DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells (original) (raw)

• Jones, P.A. & Baylin, S.B. The fundamental role of epigenetic events in cancer. Nat. Rev. Genet. 3, 415–428 (2002).
  Article CAS PubMed Google Scholar
• Esteller, M. & Herman, J.G. Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours. J. Pathol. 196, 1–7 (2002).
  Article CAS PubMed Google Scholar
• Rountree, M.R., Bachman, K.E., Herman, J.G. & Baylin, S.B. DNA methylation, chromatin inheritance, and cancer. Oncogene 20, 3156–3165 (2001).
  Article CAS PubMed Google Scholar
• Robertson, K.D. DNA methylation, methyltransferases, and cancer. Oncogene 20, 3139–3155 (2001).
  Article CAS PubMed Google Scholar
• Li, E., Bestor, T.H. & Jaenisch, R. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69, 915–926 (1992).
  Article CAS PubMed Google Scholar
• Laird, P.W. et al. Suppression of intestinal neoplasia by DNA hypomethylation. Cell 81, 197–205 (1995).
  Article CAS PubMed Google Scholar
• Fournel, M., Sapieha, P., Beaulieu, N., Besterman, J.M. & MacLeod, A.R. Downregulation of human DNA-(cytosine-5) methyltransferase induces cell cycle regulators p16(ink4A) and p21(WAF/Cip1) by distinct mechanisms. J. Biol. Chem. 274, 24250–24256 (1999).
  Article CAS PubMed Google Scholar
• Rhee, I. et al. CpG methylation is maintained in human cancer cells lacking DNMT1. Nature 404, 1003–1007 (2000).
  Article CAS PubMed Google Scholar
• Rhee, I. et al. DNMT1 and DNMT3b cooperate to silence genes in human cancer cells. Nature 416, 552–556 (2002).
  Article CAS PubMed Google Scholar
• Beaulieu, N. et al. An essential role for DNA methyltransferase DNMT3B in cancer cell survival. J. Biol. Chem. 277, 28176–28181 (2002).
  Article CAS PubMed Google Scholar
• Okano, M., Bell, D.W., Haber, D.A. & Li, E. DNA methyltransferases DNMT3a and DNMT3b are essential for de novo methylation and mammalian development. Cell 99, 247–257 (1999).
  Article CAS PubMed Google Scholar
• Li, E., Beard, C. & Jaenisch, R. Role for DNA methylation in genomic imprinting. Nature 366, 362–365 (1993).
  Article CAS PubMed Google Scholar
• Yoder, J.A., Soman, N.S., Verdine, G.L. & Bestor, T.H. DNA (cytosine-5)- methyltransferases in mouse cells and tissues. Studies with a mechanism-based probe. J. Mol. Biol. 270, 385–395 (1997).
  Article CAS PubMed Google Scholar
• Gonzalez-Zulueta, M. et al. Methylation of the 5′ CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing. Cancer Res. 55, 4531–4535 (1995).
  CAS PubMed Google Scholar
• Merlo, A. et al. 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nat. Med. 1, 633–634 (1995).
  Article Google Scholar
• Myohanen, S.K., Baylin, S.B. & Herman, J.G. Hypermethylation can selectively silence individual CDKN2A alleles in neoplasia. Cancer Res. 58, 591–593 (1998).
  CAS PubMed Google Scholar
• Herman, J.G. et al. Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc. Natl. Acad. Sci. USA 95, 6870–6875 (1999).
  Article Google Scholar
• Kane, M.F. et al. Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair–defective human tumor cell lines. Cancer Res. 57, 808–811 (1997).
  CAS PubMed Google Scholar
• Leung, S.Y. et al. hMLH1 promoter methylation and lack of hMLH1 expression in sporadic gastric carcinomas with high-frequency microsatellite instability. Cancer Res. 59, 159–164 (1999).
  CAS PubMed Google Scholar
• Pogribny, I., Yi, P. & James, S.J. A sensitive new method for rapid detection of abnormal methylation patterns in global DNA and within CpG islands. Biochem. Biophys. Res. Commun. 262, 624–628 (1999).
  Article CAS PubMed Google Scholar
• Jutterman, R., Li, E. & Jaenisch, R. Toxicity of 5-aza-2′-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation. Proc. Natl. Acad. Sci. USA 981, 11797 (1994).
• Christman, J.K., Schneiderman, N. & Acs, G. Formation of highly stable complexes between 5-azacytosine-substituted DNA and specific non-histone nuclear proteins. Implications for 5-azacytidine-mediated effects on DNA methylation and gene expression. J. Biol. Chem. 260, 4059–4068 (1985).
  CAS PubMed Google Scholar
• Haaf, T. & Schmid, M. 5′-Azadeoxycytidine-induced undercondensation in the giant X chromosomes of Microtus agrestis. Chromosoma 98, 93–98 (1989).
  Article CAS PubMed Google Scholar
• Haaf, T. The effects of 5-azacytidine and 5-azadeoxycytidine on chromosome structure and function: implications for methylation-associated cellular processes. Pharmacol. Ther. 65, 19–46 (1995).
  Article CAS PubMed Google Scholar
• Liang, G. et al. Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements. Mol. Cell Biol. 22, 480–491 (2002).
  Article CAS PubMed PubMed Central Google Scholar
• Jonkers, J. & Berns, A. Conditional mouse models of sporadic cancer. Nat. Rev. Cancer 2, 251–265 (2002).
  Article CAS PubMed Google Scholar
• Bachman, K.E., Rountree, M.R. & Baylin, S.B. Dnmt3a and Dnmt3b are transcriptional repressors that exhibit unique localization properties to heterochromatin. J. Biol. Chem. 276, 32282–32287 (2001).
  Article CAS PubMed Google Scholar
• Margot, J.B., Cardoso, M.C. & Leonhardt, H. Mammalian DNA methyltransferases show different subnuclear distributions. J. Cell. Biochem. 83, 373–379 (2001).
  Article CAS PubMed Google Scholar
• Herman, J.G., Graff, J.R., Myohanen, S., Nelkin, B.D. & Baylin, S.B. Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc. Natl. Acad. Sci. USA 93, 9821–9826 (1996).
  Article CAS PubMed PubMed Central Google Scholar
• Agathanggelou, A. et al. Methylation-associated inactivation of RASSF1A from region 3p21.3 in lung, breast and ovarian tumours. Oncogene 20, 1509–1518 (2001).
  Article CAS PubMed Google Scholar