Fine-scale recombination patterns differ between chimpanzees and humans (original) (raw)

References

1. Kong, A. et al. A high-resolution recombination map of the human genome. Nat. Genet. 31, 241–247 (2002).
   Article CAS PubMed Google Scholar
2. Kauppi, L., Jeffreys, A.J. & Keeney, S. Where the crossovers are: recombination distributions in mammals. Nat. Rev. Genet. 5, 413–424 (2004).
   Article CAS PubMed Google Scholar
3. Stumpf, M.P. & McVean, G.A. Estimating recombination rates from population-genetic data. Nat. Rev. Genet. 4, 959–968 (2003).
   Article CAS PubMed Google Scholar
4. Crawford, D.C. et al. Evidence for substantial fine-scale variation in recombination rates across the human genome. Nat. Genet. 36, 700–706 (2004).
   Article CAS PubMed Google Scholar
5. Fearnhead, P. Consistency of estimators of the population–scaled recombination rate. Theor. Popul. Biol. 64, 67–79 (2003).
   Article PubMed Google Scholar
6. Li, N. & Stephens, M. Modeling linkage disequilibrium and identifying recombination hotspots using single-nucleotide polymorphism data. Genetics 165, 2213–2233 (2003).
   CAS PubMed PubMed Central Google Scholar
7. McVean, G.A. et al. The fine-scale structure of recombination rate variation in the human genome. Science 304, 581–584 (2004).
   Article CAS PubMed Google Scholar
8. Cullen, M., Perfetto, S.P., Klitz, W., Nelson, G. & Carrington, M. High-resolution patterns of meiotic recombination across the human major histocompatibility complex. Am. J. Hum. Genet. 71, 759–776 (2002).
   Article PubMed PubMed Central Google Scholar
9. Kong, A. et al. Recombination rate and reproductive success in humans. Nat. Genet. 36, 1203–1206 (2004).
   Article CAS PubMed Google Scholar
10. Wall, J.D., Frisse, L.A., Hudson, R.R. & Di Rienzo, A. Comparative linkage-disequilibrium analysis of the beta-globin hotspot in primates. Am. J. Hum. Genet. 73, 1330–1340 (2003).
    Article CAS PubMed PubMed Central Google Scholar
11. Ptak, S.E. et al. Absence of the TAP2 human recombination hotspot in chimpanzees. PLoS Biol. 2, 849–855 (2004).
    Article CAS Google Scholar
12. Hinds, D.A. et al. Whole genome patterns of common DNA variation in diverse human populations. Science (in the press).
13. Britten, R.J. Divergence between samples of chimpanzee and human DNA sequences is 5%, counting indels. Proc. Natl. Acad. Sci. USA 99, 13633–13635 (2002).
    Article CAS PubMed PubMed Central Google Scholar
14. Ebersberger, I., Metzler, D., Schwarz, C. & Paabo, S. Genomewide comparison of DNA sequences between humans and chimpanzees. Am. J. Hum. Genet. 70, 1490–1497 (2002).
    Article CAS PubMed PubMed Central Google Scholar
15. de Massy, B. Distribution of meiotic recombination sites. Trends Genet. 19, 514–522 (2003).
    Article CAS PubMed Google Scholar
16. Petes, T.D. Meiotic recombination hot spots and cold spots. Nat. Rev. Genet. 2, 360–369 (2001).
    Article CAS PubMed Google Scholar
17. Haring, S.J., Halley, G.R., Jones, A.J. & Malone, R.E. Properties of natural double-strand-break sites at a recombination hotspot in Saccharomyces cerevisiae. Genetics 165, 101–114 (2003).
    CAS PubMed PubMed Central Google Scholar
18. Shiroishi, T., Sagai, T., Hanzawa, N., Gotoh, H. & Moriwaki, K. Genetic control of sex–dependent meiotic recombination in the major histocompatibility complex of the mouse. EMBO J. 10, 681–686 (1991).
    Article CAS PubMed PubMed Central Google Scholar
19. Jeffreys, A.J. & Neumann, R. Reciprocal crossover asymmetry and meiotic drive in a human recombination hot spot. Nat. Genet. 31, 267–271 (2002).
    Article CAS PubMed Google Scholar
20. Jeffreys, A.J., Murray, J. & Neumann, R. High-resolution mapping of crossovers in human sperm defines a minisatellite-associated recombination hotspot. Mol. Cell 2, 267–273 (1998).
    Article CAS PubMed Google Scholar
21. Patil, N. et al. Blocks of limited haplotype diversity revealed by high–resolution scanning of human chromosome 21. Science 294, 1719–1723 (2001).
    Article CAS PubMed Google Scholar
22. Altshul, S.F., Gish, W., Miller, W., Myers, E.W. & Lipman, D.J. Basic local alignment search tool. J. Mol. Biol. 215, 403–410 (1990).
    Article Google Scholar
23. Stephens, M. & Donnelly, P. A comparison of bayesian methods for haplotype reconstruction from population genotype data. Am. J. Hum. Genet. 73, 1162–1169 (2003).
    Article CAS PubMed PubMed Central Google Scholar
24. Stephens, M., Smith, N.J. & Donnelly, P. A new statistical method for haplotype reconstruction from population data. Am. J. Hum. Genet. 68, 978–989 (2001).
    Article CAS PubMed PubMed Central Google Scholar
25. Dutilleul, P. Modifying the t-test for assessing the correlation between two spatial processes. Biometrics 49, 305–314 (1993).
    Article Google Scholar
26. Hudson, R.R. Generating samples under a Wright-Fisher neutral model of genetic variation. Bioinformatics 18, 337–338 (2002).
    Article CAS PubMed Google Scholar
27. Fischer, A., Wiebe, V., Paabo, S. & Przeworski, M. Evidence for a complex demographic history of chimpanzees. Mol. Biol. Evol. 21, 799–808 (2004).
    Article CAS PubMed Google Scholar
28. Ptak, S.E., Voelpel, K. & Przeworski, M. Insights into recombination from patterns of linkage disequilibrium in humans. Genetics 167, 387–397 (2004).
    Article PubMed PubMed Central Google Scholar

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