A Robertsonian translocation suppresses a somatic recombination pathway to loss of heterozygosity (original) (raw)

• Fearnhead, N.S., Britton, M.P. & Bodmer, W.F. The ABC of APC. Hum. Mol. Genet. 10, 721–733 (2001).
  Article CAS Google Scholar
• Tucker, M., Goldstein, A., Dean, M. & Knudson, A. National Cancer Institute Workshop: the phakomatoses revisited. J. Natl. Cancer Inst. 92, 530–533 (2000).
  Article CAS Google Scholar
• Shoemaker, A.R., Gould, K.A., Luongo, C., Moser, A.R. & Dove, W.F. Studies of neoplasia in the Min mouse. Biochim. Biophys. Acta 1332, F25–F48 (1997).
  CAS PubMed Google Scholar
• Luongo, C., Moser, A.R., Gledhill, S. & Dove, W.F. Loss of Apc+ in intestinal adenomas from Min mice. Cancer Res. 54, 5947–5952 (1994).
  CAS PubMed Google Scholar
• Shoemaker, A.R. et al. A resistant genetic background leading to incomplete penetrance of intestinal neoplasia and reduced loss of heterozygosity in _Apc_Min/+ mice. Proc. Natl. Acad. Sci. USA 95, 10826–10831 (1998).
  Article CAS Google Scholar
• Haigis, K.M., Caya, J.G., Reichelderfer, M. & Dove, W.F. Intestinal adenomas can develop with a stable karyotype and stable microsatellites. Proc. Natl. Acad. Sci. USA 99, 8927–8931 (2002).
  Article CAS Google Scholar
• Robertson, W.M.R.B. Chromosome studies. I. Taxonomic relationship shown in the chromosomes of Tettegidae and Acrididiae: V-shaped chromosomes and their significance in Acrididiae, Locustidae and Grillidae: chromosome variations. J. Morphol. 27, 179–331 (1916).
  Article Google Scholar
• Gropp, A. et al. Robertsonian karyotype variation in wild house mice from Rhaeto-Lombardia. Cytogenet. Cell Genet. 34, 67–77 (1982).
  Article CAS Google Scholar
• Lane, P.W. & Eicher, E.M. Location of plucked (pk) on chromosome 18 of the mouse. J. Hered. 76, 476–477 (1985).
  Article CAS Google Scholar
• Eppig, J.T. & Eicher, E.M. Analysis of recombination in the centromere region of mouse chromosome 7 using ovarian teratoma and backcross methods. J. Hered. 79, 425–429 (1988).
  Article CAS Google Scholar
• Wallace, B.M.N., Searle, J.B. & Everett, C.A. Male meiosis and gametogenesis in wild house mice (Mus musculus domesticus) from a chromosomal hybrid zone; a comparison between “simple” Robertsonian heterozygotes and homozygotes. Cytogenet. Cell Genet. 61, 211–220 (1992).
  Article CAS Google Scholar
• Davisson, M.T. & Akeson, E.C. Recombination suppression by heterozygous Robertsonian chromosomes in the mouse. Genetics 133, 649–667 (1993).
  CAS PubMed PubMed Central Google Scholar
• Dunnett, C.W. Pairwise multiple comparisons in homogeneous variance, unequal sample size case. J. Am. Stat. Assn. 75, 789–795 (1980).
  Article Google Scholar
• Falconer, D.S. & Mackay, T.F.C. Introduction to Quantitative Genetics (Longman, Harlow, Essex, 1996).
  Google Scholar
• Shoemaker, A.R. et al. Mlh1 deficiency enhances several phenotypes of _Apc_Min/+ mice. Oncogene 19, 2774–2779 (2000).
  Article CAS Google Scholar
• Gould, K.A., Dietrich, W.F., Borenstein, N., Lander, E.S. & Dove, W.F. Mom1 is a semi-dominant modifier of intestinal adenoma size and multiplicity in Min/+ mice. Genetics 144, 1769–1776 (1996).
  CAS PubMed PubMed Central Google Scholar
• Cormier, R.T. & Dove, W.F. _Dnmt1_N/+ reduces the net growth rate and multiplicity of intestinal adenomas in C57BL/6-multiple intestinal neoplasia (Min)/+ mice independently of p53 but demonstrates strong synergy with the modifier of Min-1 (AKR) resistance allele. Cancer Res. 60, 3965–3970 (2000).
  CAS PubMed Google Scholar
• Merritt, A.J., Gould, K.A. & Dove, W.F. Polyclonal structure of intestinal adenomas in _Apc_Min/+ mice with concomitant loss of Apc+ from all tumor lineages. Proc. Natl. Acad. Sci. USA 94, 13927–13931 (1997).
  Article CAS Google Scholar
• Novelli, M.R. et al. Polyclonal origin of colonic adenomas in an XO/XY patient with FAP. Science 272, 1187–1190 (1996).
  Article CAS Google Scholar
• Shao, C., Stambrook, P.J. & Tischfield, J.A. Mitotic recombination is suppressed by chromosomal divergence in hybrids of distantly related mouse strains. Nat. Genet. 28, 169–172 (2001).
  Article CAS Google Scholar
• Rothstein, R., Michel, B. & Gangloff, S. Replication fork pausing and recombination or “gimme a break.” Genes Dev. 14, 1–10 (2000).
  CAS PubMed Google Scholar
• Kuzminov, A. DNA replication meets genetic exchange: chromosomal damage and its repair by homologous recombination. Proc. Natl. Acad. Sci. USA 98, 8461–8468 (2001).
  Article CAS Google Scholar
• Luo, G. et al. Cancer predisposition caused by elevated mitotic recombination in Bloom mice. Nat. Genet. 26, 424–429 (2000).
  Article CAS Google Scholar
• Morrison, C. et al. Genetic interaction between PARP and DNA-PK in V(D)J recombination and tumorigenesis. Nat. Genet. 17, 479–482 (1997).
  Article CAS Google Scholar
• Shao, C. et al. Chromosome instability contributes to loss of heterozygosity in mice lacking p53. Proc. Natl. Acad. Sci. USA 97, 7405–7410 (2000).
  Article CAS Google Scholar
• Johnson, R.D. & Jasin, M. Double-strand-break-induced homologous recombination in mammalian cells. Biochem. Soc. Trans. 29, 196–201 (2001).
  Article CAS Google Scholar
• Turker, M.S. et al. Solid tissues removed from ATM homozygous deficient mice do not exhibit a mutator phenotype for second-step autosomal mutations. Cancer Res. 59, 4781–4783 (1999).
  CAS PubMed Google Scholar
• de Wind, N., Dekker, M., Berns, A., Radman, M. & te Riele, H. Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer. Cell 82, 321–330 (1995).
  Article CAS Google Scholar
• Merriam, J.R. & Garcia-Bellido, A. A model for somatic pairing derived from somatic crossing over with third chromosome rearrangements in Drosophila melanogaster. Mol. Gen. Genet. 115, 294–301 (1972).
  Article CAS Google Scholar
• Garcia-Bellido, A. & Wandosell, F. The effect of inversions on mitotic recombination in Drosophila melanogaster. Mol. Gen. Genet. 161, 317–321 (1978).
  Article CAS Google Scholar
• Silver, L.M. & Artzt, K. Recombination suppression of mouse t-haplotypes due to chromatin mismatching. Nature 290, 68–70 (1981).
  Article CAS Google Scholar
• Lengauer, C., Kinzler, K.W. & Vogelstein, B. Genetic instability in colorectal cancers. Nature 386, 623–627 (1997).
  Article CAS Google Scholar
• Marx, J. Debate surges over the origin of genomic defects in cancer. Science 297, 544–546 (2002).
  Article CAS Google Scholar
• Nielsen, J. & Wohlert, M. Chromosome abnormalities found among 34,910 newborn children: results from a 13-year incidence study in Arhus, Denmark. Hum. Genet. 87, 81–83 (1991).
  Article CAS Google Scholar
• Frydman, N. et al. Assisting reproduction of infertile men carrying a Robertsonian translocation. Hum. Reprod. 16, 2274–2277 (2001).
  Article CAS Google Scholar
• Brasch, J.M. & Smith, D.R. Absence of silver bands in human Robertsonian translocation chromosomes. Cytogenet. Cell Genet. 24, 122–125 (1979).
  Article CAS Google Scholar
• Hagstrom, S.A. & Dryja, T.P. Mitotic recombination map of 13cen–13q14 derived from an investigation of loss of heterozygosity in retinoblastoma. Proc. Natl. Acad. Sci. USA 96, 2952–2957 (1999).
  Article CAS Google Scholar
• Harbour, J.W. Molecular basis of low-penetrance retinoblastoma. Arch. Ophthalmol. 119, 1699–1704 (2001).
  Article CAS Google Scholar
• Shaffer, L.G. & Lupski, J.R. Molecular mechanisms for constitutional chromosomal rearrangements in humans. Annu. Rev. Genet. 34, 297–329 (2000).
  Article CAS Google Scholar
• Su, L.K. et al. Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene. Science 256, 668–670 (1992).
  Article CAS Google Scholar
• Davisson, M.T. & Akeson, E.C. An improved method for preparing G-banded chromosomes from mouse peripheral blood. Cytogenet. Cell Genet. 45, 70–74 (1987).
  Article CAS Google Scholar
• Jacoby, R.F. et al. A juvenile polyposis tumor suppressor locus at 10q22 is deleted from non-epithelial cells in the lamina propria. Gastroenterology 112, 1398–1403 (1997).
  Article CAS Google Scholar
• Bridger, J.M., Herrmann, H., Münkel, C. & Lichter, P. Identification of an interchromosomal compartment by polymerization of nuclear-targeted vimentin. J. Cell Sci. 111, 1241–1253 (1998).
  CAS PubMed Google Scholar