MSH2 deficient mice are viable and susceptible to lymphoid tumours (original) (raw)

• Lynch, H.T. et al. Genetics, natural history, tumor spectrum, and pathology of hereditary nonpolyposis colorectal cancer: an updated review. Gastroenterology 104, 1535–1549 (1993).
  Article CAS PubMed Google Scholar
• Ponz de Leon, M., Sassatelli, R., Benatti, P. & Roncucci, L. Identification of hereditary nonpolyposis colorectal cancer in the general population. The 6-year experience of a population-based registry. Cancer 71, 3493–3501 (1993).
  Article CAS PubMed Google Scholar
• Kee, F. & Collins, B.J. How prevalent is cancer family syndrome? Gut 32, 509–512 (1991).
  Article CAS PubMed PubMed Central Google Scholar
• Cannon Albright, L.A., Skolnick, M.H., Bishop, D.T., Lee, R.G. & Burt, R.W. Common inheritance of susceptibility to colonic adenomatous polyps and associated colorectal cancers. New Engl. J. Med. 319, 533–537 (1988).
  Article CAS PubMed Google Scholar
• Bishop, D.T. & Thomas, H.J. The genetics of colorectal cancer. Cancer Surv. 9, 585–604 (1990).
  CAS PubMed Google Scholar
• Peltomaki, P. et al. Genetic mapping of a locus predisposing to human colorectal cancer. Science 260, 810–812 (1993).
  Article CAS PubMed Google Scholar
• Lindblom, A., Tannergard, P., Werelius, B. & Nordenskjold, M. Genetic mapping of a second locus predisposing to hereditary non-polyposis colon cancer. Nature Genet. 5, 279–282 (1993).
  Article CAS PubMed Google Scholar
• Nystrom-Lahti, M. et al. Mismatch repair genes on chromosomes 2p and 3p account for a major share of hereditary nonpolyposis colorectal cancer families evaluable by linkage. Am. J. hum. Genet. 55, 659–665 (1994).
  CAS PubMed PubMed Central Google Scholar
• Fishel, R. et al. The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. Cell 75, 1027–1038 (1993).
  Article CAS PubMed Google Scholar
• Leach, F.S. et al. Mutations of a MutS homolog in hereditary nonpolyposis colorectal cancer. Cell 75, 1215–1225 (1993).
  Article CAS PubMed Google Scholar
• Bronner, C.E. et al. Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer. Nature 368, 258–261 (1994).
  Article CAS PubMed Google Scholar
• Papadopoulos, N. et al. Mutation of a MutL homolog in hereditary colon cancer. Science 263, 1625–1629 (1994).
  Article CAS PubMed Google Scholar
• Modrich, P. Mechanisms and biological effects of mismatch repair. Annu. Rev. Genet. 25, 229–253 (1991).
  Article CAS PubMed Google Scholar
• Fishel, R. & Kolodner, R.D. Identification of mismatch repair genes and their role in development of cancer. Curr. Opin. Genet. Dev. 5, 382–395 (1995).
  Article CAS PubMed Google Scholar
• Nicolaides, N.C. et al. Mutations of two PMS homologues in hereditary nonpolyposis colon cancer. Nature 371, 75–80 (1994).
  Article CAS PubMed Google Scholar
• Parsons, R., Longley, M., Kinzler, K.W. & Vogelstein, B. Mismatch repair deficiency in phenotypically normal human-cells. Science 268, 738–740 (1995).
  Article CAS PubMed Google Scholar
• Aaltonen, L.A. et al. Clues to the pathogenesis of familial colorectal cancer. Science 260, 812–816 (1993).
  Article CAS PubMed Google Scholar
• Levinson, G. & Gutman, G.A. High frequencies of short frameshifts in poly-CA/TG tandem repeats borne by bacteriophage M13 in Escherichia coli K-12. Nucl. Acids Res. 15, 5323–5338 (1987).
  Article CAS PubMed PubMed Central Google Scholar
• Strand, M., Prolla, T.A., Liskay, R.M. & Petes, T.D. Destabilization of tracts of simple repetitive DMA in yeast by mutations affecting DNA mismatch repair. Nature 365, 274–276 (1993).
  Article CAS PubMed Google Scholar
• Ionov, Y., Peinado, M.A., Malkhosyan, S., Shibata, D. & Perucho, M. Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. Nature 363, 558–561 (1993).
  Article CAS PubMed Google Scholar
• Thibodeau, S.N., Bren, G. & Schaid, D. Microsatellite instability in cancer of the proximal colon. Science 260, 816–819 (1993).
  Article CAS PubMed Google Scholar
• Risinger, J.I. et al. Genetic instability of microsatellites in endometrial carcinoma. Cancer Res. 53, 5100–5103 (1993).
  CAS PubMed Google Scholar
• Young, J. et al. Genomic instability occurs in colorectal carcinomas but not in adenomas. Hum. Mut. 2, 351–354 (1993).
  Article CAS PubMed Google Scholar
• Han, H.J., Yanagisawa, A., Kato, Y., Park, J.G. & Nakamura, Y. Genetic instability in pancreatic cancer and poorly differentiated type of gastric cancer. Cancer Res. 53, 5087–5089 (1993).
  CAS PubMed Google Scholar
• Peltomaki, P. et al. Microsatellite instability is associated with tumors that characterize the hereditary non-polyposis colorectal carcinoma syndrome. Cancer Res. 53, 5853–5855 (1993).
  CAS PubMed Google Scholar
• Gonzalez-Zulueta, M. et al. Microsatellite instability in bladder cancer. Cancer Res. 53, 5620–5623 (1993).
  CAS PubMed Google Scholar
• Rhyu, M.G., Park, W.S. & Meltzer, S.J. Microsatellite instability occurs frequently in human gastric carcinoma. Oncogene 9, 29–32 (1994).
  CAS PubMed Google Scholar
• Wada, C. et al. Genomic instability of microsatellite repeats and its association with the evolution of chronic myelogenous leukemia. Blood 83, 3449–3456 (1994).
  CAS PubMed Google Scholar
• Shridhar, V., Siegfried, J., Hunt, J., del Mar Alonso, M. & Smith, D.I. Genetic instability of microsatellite sequences in many non-small cell lung carcinomas. Cancer Res. 54, 2084–2087 (1994).
  CAS PubMed Google Scholar
• Merlo, A. et al. Frequent microsatellite instability in primary small cell lung cancer. Cancer Res. 54, 2098–2101 (1994).
  CAS PubMed Google Scholar
• Wooster, R. et al. Instability of shorttandem repeats (microsatellites) in human cancers. Nature Genet. 6, 152–156 (1994).
  Article CAS PubMed Google Scholar
• Yee, C.J., Roodi, N., Verrier, C.S. & Parl, F.F. Microsatellite instability and loss of heterozygosity in breast cancer. Cancer Res. 54, 1641–1644 (1994).
  CAS PubMed Google Scholar
• Burks, R.T., Kessis, T.D., Cho, K.R. & Hedrick, L. Microsatellite instability in endometrial carcinoma. Oncogene 9, 1163–1166 (1994).
  CAS PubMed Google Scholar
• Schoenberg, M.P. et al. Microsatellite mutation (CAG24→18) in the androgen receptor gene in human prostate cancer. Biochem. Biophys. Res. Commun. 198, 74–80 (1994).
  Article CAS PubMed Google Scholar
• Honchel, R., Halling, K.C., Schaid, D.J., Pittelkow, M. & Thibodeau, S.N. Microsatellite instability in Muir-Torre syndrome. Cancer Res. 54, 1159–1163 (1994).
  CAS PubMed Google Scholar
• Shibata, D., Peinado, M.A., Ionov, Y., Malkhosyan, S. & Perucho, M. Genomic instability in repeated sequences is an early somatic event in colorectal tumorigenesis that persists after transformation. Nature Genet. 6, 273–281 (1994).
  Article CAS PubMed Google Scholar
• Aaltonen, L.A. et al. Replication errors in benign and malignant tumors from hereditary nonpolyposis colorectal cancer patients. Cancer Res. 54, 1645–1648 (1994).
  CAS PubMed Google Scholar
• Fishel, R., Ewel, A., Lee, S., Lescoe, M.K. & Griffith, J. Binding of mismatched microsatellite DNA sequences by the human MSH2 protein. Science 266, 1403–1405 (1994).
  Article CAS PubMed Google Scholar
• Fishel, R., Ewel, A. & Lescoe, M.K. Purified human MSH2 protein binds to DNA containing mismatched nucleotides. Cancer Res. 54, 5539–5542 (1994).
  CAS PubMed Google Scholar
• Kunkel, T.A. Nucleotide repeats. Slippery DNA and diseases. Nature 365, 207–208 (1993).
  Article CAS PubMed Google Scholar
• Drummond, J.T., Guo-Min, I., Longley, M.J. & Modrich, P. Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells. Science 268, 1909–1912 (1995).
  Article CAS PubMed Google Scholar
• Palombo, F. et al. GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells. Science 268, 1912–1914 (1995).
  Article CAS PubMed Google Scholar
• Papadopoulos, N. et al. Mutations of GTBP in genetically unstable cells. Science 268, 1915–1917 (1995).
  Article CAS PubMed Google Scholar
• Fishel, R.A., Siegel, E.C. & Kolodner, R. Gene conversion in Escherichia coli. Resolution of heteroallelic mismatched nucleotides by co-repair. J. molec. Biol. 188, 147–157 (1986).
  Article CAS PubMed Google Scholar
• Feinstein, S.I. & Low, K.B. Hyper-recombining recipient strains in bacterial conjugation. Genetics 113, 13–33 (1986).
  CAS PubMed PubMed Central Google Scholar
• Jones, M., Wagner, R. & Radman, M. Mismatch repair and recombination in E. coli. Cell 50, 621–626 (1987).
  Article CAS PubMed Google Scholar
• Alani, E., Reenan, R.A. & Kolodner, R.D. Interaction between mismatch repair and genetic recombination in Saccharomyces cerevisiae. Genetics 137, 19–39 (1994).
  CAS PubMed PubMed Central Google Scholar
• Rayssiguier, C., Thaler, D.S. & Radman, M. The barrier to recombination between Escherichia coli and Salmonella typhimurium is disrupted in mismatch-repair mutants. Nature 342, 396–401 (1989).
  Article CAS PubMed Google Scholar
• Selva, E.M., New, L. & Lahue, R.S. Mismatch correction acts as a barrier to homeologous recombination in saccharomyces-cerevisiae. Genetics 139, 1175–1188H1 Amge (1995).
  CAS PubMed PubMed Central Google Scholar
• Loeb, L.A. Mutator phenotype may be required for multistage carcinogenesis. Cancer Res. 51, 3075–3079 (1991).
  CAS PubMed Google Scholar
• Baker, S.M. et al. Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis. Cell 82, 302–319 (1995).
  Article Google Scholar
• Lynch, H.T. et al. Hereditary colorectal cancer. Semin. Oncol. 18, 337–366 (1991).
  CAS PubMed Google Scholar
• Cohen, P.R. Muir-Torre syndrome in patients with hematologic malignancies. Am. J. Hemat. 40, 64–65 (1992).
  Article CAS PubMed Google Scholar
• Hamilton, S.R. et al. The molecular-basis of Turcots-syndrome. New Engl. J. Med. 332, 839–847 (1995).
  Article CAS PubMed Google Scholar
• Parsons, R. et al. Hypermutability and mismatch repair deficiency in RER+ tumor cells. Cell 75, 1227–1236 (1993).
  Article CAS PubMed Google Scholar
• Bhattacharyya, N.P., Skandalis, A., Ganesh, A., Groden, J. & Meuth, M. Mutator phenotypes in human colorectal carcinoma cell lines. Proc. natn. Acad. Sci. U.S.A. 91, 6319–6323 (1994).
  Article CAS Google Scholar
• Croce, C.M. Role of chromosome translocations in human neoplasia. Cell 49, 155–156 (1987).
  Article CAS PubMed Google Scholar
• Teich, N., Wyke, J., Mak, T., Bernstein, A. & Hardy, W. Pathogenesis of Retrovirous Induced Disease in RNA tumor viruses. (eds Weiss, R., Teich, N., Varmus, H. & Coffin, J.) 785–998 (Cold Spring Harbor Laboratory, Cold Spring Harbor, 1984).
  Google Scholar
• Tybulewicz, V.L., Crawford, C.E., Jackson, P.K., Bronson, R.T., Mulligan, R.C. Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene. Cell 65, 1153–1163 (1991).
  Article CAS PubMed Google Scholar
• Fung Leung, W.P. et al. CD8 is needed for development of cytotoxic T cells but not helper T cells. Cell 65, 443–449 (1991).
  Article CAS PubMed Google Scholar
• Bradley, A., Evans, M., Kaufman, M.H., Robertson, E. Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines. Nature 309, 255–256 (1984).
  Article CAS PubMed Google Scholar
• Bradley, A. & Robertson, E. Embryo-derived stem cells: atool for elucidating the developmental genetics of the mouse. Curr. Top. Dev. Biol. 20, 357–371 (1986).
  Article CAS PubMed Google Scholar
• Thomas, K.R. & Capecchi, M.R. Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell 51, 503–512 (1987).
  Article CAS PubMed Google Scholar
• Thompson, S., Clarke, A.R., Pow, A.M., Hooper, M.L., Melton, D.W. Germ line transmission and expression of a corrected HPRT gene produced by gene targeting in embryonic stem cells. Cell 56, 313–321 (1989).
  Article CAS PubMed Google Scholar
• Maniatis, T., Fritsch, E.F. & Sambrook, J. Molecular Cloning. (Cold Spring Harbor Laboratory, Cold Spring Harbor, 1982).
  Google Scholar