Epigenetic silencing of CD4 in T cells committed to the cytotoxic lineage (original) (raw)

• von Boehmer, H. T-cell lineage fate: instructed by receptor signals? Curr. Biol. 10, R642–645 (2000).
  Article CAS Google Scholar
• Berg, L.J. & Kang, J. Molecular determinants of TCR expression and selection. Curr. Opin. Immunol. 13, 232–241 (2001).
  Article CAS Google Scholar
• Kisielow, P. & von Boehmer, H. Development and selection of T cells: facts and puzzles. Adv. Immunol. 58, 87–209 (1995).
  Article CAS Google Scholar
• Ellmeier, W., Sawada, S. & Littman, D.R. The regulation of CD4 and CD8 coreceptor gene expression during T cell development. Annu. Rev. Immunol. 17, 523–554 (1999).
  CAS Google Scholar
• Sawada, S., Scarborough, J.D., Killeen, N. & Littman, D.R. A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development. Cell 77, 917–929 (1994).
  Article CAS Google Scholar
• Siu, G., Wurster, A.L., Duncan, D.D., Soliman, T.M. & Hedrick, S.M. A transcriptional silencer controls the developmental expression of the CD4 gene. EMBO J. 13, 3570–3579 (1994).
  Article CAS Google Scholar
• Weiss, A. & Littman, D.R. Signal transduction by lymphocyte antigen receptors. Cell 76, 263–274 (1994).
  Article CAS Google Scholar
• Basson, M.A. & Zamoyska, R. The CD4/CD8 lineage decision: integration of signalling pathways. Immunol. Today 21, 509–514 (2000).
  Article CAS Google Scholar
• Marrack, P. & Kappler, J. Positive selection of thymocytes bearing αβ T cell receptors. Curr. Opin. Immunol. 9, 250–255 (1997).
  Article CAS Google Scholar
• Maldonado, E., Hampsey, M. & Reinberg, D. Repression: targeting the heart of the matter. Cell 99, 455–458 (1999).
  Article CAS Google Scholar
• Cavalli, G. & Paro, R. The Drosophila Fab-7 chromosomal element conveys epigenetic inheritance during mitosis and meiosis. Cell 93, 505–518 (1998).
  Article CAS Google Scholar
• Grunstein, M. Yeast heterochromatin: regulation of its assembly and inheritance by histones. Cell 93, 325–328 (1998).
  Article CAS Google Scholar
• Wolfer, A. et al. Inactivation of Notch 1 in immature thymocytes does not perturb CD4 or CD8T cell development. Nature Immunol. 2, 235–241 (2001).
  Article CAS Google Scholar
• Ellmeier, W., Sunshine, M.J., Losos, K., Hatam, F. & Littman, D.R. An enhancer that directs lineage-specific expression of CD8 in positively selected thymocytes and mature T cells. Immunity 7, 537–547 (1997).
  Article CAS Google Scholar
• Suzuki, H., Punt, J.A., Granger, L.G. & Singer, A. Asymmetric signaling requirements for thymocyte commitment to the CD4+ versus CD8+ T cell lineages: a new perspective on thymic commitment and selection. Immunity 2, 413–425 (1995).
  Article CAS Google Scholar
• Wolffe, A.P. & Matzke, M.A. Epigenetics: regulation through repression. Science 286, 481–486 (1999).
  Article CAS Google Scholar
• Bird, A.P. & Wolffe, A.P. Methylation-induced repression—belts, braces, and chromatin. Cell 99, 451–454 (1999).
  Article CAS Google Scholar
• Grunstein, M. Histone acetylation in chromatin structure and transcription. Nature 389, 349–352 (1997).
  Article CAS Google Scholar
• Bell, A.C. & Felsenfeld, G. Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene. Nature 405, 482–485 (2000).
  Article CAS Google Scholar
• Hark, A.T. et al. CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus. Nature 405, 486–489 (2000).
  Article CAS Google Scholar
• Panning, B. & Jaenisch, R. RNA and the epigenetic regulation of X chromosome inactivation. Cell 93, 305–308 (1998).
  Article CAS Google Scholar
• Clerc, P. & Avner, P. Genetics. Reprogramming X inactivation. Science 290, 1518–1519 (2000).
  Article CAS Google Scholar
• Cameron, E.E., Bachman, K.E., Myohanen, S., Herman, J.G. & Baylin, S.B. Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer. Nature Genet. 21, 103–107 (1999).
  Article CAS Google Scholar
• Jones, P.L. et al. Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription. Nature Genet. 19, 187–191 (1998).
  Article CAS Google Scholar
• Csankovszki, G., Nagy, A. & Jaenisch, R. Synergism of Xist RNA, DNA methylation, and histone hypoacetylation in maintaining X chromosome inactivation. J. Cell Biol. 153, 773–784 (2001).
  Article CAS Google Scholar
• Imai, S., Armstrong, C.M., Kaeberlein, M. & Guarente, L. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403, 795–800 (2000).
  Article CAS Google Scholar
• Moazed, D. Enzymatic activities of Sir2 and chromatin silencing. Curr. Opin. Cell Biol. 13, 232–238 (2001).
  Article CAS Google Scholar
• Gu, H., Zou, Y.R. & Rajewsky, K. Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-_loxP_-mediated gene targeting. Cell 73, 1155–1164 (1993).
  Article CAS Google Scholar
• DeKoter, R.P., Walsh, J.C. & Singh, H. PU.1 regulates both cytokine-dependent proliferation and differentiation of granulocyte/macrophage progenitors. EMBO J. 17, 4456–4468 (1998).
  Article CAS Google Scholar
• Kinsella, T.M. & Nolan, G.P. Episomal vectors rapidly and stably produce high-titer recombinant retrovirus. Hum. Gene. Ther. 7, 1405–1413 (1996).
  Article CAS Google Scholar
• Van Parijs, L. et al. Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death. Immunity 11, 281–288 (1999).
  Article CAS Google Scholar
• Matzinger, P. The JAM test. A simple assay for DNA fragmentation and cell death. J. Immunol. Methods 145, 185–192 (1991).
  Article CAS Google Scholar
• Clark, S.J., Harrison, J., Paul, C.L. & Frommer, M. High sensitivity mapping of methylated cytosines. Nucleic Acids Res. 22, 2990–2997 (1994).
  Article CAS Google Scholar