Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons (original) (raw)

Nature Genetics volume 37, pages 349–350 (2005)Cite this article

A Corrigendum to this article was published on 01 May 2005

Abstract

We report that Sir2 activation through increased sir-2.1 dosage or treatment with the sirtuin activator resveratrol specifically rescued early neuronal dysfunction phenotypes induced by mutant polyglutamines in transgenic Caenorhabditis elegans. These effects are dependent on daf-16 (Forkhead). Additionally, resveratrol rescued mutant polyglutamine–specific cell death in neuronal cells derived from HdhQ111 knock-in mice. We conclude that Sir2 activation may protect against mutant polyglutamines.

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Figure 1: Rescue of mutant polyQ toxicity by increased sirtuin activity in nematode and mammalian neurons.

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Acknowledgements

This work was supported by the Institut National de la Santé et de la Recherche Médicale, the Cure Huntington's Disease Initiative of the High Q Foundation and the Association France Huntington. J.A.P. is supported by a postdoctoral fellowship from the Cure Huntington's Disease Initiative. M.A. is supported by a doctoral fellowship from the Institut National de la Santé et de la Recherche Médicale and the Région Ile-de-France. H.C. is supported by a doctoral fellowship from the Ministère de la Recherche.

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Authors and Affiliations

  1. Institut National de la Santé et de la Recherche Médicale, Avenir Group, Laboratory of Genomic Biology, Centre Paul Broca, Paris, 75014, France
    J Alex Parker, Margarita Arango, Salima Abderrahmane, Emmanuel Lambert, Cendrine Tourette, Hélène Catoire & Christian Néri

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  1. J Alex Parker
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  2. Margarita Arango
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  3. Salima Abderrahmane
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  4. Emmanuel Lambert
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  5. Cendrine Tourette
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  6. Hélène Catoire
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  7. Christian Néri
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Correspondence toChristian Néri.

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The authors declare no competing financial interests.

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Parker, J., Arango, M., Abderrahmane, S. et al. Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons.Nat Genet 37, 349–350 (2005). https://doi.org/10.1038/ng1534

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