A broad band of silence (original) (raw)

Nature Genetics volume 38, pages 504–506 (2006)Cite this article

Aberrant methylation of a CpG island in cancer is thought to silence a single gene but not its neighbors. A new study in colon cancer shows that transcriptional silencing can also be unexpectedly diffuse, encompassing all the genes over the 4 Mb of chromosome band 2q14.2, marked by archipelagos of methylated islands and uniform heterochromatin modification.

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Figure 1: Diffuse transcriptional silencing of all known genes on chromosome band 2q14.2 in colon cancer.

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Authors and Affiliations

  1. Department of Neurological Surgery, University of California, San Francisco, 94143, California, USA
    Justin S Smith & Joseph F Costello

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  1. Justin S Smith
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  2. Joseph F Costello
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Smith, J., Costello, J. A broad band of silence.Nat Genet 38, 504–506 (2006). https://doi.org/10.1038/ng0506-504

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