Control of the differentiation of regulatory T cells and TH17 cells by the DNA-binding inhibitor Id3 (original) (raw)
Bluestone, J.A. & Abbas, A.K. Natural versus adaptive regulatory T cells. Nat. Rev. Immunol.3, 253–257 (2003). ArticleCAS Google Scholar
Fontenot, J.D. & Rudensky, A.Y. A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3. Nat. Immunol.6, 331–337 (2005). ArticleCAS Google Scholar
Sakaguchi, S. Regulatory T cells: key controllers of immunologic self-tolerance. Cell101, 455–458 (2000). ArticleCAS Google Scholar
Shevach, E.M. CD4+CD25+ suppressor T cells: more questions than answers. Nat. Rev. Immunol.2, 389–400 (2002). ArticleCAS Google Scholar
von Boehmer, H. Mechanisms of suppression by suppressor T cells. Nat. Immunol.6, 338–344 (2005). ArticleCAS Google Scholar
Waldmann, H., Adams, E., Fairchild, P. & Cobbold, S. Infectious tolerance and the long-term acceptance of transplanted tissue. Immunol. Rev.212, 301–313 (2006). ArticleCAS Google Scholar
Hill, J.A., Benoist, C. & Mathis, D. Treg cells: guardians for life. Nat. Immunol.8, 124–125 (2007). ArticleCAS Google Scholar
Belkaid, Y. & Tarbell, K. Regulatory T cells in the control of host-microorganism interactions. Annu. Rev. Immunol.27, 551–589 (2009). ArticleCAS Google Scholar
Chen, W. et al. Conversion of peripheral CD4+CD25− naive T cells to CD4+CD25+ regulatory T cells by TGF-β induction of transcription factor Foxp3. J. Exp. Med.198, 1875–1886 (2003). ArticleCAS Google Scholar
Curotto de Lafaille, M.A. & Lafaille, J.J. Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor? Immunity30, 626–635 (2009). CASPubMed Google Scholar
Kretschmer, K. et al. Inducing and expanding regulatory T cell populations by foreign antigen. Nat. Immunol.6, 1219–1227 (2005). ArticleCAS Google Scholar
Liu, Y. et al. A critical function for TGF-β signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells. Nat. Immunol.9, 632–640 (2008). ArticleCAS Google Scholar
Wan, Y.Y. & Flavell, R.A. Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter. Proc. Natl. Acad. Sci. USA102, 5126–5131 (2005). ArticleCAS Google Scholar
Nolting, J. et al. Retinoic acid can enhance conversion of naive into regulatory T cells independently of secreted cytokines. J. Exp. Med.206, 2131–2139 (2009). ArticleCAS Google Scholar
Tone, Y. et al. Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer. Nat. Immunol.9, 194–202 (2008). ArticleCAS Google Scholar
Yang, X.O. et al. Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity29, 44–56 (2008). ArticleCAS Google Scholar
Quintana, F.J. et al. Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor. Nature453, 65–71 (2008). ArticleCAS Google Scholar
Bettelli, E. et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature441, 235–238 (2006). ArticleCAS Google Scholar
Ivanov, I.I. et al. The orphan nuclear receptor RORγt directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell126, 1121–1133 (2006). ArticleCAS Google Scholar
Mangan, P.R. et al. Transforming growth factor-β induces development of the TH17 lineage. Nature441, 231–234 (2006). ArticleCAS Google Scholar
Veldhoen, M., Hocking, R.J., Atkins, C.J., Locksley, R.M. & Stockinger, B. TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity24, 179–189 (2006). ArticleCAS Google Scholar
Zhou, L. et al. TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function. Nature453, 236–240 (2008). ArticleCAS Google Scholar
O'Shea, J.J. & Paul, W.E. Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells. Science327, 1098–1102 (2010). ArticleCAS Google Scholar
Murre, C. Helix-loop-helix proteins and lymphocyte development. Nat. Immunol.6, 1079–1086 (2005). ArticleCAS Google Scholar
Rivera, R.R., Johns, C.P., Quan, J., Johnson, R.S. & Murre, C. Thymocyte selection is regulated by the helix-loop-helix inhibitor protein, Id3. Immunity12, 17–26 (2000). ArticleCAS Google Scholar
Kee, B.L., Rivera, R.R. & Murre, C. Id3 inhibits B lymphocyte progenitor growth and survival in response to TGF-β. Nat. Immunol.2, 242–247 (2001). ArticleCAS Google Scholar
Li, H., Dai, M. & Zhuang, Y.A. T cell intrinsic role of Id3 in a mouse model for primary Sjogren's syndrome. Immunity21, 551–560 (2004). ArticleCAS Google Scholar
Thornton, A.M. et al. Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells. J. Immunol.184, 3433–3441 (2010). ArticleCAS Google Scholar
Mucida, D. et al. Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science317, 256–260 (2007). ArticleCAS Google Scholar
Nakao, A. et al. Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling. Nature389, 631–635 (1997). ArticleCAS Google Scholar
Cohen-Kaminsky, S. et al. Chromatin immunoselection defines a TAL-1 target gene. EMBO J.17, 5151–5160 (1998). ArticleCAS Google Scholar
Ghosh, I., Bishop, P. & Chmielewski, J. DNA binding properties of basic helix-loop-helix fusion proteins of Tal and E47. J. Pept. Res.57, 354–360 (2001). ArticleCAS Google Scholar
Ikawa, T., Kawamoto, H., Goldrath, A.W. & Murre, C. E proteins and Notch signaling cooperate to promote T cell lineage specification and commitment. J. Exp. Med.203, 1329–1342 (2006). ArticleCAS Google Scholar
Sun, X.H. & Baltimore, D. An inhibitory domain of E12 transcription factor prevents DNA binding in E12 homodimers but not in E12 heterodimers. Cell64, 459–470 (1991). ArticleCAS Google Scholar
Ruan, Q. et al. Development of Foxp3+ regulatory t cells is driven by the c-Rel enhanceosome. Immunity31, 932–940 (2009). ArticleCAS Google Scholar
Jones, M.E., Kondo, M. & Zhuang, Y. A tamoxifen inducible knock-in allele for investigation of E2A function. BMC Dev. Biol.9, 51 (2009). Article Google Scholar
Wojciechowski, J., Lai, A., Kondo, M. & Zhuang, Y. E2A and HEB are required to block thymocyte proliferation prior to pre-TCR expression. J. Immunol.178, 5717–5726 (2007). ArticleCAS Google Scholar
Zheng, W. & Flavell, R.A. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell89, 587–596 (1997). ArticleCAS Google Scholar
Mantel, P.Y. et al. GATA3-driven Th2 responses inhibit TGF-beta1-induced FOXP3 expression and the formation of regulatory T cells. PLoS Biol.5, e329 (2007). Article Google Scholar
Gorelik, L., Fields, P.E. & Flavell, R.A. Cutting edge: TGF-β inhibits Th type 2 development through inhibition of GATA-3 expression. J. Immunol.165, 4773–4777 (2000). ArticleCAS Google Scholar
Zhu, J. & Paul, W.E. CD4 T cells: fates, functions, and faults. Blood112, 1557–1569 (2008). ArticleCAS Google Scholar
Sun, Z. et al. Requirement for RORγ in thymocyte survival and lymphoid organ development. Science288, 2369–2373 (2000). ArticleCAS Google Scholar
Xi, H., Schwartz, R., Engel, I., Murre, C. & Kersh, G.J. Interplay between RORγt, Egr3, and E proteins controls proliferation in response to pre-TCR signals. Immunity24, 813–826 (2006). ArticleCAS Google Scholar
Schnyder-Candrian, S. et al. Interleukin-17 is a negative regulator of established allergic asthma. J. Exp. Med.203, 2715–2725 (2006). ArticleCAS Google Scholar
Nakae, S. et al. Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses. Immunity17, 375–387 (2002). ArticleCAS Google Scholar
Rudra, D. et al. Runx-CBFβ complexes control expression of the transcription factor Foxp3 in regulatory T cells. Nat. Immunol.10, 1170–1177 (2009). ArticleCAS Google Scholar
Kim, H.P. & Leonard, W.J. CREB/ATF-dependent T cell receptor-induced FoxP3 gene expression: a role for DNA methylation. J. Exp. Med.204, 1543–1551 (2007). ArticleCAS Google Scholar
Perruche, S. et al. Lethal effect of CD3-specific antibody in mice deficient in TGF-β1 by uncontrolled flu-like syndrome. J. Immunol.183, 953–961 (2009). ArticleCAS Google Scholar
Perruche, S. et al. CD3-specific antibody-induced immune tolerance involves transforming growth factor-β from phagocytes digesting apoptotic T cells. Nat. Med.14, 528–535 (2008). ArticleCAS Google Scholar