Cancer genes and the pathways they control (original) (raw)

• Davies, H. et al. Mutations of the BRAF gene in human cancer. Nature 417, 949–954 (2002).
  Article CAS PubMed Google Scholar
• Wan, P.T. et al. Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF. Cell 116, 855–867 (2004).
  Article CAS PubMed Google Scholar
• Santarosa, M. & Ashworth, A. Haploinsufficiency for tumour suppressor genes: when you don't need to go all the way. Biochim. Biophys. Acta 1654, 105–122 (2004).
  CAS PubMed Google Scholar
• Knudson, A.G. Cancer genetics. Am. J. Med. Genet. 111, 96–102 (2002).
  Article PubMed Google Scholar
• Friedberg, E.C. DNA damage and repair. Nature 421, 436–440 (2003).
  Article PubMed CAS Google Scholar
• Nowell, P.C. Tumor progression: a brief historical perspective. Semin. Cancer Biol. 12, 261–266 (2002).
  Article CAS PubMed Google Scholar
• Maley, C.C. et al. Selectively advantageous mutations and hitchhikers in neoplasms: p16 lesions are selected in Barrett's esophagus. Cancer Res. 64, 3414–3427 (2004).
  Article CAS PubMed Google Scholar
• Van Dyke, T. & Jacks, T. Cancer modeling in the modern era: progress and challenges. Cell 108, 135–144 (2002).
  Article CAS PubMed Google Scholar
• Horvitz, H.R. Worms, life, and death. Chembiochem 4, 697–711 (2003).
  Article CAS PubMed Google Scholar
• Sherr, C.J. Cancer cell cycles revisited. Cancer Res. 60, 3689–3695 (2000).
  CAS PubMed Google Scholar
• Ortega, S., Malumbres, M. & Barbacid, M. Cyclin D-dependent kinases, INK4 inhibitors and cancer. Biochim. Biophys. Acta 1602, 73–87 (2002).
  CAS PubMed Google Scholar
• Classon, M. & Harlow, E. The retinoblastoma tumour suppressor in development and cancer. Nat. Rev. Cancer 2, 910–917 (2002).
  Article CAS PubMed Google Scholar
• Ichimura, K. et al. Deregulation of the p14ARF/MDM2/p53 pathway is a prerequisite for human astrocytic gliomas with G1-S transition control gene abnormalities. Cancer Res. 60, 417–424 (2000).
  CAS PubMed Google Scholar
• Vogelstein, B., Lane, D. & Levine, A.J. Surfing the p53 network. Nature 408, 307–310 (2000).
  Article CAS PubMed Google Scholar
• Oren, M. Decision making by p53: life, death and cancer. Cell Death Differ. 10, 431–442 (2003).
  Article CAS PubMed Google Scholar
• Prives, C. & Hall, P.A. The p53 pathway. J. Pathol. 187, 112–126 (1999).
  Article CAS PubMed Google Scholar
• Klein, G. Perspectives in studies of human tumor viruses. Front. Biosci. 7, d268–d274 (2002).
  Article CAS PubMed Google Scholar
• Munger, K. & Howley, P.M. Human papillomavirus immortalization and transformation functions. Virus Res. 89, 213–228 (2002).
  Article CAS PubMed Google Scholar
• zur Hausen, H. Oncogenic DNA viruses. Oncogene 20, 7820–7823 (2001).
  Article CAS PubMed Google Scholar
• Hunter, T. Signaling–2000 and beyond. Cell 100, 113–127 (2000).
  Article CAS PubMed Google Scholar
• Komarova, N.L., Sengupta, A. & Nowak, M.A. Mutation-selection networks of cancer initiation: tumor suppressor genes and chromosomal instability. J. Theor. Biol. 223, 433–450 (2003).
  Article CAS PubMed Google Scholar
• Rowley, J.D. The critical role of chromosome translocations in human leukemias. Annu. Rev. Genet. 32, 495–519 (1998).
  Article CAS PubMed Google Scholar
• Mitelman, F. Recurrent chromosome aberrations in cancer. Mutat. Res. 462, 247–253 (2000).
  Article CAS PubMed Google Scholar
• Verheul, H.M., Voest, E.E. & Schlingemann, R.O. Are tumours angiogenesis-dependent? J. Pathol. 202, 5–13 (2004).
  Article CAS PubMed Google Scholar
• Tlsty, T.D. & Hein, P.W. Know thy neighbor: stromal cells can contribute oncogenic signals. Curr. Opin. Genet. Dev. 11, 54–59 (2001).
  Article CAS PubMed Google Scholar
• Fata, J.E., Werb, Z. & Bissell, M.J. Regulation of mammary gland branching morphogenesis by the extracellular matrix and its remodeling enzymes. Breast Cancer Res. 6, 1–11 (2004).
  Article CAS PubMed Google Scholar
• Kerbel, R. & Folkman, J. Clinical translation of angiogenesis inhibitors. Nat. Rev. Cancer 2, 727–739 (2002).
  Article CAS PubMed Google Scholar
• Folkman, J. Role of angiogenesis in tumor growth and metastasis. Semin. Oncol. 29, 15–18 (2002).
  Article CAS PubMed Google Scholar
• Ferrara, N., Hillan, K.J., Gerber, H.P. & Novotny, W. Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer. Nat. Rev. Drug Discov. 3, 391–400 (2004).
  Article CAS PubMed Google Scholar
• Kondo, K., Klco, J., Nakamura, E., Lechpammer, M. & Kaelin, W.G. Jr. Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein. Cancer Cell 1, 237–246 (2002).
  Article CAS PubMed Google Scholar
• Semenza, G.L. Targeting HIF-1 for cancer therapy. Nat. Rev. Cancer 3, 721–732 (2003).
  Article CAS PubMed Google Scholar
• Strausberg, R.L., Simpson, A.J. & Wooster, R. Sequence-based cancer genomics: progress, lessons and opportunities. Nat. Rev. Genet. 4, 409–418 (2003).
  Article CAS PubMed Google Scholar
• Loeb, L.A., Loeb, K.R. & Anderson, J.P. Multiple mutations and cancer. Proc. Natl. Acad. Sci. USA 100, 776–781 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Rajagopalan, H., Nowak, M.A., Vogelstein, B. & Lengauer, C. The significance of unstable chromosomes in colorectal cancer. Nat. Rev. Cancer 3, 695–701 (2003).
  Article CAS PubMed Google Scholar
• Sieber, O.M., Heinimann, K. & Tomlinson, I.P. Genomic instability—the engine of tumorigenesis? Nat. Rev. Cancer 3, 701–708 (2003).
  Article CAS PubMed Google Scholar
• Wang, T.L. et al. Prevalence of somatic alterations in the colorectal cancer cell genome. Proc. Natl. Acad. Sci. USA 99, 3076–3080 (2002).
  Article CAS PubMed PubMed Central Google Scholar
• Lengauer, C., Kinzler, K.W. & Vogelstein, B. Genetic instabilities in human cancers. Nature 396, 643–649 (1998).
  Article CAS PubMed Google Scholar
• Duesberg, P. & Li, R. Multistep carcinogenesis: a chain reaction of aneuploidizations. Cell Cycle 2, 202–210 (2003).
  Article CAS PubMed Google Scholar
• Albertson, D.G. & Pinkel, D. Genomic microarrays in human genetic disease and cancer. Hum. Mol. Genet. 12 (spec. no. 2), R145–R152 (2003).
  Article CAS PubMed Google Scholar
• Shiloh, Y. & Kastan, M.B. ATM: genome stability, neuronal development, and cancer cross paths. Adv. Cancer Res. 83, 209–254 (2001).
  Article CAS PubMed Google Scholar
• Scully, R. & Livingston, D.M. In search of the tumour-suppressor functions of BRCA1 and BRCA2. Nature 408, 429–432 (2000).
  Article CAS PubMed PubMed Central Google Scholar
• Maser, R.S. & DePinho, R.A. Connecting chromosomes, crisis, and cancer. Science 297, 565–569 (2002).
  Article CAS PubMed Google Scholar
• Pihan, G. & Doxsey, S.J. Mutations and aneuploidy: co-conspirators in cancer? Cancer Cell 4, 89–94 (2003).
  Article CAS PubMed Google Scholar
• Rajagopalan, H. et al. Inactivation of hCDC4 can cause chromosomal instability. Nature 428, 77–81 (2004).
  Article CAS PubMed Google Scholar
• Shay, J.W. & Roninson, I.B. Hallmarks of senescence in carcinogenesis and cancer therapy. Oncogene 23, 2919–2933 (2004).
  Article CAS PubMed Google Scholar
• Chambers, A.F., Groom, A.C. & MacDonald, I.C. Dissemination and growth of cancer cells in metastatic sites. Nat. Rev. Cancer 2, 563–572 (2002).
  Article CAS PubMed Google Scholar
• Fidler, I.J. Critical determinants of metastasis. Semin. Cancer Biol. 12, 89–96 (2002).
  Article PubMed Google Scholar
• Hunter, K.W. Host genetics and tumour metastasis. Br. J. Cancer 90, 752–755 (2004).
  Article CAS PubMed PubMed Central Google Scholar
• Hruban, R.H., Goggins, M., Parsons, J. & Kern, S.E. Progression model for pancreatic cancer. Clin. Cancer Res. 6, 2969–2972 (2000).
  CAS PubMed Google Scholar
• Aguirre, A.J. et al. Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma. Genes Dev. 17, 3112–3126 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Jen, J. et al. Molecular determinants of dysplasia in colorectal lesions. Cancer Res. 54, 5523–5526 (1994).
  CAS PubMed Google Scholar
• Pretlow, T.P. Aberrant crypt foci and K-ras mutations: earliest recognized players or innocent bystanders in colon carcinogenesis? Gastroenterology 108, 600–603 (1995).
  Article CAS PubMed Google Scholar
• Sieben, N.L. et al. In ovarian neoplasms, BRAF, but not KRAS, mutations are restricted to low-grade serous tumours. J. Pathol. 202, 336–340 (2004).
  Article CAS PubMed Google Scholar
• Kinzler, K.W. & Vogelstein, B. Colorectal Tumors. in The Genetic Basis of Human Cancer (eds. Vogelstein, B. & Kinzler, K.W.) 565–587 (McGraw-Hill, New York, 1998).
  Google Scholar
• Barbacid, M. ras genes. Annu. Rev. Biochem. 56, 779–827 (1987).
  Article CAS PubMed Google Scholar
• Bos, J.L. ras oncogenes in human cancer: a review. Cancer Res. 49, 4682–4689 (1989).
  CAS PubMed Google Scholar
• Zhang, Z. et al. Wildtype Kras2 can inhibit lung carcinogenesis in mice. Nat. Genet. 29, 25–33 (2001).
  Article CAS PubMed Google Scholar
• Diaz, R. et al. The N-ras proto-oncogene can suppress the malignant phenotype in the presence or absence of its oncogene. Cancer Res. 62, 4514–4518 (2002).
  CAS PubMed Google Scholar
• Bronner-Fraser, M. Development. Making sense of the sensory lineage. Science 303, 966–968 (2004).
  Article CAS PubMed Google Scholar
• Jiricny, J. Eukaryotic mismatch repair: an update. Mutat. Res. 409, 107–121 (1998).
  Article CAS PubMed Google Scholar
• Fishel, R. & Wilson, T. MutS homologs in mammalian cells. Curr. Opin. Genet. Dev. 7, 105–113 (1997).
  Article CAS PubMed Google Scholar
• Lynch, H.T. & de la Chapelle, A. Hereditary colorectal cancer. N. Engl. J. Med. 348, 919–932 (2003).
  Article CAS PubMed Google Scholar
• Yamamoto, H., Imai, K. & Perucho, M. Gastrointestinal cancer of the microsatellite mutator phenotype pathway. J. Gastroenterol. 37, 153–163 (2002).
  Article CAS PubMed Google Scholar
• Honchel, R., Halling, K.C. & Thibodeau, S.N. Genomic instability in neoplasia. Semin. Cell Biol. 6, 45–52 (1995).
  Article CAS PubMed Google Scholar
• Brown, P.O. & Botstein, D. Exploring the new world of the genome with DNA microarrays. Nat. Genet. 21, 33–37 (1999).
  Article CAS PubMed Google Scholar
• Polyak, K. & Riggins, G.J. Gene discovery using the serial analysis of gene expression technique: implications for cancer research. J. Clin. Oncol. 19, 2948–2958 (2001).
  Article CAS PubMed Google Scholar
• Jones, P.A. & Baylin, S.B. The fundamental role of epigenetic events in cancer. Nat. Rev. Genet. 3, 415–428 (2002).
  Article CAS PubMed Google Scholar
• Feinberg, A.P. & Tycko, B. The history of cancer epigenetics. Nat. Rev. Cancer 4, 143–153 (2004).
  Article CAS PubMed Google Scholar
• Collins, F.S., Green, E.D., Guttmacher, A.E. & Guyer, M.S. A vision for the future of genomics research. Nature 422, 835–847 (2003).
  Article CAS PubMed Google Scholar
• Schadt, E.E., Monks, S.A. & Friend, S.H. A new paradigm for drug discovery: integrating clinical, genetic, genomic and molecular phenotype data to identify drug targets. Biochem. Soc. Trans. 31, 437–443 (2003).
  Article CAS PubMed Google Scholar
• Paddison, P.J. et al. A resource for large-scale RNA-interference-based screens in mammals. Nature 428, 427–431 (2004).
  Article CAS PubMed Google Scholar
• Berns, K. et al. A large-scale RNAi screen in human cells identifies new components of the p53 pathway. Nature 428, 431–437 (2004).
  Article CAS PubMed Google Scholar
• Rosenblatt, K.P. et al. Serum proteomics in cancer diagnosis and management. Annu. Rev. Med. 55, 97–112 (2004).
  Article CAS PubMed Google Scholar
• Luo, J., Isaacs, W.B., Trent, J.M. & Duggan, D.J. Looking beyond morphology: cancer gene expression profiling using DNA microarrays. Cancer Invest. 21, 937–949 (2003).
  Article CAS PubMed Google Scholar
• Ma, X.J. et al. A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen. Cancer Cell 5, 607–616 (2004).
  Article CAS PubMed Google Scholar
• Futreal, P.A. et al. A census of human cancer genes. Nat. Rev. Cancer 4, 177–183 (2004).
  Article CAS PubMed PubMed Central Google Scholar
• Masayesva, B.G. et al. Gene expression alterations over large chromosomal regions in cancers include multiple genes unrelated to malignant progression. Proc. Natl. Acad. Sci. USA 101, 8715–8720 (2004).
  Article CAS PubMed PubMed Central Google Scholar
• Stewart, S.A. & Weinberg, R.A. Senescence: does it all happen at the ends? Oncogene 21, 627–630 (2002).
  Article CAS PubMed Google Scholar
• Feldser, D.M., Hackett, J.A. & Greider, C.W. Telomere dysfunction and the initiation of genome instability. Nat. Rev. Cancer 3, 623–627 (2003).
  Article CAS PubMed Google Scholar
• Chan, S.R. & Blackburn, E.H. Telomeres and telomerase. Phil. Trans. R. Soc. Lond. B 359, 109–121 (2004).
  Article CAS Google Scholar
• Cech, T.R. Beginning to understand the end of the chromosome. Cell 116, 273–279 (2004).
  Article CAS PubMed Google Scholar
• Miklos, G.L. & Maleszka, R. Microarray reality checks in the context of a complex disease. Nat. Biotechnol. 22, 615–621 (2004).
  Article CAS PubMed Google Scholar
• Hope, K.J., Jin, L. & Dick, J.E. Human acute myeloid leukemia stem cells. Arch. Med. Res. 34, 507–514 (2003).
  Article CAS PubMed Google Scholar
• Berking, C. & Herlyn, M. Human skin reconstruct models: a new application for studies of melanocyte and melanoma biology. Histol. Histopathol. 16, 669–674 (2001).
  CAS PubMed Google Scholar
• Kuperwasser, C. et al. Reconstruction of functionally normal and malignant human breast tissues in mice. Proc. Natl Acad. Sci. USA 101, 4966–4971 (2004).
  Article CAS PubMed PubMed Central Google Scholar
• Frei, E.I. & Eder, J.P. Principles of dose, schedule, and combination Therapy. in Cancer Medicine (eds. Kufe, D.W. et al.) 669–677 (B.C. Decker, Inc., Hamilton, Ontario, 2003).
  Google Scholar
• Pegram, M.D., Konecny, G. & Slamon, D.J. The molecular and cellular biology of HER2/neu gene amplification/overexpression and the clinical development of herceptin (trastuzumab) therapy for breast cancer. Cancer Treat. Res. 103, 57–75 (2000).
  Article CAS PubMed Google Scholar
• Druker, B.J. et al. Chronic myelogenous leukemia. in Hematology 2001 (American Society of Hematology Education Program) 87–112 (American Society of Hematology, 2001).
  Google Scholar
• Mechtersheimer, G. et al. Gastrointestinal stromal tumours and their response to treatment with the tyrosine kinase inhibitor imatinib. Virchows Arch. 444, 108–118 (2004).
  Article CAS PubMed Google Scholar
• Langer, C.J. Emerging role of epidermal growth factor receptor inhibition in therapy for advanced malignancy: focus on NSCLC. Int. J. Radiat. Oncol. Biol. Phys. 58, 991–1002 (2004).
  Article CAS PubMed Google Scholar
• Duensing, A., Heinrich, M.C., Fletcher, C.D. & Fletcher, J.A. Biology of gastrointestinal stromal tumors: KIT mutations and beyond. Cancer Invest. 22, 106–116 (2004).
  Article CAS PubMed Google Scholar
• Paez, J.G. et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 304, 1497–1500 (2004).
  Article CAS PubMed Google Scholar
• Lynch, T.J. et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N. Engl. J. Med. 350, 2129–2139 (2004).
  Article CAS PubMed Google Scholar
• Schmitt, C.A. & Lowe, S.W. Apoptosis and therapy. J. Pathol. 187, 127–137 (1999).
  Article CAS PubMed Google Scholar
• Danial, N.N. & Korsmeyer, S.J. Cell death: critical control points. Cell 116, 205–219 (2004).
  Article CAS PubMed Google Scholar
• Brown, J.M. & Wouters, B.G. Apoptosis: mediator or mode of cell killing by anticancer agents? Drug Resist. Updat. 4, 135–136 (2001).
  Article CAS PubMed Google Scholar
• Weinstein, I.B. et al. Disorders in cell circuitry associated with multistage carcinogenesis: exploitable targets for cancer prevention and therapy. Clin. Cancer Res. 3, 2696–2702 (1997).
  CAS PubMed Google Scholar
• Nygren, P. & Larsson, R. Overview of the clinical efficacy of investigational anticancer drugs. J. Intern. Med. 253, 46–75 (2003).
  Article CAS PubMed Google Scholar
• Shih, L.Y. et al. Heterogeneous patterns of FLT3 Asp(835) mutations in relapsed de novo acute myeloid leukemia: a comparative analysis of 120 paired diagnostic and relapse bone marrow samples. Clin. Cancer Res. 10, 1326–1332 (2004).
  Article CAS PubMed Google Scholar
• Kinzler, K.W. & Vogelstein, B. Lessons from hereditary colon cancer. Cell 87, 159–170 (1996).
  Article CAS PubMed Google Scholar
• Weissleder, R. & Ntziachristos, V. Shedding light onto live molecular targets. Nat. Med. 9, 123–128 (2003).
  Article CAS PubMed Google Scholar
• Sidransky, D. Emerging molecular markers of cancer. Nat. Rev. Cancer 2, 210–219 (2002).
  Article CAS PubMed Google Scholar
• Gschwind, A., Fischer, O.M. & Ullrich, A. The discovery of receptor tyrosine kinases: targets for cancer therapy. Nat. Rev. Cancer 4, 361–370 (2004).
  Article CAS PubMed Google Scholar
• Downward, J. Targeting RAS signalling pathways in cancer therapy. Nat. Rev. Cancer 3, 11–22 (2003).
  Article CAS PubMed Google Scholar
• Malumbres, M. & Barbacid, M. To cycle or not to cycle: a critical decision in cancer. Nat. Rev. Cancer 1, 222–231 (2001).
  Article CAS PubMed Google Scholar
• Giles, R.H., van Es, J.H. & Clevers, H. Caught up in a Wnt storm: Wnt signaling in cancer. Biochim. Biophys. Acta 1653, 1–24 (2003).
  CAS PubMed Google Scholar
• Cantley, L.C. The phosphoinositide 3-kinase pathway. Science 296, 1655–1657 (2002).
  Article CAS PubMed Google Scholar
• Shi, Y. & Massague, J. Mechanisms of TGF-β signaling from cell membrane to the nucleus. Cell 113, 685–700 (2003).
  Article CAS PubMed Google Scholar
• Ruiz i Altaba. A., Stecca, B. & Sanchez, P. Hedgehog–Gli signaling in brain tumors: stem cells and paradevelopmental programs in cancer. Cancer Lett. 204, 145–157 (2004).
  Article CAS PubMed Google Scholar
• Adams, J.M. Ways of dying: multiple pathways to apoptosis. Genes Dev. 17, 2481–2495 (2003).
  Article CAS PubMed Google Scholar
• Blagosklonny, M.V. & Pardee, A.B. The restriction point of the cell cycle. Cell Cycle 1, 103–110 (2002).
  CAS PubMed Google Scholar
• Plas, D.R. & Thompson, C.B. Cell metabolism in the regulation of programmed cell death. Trends Endocrinol. Metab. 13, 75–78 (2002).
  Article PubMed Google Scholar
• Green, D.R. & Evan, G.I. A matter of life and death. Cancer Cell 1, 19–30 (2002).
  Article CAS PubMed Google Scholar
• Eng, C., Kiuru, M., Fernandez, M.J. & Aaltonen, L.A. A role for mitochondrial enzymes in inherited neoplasia and beyond. Nat. Rev. Cancer 3, 193–202 (2003).
  Article CAS PubMed Google Scholar
• Lum, L. & Beachy, P.A. The Hedgehog response network: sensors, switches, and routers. Science 304, 1755–1759 (2004).
  Article CAS PubMed Google Scholar
• Brivanlou, A.H. & Darnell, J.E. Jr. Signal transduction and the control of gene expression. Science 295, 813–818 (2002).
  Article CAS PubMed Google Scholar
• Vogelstein, B. & Kinzler, K.W. The Genetic Basis of Human Cancer (McGraw-Hill, Toronto, 2002).
  Google Scholar
• Cameron, E.R. & Neil, J.C. The Runx genes: lineage-specific oncogenes and tumor suppressors. Oncogene 23, 4308–4314 (2004).
  Article CAS PubMed Google Scholar