Miller, D.G. On the nature of susceptibility to cancer. The presidential address. Cancer46, 1307–1318 (1980). ArticleCAS Google Scholar
Beerenwinkel, N. et al. Genetic progression and the waiting time to cancer. PLOS Comput. Biol.3, e225 (2007). ArticlePubMed Central Google Scholar
Schinzel, A.C. & Hahn, W.C. Oncogenic transformation and experimental models of human cancer. Front. Biosci.13, 71–84 (2008). ArticleCAS Google Scholar
Kinzler, K.W. & Vogelstein, B. Lessons from hereditary colorectal cancer. Cell87, 159–170 (1996). ArticleCAS Google Scholar
Vogelstein, B. et al. Genetic alterations during colorectal-tumor development. N. Engl. J. Med.319, 525–532 (1988). ArticleCAS Google Scholar
Rustgi, A.K. The genetics of hereditary colon cancer. Genes Dev.21, 2525–2538 (2007). ArticleCAS Google Scholar
Starr, T.K. et al. A transposon-based genetic screen in mice identifies genes altered in colorectal cancer. Science323, 1747–1750 (2009). ArticleCASPubMed Central Google Scholar
Collier, L.S., Carlson, C.M., Ravimohan, S., Dupuy, A.J. & Largaespada, D.A. Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouse. Nature436, 272–276 (2005). ArticleCAS Google Scholar
Lüchtenborg, M. et al. APC mutations in sporadic colorectal carcinomas from The Netherlands Cohort Study. Carcinogenesis25, 1219–1226 (2004). Article Google Scholar
Collier, L.S. & Largaespada, D.A. Hopping around the tumor genome: transposons for cancer gene discovery. Cancer Res.65, 9607–9610 (2005). ArticleCAS Google Scholar
Dupuy, A.J., Akagi, K., Largaespada, D.A., Copeland, N.G. & Jenkins, N.A. Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system. Nature436, 221–226 (2005). ArticleCAS Google Scholar
Collier, L.S. et al. Whole-body sleeping beauty mutagenesis can cause penetrant leukemia/lymphoma and rare high-grade glioma without associated embryonic lethality. Cancer Res.69, 8429–8437 (2009). ArticleCASPubMed Central Google Scholar
Dupuy, A.J. et al. A modified sleeping beauty transposon system that can be used to model a wide variety of human cancers in mice. Cancer Res.69, 8150–8156 (2009). ArticleCASPubMed Central Google Scholar
Keng, V.W. et al. A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma. Nat. Biotechnol.27, 264–274 (2009). ArticleCASPubMed Central Google Scholar
Moser, A.R., Pitot, H.C. & Dove, W.F. A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse. Science247, 322–324 (1990). ArticleCAS Google Scholar
Shibata, H. et al. Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene. Science278, 120–123 (1997). ArticleCAS Google Scholar
de Ridder, J., Uren, A., Kool, J., Reinders, M. & Wessels, L. Detecting statistically significant common insertion sites in retroviral insertional mutagenesis screens. PLOS Comput. Biol.2, e166 (2006). ArticlePubMed Central Google Scholar
Uren, A.G. et al. A high-throughput splinkerette-PCR method for the isolation and sequencing of retroviral insertion sites. Nat. Protoc.4, 789–798 (2009). ArticleCASPubMed Central Google Scholar
Segditsas, S. et al. APC and the three-hit hypothesis. Oncogene28, 146–155 (2009). ArticleCAS Google Scholar
Uren, A.G. et al. Large-scale mutagenesis in p19 _ARF_- and _p53_-deficient mice identifies cancer genes and their collaborative networks. Cell133, 727–741 (2008). ArticleCASPubMed Central Google Scholar
Bos, J.L. et al. Prevalence of ras gene mutations in human colorectal cancers. Nature327, 293–297 (1987). ArticleCAS Google Scholar
Forrester, K., Almoguera, C., Han, K., Grizzle, W.E. & Perucho, M. Detection of high incidence of K-ras oncogenes during human colon tumorigenesis. Nature327, 298–303 (1987). ArticleCAS Google Scholar
Hung, K.E. et al. Comprehensive proteome analysis of an Apc mouse model uncovers proteins associated with intestinal tumorigenesis. Cancer Prev. Res. (Phila.)2, 224–233 (2009). ArticleCAS Google Scholar
Paoni, N.F., Feldman, M.W., Gutierrez, L.S., Ploplis, V.A. & Castellino, F.J. Transcriptional profiling of the transition from normal intestinal epithelia to adenomas and carcinomas in the _Apc_min/+ mouse. Physiol. Genomics15, 228–235 (2003). ArticleCAS Google Scholar
McAlpine, C.A., Barak, Y., Matise, I. & Cormier, R.T. Intestinal-specific PPARγ deficiency enhances tumorigenesis in _Apc_min/+ mice. Int. J. Cancer119, 2339–2346 (2006). ArticleCAS Google Scholar
Shao, J., Washington, M.K., Saxena, R. & Sheng, H. Heterozygous disruption of the PTEN promotes intestinal neoplasia in _Apc_min/+ mouse: roles of osteopontin. Carcinogenesis28, 2476–2483 (2007). ArticleCAS Google Scholar
Kucherlapati, M.H. et al. Loss of Rb1 in the gastrointestinal tract of _Apc_1638N mice promotes tumors of the cecum and proximal colon. Proc. Natl. Acad. Sci. USA105, 15493–15498 (2008). ArticleCAS Google Scholar
Musteanu, M. et al. Stat3 is a negative regulator of intestinal tumor progression in _Apc_min mice. Gastroenterology138, 1003–1011 (2010). ArticleCAS Google Scholar
Dopeso, H. et al. The receptor tyrosine kinase EPHB4 has tumor suppressor activities in intestinal tumorigenesis. Cancer Res.69, 7430–7438 (2009). ArticleCAS Google Scholar
Ciznadija, D. et al. Intestinal adenoma formation and MYC activation are regulated by cooperation between MYB and Wnt signaling. Cell Death Differ.16, 1530–1538 (2009). ArticleCAS Google Scholar
Zeilstra, J. et al. Deletion of the WNT target and cancer stem cell marker CD44 in _Apc_min/+ mice attenuates intestinal tumorigenesis. Cancer Res.68, 3655–3661 (2008). ArticleCAS Google Scholar
Sodir, N.M. et al. Smad3 deficiency promotes tumorigenesis in the distal colon of _Apc_min/+ mice. Cancer Res.66, 8430–8438 (2006). ArticleCAS Google Scholar
Alberici, P. et al. Aneuploidy arises at early stages of Apc-driven intestinal tumorigenesis and pinpoints conserved chromosomal loci of allelic imbalance between mouse and human. Am. J. Pathol.170, 377–387 (2007). ArticleCASPubMed Central Google Scholar
Knüppel, R., Dietze, P., Lehnberg, W., Frech, K. & Wingender, E. TRANSFAC retrieval program: a network model database of eukaryotic transcription regulating sequences and proteins. J. Comput. Biol.1, 191–198 (1994). Article Google Scholar
Joo, M., Shahsafaei, A. & Odze, R.D. Paneth cell differentiation in colonic epithelial neoplasms: evidence for the role of the Apc/β-catenin/Tcf pathway. Hum. Pathol.40, 872–880 (2009). ArticleCAS Google Scholar
Pollard, P. et al. The _Apc_1322T mouse develops severe polyposis associated with submaximal nuclear β-catenin expression. Gastroenterology136, 2204–2213 (2009). ArticleCAS Google Scholar
Simmen, F.A. et al. Dysregulation of intestinal crypt cell proliferation and villus cell migration in mice lacking Kruppel-like factor 9. Am. J. Physiol. Gastrointest. Liver Physiol.292, G1757–G1769 (2007). ArticleCAS Google Scholar
Katoh, M. Cross-talk of WNT and FGF signaling pathways at GSK3β to regulate β-catenin and SNAIL signaling cascades. Cancer Biol. Ther.5, 1059–1064 (2006). ArticleCAS Google Scholar
Poynter, J.N. et al. Variants on 9p24 and 8q24 are associated with risk of colorectal cancer: results from the Colon Cancer Family Registry. Cancer Res.67, 11128–11132 (2007). ArticleCAS Google Scholar
Mosquera, J.M. et al. Prevalence of _TMPRSS2_-ERG fusion prostate cancer among men undergoing prostate biopsy in the United States. Clin. Cancer Res.15, 4706–4711 (2009). ArticleCASPubMed Central Google Scholar
Müller, T. et al. ASAP1 promotes tumor cell motility and invasiveness, stimulates metastasis formation in vivo, and correlates with poor survival in colorectal cancer patients. Oncogene29, 2393–2403 (2010). Article Google Scholar
Firestein, R. et al. CDK8 is a colorectal cancer oncogene that regulates β-catenin activity. Nature455, 547–551 (2008). ArticleCASPubMed Central Google Scholar
Tomlinson, I. & Bodmer, W. Selection, the mutation rate and cancer: ensuring that the tail does not wag the dog. Nat. Med.5, 11–12 (1999). ArticleCAS Google Scholar
Wood, L.D. et al. The genomic landscapes of human breast and colorectal cancers. Science318, 1108–1113 (2007). ArticleCAS Google Scholar
Campbell, P.J. et al. Subclonal phylogenetic structures in cancer revealed by ultra-deep sequencing. Proc. Natl. Acad. Sci. USA105, 13081–13086 (2008). ArticleCAS Google Scholar
Joseph, S.B. & Hall, D.W. Spontaneous mutations in diploid Saccharomyces cerevisiae: more beneficial than expected. Genetics168, 1817–1825 (2004). ArticlePubMed Central Google Scholar
Klein, A.M., Brash, D.E., Jones, P.H. & Simons, B.D. Stochastic fate of _p53_-mutant epidermal progenitor cells is tilted toward proliferation by UV B during preneoplasia. Proc. Natl. Acad. Sci. USA107, 270–275 (2010). ArticleCAS Google Scholar
Segditsas, S. & Tomlinson, I. Colorectal cancer and genetic alterations in the Wnt pathway. Oncogene25, 7531–7537 (2006). ArticleCASPubMed Central Google Scholar
Suzuki, H. et al. Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer. Nat. Genet.36, 417–422 (2004). ArticleCAS Google Scholar
Caldwell, G.M. et al. The Wnt antagonist sFRP1 in colorectal tumorigenesis. Cancer Res.64, 883–888 (2004). ArticleCAS Google Scholar
Janssen, K.P. et al. APC and oncogenic KRAS are synergistic in enhancing Wnt signaling in intestinal tumor formation and progression. Gastroenterology131, 1096–1109 (2006). ArticleCAS Google Scholar
Albrethsen, J. et al. Subnuclear proteomics in colorectal cancer: identification of proteins enriched in the nuclear matrix fraction and regulation in adenoma to carcinoma progression. Mol. Cell. Proteomics9, 988–1005 (2010). ArticleCASPubMed Central Google Scholar
Forbes, S.A. et al. COSMIC (the Catalogue of Somatic Mutations in Cancer): a resource to investigate acquired mutations in human cancer. Nucleic Acids Res.38, D652–657 (2010). ArticleCAS Google Scholar
Su, L.K. et al. Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene. Science256, 668–670 (1992). ArticleCAS Google Scholar
Ireland, H. et al. Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of β-catenin. Gastroenterology126, 1236–1246 (2004). ArticleCAS Google Scholar
Ning, Z., Cox, A.J. & Mullikin, J.C. SSAHA: a fast search method for large DNA databases. Genome Res.11, 1725–1729 (2001). ArticleCASPubMed Central Google Scholar