In search of the tumour-suppressor functions of BRCA1 and BRCA2 (original) (raw)

• Welcsh, P. L., Owens, K. N. & King, M. C. Insights into the functions of BRCA1 and BRCA2. Trends Genet. 16, 69–74 (2000).
  Article CAS PubMed Google Scholar
• Scully, R. et al. Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell 88, 265–275 (1997).
  Article CAS PubMed Google Scholar
• Sharan, S. K. et al. Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2. Nature 386, 804–810 (1997).
  Article ADS CAS PubMed Google Scholar
• Chen, J. et al. Stable interaction between the products of the BRCA1 and BRCA2 tumoursuppressor genes in mitotic and meiotic cells. Mol. Cell 2, 317–328 (1998).
  Article CAS PubMed Google Scholar
• Scully, R. et al. Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage. Cell 90, 425–435 (1997).
  Article CAS PubMed Google Scholar
• Wu, L. C. et al. Identification of a RING protein that can interact in vivo with the BRCA1 gene product. Nature Genet. 14, 430–440 (1996).
  Article CAS PubMed Google Scholar
• Keegan, K. S. et al. The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes. Genes Dev. 10 , 2423–2437 (1996).
  Article CAS PubMed Google Scholar
• Cortez, D., Wang, Y., Qin, J. & Elledge, S. J. Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks. Science 286, 1162– 1166 (1999).
  Article CAS PubMed Google Scholar
• Deng, C. X. & Scott, F. Role of the tumor suppressor gene Brca1 in genetic stability and mammary gland tumor formation. Oncogene 19, 1059–1064 ( 2000).
  Article CAS PubMed Google Scholar
• Hakem, R. et al. The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse. Cell 85, 1009 –1023 (1996).
  Article CAS PubMed Google Scholar
• Patel, K. J. et al. Involvement of Brca2 in DNA repair. Mol. Cell 1, 347–357 (1998).
  Article CAS PubMed Google Scholar
• Sonoda, E. et al. Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death. EMBO J. 17, 598– 608 (1998).
  Article CAS PubMed PubMed Central Google Scholar
• Scully, R. et al. Genetic analysis of BRCA1 function in a defined tumor cell line. Mol. Cell 4, 1093– 1099 (1999).
  Article CAS PubMed Google Scholar
• Moynahan, M. E., Chiu, J. W., Koller, B. H. & Jasin, M. Brca1 controls homology-directed DNA repair. Mol. Cell 4, 511–518 (1999).
  Article CAS PubMed Google Scholar
• Snouwaert, J. N. et al. BRCA1 deficient embryonic stem cells display a decreased homologous recombination frequency and an increased frequency of non-homologous recombination that is corrected by expression of a brca1 transgene. Oncogene 18, 7900–7907 ( 1999).
  Article CAS PubMed Google Scholar
• Scully, R., Puget, N. & Vlasakova, K. DNA polymerase stalling, sister chromatid recombination and the BRCA genes. Oncogene (in the press).
• Fornace, A. J. Jr Recombination of parent and daughter strand DNA after UV-irradiation in mammalian cells. Nature 304, 552–554 (1983).
  Article ADS CAS PubMed Google Scholar
• Kowalczykowski, S. C. Initiation of genetic recombination and recombination-dependent replication. Trends Biochem. Sci. 25, 156– 165 (2000).
  Article CAS PubMed Google Scholar
• Cordeiro-Stone, M., Makhov, A. M., Zaritskaya, L. S. & Griffith, J. D. Analysis of DNA replication forks encountering a pyrimidine dimer in the template to the leading strand. J. Mol. Biol. 289, 1207–1218 (1999).
  Article CAS PubMed Google Scholar
• Brown, E. J. & Baltimore, D. ATR disruption leads to chromosomal fragmentation and early embryonic lethality. Genes Dev. 14, 397–402 (2000).
  CAS PubMed PubMed Central Google Scholar
• Rotman, G. & Shiloh, Y. ATM: a mediator of multiple responses to genotoxic stress. Oncogene 18, 6135– 6144 (1999).
  Article CAS PubMed Google Scholar
• Lee, J. S., Collins, K. M., Brown, A. L., Lee, C. H. & Chung, J. H. hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response. Nature 404, 201–204 (2000).
  Article ADS CAS PubMed Google Scholar
• Gowen, L. C., Avrutskaya, A. V., Latour, A. M., Koller, B. H. & Leadon, S. A. BRCA1 required for transcription-coupled repair of oxidative DNA damage. Science 281, 1009–1012 (1998).
  Article ADS CAS PubMed Google Scholar
• Wang, Y. et al. BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures. Genes Dev. 14, 927–939 ( 2000).
  CAS PubMed PubMed Central Google Scholar
• Chapman, M. S. & Verma, I. M. Transcriptional activation by BRCA1. Nature 382, 678– 679 (1996).
  Article ADS CAS PubMed Google Scholar
• Monteiro, A. N., August, A. & Hanafusa, H. Evidence for a transcriptional activation function of BRCA1 C-terminal region. Proc. Natl Acad. Sci. USA 93, 13595–13599 (1996).
  Article ADS CAS PubMed PubMed Central Google Scholar
• Milner, J., Ponder, B., Hughes-Davies, L., Seltmann, M. & Kouzarides, T. Transcriptional activation functions in BRCA2. Nature 386, 772– 773 (1997).
  Article ADS CAS PubMed Google Scholar
• Irminger-Finger, I., Siegel, B. D. & Leung, W. C. The functions of breast cancer susceptibility gene 1 (BRCA1) product and its associated proteins. Biol. Chem. 380, 117–128 (1999).
  Article CAS PubMed Google Scholar
• Bochar, D. A. et al. BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer. Cell 102, 257–265 (2000).
  Article CAS PubMed Google Scholar
• Guarente, L. Diverse and dynamic functions of the Sir silencing complex. Nature Genet. 23, 281–285 ( 1999).
  Article CAS PubMed Google Scholar
• Paul, T. P. et al. A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr. Biol. 10, 886–895 (2000).
  Article Google Scholar
• Lorick, K. L. et al. RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination. Proc. Natl Acad. Sci. USA 96, 11364–11369 (1999).
  Article ADS CAS PubMed PubMed Central Google Scholar
• Kordon, E. C. & Smith, G. H. An entire functional mammary gland may comprise the progeny from a single cell. Development 125, 1921–1930 (1998).
  CAS PubMed Google Scholar
• Tokunaga, M. et al. Malignant breast tumors among atomic bomb survivors, Hiroshima and Nagasaki, 1950–74. J. Natl Cancer Inst. 62 , 1347–1359 (1979).
  CAS PubMed Google Scholar
• Wolden, S. L., Lamborn, K. R., Cleary, S. F., Tate, D. J. & Donaldson, S. S. Second cancers following pediatric Hodgkin's disease. J. Clin. Oncol. 16, 536 –544 (1998).
  Article CAS PubMed Google Scholar
• Kinzler, K. W. & Vogelstein, B. Cancer-susceptibility genes. Gatekeepers and caretakers. Nature 386, 761–763 (1997).
  Article ADS CAS PubMed Google Scholar
• Fishman, J., Osborne, M. P. & Telang, N. T. The role of estrogen in mammary carcinogenesis. Ann. NY Acad. Sci. 768, 91–100 (1995).
  Article ADS CAS PubMed Google Scholar
• Henikoff, S. Nuclear organization and gene expression: homologous pairing and long-range interactions. Curr. Opin. Cell Biol. 9, 388–395 (1997).
  Article CAS PubMed Google Scholar
• Ashe, H. L., Monks, J., Wijgerde, M., Fraser, P. & Proudfoot, N. J. Intergenic transcription and transinduction of the human beta-globin locus. Genes Dev. 11, 2494–2509 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Miki, Y. et al. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 266, 66– 71 (1994).
  Article ADS CAS PubMed Google Scholar
• Tibbetts, R. S. et al. Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress. Genes Dev. (in the press).
• Le Page, F. et al. BRCA1 and BRCA2 are necessary for the transcription-coupled repair of the oxidative 8-oxoguanine lesion in human cells.. Cancer Res. 60, 5548–5552 ( 2000).
  CAS PubMed Google Scholar