Deactivation of the kinase IKK by CUEDC2 through recruitment of the phosphatase PP1 (original) (raw)
Chen, G. & Goeddel, D.V. TNF-R1 signaling: a beautiful pathway. Science296, 1634–1635 (2002). ArticleCAS Google Scholar
Wajant, H., Pfizenmaier, K. & Scheurich, P. Tumor necrosis factor signaling. Cell Death Differ.10, 45–65 (2003). ArticleCAS Google Scholar
Karin, M. & Ben-Neriah, Y. Phosphorylation meets ubiquitination: the control of NF-κB activity. Annu. Rev. Immunol.18, 621–663 (2000). ArticleCAS Google Scholar
Maniatis, T. A ubiquitin ligase complex essential for the NF-κB, Wnt/Wingless, and Hedgehog signaling pathways. Genes Dev.13, 505–510 (1999). ArticleCAS Google Scholar
Häcker, H. & Karin, M. Regulation and function of IKK and IKK-related kinases. Sci. STKE357, re13 (2006). Google Scholar
Li, Q., Estepa, G., Memet, S., Israel, A. & Verma, I.M. Complete lack of NF-κB activity in IKK1 and IKK2 double deficient mice: additional defect in neurulation. Genes Dev.14, 1729–1733 (2000). CASPubMedPubMed Central Google Scholar
Ghosh, S. & Karin, M. Missing pieces in the NF-κB puzzle. Cell109, S81–S96 (2002). ArticleCAS Google Scholar
Yamaoka, S. et al. Complementation cloning of NEMO, a component of the IκB kinase complex essential for NF-κB activation. Cell93, 1231–1240 (1998). ArticleCAS Google Scholar
Delhase, M., Hayakawa, M., Chen, Y. & Karin, M. Positive and negative regulation of IκB kinase activity through IKKβ subunit phosphorylation. Science284, 309–313 (1999). ArticleCAS Google Scholar
Mercurio, F. et al. IKK-1 and IKK-2: cytokine-activated IκB kinases essential for NF-κB activation. Science278, 860–866 (1997). ArticleCAS Google Scholar
Jackman, J., Alamo, I. & Fornace, A.J. Jr. Genotoxic stress confers preferential and coordinate messenger RNA stability on the five gadd genes. Cancer Res.54, 5656–5662 (1994). CASPubMed Google Scholar
Aggen, J.B., Nairn, A.C. & Chamberlin, R. Regulation of protein phosphatase-1. Chem. Biol.7, R13–R23 (2000). ArticleCAS Google Scholar
Bollen, M. Combinatorial control of protein phosphatase-1. Trends Biochem. Sci.26, 426–431 (2001). ArticleCAS Google Scholar
Egloff, M.P. et al. Structural basis for the recognition of regulatory subunits by the catalytic subunit of protein phosphatase 1. EMBO J.16, 1876–1887 (1997). ArticleCAS Google Scholar
Donaldson, K.M., Yin, H., Gekakis, N., Supek, F. & Hoazeiro, C.A. Ubiquitin signals protein trafficking via interaction with a novel ubquitin binding domain in the membrane fusion regulator, Vps9p. Curr. Biol.13, 258–262 (2003). ArticleCAS Google Scholar
Ponting, C.P. Proteins of the endoplasmic-retivulum-associated degradation pathway: domain detection and function prediction. Biochem. J.351, 527–535 (2000). ArticleCAS Google Scholar
Shih, S.C. et al. A ubiquitin-binding motif required for intramolecular monoubiquitylation, the CUE domain. EMBO J.22, 1273–1281 (2003). ArticleCAS Google Scholar
Zhang, P.J. et al. CUE domain containing 2 regulates degradation of progesterone receptor by ubiquitin–proteasome. EMBO J.26, 1831–1842 (2007). ArticleCAS Google Scholar
Bender, K., Gottlicher, M., Whiteside, S., Rahmsdorf, H.J. & Herrlich, P. Sequential DNA damage-independent and -dependent activation of NF-κB by UV. EMBO J.17, 5170–5181 (1998). ArticleCAS Google Scholar
Li, N. & Karin, M. Ionizing radiation and short wavelength UV activate NF-κB through two distinct mechanisms. Proc. Natl. Acad. Sci. USA95, 13012–13017 (1998). ArticleCAS Google Scholar
DiDonato, J.A., Hayakawa, M., Rothwarf, D.M., Zandi, E. & Karin, M. A cytokine-responsive IκB kinase that activates the transcription factor NF-κB. Nature388, 548–554 (1997). ArticleCAS Google Scholar
Devin, A. et al. The distinct roles of TRAF2 and RIP in IKK activation by TNF-R1: TRAF2 recruits IKK to TNF-R1 while RIP mediates IKK activation. Immunity12, 419–429 (2000). ArticleCAS Google Scholar
Devin, A. et al. The α and β subunits of IκB kinase (IKK) mediate TRAF2-dependent IKK recruitment to tumor necrosis factor (TNF) receptor 1 in response to TNF. Mol. Cell. Biol.21, 3986–3994 (2001). ArticleCAS Google Scholar
Naka, T., Nishimoto, N. & Kishimoto, T. The paradigm of IL-6: from basic science to medicine. Arthritis Res.4, S233–S242 (2002). Article Google Scholar
Yang, J. et al. The essential role of MEKK3 in TNF-induced NF-κB activation. Nat. Immunol.2, 620–624 (2001). ArticleCAS Google Scholar
Huang, Q. et al. Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3. Nat. Immunol.5, 98–103 (2004). ArticleCAS Google Scholar
Hsu, H., Huang, J., Shu, H.B., Baichwal, V. & Goeddel, D.V. TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. Immunity4, 387–396 (1996). ArticleCAS Google Scholar
Nakano, H. et al. Differential regulation of IκB kinase α and β by two upstream kinases, NF-κB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1. Proc. Natl. Acad. Sci. USA95, 3537–3542 (1998). ArticleCAS Google Scholar
Brummelkamp, T.R., Nijman, S.M.B., Dirac, A.M.G. & Bernards, R. Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB. Nature424, 797–801 (2003). ArticleCAS Google Scholar
Kovalenko, A. et al. The tumour suppressor CYLD negatively regulates NF-κB signaling by deubiquitination. Nature424, 801–805 (2003). ArticleCAS Google Scholar
Lee, E.G. et al. Failure to regulate TNF-induced NF-κB and cell death responses in A20-deficient mice. Science289, 2350–2354 (2000). ArticleCAS Google Scholar
Trompouki, E. et al. CYLD is a deubiquitinating enzyme that negatively regulates NF-κB activation by TNFR family members. Nature424, 793–796 (2003). ArticleCAS Google Scholar
Wertz, I.E. et al. De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signaling. Nature430, 694–699 (2004). ArticleCAS Google Scholar
Jobin, C. & Sartor, R.B. The IκB/NF-κB system: a key determinant of mucosalinflammation and protection. Am. J. Physiol. Cell Physiol.278, C451–C462 (2000). ArticleCAS Google Scholar
Li, Q. & Verma, I.M. NF-κB regulation in the immune system. Nat. Rev. Immunol.2, 725–734 (2002). ArticleCAS Google Scholar
Prajapati, S.S., Verma, U., Yamamoto, Y.M., Kwak, Y.T. & Gaynor, R.B. Protein phosphatase 2Cβ association with the IκB kinase complex is involved in regulating NF-κB activity. J. Biol. Chem.279, 1739–1746 (2004). ArticleCAS Google Scholar
Li, S.T., Wang, L.Y., Berman, M.A., Zhang, Y. & Dorf, M.E. RNAi screen in mouse astrocytes identifies phosphatases that regulate NF-κB signaling. Mol. Cell24, 497–509 (2006). ArticleCAS Google Scholar
Man, J.H. et al. PIAS3 induction of PRB sumoylation represses PRB transactivation by destabilizing its retention in the nucleus. Nucleic Acids Res.34, 5552–5566 (2006). ArticleCAS Google Scholar
Pan, X. et al. Ubc9 interacts with SOX4 and represses its transcriptional activity. Biochem. Biophys. Res. Commun.344, 727–734 (2006). ArticleCAS Google Scholar