A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2 (original) (raw)
Hamilton, B.S. Paglia, D. Kwan, A.Y.M. & Deitel, M. Increased obese mRNA expression in omental fat cells from massively obese humans. Nature Med.9, 953–956 (1995). Article Google Scholar
Lönnqvist, F. Arner, P. Nordfors, L. & Schalling, M. Overexpression of the obese (ob) gene in adipose tissue of human obese subjects. Nature Med.1, 950–953 (1995). ArticlePubMed Google Scholar
Masuzaki, H. et al. Human obese gene expression: adipocyte-specific expression and regional differences in the adipose tissue. Diabetes44, 855–858 (1995). ArticleCASPubMed Google Scholar
Klein, S. Coppack, W. Mohamed-Ali, V. & Landt, M. Adipose tissue leptin production and plasma leptin kinetics in humans. Diabetes45, 984–987 (1996). ArticleCASPubMed Google Scholar
Campfield, L.A. Smith, F.J. Guisez, Y. Devos, R. & Burn, P. Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks. Science269, 546–549 (1995). ArticleCASPubMed Google Scholar
Halaas, J.L. et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science269, 543–546 (1995). ArticleCASPubMed Google Scholar
Pelleymounter, M.A. et al. Effects of the obese gene product on body weight regulation in ob/ob mice. Science269, 540–543 (1995). ArticleCASPubMed Google Scholar
Maffei, M. et al. Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nature Med.1, 1155–1161 (1995). ArticleCASPubMed Google Scholar
Considine, R.V. et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. New Eng. J. Med.334, 292–325 (1996). ArticleCASPubMed Google Scholar
Frisancho, A.R. Anthropometric Standards for the Assessment of Growth and Nutritional Status. (University of Michigan Press, Ann Arbor, 1990).
Hazuda, H.P. Mitchell, B.D. Haffner, S.M. & Stern, M.P. Obesity in Mexican American subgroups: findings from the San Antonio Heart study. Am. J. Clin. Nutr.53, 1529S–1534s (1991). ArticleCASPubMed Google Scholar
Comuzzie, A.G. et al. Major gene with sex-specific effects influences fat mass in Mexican Americans. Genet. Epidemiol.12, 475–488 (1995). ArticleCASPubMed Google Scholar
Hasstedt, S.J. Ramirez, M.E. Kuida, H. & Williams, R.R. Recessive inheritance of a relative fat pattern. Am. J. Hum. Genet.45, 917–925 (1989). CASPubMedPubMed Central Google Scholar
Price, R.A. Ness, R. & Laskarzewski, P. Common major gene inheritance of extreme overweight. Hum. Biol.62, 747–765 (1990). CASPubMed Google Scholar
Rice, T. Borecki, I.B. Bouchard, C. & Rao, D.C. Segregation analysis of fat mass and other body composition measures derived from underwater weighing. Am. J. Hum. Genet.52, 967–973 (1993). CASPubMedPubMed Central Google Scholar
Zhang, Y. et al. Positional cloning of the mouse obese gene and its human homologue. Nature372, 425–432 (1994). ArticleCASPubMed Google Scholar
Clement, K. et al. Indication for linkage of the human OB gene region with extreme obesity. Diabetes45, 687–690 (1996). ArticleCASPubMed Google Scholar
Reed, D.R. et al. Extreme obesity may be linked to markers flanking the human OB gene. Diabetes45, 691–694 (1996). ArticleCASPubMed Google Scholar
Duggirala, R. et al. Quantitative variation in obesity-related traits and insulin precursors linked to the OB gene region on human chromosome 7. Am. J. Hum. Genet.59, 694–703 (1996). CASPubMedPubMed Central Google Scholar
Lander, E. & Kruglyak, L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nature Genet.11, 241–247 (1995). ArticleCASPubMed Google Scholar
Bray, G.A. & York, D.A. Hypothalamic and genetic obesity in experimental animals: an autonomic and endocrine hypothesis. Physiol. Rev.59, 719–809 (1979). ArticleCASPubMed Google Scholar
Hautanen, A. & Adlercreutz, H. Altered adrenocorticotropin and cortisol secretion in abdominal obesity: implications for the insulin resistance syndrome. J. Intern.Med.234, 461–469 (1993). ArticleCASPubMed Google Scholar
De Vos, P. Saladin, R. Auwerx, J. & Staels, B. Induction of ob gene expression by corticosteroids is accompanied by body weight loss and reduced food intake. J. Biol. Chem.270, 15958–15961 (1995). ArticleCASPubMed Google Scholar
Murakami, T. Iida, M. & Shima, K. Dexamethasone regulates obese expression in isolated rat adipocytes. Biochem. Biophys. Res. Comm.214, 1260–1267 (1995). ArticleCASPubMed Google Scholar
Warner, J.P. Leek, J.P. Intody, S. Markham, A.F. & Bonthron, D.T. Human glucokinase regulatory protein (GCKR): cDNA and genomic cloning, complete primary structure, and chromosomal localization. Mammalian Genome6, 532–536 (1995). ArticleCASPubMed Google Scholar
Clemént, K. et al. Genetic variation in the β3-adrenergic receptor and increased capacity to gain weight in patients with morbid obesity. JAMA.333, 352–354 (1995). Google Scholar
Bottini, E. et al. Enzyme polymorphism and clinical variability of diseases: study of acid phosphatase locus 1 (ACP1) in obese subjects. Hum Biol.62, 403–411 (1990). CASPubMed Google Scholar
Pouliot, M.-C. et al. ApoB-100 gene EcoRI polymorphism: Relations to plasma lipoprotein changes associated with abdominal visceral obesity. Arterioscler. Thromb.14, 527–533 (1994). ArticleCASPubMed Google Scholar
Rajput-Williams, J. et al. Variation of apolipoprotein-B gene is associated with obesity, high blood cholesterol levels, and increased risk of coronary heart disease. Lancet2, 1442–1445 (1988). ArticleCASPubMed Google Scholar
Saha, N. Tay, J.S.H. Heng, C.K. & Humphries, S.E. DNA polymorphisms of the apolipoprotein B gene are associated with obesity and serum lipids in healthy Indians in Singapore. Clin. Genet.44, 113–120 (1993). ArticleCASPubMed Google Scholar
Mahaney, M.C. et al. Plasma HDL cholesterol, triglycerides, and adiposity: A quantitative genetic test of the conjoint trait hypothesis in the San Antonio family heart study. Circulation92, 3240–3248 (1995). ArticleCASPubMed Google Scholar
Mitchell, B.D. et al. Genetic analysis of the IRS: Pleiotropic effects of genes influencing insulin levels on lipoprotein and obesity measures. Arterioscler. Thromb. Vase. Biol.16, 281–288 (1996). ArticleCAS Google Scholar
Mitchell, B.D. et al. A comparison of three methods for assessing Amerindian admixture in Mexican Americans. Ethnicity Dis.3, 22–31 (1993). CAS Google Scholar
Ma, Z. et al. Analysis of human plasma leptin by radioimmunoassay. Clin. Chem. J.42, 942–946 (1996). CAS Google Scholar
Amos, C.I. Robust variance-components approach for assessing genetic linkage in pedigrees. Am. J. Hum. Genet.54, 535–543 (1994). CASPubMedPubMed Central Google Scholar
Hopper, J.L. & Mathews, J.D. Extensions to multivariate normal models for pedigree analysis. Ann. Hum. Genet.46, 373–383 (1982). ArticleCASPubMed Google Scholar
Blangero, J. & Almasy, L.A. SOLAR: Sequential Oligogenic Linkage Analysis Routines. Population Genetics Laboratory Technical Report No. 6, Southwest Foundation for Biomedical Research, San Antonio, Texas (1996).
Lange, K. Weeks, D. & Boehnke, M. Programs for pedigree analysis: Mendel, Fisher, and dGene. Genet. Epidemiol.5, 471–472 (1988). ArticleCASPubMed Google Scholar
Davis, S. Schoeder, M. Goldin, L.R. & Weeks, D.E. Nonparametric simulation-based statistics for detecting linkage in general pedigrees. Am. J. Hum. Genet.58, 867–880 (1996). CASPubMedPubMed Central Google Scholar
Fulker, D.W. Cherny, S.S. & Cardon, L.R. Multipoint interval mapping of quantitative trait loci, using sib pairs. Am. J. Hum. Genet.56, 1224–1233 (1995). CASPubMedPubMed Central Google Scholar
Green, P. Falls, K. & Crooks, S. Documentation for CRI-MAP. Version 2.4. Department of Genetics, School of Medicine, Washington University, St. Louis (1990).