The ciliary proteome database: an integrated community resource for the genetic and functional dissection of cilia (original) (raw)

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• Published: 01 September 2006

Nature Genetics volume 38, pages 961–962 (2006)Cite this article

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To the Editor:

Cilia are specialized organelles found in most species, where they serve diverse roles1. In mammals, ciliary dysfunction has been linked to a number of phenotypes, from motile cilia defects in Kartagener syndrome, to left-right axis specification defects and polycystic kidney disease. Recently, the impact of ciliary dysfunction was expanded with the demonstration that defects in the cilium and its anchoring structure, the basal body, are also associated with pleiotropic phenotypes such as the Bardet-Biedl, Alstrom and Meckel-Gruber syndromes2,3. These observations have highlighted the existence of the ciliopathies, an expanding group of overlapping clinical entities, and have suggested that an improved understanding of the cilium has the potential to inform the genetic and cellular basis of such phenotypes.

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Authors and Affiliations

1. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, 21205, Maryland, USA
   Adrian Gherman, Erica E Davis & Nicholas Katsanis

Authors

1. Adrian Gherman
2. Erica E Davis
3. Nicholas Katsanis

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Gherman, A., Davis, E. & Katsanis, N. The ciliary proteome database: an integrated community resource for the genetic and functional dissection of cilia.Nat Genet 38, 961–962 (2006). https://doi.org/10.1038/ng0906-961

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• Issue Date: 01 September 2006
• DOI: https://doi.org/10.1038/ng0906-961

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