fernando Rivadeneira, Eric J G Sijbrands & Andre G Uitterlinden
4. Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), The Netherlands
   Germaine C Verwoert, Fernando Rivadeneira, Andre G Uitterlinden, Janine F Felix, Jacqueline C M Witteman & Cornelia M van Duijn
5. Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK
   Paul F O'Reilly, John C Chambers, Weihua Zhang, Xinzhong Li, Marjo-Riitta Jarvelin & Paul Elliott
6. Division of Biostatistics, Washington University in St. Louis, School of Medicine, Saint Louis, Missouri, USA
   Gang Shi & Dabeeru C Rao
7. Department of Genetics, Washington University in St. Louis, School of Medicine, Saint Louis, Missouri, USA
   Gang Shi & Dabeeru C Rao
8. Clinical Pharmacology and The Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
   Toby Johnson, Patricia B Munroe & Mark J Caulfield
9. Framingham Heart Study, Framingham, Massachusetts, USA
   Andrew D Johnson, Martin G Larson, Shih-Jen Hwang, Ramachandran S Vasan, Thomas J Wang & Daniel Levy
10. National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA
    Andrew D Johnson, Shih-Jen Hwang & Daniel Levy
11. Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Murielle Bochud
12. University of Lausanne, Lausanne, Switzerland
    Murielle Bochud
13. Department of Biostatistics, University of Washington, Seattle, Washington, USA
    Kenneth M Rice
14. Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Peter Henneman, Peter A C 't Hoen & Ko Willems van Dijk
15. Icelandic Heart Association, Kopavogur, Iceland
    Albert V Smith, Thor Aspelund, Valur Emilsson & Vilmundur Gudnason
16. University of Iceland, Reykajvik, Iceland
    Albert V Smith, Thor Aspelund & Vilmundur Gudnason
17. Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Georg B Ehret, Vasyl Pihur & Aravinda Chakravarti
18. Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland
    Georg B Ehret
19. Department of Specialties of Internal Medicine, Cardiology, Geneva University Hospital, Geneva, Switzerland
    Georg B Ehret
20. Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Najaf Amin, A Cecile J W Janssens, Albert Hofman, Suman Kundu, Francesco U S Mattace-Raso, Eric J G Sijbrands, Yurii Aulchenko, Janine F Felix, Monique Breteler, Jacqueline C M Witteman & Cornelia M van Duijn
21. Department of Mathematics, Boston University, Boston, Massachusetts, USA
    Martin G Larson
22. Genetics Division R&D, GlaxoSmithKline, King of Prussia, Pennsylvania, USA
    Vincent Mooser
23. Division of Community Health Sciences, St George's, University of London, London, UK
    David Hadley & David P Strachan
24. Pediatric Epidemiology Center, University of South Florida, Tampa, Florida, USA
    David Hadley
25. Department of Internal Medicine B, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany
    Marcus Dörr
26. Division of Internal Medicine, Department of Medicine, Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA
    Joshua C Bis, David Siscovick & Bruce M Psaty
27. Estonian Genome Center, University of Tartu, Tartu, Estonia
    Tõnu Esko, Helene Alavere, Toomas Haller, Aime Keis, Mari-Liis Tammesoo & Andres Metspalu
28. Estonian Biocenter, Tartu, Estonia
    Tõnu Esko & Andres Metspalu
29. Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia
    Tõnu Esko, Maris Laan, Elin Org, Siim Sõber & Andres Metspalu
30. Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    Jing Hua Zhao, Jian'an Luan, Ruth J F Loos & Nicholas J Wareham
31. Centre National de Génotypage, Commissariat à L'Energie Atomique, Institut de Génomique, Evry, France
    Simon Heath & Mark Lathrop
32. Department of Epidemiology, Unit of Genetic Epidemiology and Bioinformatics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Jingyuan Fu, Behrooz Z Alizadeh, Xiaowen Lu, Ilja M Nolte & Harold Snieder
33. Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Jingyuan Fu
34. Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano, Italy
    Giorgio Pistis, Tanguy Corre, Corrado Masciullo, Cinzia Sala & Daniela Toniolo
35. Center for Human Genetic Research, Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA
    Pankaj Arora & Christopher Newton-Cheh
36. Cardiovascular Epidemiology and Genetics, Institut Municipal d'Investigacio Medica, Barcelona Biomedical Research Park, Barcelona, Spain
    Gavin Lucas
37. Institute for Maternal and Child Health–Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS) 'Burlo Garofolo'—Trieste, University of Trieste, Trieste, Italy
    Nicola Pirastu, Adamo Pio d'Adamo & Paolo Gasparini
38. Institute of Genetic Medicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy. Affiliated Institute of the University of Lübeck, Lübeck, Germany.,
    Irene Pichler, Fabiola Del Greco M, Maurizio Facheris & Arne Pfeufer
39. Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA
    Anne U Jackson, Jennifer L Bragg-Gresham, Michael Boehnke & Goncalo R Abecasis
40. Centre for Genetic Epidemiology and Biostatistics, University of Western Australia, Crawley, Western Australia, Australia
    Rebecca J Webster & Lyle J Palmer
41. Department of Twin Research and Genetic Epidemiology, King's College London, London, UK
    Feng Zhang, Massimo Mangino, So-Youn Shin, Nicole Soranzo & Tim D Spector
42. Department of Cardiovascular Medicine, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    John F Peden, Hugh Watkins, Anuj Goel, Halit Ongen & Martin Farrall
43. Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, UK
    John F Peden, Hugh Watkins, Anuj Goel & Martin Farrall
44. Institute of Molecular Biology and Biochemistry, Medical University Graz, Graz, Austria
    Helena Schmidt, Pierre Gider & Marion Zeginigg
45. Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, USA
    Toshiko Tanaka, Yuri Milaneschi & Luigi Ferrucci
46. Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK
    Harry Campbell, Sarah H Wild, Igor Rudan & James F Wilson
47. Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
    Wilmar Igl & Ulf B Gyllensten
48. Department of Biological Psychology, Neuroscience Campus Amsterdam (NCA), VU University, Amsterdam, The Netherlands
    Jouke-Jan Hottenga
49. MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK
    Veronique Vitart, Pau Navarro, Caroline Hayward & Alan F Wright
50. Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA
    Daniel I Chasman, Lynda M Rose & Paul M Ridker
51. Harvard Medical School, Boston, Massachusetts, USA
    Daniel I Chasman & Paul M Ridker
52. Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Stella Trompet & J Wouter Jukema
53. Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    Stella Trompet
54. Ealing Hospital National Health Service (NHS) Trust, Middlesex, UK
    John C Chambers, Weihua Zhang & Jaspal S Kooner
55. Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA
    Xiuqing Guo, Kent D Taylor & Yii-Der Ida Chen
56. Department of Clinical Chemistry, University of Tampere and Tampere University Hospital, Tampere, Finland
    Terho Lehtimäki
57. Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany
    Brigitte Kühnel & Christian Gieger
58. Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK
    Lorna M Lopez, John M Starr & Ian J Deary
59. Department of Psychology, The University of Edinburgh, Edinburgh, UK
    Lorna M Lopez, Gail Davies & Ian J Deary
60. Department of Public Health, Medical School, University of Split, Split, Croatia
    Ozren Polašek
61. Department of Pharmacology, Medical School, University of Split, Split, Croatia
    Mladen Boban
62. Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, UK
    Christopher P Nelson & Nilesh J Samani
63. Division of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas at Houston Health Science Center, Houston, Texas, USA
    Alanna C Morrison
64. Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan Medical Center, Ann Arbor, Michigan, USA
    Santhi K Ganesh
65. Center for Population Studies, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA
    Shih-Jen Hwang & Daniel Levy
66. Division of Epidemiology and Prevention, Boston University School of Medicine, Boston, Massachusetts, USA
    Ramachandran S Vasan
67. Division of Cardiology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Thomas J Wang
68. Département de Génétique Médicale, Université de Lausanne, Lausanne, Switzerland
    Sven Bergmann & Jacques S Beckmann
69. Swiss Institute of Bioinformatics, Lausanne, Switzerland
    Sven Bergmann
70. Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Peter Vollenweider & Gérard Waeber
71. Finnish Institute of Occupational Health, Oulu, Finland
    Jaana Laitinen
72. Department of Children, National Institute of Health and Welfare, Young People and Families, Oulu, Finland
    Anneli Pouta
73. Institute of Clinical Medicine, Obstetrics and Gynaecology, University of Oulu, Oulu, Finland
    Anneli Pouta
74. Department of Physiatrics, Lapland Central Hospital, Rovaniemi, Finland
    Paavo Zitting
75. Department of Social Medicine, Avon Longitudinal Study of Parents and Children (ALSPAC) Laboratory, University of Bristol, Bristol, UK
    Wendy L McArdle
76. Institute of Pharmacology, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany
    Heyo K Kroemer
77. Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany
    Uwe Völker
78. Institute for Community Medicine, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany
    Henry Völzke
79. Department of Medicine, Section of Preventive Medicine and Epidemiology, Boston University School of Medicine, Boston, Massachusetts, USA
    Nicole L Glazer
80. National Institute of Aging's Laboratory for Epidemiology, Demography and Biometry, Bethesda, Maryland, USA
    Tamara B Harris
81. Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Inês Barroso, So-Youn Shin & Nicole Soranzo
82. University of Cambridge Metabolic Research Labs, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK
    Inês Barroso
83. Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK
    Kay-Tee Khaw
84. U557 Institut National de la Santé et de la Recherche Médicale, Paris, France
    Pilar Galan & Serge Hercberg
85. U1125 Institut National de la Recherche Agronomique, Paris, France
    Pilar Galan & Serge Hercberg
86. Université Paris 13, Bobigny, France
    Pilar Galan & Serge Hercberg
87. Department of Statistics, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Susana Eyheramendy
88. Department of Psychiatry/EMGO Institute/Neuroscience Campus, VU University Medical Centre, Amsterdam, The Netherlands
    Brenda W Penninx
89. Department of Psychiatry, Leiden University Medical Centre, Leiden, The Netherlands
    Brenda W Penninx
90. Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Brenda W Penninx
91. Department of Clinical Sciences, Diabetes and Endocrinology Research Unit, Lund University, University Hospital Malmö, Malmö, Sweden
    Leif Groop
92. Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA
    Benjamin F Voight, David Altshuler & Christopher Newton-Cheh
93. Department of Clinical Sciences, Hypertension and Cardiovascular Diseases, University Hospital Malmö, Lund University, Malmö, Sweden
    Olle Melander
94. National Heart, Lung, and Blood Institute and its Framingham Heart Study, Framingham, Massachusetts, USA
    Christopher J O'Donnell
95. Department of Chronic Disease Prevention, THL-National Institute for Health and Welfare, Helsinki, Finland
    Veikko Salomaa
96. Institute for Maternal and Child Health-Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS) 'Burlo Garofolo'—Trieste, Italy
    Antonella Fabretto, Flavio Faletra, Sheila Ulivi & Paolo Gasparini
97. National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA
    Francis S Collins
98. Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Richard N Bergman
99. Pathology and Laboratory Medicine, University of Western Australia, Crawley, Western Australia, Australia
    John P Beilby
100. Molecular Genetics, PathWest Laboratory Medicine, Nedlands, Western Australia, Australia
     John P Beilby
101. Busselton Population Medical Research Foundation, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia
     John P Beilby, Joseph Hung, A William Musk & Lyle J Palmer
102. School of Medicine and Pharmacology, University of Western Australia, Crawley, Western Australia, Australia
     Joseph Hung
103. School of Medicine and Pharmacology, University of Western Australia, Crawley, Western Australia, Australia
     A William Musk
104. Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia
     A William Musk
105. Department of Medicine, Atherosclerosis Research Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
     Anders Hamsten
106. Department of Neurology Section of Special Neurology, Medical University Graz, Graz, Austria
     Marisa Loitfelder & Reinhold Schmidt
107. National Institute of Aging's Laboratory of Neurogenetics, Bethesda, Maryland, USA
     Dena Hernandez & Andrew Singleton
108. Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIH, Baltimore, Maryland, USA
     Samer S Najjar
109. Cardiovascular Research Institute, MedStar Health Research Institute, Washington Hospital Center, Washington, DC, USA
     Samer S Najjar
110. Tuscany Regional Health Agency, Florence, Italy
     Anna Maria Corsi
111. Department of Biological Psychology, EMGO+ institute, VU University, Amsterdam, The Netherlands
     Eco J C de Geus, Gonneke Willemsen & Dorret I Boomsma
112. Amgen, Cambridge, Massachusetts, USA
     Alex N Parker
113. Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland
     Brendan Buckley
114. Institute of Cardiovascular and Medical Sciences, School of Medicine, University of Glasgow, Glasgow, UK
     David Stott
115. Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Monserrato, Italy
     Marco Orru & Manuela Uda
116. Department of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
     Melanie M van der Klauw
117. National Heart and Lung Institute, Imperial College London, Hammersmith Hospital, London, UK
     James Scott & Jaspal S Kooner
118. Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA
     Gregory L Burke
119. Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland
     Mika Kähönen
120. Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland
     Jorma Viikari
121. Institute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany
     Angela Döring & H-Erich Wichmann
122. Institute of Epidemiology II, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany
     Angela Döring
123. Institute of Human Genetics, Helmholtz Zentrum München–German Research Centre for Environmental Health, Neuherberg, Germany
     Thomas Meitinger
124. Institute of Human Genetics, Technische Universität München, Munich, Germany
     Thomas Meitinger
125. Geriatric Medicine Unit, The University of Edinburgh, Royal Victoria, Edinburgh, UK
     John M Starr
126. Cardiovascular Disease Franchise, Merck Research Laboratory, Rahway, New Jersey, USA
     Andrew Plump
127. Department of Vascular Surgery, Leiden University Medical Center, Leiden, The Netherlands
     Jan H Lindeman
128. Leiden Genome Technology Center, Leiden University Medical Center, Leiden, The Netherlands
     Peter A C 't Hoen
129. Institut für Medizinische Biometrie und Statistik, Universität zu Lübeck, Lübeck, Germany
     Inke R König & Michael Preuss
130. Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
     Janine F Felix
131. Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Oxford, UK
     Robert Clarke & Jemma C Hopewell
132. Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
     Stéphanie Debette
133. Boston University School of Public Health, Boston, Massachusetts, USA
     Anita L DeStefano
134. Brown Foundation Institute of Molecular Medicine and Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, USA
     Myriam Fornage
135. Cardiovascular Engineering, Inc., Norwood, Massachusetts, USA
     Gary F Mitchell
136. Department of Epidemiology, University of Washington, Seattle, Washington, USA
     Nicholas L Smith, David Siscovick & Bruce M Psaty
137. Center of the Department of Veterans Affairs Office of Research and Development, Seattle Epidemiologic Research and Information, Seattle, Washington, USA
     Nicholas L Smith
138. Group Health Research Institute, Group Health Cooperative, Seattle, Washington, USA
     Nicholas L Smith & Bruce M Psaty
139. deCODE genetics Inc, Reykjavik, Iceland
     Hilma Holm, Kari Stefansson, Gudmar Thorleifsson & Unnur Thorsteinsdottir
140. Faculty of Medicine, University of Iceland, Reykjavik, Iceland
     Kari Stefansson & Unnur Thorsteinsdottir
141. Leicester National Institute of Health Research (NIHR) Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester, UK
     Nilesh J Samani
142. Medizinische Klinik II, Universität zu Lübeck, Lübeck, Germany
     Michael Preuss & Jeanette Erdmann
143. Croatian Centre for Global Health, University of Split Medical School, Split, Croatia
     Igor Rudan
144. Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität and Klinikum Grosshadern, Munich, Germany
     H-Erich Wichmann
145. University of Turku and the Department of Clinical Physiology, Research Centre of Applied and Preventive Cardiovascular Medicine, Turku University Hospital, Turku, Finland
     Olli T Raitakari
146. Columbia University, New York, New York, USA
     Walter Palmas
147. Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
     Ronald P Stolk
148. Durrer Center for Cardiogenetic Research, Amsterdam, The Netherlands
     J Wouter Jukema
149. Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands
     J Wouter Jukema
150. Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy
     Stefania Bandinelli
151. Ontario Institute for Cancer Research, Toronto, Ontario, Canada
     Lyle J Palmer
152. Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada
     Lyle J Palmer
153. National Institute for Health and Welfare, Diabetes Prevention Unit, Helsinki, Finland
     Jaakko Tuomilehto
154. Department of Public Health, Hjelt Institute, University of Helsinki, Helsinki, Finland
     Jaakko Tuomilehto
155. South Ostrobothnia Central Hospital, Seinajoki, Finland
     Jaakko Tuomilehto
156. Institute of Human Genetics, Klinikum rechts der Isar der Technischen Universität München, Munich, Germany
     Arne Pfeufer
157. Institute of Human Genetics, Helmholtz Zentrum München, Neuherberg, Germany
     Arne Pfeufer
158. Department of Medicine, University of Washington, Seattle, Washington, USA
     David Siscovick
159. Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
     David Altshuler
160. Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA
     David Altshuler
161. Diabetes Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
     David Altshuler
162. Institute of Molecular Genetics–Consiglio Nazionale delle Ricerche (CNR), Pavia, Italy
     Daniela Toniolo
163. U872 Institut National de la Santé et de la Recherche Médicale, Centre de Recherche des Cordeliers, Paris, France
     Pierre Meneton
164. Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands
     Ben A Oostra
165. National Institute of Aging's Laboratory for Epidemiology, Demography and Biometry, Bethesda, Maryland, USA
     Lenore Launer
166. Institute of Physiology, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany
     Rainer Rettig
167. Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
     Jacques S Beckmann
168. Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands
     Ko Willems van Dijk
169. Human Genetics Center, Houston, Texas, USA
     Eric Boerwinkle
170. Division of Cardiology, Brigham and Women's Hospital, Boston, Massachusetts, USA
     Paul M Ridker
171. Institute of Health Sciences, University of Oulu, Oulu, Finland
     Marjo-Riitta Jarvelin
172. Biocenter, University of Oulu, Oulu, Finland
     Marjo-Riitta Jarvelin
173. Department of Health Services, University of Washington, Seattle, Washington, USA
     Bruce M Psaty
174. Department of Psychiatry, Washington University in St. Louis, School of Medicine, Saint Louis, Missouri, USA
     Dabeeru C Rao
175. Department of Mathematics, Washington University in St. Louis, School of Medicine, Saint Louis, Missouri, USA
     Dabeeru C Rao
176. MRC-Health Protection Agency (HPA) Centre for Environment and Health, Imperial College London, London, UK
     Paul Elliott
177. Centre of Medical Systems Biology, Erasmus University Medical Center, Rotterdam, The Netherlands
     Cornelia M van Duijn

Authors

1. Louise V Wain
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Consortia

LifeLines Cohort Study

EchoGen consortium

AortaGen Consortium

CHARGE Consortium Heart Failure Working Group

KidneyGen consortium

CKDGen consortium

Cardiogenics consortium

CardioGram

Contributions

ICBP-GWAS PP and MAP Working and Writing Sub-Group (alphabetical order): M.J.C., P.E. (co-chair), T.J., P.B.M., P.F.O., M.D.T. (co-chair), C.M.v.D. (co-chair), G.C.V., L.V.W. ICBP-GWAS Steering Committee (alphabetical order): G.R.A., M. Bochud, M. Boehnke, M.J.C. (co-chair), A.C., G.B.E., P.E., T.B.H., M.-R.J., A.D.J., T.J., M.G.L., L.L., D.L. (co-chair), P.B.M.(co-chair), C.N.-C. (co-chair), B.M.P., K.M.R., A.V.S., M.D.T., C.M.v.D., G.C.V. Analysis: L.V.W., G.C.V., P.F.O., T.J. Expression analyses: V.E., P.H., A.D.J., D.L., J.H.L., C.P.N., A. Plump, P.A.C.'t H., K.W.v.D. Cohort contributions (alphabetical order): Study concept/design: AGES: T.A., V.G., T.B.H., L.L., A.V.S. AortaGen Consortium: G.F.M. ARIC: E.B., A.C., S.K.G. ASPS: H. Schmidt, R.S. BLSA: L.F. B58C-T1DGC: D.P.S. B58C-WTCCC: D.P.S. BHS: L.J.P. CARDIoGRAM Consortium: N.J.S. C4D Consortium: R. Clarke, CHS: J.C.B., N.L.G., B.M.P., K.M.R., K.D.T. CHARGE Consortium Heart Failure Working Group: N.L.S. CoLaus: V.M., P. Vollenweider, G. Waeber CROATIA-Korcula: C.H. CROATIA-Split: M. Boban, I.R. CROATIA-Vis: A.F.W. DeCode Genetics: H.H., K.S., G.T., U.T. DGI controls: D.A., L.G., C.N.-C. ENGAGE: J.E., I.R.K. EGCUT: H.A., A.M. EPIC: K.-T.K. ERF: B.A.O. Fenland: N.J.W. FUSION: M. Boehnke, F.S.C., R.N.B., J.T. INGI CARL: A.P.d'A., P. Gasparini INGI-FVG: A.P.d'A., P. Gasparini INCHIANTI: S. Bandinelli., Y.M. KORA S3: C.G., M. Laan, E.O. KORA F4: T.M., H.-E.W. LifeLines: R.P.S., M.M.v.d.K. LOLIPOP: J.C.C., P.E., J.S.K. LBC1921/LBC1936: I.J.D., J.M.S. MICROS: A. Pfeufer MESA: G.L.B., X.G., W.P. MIGen controls: O.M., C.J.O., V.S., D. Siscovick NESDA: B.W.P., H. Snieder NEURO-CHARGE Consortium: M. Breteler, M. Fornage NFBC1966: M.-R.J., P.Z. NSPHS: U.B.G. NTR: D.I.B., E.J.C.d.G. ORCADES: H.C., J.F.W. PROCARDIS controls: M. Farrall, A. Hamsten, J.F.P., H.W. PROSPER/PHASE: B.B., J.W.J., D. Stott RSI/RSII/RSIII: A. Hofman, C.M.v.D., J.C.M.W. SardiNIA: G.R.A., M.U. SHIP: M.D., H.K.K., R.R., U.V., H.V. SUVIMAX: P. Galan, S. Hercberg, P.M. TwinsUK: T.D.S. WGHS: P.M.R. YFS: M.K., T.L., O.T.R., J.V. Phenotype data acquisition and quality control: AGES: T.A., V.G., T.B.H., L.L. ARIC: A.C., S.K.G., A.C.M., D.C.R. ASPS: M. Loitfelder, R.S. BLSA: S.S.N. B58C-T1DGC: D.P.S. B58C-WTCCC: D.P.S. BHS: J.P.B., J.H. C4D Consortium: R. Clarke, J.C.H. CHS: B.M.P. CoLaus: M. Bochud, V.M., P. Vollenweider CROATIA-Korcula: C.H., O.P. CROATIA-Split: M. Boban, I.R. DGI controls: L.G., C.N.-C. EGCUT: H.A., A.K., A.M., M.-L.T. EPIC: N.J.W. Fenland: N.J.W. FHS: S.-J.H., M.G.L., D.L., R.S.V., T.J.W. FUSION: J.T. INGI CARL: A.F., F.F., P. Gasparini, S.U. INGI FVG: A.F., F.F., P. Gasparini, S.U. INGI-Val Borbera: C. Masciullo, C.S., D.T. INCHIANTI: A.M.C. KORA S3: C.G. KORA F4: A.D. LifeLines: M.M.v.d.K. LOLIPOP: J.C.C., J.S.K., J.S. LBC1921/LBC1936: I.J.D., L.M.L., J.M.S. MICROS: M. Facheris, A. Pfeufer MESA: G.L.B., X.G., W.P. MIGen controls: G.L., O.M., C.J.O., V.S., D. Siscovick NESDA: X. Lu, I.M.N., B.W.P., H. Snieder NEURO-CHARGE Consortium: M. Breteler, S.D., A.L.D., M. Fornage NFBC1966: P.E., M.-R.J., J. Laitinen, A. Pouta, P.Z. NSPHS: U.B.G. NTR: D.I.B., E.J.C.d.G., G. Willemsen ORCADES: S.H.W., J.F.W. PROCARDIS controls: J.F.P. PROSPER/PHASE: D. Stott, S.T. RSI/RSII/RSIII: F.U.S.M.-R., E.J.G.S., C.M.v.D., G.C.V., J.C.M.W. SardiNIA: M.O., M.U. SHIP: M.D., R.R., H.V. SUVIMAX: P. Galan, M. Lathrop TwinsUK: T.D.S. WGHS: P.M.R. YFS: M.K., T.L., O.T.R., J.V. Genotype data acquisition and quality control: AGES: A.V.S. ARIC: A.C., G.B.E., S.K.G., A.C.M., D.C.R., G.S. ASPS: P. Gider, H. Schmidt, M.Z. BLSA: D. Hernandez B58C-T1DGC: S. Heath, W.L.M. B58C-WTCCC: W.L.M. BHS: J.P.B., R.J.W. C4D Consortium: J.C.H., H.O. CHS: J.C.B., N.L.G., K.D.T. CoLaus: V.M., P. Vollenweider CROATIA-Korcula: C.H., O.P. CROATIA-Split: I.R. CROATIA-Vis: V.V. DGI controls: D.A., B.F.V. EGCUT: T.E., T.H. EPIC: N.J.W. Fenland: R.J.F.L., J. Luan, N.J.W. FHS: S.-J.H., M.G.L. FUSION: F.S.C. INGI CARL: A.P.d'A. INGI FVG: A.P.d'A. INGI Val Borbera: C. Masciullo, C.S., D.T. INCHIANTI: A.S. KORA S3: C.G., M. Laan, E.O. KORA F4: T.M., H.-E.W. LifeLines: B.Z.A. LOLIPOP: J.C.C., J.S.K., J.S., W.Z. LBC1921/LBC1936: G.D., I.J.D. MICROS: I.P. MESA: G.L.B., Y.-D.I.C., X.G. MIGen controls: G.L., O.M., C.J.O., V.S., D.S. NESDA: J.F., X. Lu, I.M.N., B.W.P., H. Snieder NFBC1966: P.E., M.-R.J., J. Laitinen, P.Z. NTR: D.I.B., E.J.C.d.G., J.-J.H., G. Willemsen ORCADES: H.C., J.F.W. PROCARDIS controls: A.G., J.F.P. PROSPER/PHASE: S.T. RSI/RSII/RSIII: F.R., A.G.U. SardiNIA: G.R.A. SHIP: H.K.K., U.V., H.V. SUVIMAX: S. Heath, M. Lathrop TwinsUK: M.M., S.-Y.S., N.S., F.Z. WGHS: D.I.C., A.N.P. YFS: T.L., O.T.R. Data analysis: AGES: T.A., A.V.S. ARIC: A.C., G.B.E., A.C.M., V.P., D.C.R., G.S. ASPS: P. Gider, H. Schmidt, M.Z. BLSA: T.T. B58C-T1DGC: D.P.S. B58C-WTCCC: D. Hadley, D.P.S. BHS: A.W.M., L.J.P., R.J.W. C4D Consortium: J.C.H., H.O., CHS: J.C.B., N.L.G., K.M.R. CoLaus: J.S.B., S. Bergmann, M. Bochud, T.J. CROATIA-Korcula: C.H., O.P. CROATIA-Split: C.H. CROATIA-Vis: V.V. DGI controls: P.A., C.N.-C., B.F.V. EchoGen Consortium: J.F.F. EGCUT: T.E., T.H. ENGAGE: M.P. EPIC: I.B., R.J.F.L., N.J.W., J.H.Z. ERF: A.C.J.W.J., Y.A. Fenland: R.J.F.L., J. Luan FHS: S.-J.H., M.G.L. FUSION: A.U.J. INGI CARL: N.P. INGI FVG: N.P. INGI Val Borbera: T.C., G.P., C.S., D.T. KORA S3: S.E., S.S. KORA F4: B.K. LifeLines: B.Z.A. LOLIPOP: J.C.C., J.S.K., X. Li, J.S., W.Z. LBC1921/LBC1936: L.M.L. MICROS: F.D.G.M. MESA: Y-D.I.C., X.G., W.P. MIGen controls: G.L. NESDA: J.F., X. Lu NEURO-CHARGE Consortium: S.D., A.L.D., M. Fornage NFBC1966: P.F.O. _NSPHS:_W.I. NTR: J.-J.H. ORCADES: P.N., S.H.W., J.F.W. PROCARDIS controls: M. Farrall, A.G., J.F.P. PROSPER/PHASE: J.W.J., S.T. RSI/RSII/RSIII: N.A., S.K., C.M.v.D., G.C.V. SardiNIA: J.L.B.-G. SHIP: U.V. SUVIMAX: T.J., P.M. TwinsUK: N.S., F.Z. WGHS: D.I.C., L.M.R., YFS: T.L., O.T.R.

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Correspondence toMartin D Tobin, Paul Elliott or Cornelia M van Duijn.

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A.C. is managed by Johns Hopkins Medicine. I.B. and spouse own stock in Incyte Ltd and GlaxoSmithKline. A.N.P. is an employee of Amgen. G.F.M. is owner of Cardiovascular Engineering, Inc, a company that designs and manufactures devices that measure vascular stiffness. The company uses these devices in clinical studies that evaluate the effects of diseases and interventions on vascular stiffness. V.M. is an employee of GlaxoSmithKline plc. A. Plump is an employee of Merck and Co, Inc.

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Wain, L., Verwoert, G., O'Reilly, P. et al. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.Nat Genet 43, 1005–1011 (2011). https://doi.org/10.1038/ng.922

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• Received: 10 February 2011
• Accepted: 04 August 2011
• Published: 11 September 2011
• Issue Date: October 2011
• DOI: https://doi.org/10.1038/ng.922