A role for the Rb family of proteins in controlling telomere length (original) (raw)

• Blackburn, E.H. Switching and signaling at the telomere. Cell 106, 661–673 (2001).
  Article CAS Google Scholar
• Chan, S.W.-L. & Blackburn, E.H. New ways not to make ends meet: telomerase, DNA damage proteins and heterochromatin. Oncogene 21, 553–563 (2002).
  Article CAS Google Scholar
• de Lange, T. Protection of mammalian telomeres. Oncogene 21, 532–540 (2002).
  Article CAS Google Scholar
• Goytisolo, F.A. & Blasco, M.A. Many ways to telomere dysfunction: in vivo studies using mouse models. Oncogene 21, 584–591 (2002).
  Article CAS Google Scholar
• Harley, C.B., Futcher, A.B. & Greider, C.W. Telomeres shorten during ageing of human fibroblasts. Nature 31, 458–460 (1990).
  Article Google Scholar
• Collins, K. & Mitchell, J.R. Telomerase in the human organism. Oncogene 21, 564–579 (2002).
  Article CAS Google Scholar
• Blasco, M.A. et al. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 91, 25–34 (1997).
  Article CAS Google Scholar
• Lee, H.-W. et al. Essential role of mouse telomerase in highly proliferative organs. Nature 392, 569–574 (1998).
  Article CAS Google Scholar
• Samper, E., Flores, J.M. & Blasco, M.A. Restoration of telomerase activity rescues chromosomal instability and premature aging in _Terc_−/− mice with short telomeres. EMBO Reports 2, 800–807 (2001).
  Article CAS Google Scholar
• Hemann, M.T., Strong, M.A., Hao, L.Y. & Greider, C.W. The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability. Cell 107, 67–77 (2001).
  Article CAS Google Scholar
• Bodnar, A.G. et al. Extension of life-span by introduction of telomerase into normal human cells. Science 279, 349–352 (1998).
  Article CAS Google Scholar
• Kiyono, T. et al. Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells. Nature 396, 84–88 (1998).
  Article CAS Google Scholar
• Farwell, D.G. et al. Genetic and epigenetic changes in human epithelial cells immortalized by telomerase. Am. J. Pathol. 156, 1537–1547 (2000).
  Article CAS Google Scholar
• Stoppler, H., Hartmann, D.P., Sherman, L. & Schlegel, R. The human papillomavirus type 16 E6 and E7 oncoproteins dissociate cellular telomerase activity from the maintenance of telomere length. J. Biol. Chem. 272, 13332–13337 (1997).
  Article CAS Google Scholar
• Sage, J. et al. Targeted disruption of the three Rb-related genes leads to loss of G1 control and immortalization. Genes Dev. 14, 3037–3050 (2000).
  Article CAS Google Scholar
• van Steensel, B., Smogorzewska, A. & de Lange, T. TRF2 protects human telomeres from end-to-end fusions. Cell 92, 401–413 (1998).
  Article CAS Google Scholar
• Samper, E., Goytisolo, F., Slijepcevic, P., van Buul, P. & Blasco, M.A. Mammalian Ku86 prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang. EMBO Reports 1, 244–252 (2000).
  Article CAS Google Scholar
• Goytisolo, F., Samper, E., Edmonson, S., Taccioli, G.E. & Blasco, M.A. Absence of DNA-PKcs in mice results in anaphase bridges and in increased telomeric fusions with normal telomere length and G-strand overhang. Mol. Cell. Biol. 21, 3642–3651 (2001).
  Article CAS Google Scholar
• Hande, P.M., Samper, E., Lansdorp, P. & Blasco, M.A. Telomere length dynamics in cultured cells from normal and telomerase-null mice. J. Cell Biol. 144, 589–601 (1999).
  Article CAS Google Scholar
• Chong, L. et al. A human telomeric protein. Science 270, 1663–1667 (1995).
  Article CAS Google Scholar
• Smogorzewska, A. et al. Control of human telomere length by TRF1 and TRF2. Mol. Cell. Biol. 20, 1659–1668 (2000).
  Article CAS Google Scholar
• van Steensel, B. & de Lange, T. Control of telomere length by the human telomeric protein TRF1. Nature 385, 740–743 (1997).
  Article CAS Google Scholar
• Espejel, S. et al. Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres. EMBO J. 21, 2207–2219 (2002).
  Article CAS Google Scholar
• Henson, J.D., Neumann, A.A., Yeager, T.R. & Reddel, R.R. Alternative lengthening of telomeres in mammalian cells. Oncogene 21, 598–610 (2002).
  Article CAS Google Scholar
• Perrem, K., Colgin, L.M., Neumann, A.A., Yeager, T.R. & Reddel, R.R. Co-existence of alternative lengthening of telomeres and telomerase in hTERT-transfected GM847 cells. Mol. Cell. Biol. 21, 3862–3875 (2001).
  Article CAS Google Scholar
• Murga, M. et al. Mutation of the E2F2 in mice causes enhanced T lymphocyte proliferation, leading to the development of autoimmunity. Immunity 15, 959–970 (2001).
  Article CAS Google Scholar
• McIlrath, J.S. et al. Telomere length abnormalities in mammalian radiosensitive cells. Cancer Res. 61, 912–915 (2001).
  CAS PubMed Google Scholar
• Herrera, E. et al. Disease states associated with telomerase deficiency appear earlier in mice with short telomeres. EMBO J. 18, 2950–2960 (1999).
  Article CAS Google Scholar
• Zijlmans, J.M. et al. Telomeres in the mouse have large inter-chromosomal variations in the number of T2AG3 repeats. Proc. Natl Acad. Sci. USA 94, 7423–7428 (1997).
  Article CAS Google Scholar