An international two–stage genome–wide search for schizophrenia susceptibility genes (original) (raw)

• Letter
• Published: 01 November 1995
• L. Yang1,
• H. Kristbjarnarson2,
• C. Wiese1,
• W. Byerley3,
• F. Macciardi4,
• V. Arolt5,
• D. Blackwood6,
• X. Liu7,
• B. Sjögren8,
• H.N. Aschauer9,
• H.-G. Hwu10,
• K. Jang11,
• W.J. Livesley11,
• J.L. Kennedy12,
• T. Zoega2,
• O. Ivarsson2,
• M.-T. Bui1,
• M.-H. Yu1,
• B. Havsteen13,
• D. Commenges14,
• J. Weissenbach15,
• E. Schwinger16,
• I.I. Gottesman17,
• A.J. Pakstis18,
• L. Wetterberg8,
• K.K. Kidd18 &
• …
• T. Helgason2

Nature Genetics volume 11, pages 321–324 (1995)Cite this article

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Abstract

Schizophrenia is thought to be a multifactorial disease with complex mode of inheritance1,2. Using a two-stage strategy for another complex disorder, a number of putative IDDM-susceptibility genes have recently been mapped3. We now report the results of a two-stage genome-wide search for genes conferring susceptibility to schizophrenia. In stage I, model-free linkage analyses of large pedigrees from Iceland, a geographical isolate, revealed 26 loci suggestive of linkage. In stage II, ten of these were followed-up in a second international collaborative study comprising families from Austria, Canada, Germany, Italy, Scotland, Sweden, Taiwan and the United States. Potential linkage findings of stage I on chromosomes 6p, 9 and 20 were observed again in the second sample. Furthermore, in a third sample from China, fine mapping of the 6p region by association studies also showed evidence for linkage or linkage disequilibrium. Combining our results with other recent findings4,5 revealed significant evidence for linkage to an area distal of the HLA region on chromosome 6p. However, in a fourth sample from Europe, the 6p fine mapping finding observed in the Chinese sample could not be replicated. Finally, evidence suggestive of locus heterogeneity and oligogenic transmission in schizophrenia was obtained.

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Authors and Affiliations

1. Dept. of Psych., Kiel Univ Hosp., Niemannsweg 147, 24105, Kiel, Germany
   H.W. Moises, L. Yang, C. Wiese, M.-T. Bui & M.-H. Yu
2. Dept. of Psych., Natl Univ Hosp., Reykjavik, 121, Iceland
   H. Kristbjarnarson, T. Zoega, O. Ivarsson & T. Helgason
3. Dept. of Psych., Univ. of Utah, Salt Lake City, UT, 84132, USA
   W. Byerley
4. Dept. of Neurosci., Scientific Inst. Hosp. St. Raffael, Univ. of Milan, Milan, 20127, Italy
   F. Macciardi
5. Dept. of Psych., Med. Univ. at Lübeck, Lübeck, 23538, Germany
   V. Arolt
6. Dept. of Psych., Univ. of Edinburgh, Edinburgh, EH10 5HF, UK
   D. Blackwood
7. Dept. of Psych. Research, West China Univ. of Med. Sci., Chengdu, Sichuan, 610041, China
   X. Liu
8. Dept. of Psych., Karolinska Inst., St. Göran's Hosp., Stockholm, 11281, Sweden
   B. Sjögren & L. Wetterberg
9. Dept. of General Psych., Vienna Univ. Hosp., Vienna, 1090, Austria
   H.N. Aschauer
10. Dept. of Psych., Natl. Taiwan Univ. Hosp., Taipei, 100, Taiwan
    H.-G. Hwu
11. Dept. of Psych., Univ. of British Columbia, Vancouver, BC, V6T 2A1, Canada
    K. Jang & W.J. Livesley
12. Clarke Inst. of Psych., Univ. of Toronto, Ontario, M5T 1R8, Canada
    J.L. Kennedy
13. Dept. of Biochem., Kiel Univ., Kiel, 24118, Germany
    B. Havsteen
14. I'INSERM, Université de Bordeaux II, Bordeaux, France
    D. Commenges
15. Généthon, 91000, Evry, France
    J. Weissenbach
16. Dept. of Human Genetics, Med Univ at Lübeck, Lübeck, 23538, Germany
    E. Schwinger
17. Dept. of Psych., Univ. of Virginia, Charlottesville, VA, 22903, USA
    I.I. Gottesman
18. Dept. of Genetics, Yale Univ. School of Medicine, New Haven, CT, 06510, USA
    A.J. Pakstis & K.K. Kidd

Authors

1. H.W. Moises
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2. L. Yang
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3. H. Kristbjarnarson
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4. C. Wiese
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5. W. Byerley
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6. F. Macciardi
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7. V. Arolt
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8. D. Blackwood
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9. X. Liu
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10. B. Sjögren
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11. H.N. Aschauer
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12. H.-G. Hwu
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13. K. Jang
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14. W.J. Livesley
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15. J.L. Kennedy
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16. T. Zoega
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17. M.-T. Bui
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18. M.-H. Yu
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19. B. Havsteen
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20. D. Commenges
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21. J. Weissenbach
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22. E. Schwinger
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23. I.I. Gottesman
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24. A.J. Pakstis
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25. L. Wetterberg
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26. K.K. Kidd
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27. T. Helgason
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Moises, H., Yang, L., Kristbjarnarson, H. et al. An international two–stage genome–wide search for schizophrenia susceptibility genes.Nat Genet 11, 321–324 (1995). https://doi.org/10.1038/ng1195-321

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• Received: 02 June 1995
• Accepted: 30 August 1995
• Issue Date: 01 November 1995
• DOI: https://doi.org/10.1038/ng1195-321

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