Growth and specification of the eye are controlled independently by Eyegone and Eyeless in Drosophila melanogaster (original) (raw)

References

  1. Martinez, S. The isthmic organizer and brain regionalisation. Int. J. Dev. Biol. 45, 367–371 (2001).
    CAS Google Scholar
  2. Ohuchi, H. & Noji, S. Fibroblast-growth-factor induced additional limbs in the study of initiation of limb formation, limb identity, myogenesis, and innervation. Cell. Tissue Res. 199, 247–261 (1999).
    Google Scholar
  3. Irvine, K.D. & Rauskolb, C. Boundaries in development: formation and function. Annu. Rev. Cell Dev. Biol. 17, 189–214 (2001).
    Article CAS Google Scholar
  4. Neumann, C. & Cohen, S. Morphogens and pattern formation. Bioessays 19, 721–729 (1997).
    Article CAS Google Scholar
  5. Dahl, E., Koseki, H. & Balling, R. Pax genes and organogenesis. Bioessays 18, 755–765 (1997).
    Article Google Scholar
  6. Chi, N. & Epstein, J. Getting your Pax straight: Pax proteins in development and disease. Trends Genet. 18, 41–47 (2002).
    Article CAS Google Scholar
  7. Das, P. et al. Haploinsufficiency of PAX9 is associated with autosomal dominant hypodontia. Hum. Genet. 110, 371–376 (2002).
    Article CAS Google Scholar
  8. Glaser, T. et al. PAX6 gene dosage effect in a family with congenital cataracts, aniridia, anophthalmia and central nervous system defects. Nat. Genet. 7, 463–471 (1994).
    Article CAS Google Scholar
  9. Ton, C.T. et al. Positional cloning and characterisation of a paired box- and homeobox-containing gene from aniridia region. Cell 68, 491–505 (1991).
    Google Scholar
  10. van Heyningen, V. & Williamson, K. PAX6 in sensory development. Hum. Mol. Genet. 11, 1161–1167 (2002).
    Article CAS Google Scholar
  11. Cillo, C., Cantile, M., Faiella, A. & Boncinelli, E. Homeobox genes in normal and malignant cells. J. Cell Physiol. 188, 161–169 (2001).
    Article CAS Google Scholar
  12. Gnarra, J.R. & Dressler, G.R. Expression of Pax-2 in human renal cell carcinoma and growth inhibition by antisense oligonucleotides. Cancer Res. 55, 4092–4098 (1995).
    CAS Google Scholar
  13. Scholl, F.A. et al. PAX3 is expressed in human melanomas and contributes to tumor cells survival. Cancer Res. 61, 823–826 (2001).
    CAS Google Scholar
  14. Winyard, P.J. et al. The PAX2 transcription factor is expressed in cystic and hyperproliferative dysplastic epithelium in human kidney malformations. J. Clin. Invest. 98, 451–459 (1996).
    Article CAS Google Scholar
  15. Kroll, T.G. et al. PAX8-PPARgamma1 fusion oncogene in human thyroid carcinoma. Science 289, 1357–1360 (2000).
    Article CAS Google Scholar
  16. Maulbecker, C.C. & Gruss, P. The oncogenic potential of Pax genes. EMBO J. 12, 2361–2367 (1993).
    Article CAS Google Scholar
  17. Steinbach, J.P., Kozmik, Z., Pfeffer, P. & Aguzzi A. Overexpression of Pax5 is not sufficient for neoplastic transformation of mouse neuroectoderm. Int. J. Cancer 15, 459–467 (2001).
    Article Google Scholar
  18. Czerny, T., Schaffner, G. & Busslinger, M. DNA sequence recognition by Pax proteins: bipartite structure of the paired domain and its binding site. Genes Dev. 7, 2048–2061 (1993).
    Article CAS Google Scholar
  19. Epstein, J. et al. Two independent and interactive DNA-binding subdomains of the Pax6 paired domain are regulated by alternative splicing. Genes Dev. 8, 2022–2034 (1994).
    Article CAS Google Scholar
  20. Kozmik, Z., Czerny, T. & Busslinger, M. Alternatively spliced insertions in the paired domain restrict the DNA sequence specificity of Pax6 and Pax8. EMBO J. 16, 6793–6803 (1997).
    Article CAS Google Scholar
  21. Cavodeassi, F., Diez del Corral, R., Campuzano, S. & Dominguez, M. Compartments and organizing boundaries in the Drosophila eye: the role of the homeodomain Iroquois proteins. Development 126, 4933–4942 (1999).
    CAS Google Scholar
  22. Yang, C., Simon, M.A. & McNeill, H. mirror controls planar polarity and equator formation through repression of fringe expression and through control of cell affinities. Development 126, 5857–5866 (1999).
    CAS Google Scholar
  23. Cho, K.O. & Choi, K.W. Fringe is essential for mirror symmetry and morphogenesis in the Drosophila eye. Nature 396, 272–276 (1998).
    Article CAS Google Scholar
  24. Dominguez, M. & de Celis, J.F. A dorsal/ventral boundary established by Notch controls growth and polarity in the Drosophila eye. Nature 396, 276–278 (1998).
    Article CAS Google Scholar
  25. Papayannopoulos, V., Tomlinson, A., Panin, V.M., Rauskolb, C. & Irvine, K.D. Dorsal-ventral signaling in the Drosophila eye. Science 281, 2031–2034 (1998).
    Article CAS Google Scholar
  26. Quiring, R., Walldorf, U., Kloter, U. & Gehring, W.J. Homology of the eyeless gene of Drosophila to the Small eye gene in mice and Aniridia in humans. Science 265, 785–789 (1994).
    Article CAS Google Scholar
  27. Czerny, T. et al. Twin of eyeless, a second Pax-6 gene in Drosophila, acts upstream of eyeless in the control of eye development. Mol. Cell 3, 297–307 (1999).
    Article CAS Google Scholar
  28. Halder, G., Callaerts, P. & Gehring, W.J. Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila. Science 267, 1788–1792 (1995).
    Article CAS Google Scholar
  29. Onuma, Y., Takahashi, S., Asashima, M., Kurata, S. & Gehring W.J. Conservation of Pax 6 function and upstream activation by Notch signaling in eye development of frogs and flies. Proc. Natl. Acad. Sci. USA 99, 2020–2025(2002).
    Article CAS Google Scholar
  30. Jun, S., Wallen, R.V., Goriely, A., Kalionis, B. & Desplan, C. Lune/eye gone, a Pax-like protein, uses a partial paired domain and a homeodomain for DNA recognition. Proc. Natl. Acad. Sci. USA 95, 13720–13725 (1998).
    Article CAS Google Scholar
  31. Jang, C.C. et al. Two Pax genes, eye gone and eyeless, act cooperatively in promoting Drosophila eye development. Development 130, 2939–2951 (2003).
    Article CAS Google Scholar
  32. Hazelett, D.J., Bourouis, M., Walldorf, U. & Treisman, J.E. decapentaplegic and wingless are regulated by eyes absent and eyegone and interact to direct the pattern of retinal differentiation in the eye disc. Development 125, 3741–3751 (1998).
    CAS Google Scholar
  33. Heberlein, U. & Treisman, J.E. Early retinal development in Drosophila. Fini 2000, 37–50 (2000).
    Google Scholar
  34. Kurata, S., Go, M.J., Artavanis-Tsakonas, S. & Gehring, W.J. Notch signaling and the determination of appendage identity. Proc. Natl. Acad. Sci. USA 97, 2117–2122 (2000).
    Article CAS Google Scholar
  35. Kumar, J.P. & Moses, K. EGR Receptor and Notch signaling act upstream of Eyeless/Pax6 to control eye specification. Cell 104, 687–697 (2001).
    Article CAS Google Scholar
  36. Go, M.J., Eastman, D.S. & Artavanis-Tsakonas, S. Cell proliferation control by Notch signaling in Drosophila development. Development 125, 2031–2040 (1998).
    CAS Google Scholar
  37. Aldaz, S., Morata, G. & Azpiazu, N. The Pax-homeobox gene eyegone is involved in the subdivision of the thorax of Drosophila. Development 130, 4473–4482 (2003).
    Article CAS Google Scholar
  38. Brand, A.H. & Perrimon, N. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118, 401–415 (1993).
    CAS Google Scholar
  39. Callaerts, P. et al. Drosophila Pax-6/eyeless is essential for normal adult brain structure and function. J. Neurobiol. 46, 73–88 (2001).
    Article CAS Google Scholar
  40. Kronhamn, J. et al. Headless flies produced by mutations in the paralogous Pax6 genes eyeless and twin of eyeless. Development 129, 1015–1026 (2002).
    CAS Google Scholar
  41. Panganiban, G. & Rubenstein, J.L. Developmental functions of the _Distal-less/_Dlx homeobox genes. Development 129, 4371–4386 (2002).
    CAS Google Scholar
  42. Day, S.J. & Lawrence, P.A. Measuring dimensions: the regulation of size and shape. Development 127, 2977–2987 (2000).
    CAS Google Scholar
  43. Brook, W., Diaz-Benjumea, F. & Cohen, S. Organizing spatial pattern in limb development. Annu. Rev. Cell Dev. Biol. 12, 161–180 (1996).
    Article CAS Google Scholar
  44. Serrano, N. & O'Farrell, P.H. Limb morphogenesis: connections between patterning and growth. Curr. Biol. 7, 186–195 (1997).
    Article Google Scholar
  45. Azuma, N. et al. Missense mutation in the alternative splice region of the PAX6 gene in eye anomalies. Am. J. Hum. Genet. 65, 656–663 (1999).
    Article CAS Google Scholar
  46. Sepp, K.J. & Auld, V.J. Conversion of lacZ enhancer trap lines to GAL4 lines using targeted transposition in Drosophila melanogaster. Genetics 151, 1093–1101 (1999).
    CAS Google Scholar
  47. Lee, T. & Luo, L. Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis. Neuron 22, 451–461 (1999).
    Article CAS Google Scholar
  48. Xu, T. & Rubin, G.M. Analysis of genetic mosaics in developing and adult Drosophila tissues. Development 117, 1223–1237 (1993).
    CAS Google Scholar
  49. Newsome, T.P., Asling, B. & Dickson, B.J. Analysis of Drosophila photoreceptor axon guidance in eye-specific mosaics. Development 127, 851–860 (2000).
    CAS Google Scholar
  50. Morata, G. & Ripoll, P. Minutes: Mutants of Drosophila autonomously affecting cell division rate. Dev. Biol. 42, 211–221 (1975).
    Article CAS Google Scholar

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