MMTV insertional mutagenesis identifies genes, gene families and pathways involved in mammary cancer (original) (raw)

• Nusse, R. & Varmus, H.E. Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome. Cell 31, 99–109 (1982).
  Article CAS Google Scholar
• Johansson, F.K. et al. Identification of candidate cancer-causing genes in mouse brain tumors by retroviral tagging. Proc. Natl. Acad. Sci. USA 101, 11334–11337 (2004).
  Article CAS Google Scholar
• Mikkers, H. et al. High-throughput retroviral tagging to identify components of specific signaling pathways in cancer. Nat. Genet. 32, 153–159 (2002).
  Article CAS Google Scholar
• Suzuki, T. et al. New genes involved in cancer identified by retroviral tagging. Nat. Genet. 32, 166–174 (2002).
  Article CAS Google Scholar
• Chatterjee, G. et al. Acceleration of mouse mammary tumor virus-induced murine mammary tumorigenesis by a p53 172H transgene: influence of FVB background on tumor latency and identification of novel sites of proviral insertion. Am. J. Pathol. 161, 2241–2253 (2002).
  Article CAS Google Scholar
• Callahan, R. & Smith, G.H. MMTV-induced mammary tumorigenesis: gene discovery, progression to malignancy and cellular pathways. Oncogene 19, 992–1001 (2000).
  Article CAS Google Scholar
• Lazo, P.A., Lee, J.S. & Tsichlis, P.N. Long-distance activation of the Myc protooncogene by provirus insertion in Mlvi-1 or Mlvi-4 in rat T-cell lymphomas. Proc. Natl. Acad. Sci. USA 87, 170–173 (1990).
  Article CAS Google Scholar
• Lammie, G.A. et al. Proviral insertions near cyclin D1 in mouse lymphomas: a parallel for BCL1 translocations in human B-cell neoplasms. Oncogene 7, 2381–2387 (1992).
  CAS PubMed Google Scholar
• Sakatani, T. et al. Loss of imprinting of Igf2 alters intestinal maturation and tumorigenesis in mice. Science 307, 1976–1978 (2005).
  Article CAS Google Scholar
• van Roozendaal, C.E. et al. Loss of imprinting of IGF2 and not H19 in breast cancer, adjacent normal tissue and derived fibroblast cultures. FEBS Lett. 437, 107–111 (1998).
  Article CAS Google Scholar
• Shackleford, G.M., MacArthur, C.A., Kwan, H.C. & Varmus, H.E. Mouse mammary tumor virus infection accelerates mammary carcinogenesis in Wnt-1 transgenic mice by insertional activation of int-2/Fgf-3 and hst/Fgf-4. Proc. Natl. Acad. Sci. USA 90, 740–744 (1993).
  Article CAS Google Scholar
• Gallahan, D. & Callahan, R. Mammary tumorigenesis in feral mice: identification of a new int locus in mouse mammary tumor virus (Czech II)-induced mammary tumors. J. Virol. 61, 66–74 (1987).
  CAS PubMed PubMed Central Google Scholar
• Gallahan, D. & Callahan, R. The mouse mammary tumor associated gene INT3 is a unique member of the Notch gene family (Notch4). Oncogene 14, 1883–1890 (1997).
  Article CAS Google Scholar
• Takahashi, K., Mitsui, K. & Yamanaka, S. Role of ERas in promoting tumour-like properties in mouse embryonic stem cells. Nature 423, 541–545 (2003).
  Article CAS Google Scholar
• Zhang, S. et al. p16 INK4a gene promoter variation and differential binding of a repressor, the ras-responsive zinc-finger transcription factor, RREB. Oncogene 22, 2285–2295 (2003).
  Article CAS Google Scholar
• Erny, K.M., Peli, J., Lambert, J.F., Muller, V. & Diggelmann, H. Involvement of the Tpl-2/cot oncogene in MMTV tumorigenesis. Oncogene 13, 2015–2020 (1996).
  CAS PubMed Google Scholar
• Ceci, J.D. et al. Tpl-2 is an oncogenic kinase that is activated by carboxy-terminal truncation. Genes Dev. 11, 688–700 (1997).
  Article CAS Google Scholar
• Sourvinos, G., Tsatsanis, C. & Spandidos, D.A. Overexpression of the Tpl-2/Cot oncogene in human breast cancer. Oncogene 18, 4968–4973 (1999).
  Article CAS Google Scholar
• Chen, J.Z. et al. Cloning and identification of a cDNA that encodes a novel human protein with thrombospondin type I repeat domain, hPWTSR. Mol. Biol. Rep. 29, 287–292 (2002).
  Article CAS Google Scholar
• Lowther, W., Wiley, K., Smith, G.H. & Callahan, R. A new common integration site, Int7, for the mouse mammary tumor virus in mouse mammary tumors identifies a gene whose product has furin-like and thrombospondin-like sequences. J. Virol. 79, 10093–10096 (2005).
  Article CAS Google Scholar
• Adams, N.C., Tomoda, T., Cooper, M., Dietz, G. & Hatten, M.E. Mice that lack astrotactin have slowed neuronal migration. Development 129, 965–972 (2002).
  CAS PubMed Google Scholar
• Zagha, E. et al. DPP10 modulates Kv4-mediated A-type potassium channels. J. Biol. Chem. 280, 18853–18861 (2005).
  Article CAS Google Scholar
• Theodorou, V. et al. Fgf10 is an oncogene activated by MMTV insertional mutagenesis in mouse mammary tumors and overexpressed in a subset of human breast carcinomas. Oncogene 23, 6047–6055 (2004).
  Article CAS Google Scholar
• Dennis, G. Jr. et al. DAVID: database for annotation, visualization, and integrated discovery. Genome Biol. 4, P3 (2003).
  Article Google Scholar
• Vogelstein, B. & Kinzler, K.W. Cancer genes and the pathways they control. Nat. Med. 10, 789–799 (2004).
  Article CAS Google Scholar
• van de Vijver, M.J. et al. A gene-expression signature as a predictor of survival in breast cancer. N. Engl. J. Med. 347, 1999–2009 (2002).
  Article CAS Google Scholar
• Payton, M., Scully, S., Chung, G. & Coats, S. Deregulation of cyclin E2 expression and associated kinase activity in primary breast tumors. Oncogene 21, 8529–8534 (2002).
  Article CAS Google Scholar
• Kwan, H. et al. Transgenes expressing the Wnt-1 and int-2 proto-oncogenes cooperate during mammary carcinogenesis in doubly transgenic mice. Mol. Cell. Biol. 12, 147–154 (1992).
  Article CAS Google Scholar
• Peters, G., Lee, A.E. & Dickson, C. Concerted activation of two potential proto-oncogenes in carcinomas induced by mouse mammary tumour virus. Nature 320, 628–631 (1986).
  Article CAS Google Scholar
• Dontu, G. et al. Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells. Breast Cancer Res. 6, R605–R615 (2004).
  Article CAS Google Scholar
• Kazanskaya, O. et al. R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis. Dev. Cell 7, 525–534 (2004).
  Article CAS Google Scholar
• Kim, K.A. et al. Mitogenic influence of human R-spondin1 on the intestinal epithelium. Science 309, 1256–1259 (2005).
  Article CAS Google Scholar
• Liu, Y.J., Xu, Y. & Yu, Q. Full-length ADAMTS-1 and the ADAMTS-1 fragments display pro- and antimetastatic activity, respectively. Oncogene 25, 2452–2467 (2006).
  Article CAS Google Scholar
• Takeuchi, J.K. et al. Tbx5 and Tbx4 trigger limb initiation through activation of the Wnt/Fgf signaling cascade. Development 130, 2729–2739 (2003).
  Article CAS Google Scholar
• Prasad, V. et al. Haploinsufficiency of Atp2a2, encoding the sarco(endo)plasmic reticulum Ca2+-ATPase isoform 2 Ca2+ pump, predisposes mice to squamous cell tumors via a novel mode of cancer susceptibility. Cancer Res. 65, 8655–8661 (2005).
  Article CAS Google Scholar
• Bissell, M.J. & Radisky, D. Putting tumours in context. Nat. Rev. Cancer 1, 46–54 (2001).
  Article CAS Google Scholar
• Tlsty, T.D. Stromal cells can contribute oncogenic signals. Semin. Cancer Biol. 11, 97–104 (2001).
  Article CAS Google Scholar
• Wu, X., Li, Y., Crise, B. & Burgess, S.M. Transcription start regions in the human genome are favored targets for MLV integration. Science 300, 1749–1751 (2003).
  Article CAS Google Scholar
• Dupuy, A.J., Akagi, K., Largaespada, D.A., Copeland, N.G. & Jenkins, N.A. Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system. Nature 436, 221–226 (2005).
  Article CAS Google Scholar
• Penault-Llorca, F. et al. Expression of FGF and FGF receptor genes in human breast cancer. Int. J. Cancer 61, 170–176 (1995).
  Article CAS Google Scholar
• Sjoblom, T. et al. The consensus coding sequences of human breast and colorectal cancers. Science 314, 268–274 (2006).
  Article Google Scholar
• van der Valk, M.A. Tumor incidence of the inbred mouse strains in the Netherlands Cancer Institute. in Mammary Tumors in the Mouse 45–115 (Elsevier, Amsterdam, 1981).
  Google Scholar
• Hynes, N.E., Groner, B., Diggelmann, H., van Nie, R. & Michalides, R. Genomic location of mouse mammary tumor virus proviral DNA in normal mouse tissue and in mammary tumors. Cold Spring Harb. Symp. Quant. Biol. 44, 1161–1168 (1980).
  Article CAS Google Scholar
• Devon, R.S., Porteous, D.J. & Brookes, A.J. Splinkerettes–improved vectorettes for greater efficiency in PCR walking. Nucleic Acids Res. 23, 1644–1645 (1995).
  Article CAS Google Scholar
• Jonkers, J. & Berns, A. Retroviral insertional mutagenesis as a strategy to identify cancer genes. Biochim. Biophys. Acta 1287, 29–57 (1996).
  PubMed Google Scholar
• Merlo, G.R. et al. Growth suppression of normal mammary epithelial cells by wild-type p53. Ann. NY Acad. Sci. 698, 108–113 (1993).
  Article CAS Google Scholar
• Sheskin, D. Handbook of Parametric and Nonparametric Statistical Procedures (CRC Press New York, 1997).
  Google Scholar
• Pavlidis, P. Using ANOVA for gene selection from microarray studies of the nervous system. Methods 31, 282–289 (2003).
  Article CAS Google Scholar
• Roberts, C.J. et al. Signaling and circuitry of multiple MAPK pathways revealed by a matrix of global gene expression profiles. Science 287, 873–880 (2000).
  Article CAS Google Scholar